Blast performed on August-30-2010
BLASTP 2.2.13 [Nov-27-2005]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Database: uniref100 
           10,711,464 sequences; 3,761,183,004 total letters

Query= EG10326 folA 
         (159 letters)

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef100_A1A797 Dihydrofolate reductase n=5 Tax=Escherichia Rep...   333   3e-90 
UniRef100_P0ABQ5 Dihydrofolate reductase n=48 Tax=Enterobacteria...   333   3e-90 
UniRef100_A7ZHE1 Dihydrofolate reductase n=1 Tax=Escherichia col...   332   6e-90 
UniRef100_C3TR67 Dihydrofolate reductase type I; trimethoprim re...   332   6e-90 
UniRef100_D3H430 Dihydrofolate reductase n=1 Tax=Escherichia col...   330   2e-89 
UniRef100_Q8Z9J9 Dihydrofolate reductase type I n=3 Tax=Salmonel...   328   9e-89 
UniRef100_B4T6L3 Dihydrofolate reductase n=24 Tax=Salmonella ent...   328   1e-88 
UniRef100_C3TR68 Dihydrofolate reductase type I; trimethoprim re...   328   1e-88 
UniRef100_D2TGF3 Dihydrofolate reductase n=1 Tax=Citrobacter rod...   327   3e-88 
UniRef100_B1EML8 Dihydrofolate reductase n=1 Tax=Escherichia alb...   327   3e-88 
UniRef100_B4A3Q1 Dihydrofolate reductase n=1 Tax=Salmonella ente...   327   3e-88 
UniRef100_Q32K48 Dihydrofolate reductase type I n=1 Tax=Shigella...   326   4e-88 
UniRef100_B5BL24 Dihydrofolate reductase type I n=2 Tax=Salmonel...   326   4e-88 
UniRef100_A8ALQ3 Putative uncharacterized protein n=1 Tax=Citrob...   326   4e-88 
UniRef100_P31073 Dihydrofolate reductase n=3 Tax=Citrobacter Rep...   326   6e-88 
UniRef100_A9MQG5 Putative uncharacterized protein n=1 Tax=Salmon...   325   1e-87 
UniRef100_D2Z9N8 Putative uncharacterized protein n=1 Tax=Entero...   316   6e-85 
UniRef100_D5CH31 Dihydrofolate reductase n=1 Tax=Enterobacter cl...   314   2e-84 
UniRef100_C4X343 Trimethoprim resistance dihydrofolate reductase...   313   4e-84 
UniRef100_A4W6F4 Dihydrofolate reductase n=1 Tax=Enterobacter sp...   312   9e-84 
UniRef100_B5Y1Z7 Dihydrofolate reductase n=3 Tax=Klebsiella RepI...   311   1e-83 
UniRef100_P31074 Dihydrofolate reductase n=1 Tax=Enterobacter ae...   311   1e-83 
UniRef100_C8TBI7 Dihydrofolate reductase n=1 Tax=Klebsiella pneu...   306   5e-82 
UniRef100_P27498 Dihydrofolate reductase n=1 Tax=Klebsiella aero...   303   3e-81 
UniRef100_C9XVK4 Dihydrofolate reductase n=2 Tax=Cronobacter Rep...   302   7e-81 
UniRef100_C4UXT8 Dihydrofolate reductase n=1 Tax=Yersinia rohdei...   282   7e-75 
UniRef100_C4U0S2 Dihydrofolate reductase n=1 Tax=Yersinia kriste...   281   1e-74 
UniRef100_C4SIW8 Dihydrofolate reductase n=1 Tax=Yersinia freder...   281   2e-74 
UniRef100_C4RWF7 Dihydrofolate reductase n=1 Tax=Yersinia bercov...   279   6e-74 
UniRef100_D2BWQ4 Dihydrofolate reductase n=1 Tax=Dickeya dadanti...   279   8e-74 
UniRef100_C6C9F9 Dihydrofolate reductase n=1 Tax=Dickeya dadanti...   278   1e-73 
UniRef100_C8QA90 Dihydrofolate reductase n=1 Tax=Pantoea sp. At-...   278   2e-73 
UniRef100_A4TQE3 Dihydrofolate reductase n=24 Tax=Yersinia RepID...   277   2e-73 
UniRef100_UPI0001A4292B dihydrofolate reductase n=1 Tax=Pectobac...   277   3e-73 
UniRef100_C4SD95 Dihydrofolate reductase n=1 Tax=Yersinia mollar...   276   4e-73 
UniRef100_C4U9J8 Dihydrofolate reductase n=1 Tax=Yersinia aldova...   276   5e-73 
UniRef100_D0KML9 Dihydrofolate reductase n=1 Tax=Pectobacterium ...   276   7e-73 
UniRef100_C4T7L5 Dihydrofolate reductase n=1 Tax=Yersinia interm...   276   7e-73 
UniRef100_C6DEZ2 Dihydrofolate reductase n=1 Tax=Pectobacterium ...   275   9e-73 
UniRef100_UPI000190DAB1 dihydrofolate reductase n=1 Tax=Salmonel...   274   2e-72 
UniRef100_Q6D0D5 Dihydrofolate reductase n=1 Tax=Pectobacterium ...   274   2e-72 
UniRef100_C6CJ62 Dihydrofolate reductase n=1 Tax=Dickeya zeae Ec...   271   2e-71 
UniRef100_D4DXA7 Dihydrofolate reductase n=1 Tax=Serratia odorif...   271   2e-71 
UniRef100_C4ULN4 Dihydrofolate reductase n=1 Tax=Yersinia rucker...   271   2e-71 
UniRef100_D2T4F9 FolA protein n=2 Tax=Erwinia pyrifoliae RepID=D...   270   4e-71 
UniRef100_A8G9N6 Dihydrofolate reductase n=1 Tax=Serratia protea...   270   5e-71 
UniRef100_D1RWX7 Dihydrofolate reductase n=1 Tax=Serratia odorif...   270   5e-71 
UniRef100_D4GJN7 FolA n=1 Tax=Pantoea ananatis LMG 20103 RepID=D...   269   6e-71 
UniRef100_A1JJF1 Dihydrofolate reductase n=1 Tax=Yersinia entero...   269   8e-71 
UniRef100_Q7N8W0 Dihydrofolate reductase n=1 Tax=Photorhabdus lu...   268   1e-70 
UniRef100_D3VCQ8 Dihydrofolate reductase type I, trimethoprim re...   268   1e-70 
UniRef100_D4I0G8 Dihydrofolate reductase n=2 Tax=Erwinia amylovo...   268   1e-70 
UniRef100_B2VGQ7 Dihydrofolate reductase n=1 Tax=Erwinia tasmani...   268   1e-70 
UniRef100_D3V2G6 Dihydrofolate reductase type I, trimethoprim re...   263   4e-69 
UniRef100_C7BKH0 Dihydrofolate reductase n=1 Tax=Photorhabdus as...   262   8e-69 
UniRef100_Q2NVX9 Dihydrofolate reductase n=1 Tax=Sodalis glossin...   260   3e-68 
UniRef100_B4F2I5 Dihydrofolate reductase n=2 Tax=Proteus mirabil...   257   3e-67 
UniRef100_C0AT60 Putative uncharacterized protein n=1 Tax=Proteu...   255   1e-66 
UniRef100_D4BWU0 Dihydrofolate reductase n=1 Tax=Providencia ret...   249   9e-65 
UniRef100_D0ZC43 Dihydrofolate reductase n=1 Tax=Edwardsiella ta...   248   2e-64 
UniRef100_C5B7N8 Dihydrofolate reductase, putative n=1 Tax=Edwar...   247   3e-64 
UniRef100_B2PX52 Putative uncharacterized protein n=1 Tax=Provid...   245   1e-63 
UniRef100_D1P1H8 Putative uncharacterized protein n=1 Tax=Provid...   244   2e-63 
UniRef100_D4F219 Dihydrofolate reductase n=1 Tax=Edwardsiella ta...   244   3e-63 
UniRef100_B6XFY1 Putative uncharacterized protein n=1 Tax=Provid...   240   4e-62 
UniRef100_D2U2B2 Dihydrofolate reductase n=1 Tax=Arsenophonus na...   239   5e-62 
UniRef100_A0KNL5 Dihydrofolate reductase n=1 Tax=Aeromonas hydro...   191   3e-47 
UniRef100_C4K6P5 Dihydrofolate reductase type I, trimethoprim re...   186   9e-46 
UniRef100_C9QCG5 Dihydrofolate reductase n=1 Tax=Vibrio oriental...   183   5e-45 
UniRef100_A4SJJ4 Dihydrofolate reductase n=1 Tax=Aeromonas salmo...   182   8e-45 
UniRef100_A5L1A1 Dihydrofolate reductase n=1 Tax=Vibrionales bac...   182   1e-44 
lcl|unknown  Unknown                                              181   2e-44
UniRef100_A3UY31 Dihydrofolate reductase n=1 Tax=Vibrio splendid...   181   2e-44 
UniRef100_Q70YQ6 Dihydrofolate reductase n=1 Tax=Moritella profu...   181   3e-44 
UniRef100_C9NN44 Dihydrofolate reductase n=1 Tax=Vibrio corallii...   181   3e-44 
UniRef100_B8KEM2 Dihydrofolate reductase n=1 Tax=Vibrio parahaem...   180   4e-44 
UniRef100_B7VID9 Dihydrofolate reductase n=2 Tax=Vibrio RepID=B7...   180   4e-44 
UniRef100_Q6LV44 Putative Dihydrofolate reductase n=1 Tax=Photob...   180   5e-44 
UniRef100_Q1Z4P4 Putative Dihydrofolate reductase n=1 Tax=Photob...   180   5e-44 
UniRef100_D1MX71 Dihydrofolate reductase n=1 Tax=Moritella yayan...   179   7e-44 
UniRef100_Q5R038 Dihydrofolate reductase n=1 Tax=Idiomarina loih...   179   1e-43 
UniRef100_A6VM90 Dihydrofolate reductase n=1 Tax=Actinobacillus ...   178   1e-43 
UniRef100_Q1ZLZ5 Putative Dihydrofolate reductase n=1 Tax=Photob...   178   2e-43 
UniRef100_Q3LT92 FolA n=2 Tax=Vibrio harveyi RepID=Q3LT92_VIBHA       177   3e-43 
UniRef100_D0X9A9 Dihydrofolate reductase n=1 Tax=Vibrio harveyi ...   177   3e-43 
UniRef100_D0WT35 Dihydrofolate reductase n=2 Tax=Vibrio alginoly...   177   3e-43 
UniRef100_A6F6E6 Putative Dihydrofolate reductase n=1 Tax=Morite...   177   3e-43 
UniRef100_A6B5Q2 Dihydrofolate reductase n=2 Tax=Vibrio parahaem...   177   3e-43 
UniRef100_D1MX70 Dihydrofolate reductase n=1 Tax=Photobacterium ...   177   4e-43 
UniRef100_Q0EWL5 Dihydrofolate reductase n=1 Tax=Mariprofundus f...   176   6e-43 
UniRef100_C9P2R4 Dihydrofolate reductase n=1 Tax=Vibrio metschni...   176   6e-43 
UniRef100_Q2BZR8 Putative Dihydrofolate reductase n=1 Tax=Photob...   176   7e-43 
UniRef100_D0GU26 Dihydrofolate reductase n=1 Tax=Vibrio mimicus ...   176   1e-42 
UniRef100_D0M2N3 Dihydrofolate reductase n=1 Tax=Vibrio sp. Ex25...   175   1e-42 
UniRef100_D2YUL8 Dihydrofolate reductase n=1 Tax=Vibrio mimicus ...   175   1e-42 
UniRef100_A8T8F4 GTPase ObgE n=1 Tax=Vibrio sp. AND4 RepID=A8T8F...   175   1e-42 
UniRef100_A3WNK2 Dihydrofolate reductase n=1 Tax=Idiomarina balt...   175   1e-42 
UniRef100_C9PMD9 Dihydrofolate reductase n=1 Tax=Pasteurella dag...   175   2e-42 
UniRef100_D0IJU2 Dihydrofolate reductase n=1 Tax=Vibrio sp. RC58...   174   2e-42 
UniRef100_Q65RE5 FolA protein n=1 Tax=Mannheimia succiniciproduc...   174   3e-42 
UniRef100_A5UDH5 Dihydrofolate reductase n=3 Tax=Haemophilus inf...   174   3e-42 
UniRef100_A4N7X6 ATP-dependent RNA helicase n=3 Tax=Haemophilus ...   174   3e-42 
UniRef100_A6AS75 Dihydrofolate reductase n=1 Tax=Vibrio harveyi ...   174   4e-42 
UniRef100_Q4QM09 Dihydrofolate reductase n=1 Tax=Haemophilus inf...   172   8e-42 
UniRef100_Q9CJU8 FolA n=1 Tax=Pasteurella multocida RepID=Q9CJU8...   172   1e-41 
UniRef100_D4EE88 Dihydrofolate reductase n=1 Tax=Aggregatibacter...   172   1e-41 
UniRef100_C9R6T6 Putative uncharacterized protein n=1 Tax=Aggreg...   172   1e-41 
UniRef100_D2YI02 Dihydrofolate reductase n=1 Tax=Vibrio mimicus ...   172   1e-41 
UniRef100_P43791 Dihydrofolate reductase n=8 Tax=Haemophilus inf...   172   1e-41 
UniRef100_Q7MP89 Dihydrofolate reductase n=1 Tax=Vibrio vulnific...   171   2e-41 
UniRef100_Q8DEC9 Dihydrofolate reductase n=1 Tax=Vibrio vulnific...   171   2e-41 
UniRef100_Q5E867 Dihydrofolate reductase n=1 Tax=Vibrio fischeri...   171   3e-41 
UniRef100_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicad...   171   3e-41 
UniRef100_C4L9L7 Dihydrofolate reductase n=1 Tax=Tolumonas auens...   171   3e-41 
UniRef100_A6D791 Dihydrofolate reductase n=1 Tax=Vibrio shilonii...   171   3e-41 
UniRef100_C6APV3 Dihydrofolate reductase n=1 Tax=Aggregatibacter...   170   4e-41 
UniRef100_B5FGG3 Dihydrofolate reductase n=1 Tax=Vibrio fischeri...   170   4e-41 
UniRef100_D0I8H5 Dihydrofolate reductase n=1 Tax=Grimontia holli...   170   5e-41 
UniRef100_D7HDE4 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...   169   9e-41 
UniRef100_A6Y0I5 Dihydrofolate reductase n=3 Tax=Vibrio cholerae...   169   9e-41 
UniRef100_A6A7Q6 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...   169   9e-41 
UniRef100_A4NZZ8 Dihydrofolate reductase n=1 Tax=Haemophilus inf...   169   9e-41 
UniRef100_A2PXK6 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...   169   1e-40 
UniRef100_C9P9B7 Dihydrofolate reductase n=1 Tax=Vibrio furnissi...   167   3e-40 
UniRef100_C2IN22 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...   167   3e-40 
UniRef100_A2PC61 Dihydrofolate reductase n=2 Tax=Vibrio cholerae...   166   8e-40 
UniRef100_D0HUH5 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...   166   1e-39 
UniRef100_C9Q1P5 Dihydrofolate reductase n=1 Tax=Vibrio sp. RC34...   165   1e-39 
UniRef100_A5F8P5 Dihydrofolate reductase n=15 Tax=Vibrio cholera...   165   2e-39 
UniRef100_A4C912 Dihydrofolate reductase type I, trimethoprim re...   164   3e-39 
UniRef100_P12833 Dihydrofolate reductase type 3 n=1 Tax=Salmonel...   164   3e-39 
UniRef100_A6AHG6 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...   163   6e-39 
UniRef100_Q47VL9 Dihydrofolate reductase n=1 Tax=Colwellia psych...   162   8e-39 
UniRef100_Q1ZCG4 Dihydrofolate reductase n=1 Tax=Psychromonas sp...   162   1e-38 
UniRef100_D0KZ69 Dihydrofolate reductase n=1 Tax=Halothiobacillu...   160   3e-38 
UniRef100_B6EL46 Dihydrofolate reductase type 3 n=1 Tax=Aliivibr...   160   3e-38 
UniRef100_B0UV15 Dihydrofolate reductase n=2 Tax=Histophilus som...   160   3e-38 
UniRef100_C7R934 Dihydrofolate reductase n=1 Tax=Kangiella koree...   159   7e-38 
UniRef100_A1S9H0 Dihydrofolate reductase n=1 Tax=Shewanella amaz...   159   1e-37 
UniRef100_A0Y6E2 Dihydrofolate reductase type I, trimethoprim re...   158   2e-37 
UniRef100_B8GN07 Dihydrofolate reductase n=1 Tax=Thioalkalivibri...   157   3e-37 
UniRef100_C0N5C2 Dihydrofolate reductase n=1 Tax=Methylophaga th...   157   3e-37 
UniRef100_UPI0000E0ED99 Dihydrofolate reductase n=1 Tax=Rhodobac...   156   8e-37 
UniRef100_Q2BL89 Dihydrofolate reductase n=1 Tax=Neptuniibacter ...   156   8e-37 
UniRef100_Q15PF1 Dihydrofolate reductase n=1 Tax=Pseudoalteromon...   155   1e-36 
UniRef100_A0L069 Dihydrofolate reductase n=1 Tax=Shewanella sp. ...   155   1e-36 
UniRef100_Q07YJ3 Dihydrofolate reductase n=1 Tax=Shewanella frig...   155   2e-36 
UniRef100_Q0HS01 Dihydrofolate reductase n=1 Tax=Shewanella sp. ...   154   3e-36 
UniRef100_Q31I54 Dihydrofolate reductase n=1 Tax=Thiomicrospira ...   154   4e-36 
UniRef100_B1KGH4 Dihydrofolate reductase n=1 Tax=Shewanella wood...   154   4e-36 
UniRef100_A2V5V4 Dihydrofolate reductase region n=1 Tax=Shewanel...   153   5e-36 
UniRef100_Q8K9Z8 Dihydrofolate reductase n=1 Tax=Buchnera aphidi...   153   7e-36 
UniRef100_Q0HLT7 Dihydrofolate reductase n=1 Tax=Shewanella sp. ...   152   9e-36 
UniRef100_C5BMA4 Dihydrofolate reductase n=1 Tax=Teredinibacter ...   152   9e-36 
UniRef100_B0TUI5 Dihydrofolate reductase n=1 Tax=Shewanella hali...   152   1e-35 
UniRef100_D6RUA1 Dihydrofolate reductase n=1 Tax=Shewanella bent...   152   1e-35 
UniRef100_B4RZH2 Dihydrofolate reductase type I, trimethoprim re...   151   2e-35 
UniRef100_A8H0U7 Dihydrofolate reductase n=1 Tax=Shewanella peal...   151   2e-35 
UniRef100_P57243 Dihydrofolate reductase n=3 Tax=Buchnera aphidi...   151   2e-35 
UniRef100_A3QB98 Dihydrofolate reductase n=1 Tax=Shewanella loih...   151   3e-35 
UniRef100_D1KC52 Dihydrofolate reductase n=1 Tax=uncultured SUP0...   150   3e-35 
UniRef100_UPI0001AEC2DE dihydrofolate reductase type I, trimetho...   150   4e-35 
UniRef100_Q0ABL0 Dihydrofolate reductase n=1 Tax=Alkalilimnicola...   150   4e-35 
UniRef100_A9D6G1 Dihydrofolate reductase n=1 Tax=Shewanella bent...   150   4e-35 
UniRef100_Q8EB86 Dihydrofolate reductase n=1 Tax=Shewanella onei...   150   6e-35 
UniRef100_D6RUA3 Dihydrofolate reductase n=1 Tax=Shewanella bent...   150   6e-35 
UniRef100_D4XJC4 Dihydrofolate reductase n=1 Tax=Achromobacter p...   149   7e-35 
UniRef100_B0BPG8 Dihydrofolate reductase n=1 Tax=Actinobacillus ...   149   1e-34 
UniRef100_D5C3K8 Dihydrofolate reductase n=1 Tax=Nitrosococcus h...   149   1e-34 
UniRef100_D6RUA2 Dihydrofolate reductase n=1 Tax=Shewanella bent...   148   2e-34 
UniRef100_D0U4K0 Dihydrofolate reductase n=1 Tax=uncultured SUP0...   148   2e-34 
UniRef100_A1RMV3 Dihydrofolate reductase n=2 Tax=Shewanella RepI...   148   2e-34 
UniRef100_A3N0P3 Dihydrofolate reductase n=2 Tax=Actinobacillus ...   147   3e-34 
UniRef100_A7JRD3 Dihydrofolate reductase n=1 Tax=Mannheimia haem...   147   3e-34 
UniRef100_B0QU50 Dihydrofolate reductase n=1 Tax=Haemophilus par...   147   4e-34 
UniRef100_Q603S1 Dihydrofolate reductase n=1 Tax=Methylococcus c...   147   5e-34 
UniRef100_C1DK10 Dihydrofolate reductase n=1 Tax=Azotobacter vin...   147   5e-34 
UniRef100_B8EC01 Dihydrofolate reductase n=1 Tax=Shewanella balt...   147   5e-34 
UniRef100_Q3JEI1 Dihydrofolate reductase n=2 Tax=Nitrosococcus o...   147   5e-34 
UniRef100_A3D183 Dihydrofolate reductase n=1 Tax=Shewanella balt...   146   8e-34 
UniRef100_A3YH55 Dihydrofolate reductase n=1 Tax=Marinomonas sp....   146   8e-34 
UniRef100_A6WK54 Dihydrofolate reductase n=2 Tax=Shewanella balt...   145   1e-33 
UniRef100_Q1MYJ4 Dihydrofolate reductase n=1 Tax=Bermanella mari...   145   1e-33 
UniRef100_C8KWH5 Dihydrofolate reductase n=1 Tax=Actinobacillus ...   145   1e-33 
UniRef100_A8FRU7 Dihydrofolate reductase n=1 Tax=Shewanella sedi...   145   2e-33 
UniRef100_C4WF14 Dihydrofolate reductase type 3 n=1 Tax=Ochrobac...   145   2e-33 
UniRef100_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorift...   144   2e-33 
UniRef100_A6W1R3 Dihydrofolate reductase n=1 Tax=Marinomonas sp....   144   3e-33 
UniRef100_A4Y040 Dihydrofolate reductase n=1 Tax=Pseudomonas men...   144   3e-33 
UniRef100_A0Y9U0 Dihydrofolate reductase n=1 Tax=marine gamma pr...   144   3e-33 
UniRef100_Q89AV2 Dihydrofolate reductase n=1 Tax=Buchnera aphidi...   144   3e-33 
UniRef100_Q7VUE2 Dihydrofolate reductase n=1 Tax=Bordetella pert...   144   4e-33 
UniRef100_Q3IFF7 Dihydrofolate reductase type I, trimethoprim re...   143   5e-33 
UniRef100_A1U3D7 Dihydrofolate reductase n=1 Tax=Marinobacter aq...   143   5e-33 
UniRef100_UPI0001DAD9D5 UPI0001DAD9D5 related cluster n=1 Tax=un...   143   7e-33 
UniRef100_Q7WP14 Dihydrofolate reductase n=1 Tax=Bordetella bron...   143   7e-33 
UniRef100_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidat...   142   9e-33 
UniRef100_B8F4S8 Dihydrofolate reductase n=1 Tax=Haemophilus par...   142   9e-33 
UniRef100_A4VRN9 Dihydrofolate reductase n=1 Tax=Pseudomonas stu...   142   9e-33 
UniRef100_Q7W1B0 Dihydrofolate reductase n=1 Tax=Bordetella para...   142   1e-32 
UniRef100_B5JTJ3 Dihydrofolate reductase n=1 Tax=gamma proteobac...   142   2e-32 
UniRef100_A3JA79 Dihydrofolate reductase n=1 Tax=Marinobacter sp...   142   2e-32 
UniRef100_P11045 Dihydrofolate reductase n=1 Tax=Bacillus subtil...   142   2e-32 
UniRef100_UPI0001694629 Dihydrofolate reductase n=1 Tax=Paenibac...   141   2e-32 
UniRef100_Q8Y0U7 Probable dihydrofolate reductase oxidoreductase...   141   2e-32 
UniRef100_D5MV32 Dihydrofolate reductase n=1 Tax=Bacillus subtil...   141   2e-32 
UniRef100_C5S0S9 Dihydrofolate reductase n=1 Tax=Actinobacillus ...   141   2e-32 
UniRef100_Q12K26 Dihydrofolate reductase n=1 Tax=Shewanella deni...   141   3e-32 
UniRef100_Q0VM07 Dihydrofolate reductase n=1 Tax=Alcanivorax bor...   141   3e-32 
UniRef100_B4WYY5 Dihydrofolate reductase n=1 Tax=Alcanivorax sp....   141   3e-32 
UniRef100_B4SK37 Dihydrofolate reductase n=1 Tax=Stenotrophomona...   140   3e-32 
UniRef100_A6UYF3 Dihydrofolate reductase n=1 Tax=Pseudomonas aer...   140   3e-32 
UniRef100_C6MAK4 Dihydrofolate reductase n=1 Tax=Neisseria sicca...   140   3e-32 
UniRef100_Q9K7B6 Dihydrofolate reductase n=1 Tax=Bacillus halodu...   140   4e-32 
UniRef100_Q2W7P5 Dihydrofolate reductase n=1 Tax=Magnetospirillu...   140   4e-32 
UniRef100_A9I779 FolA protein n=1 Tax=Bordetella petrii DSM 1280...   140   4e-32 
UniRef100_A9M656 Dihydrofolate reductase type 3 n=2 Tax=Brucella...   140   4e-32 
UniRef100_B7S3D0 Dihydrofolate reductase n=1 Tax=marine gamma pr...   140   4e-32 
UniRef100_A5VRE6 Dihydrofolate reductase n=1 Tax=Brucella ovis A...   140   6e-32 
UniRef100_D6RUA4 Dihydrofolate reductase n=1 Tax=Shewanella geli...   140   6e-32 
UniRef100_D6LNG9 Dihydrofolate reductase n=1 Tax=Brucella sp. NV...   140   6e-32 
UniRef100_D5VFQ9 Dihydrofolate reductase n=1 Tax=Caulobacter seg...   140   6e-32 
UniRef100_C5PXK6 Dihydrofolate reductase n=1 Tax=Sphingobacteriu...   140   6e-32 
UniRef100_D1UG82 Dihydrofolate reductase n=1 Tax=Burkholderia sp...   139   8e-32 
UniRef100_D0B8M8 Dihydrofolate reductase n=29 Tax=Brucella RepID...   139   8e-32 
UniRef100_C0DS23 Putative uncharacterized protein n=1 Tax=Eikene...   139   8e-32 
UniRef100_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia...   139   1e-31 
UniRef100_B8CSY0 Dihydrofolate reductase n=1 Tax=Shewanella piez...   139   1e-31 
UniRef100_D4FXU4 Dihydrofolate reductase n=1 Tax=Bacillus subtil...   139   1e-31 
UniRef100_C9T7B2 Dihydrofolate reductase n=2 Tax=Brucella ceti R...   139   1e-31 
UniRef100_C2FZ23 Dihydrofolate reductase n=1 Tax=Sphingobacteriu...   139   1e-31 
UniRef100_B4AKS8 Dihydrofolate reductase n=1 Tax=Bacillus pumilu...   139   1e-31 
UniRef100_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnet...   139   1e-31 
UniRef100_Q02U65 Dihydrofolate reductase n=3 Tax=Pseudomonas aer...   139   1e-31 
UniRef100_UPI0001AF545F dihydrofolate reductase n=1 Tax=Pseudomo...   139   1e-31 
UniRef100_Q82WU4 Dihydrofolate reductase n=1 Tax=Nitrosomonas eu...   139   1e-31 
UniRef100_Q4K492 Dihydrofolate reductase n=1 Tax=Pseudomonas flu...   139   1e-31 
UniRef100_Q11HI1 Dihydrofolate reductase n=1 Tax=Chelativorans s...   139   1e-31 
UniRef100_B7V2R3 Dihydrofolate reductase n=1 Tax=Pseudomonas aer...   139   1e-31 
UniRef100_A6WZV5 Dihydrofolate reductase n=1 Tax=Ochrobactrum an...   139   1e-31 
UniRef100_C6MH59 Dihydrofolate reductase n=1 Tax=Nitrosomonas sp...   139   1e-31 
UniRef100_Q7VM78 Dihydrofolate reductase n=1 Tax=Haemophilus duc...   138   2e-31 
UniRef100_D5DPX0 Dihydrofolate reductase n=1 Tax=Bacillus megate...   138   2e-31 
UniRef100_D4ZGG4 Dihydrofolate reductase n=2 Tax=Shewanella viol...   138   2e-31 
UniRef100_D1CYY5 Dihydrofolate reductase n=1 Tax=Brucella sp. 83...   138   2e-31 
UniRef100_Q2SA18 Dihydrofolate reductase n=1 Tax=Hahella chejuen...   138   2e-31 
UniRef100_D3E9M7 Dihydrofolate reductase n=1 Tax=Geobacillus sp....   138   2e-31 
UniRef100_B2U8M3 Dihydrofolate reductase n=1 Tax=Ralstonia picke...   138   2e-31 
UniRef100_D5NDB7 Dihydrofolate reductase n=1 Tax=Burkholderia sp...   138   2e-31 
UniRef100_Q4ZM58 Dihydrofolate reductase n=1 Tax=Pseudomonas syr...   137   3e-31 
UniRef100_Q13VG2 Dihydrofolate reductase n=1 Tax=Burkholderia xe...   137   3e-31 
UniRef100_D5DJI3 Dihydrofolate reductase n=1 Tax=Bacillus megate...   137   3e-31 
UniRef100_C6BF02 Dihydrofolate reductase n=1 Tax=Ralstonia picke...   137   3e-31 
UniRef100_B8GXW8 Dihydrofolate reductase n=2 Tax=Caulobacter vib...   137   3e-31 
UniRef100_B7GI36 Dihydrofolate reductase n=1 Tax=Anoxybacillus f...   137   3e-31 
UniRef100_A8FEB8 Dihydrofolate reductase n=1 Tax=Bacillus pumilu...   137   3e-31 
UniRef100_A7GP91 Dihydrofolate reductase n=1 Tax=Bacillus cytoto...   137   3e-31 
UniRef100_A3NBZ0 Dihydrofolate reductase n=1 Tax=Burkholderia ps...   137   3e-31 
UniRef100_B7IV73 Dihydrofolate reductase n=4 Tax=Bacillus cereus...   137   3e-31 
UniRef100_UPI0001BC9B3D dihydrofolate reductase n=2 Tax=Pseudomo...   137   4e-31 
UniRef100_B8I0T9 Dihydrofolate reductase region n=1 Tax=Clostrid...   137   4e-31 
UniRef100_B2FPG1 Putative dihydrofolate reductase n=1 Tax=Stenot...   137   4e-31 
UniRef100_Q1YUR3 FolA, dihydrofolate reductase n=1 Tax=gamma pro...   137   4e-31 
UniRef100_D2LYG2 Dihydrofolate reductase n=1 Tax=Bacillus cellul...   137   4e-31 
UniRef100_C2PVF9 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   137   4e-31 
UniRef100_A3RP92 Dihydrofolate reductase n=3 Tax=Ralstonia solan...   137   4e-31 
UniRef100_Q0K888 Dihydrofolate reductase n=1 Tax=Ralstonia eutro...   137   5e-31 
UniRef100_A3L075 Dihydrofolate reductase n=1 Tax=Pseudomonas aer...   137   5e-31 
UniRef100_Q88AF3 Dihydrofolate reductase n=1 Tax=Pseudomonas syr...   136   6e-31 
UniRef100_B3R5A7 Dihydrofolate reductase type I n=1 Tax=Cupriavi...   136   6e-31 
UniRef100_B2T5Z4 Dihydrofolate reductase n=1 Tax=Burkholderia ph...   136   6e-31 
UniRef100_B1HZG5 Dihydrofolate reductase type 3 n=1 Tax=Lysiniba...   136   6e-31 
UniRef100_D7BGN7 Dihydrofolate reductase n=1 Tax=Meiothermus sil...   136   6e-31 
UniRef100_Q0AHA5 Dihydrofolate reductase n=1 Tax=Nitrosomonas eu...   136   8e-31 
UniRef100_B7JMG6 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   136   8e-31 
UniRef100_Q4MHD3 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   136   8e-31 
UniRef100_C7ILG0 Dihydrofolate reductase n=1 Tax=Clostridium pap...   136   8e-31 
UniRef100_C3I065 Dihydrofolate reductase n=9 Tax=Bacillus cereus...   136   8e-31 
UniRef100_D5TYB8 Dihydrofolate reductase n=9 Tax=Bacillus cereus...   136   8e-31 
UniRef100_A1V6H9 Dihydrofolate reductase n=17 Tax=pseudomallei g...   136   8e-31 
UniRef100_Q7NZ94 Dihydrofolate reductase n=1 Tax=Chromobacterium...   135   1e-30 
UniRef100_D2ZXL7 Dihydrofolate reductase n=1 Tax=Neisseria mucos...   135   1e-30 
UniRef100_D1F9R4 Dihydrofolate reductase n=1 Tax=Brucella melite...   135   1e-30 
UniRef100_C3H0I3 Dihydrofolate reductase n=1 Tax=Bacillus thurin...   135   1e-30 
UniRef100_C2QSJ2 Dihydrofolate reductase n=2 Tax=Bacillus cereus...   135   1e-30 
UniRef100_B5UX12 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   135   1e-30 
UniRef100_B1GA87 Dihydrofolate reductase n=1 Tax=Burkholderia gr...   135   1e-30 
UniRef100_A6F446 Dihydrofolate reductase n=1 Tax=Marinobacter al...   135   1e-30 
UniRef100_A3I5X4 Dihydrofolate reductase n=1 Tax=Bacillus sp. B1...   135   1e-30 
UniRef100_D3RVQ7 Dihydrofolate reductase n=1 Tax=Allochromatium ...   135   1e-30 
UniRef100_D7HV19 Dihydrofolate reductase n=1 Tax=Pseudomonas sav...   135   1e-30 
UniRef100_Q48CM2 Dihydrofolate reductase n=1 Tax=Pseudomonas syr...   135   2e-30 
UniRef100_C3AL65 Dihydrofolate reductase n=3 Tax=Bacillus RepID=...   135   2e-30 
UniRef100_C2QBJ3 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   135   2e-30 
UniRef100_B8L0L5 Dihydrofolate reductase n=1 Tax=Stenotrophomona...   135   2e-30 
UniRef100_A9VTX1 Dihydrofolate reductase n=22 Tax=Bacillus cereu...   135   2e-30 
UniRef100_A6DH01 Dihydrofolate reductase n=1 Tax=Lentisphaera ar...   135   2e-30 
UniRef100_Q3K556 Dihydrofolate reductase n=1 Tax=Pseudomonas flu...   134   2e-30 
UniRef100_B7KQG1 Dihydrofolate reductase n=1 Tax=Methylobacteriu...   134   2e-30 
UniRef100_A0RDM0 Dihydrofolate reductase n=4 Tax=Bacillus cereus...   134   2e-30 
UniRef100_C4KS28 Dihydrofolate reductase n=1 Tax=Burkholderia ps...   134   2e-30 
UniRef100_C0Y9S3 Dihydrofolate reductase n=1 Tax=Burkholderia ps...   134   2e-30 
UniRef100_B3ZGR0 Dihydrofolate reductase n=3 Tax=Bacillus cereus...   134   2e-30 
UniRef100_Q3JQ22 Dihydrofolate reductase n=4 Tax=Burkholderia ps...   134   2e-30 
UniRef100_A6EGV0 Dihydrofolate reductase n=1 Tax=Pedobacter sp. ...   134   2e-30 
UniRef100_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia rucker...   134   3e-30 
UniRef100_UPI00016A667D Dihydrofolate reductase n=1 Tax=Burkhold...   134   4e-30 
UniRef100_Q3SH97 Dihydrofolate reductase n=1 Tax=Thiobacillus de...   134   4e-30 
UniRef100_D3SBJ1 Dihydrofolate reductase n=1 Tax=Thioalkalivibri...   134   4e-30 
UniRef100_C4ZPF3 Dihydrofolate reductase n=1 Tax=Thauera sp. MZ1...   134   4e-30 
UniRef100_C5TPR0 Dihydrofolate reductase n=1 Tax=Neisseria flave...   134   4e-30 
UniRef100_C0ER02 Putative uncharacterized protein n=1 Tax=Neisse...   134   4e-30 
UniRef100_UPI00016AD9D2 dihydrofolate reductase n=1 Tax=Burkhold...   133   5e-30 
UniRef100_Q2KYI7 Dihydrofolate reductase n=1 Tax=Bordetella aviu...   133   5e-30 
UniRef100_Q1IGG6 Dihydrofolate reductase type I, trimethoprim re...   133   5e-30 
UniRef100_D2QJY0 Dihydrofolate reductase n=1 Tax=Spirosoma lingu...   133   5e-30 
UniRef100_C7C7F5 Dihydrofolate reductase n=1 Tax=Methylobacteriu...   133   5e-30 
UniRef100_C5AD54 Dihydrofolate reductase n=1 Tax=Burkholderia gl...   133   5e-30 
UniRef100_C1D4I6 Dihydrofolate reductase n=1 Tax=Laribacter hong...   133   5e-30 
UniRef100_B1M531 Dihydrofolate reductase n=1 Tax=Methylobacteriu...   133   5e-30 
UniRef100_C2UUU4 Dihydrofolate reductase n=4 Tax=Bacillus cereus...   133   5e-30 
UniRef100_Q738X6 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   133   7e-30 
UniRef100_C3K3P6 Dihydrofolate reductase n=1 Tax=Pseudomonas flu...   133   7e-30 
UniRef100_B1ZDL8 Dihydrofolate reductase n=1 Tax=Methylobacteriu...   133   7e-30 
UniRef100_C5AUJ5 Dihydrofolate reductase n=2 Tax=Methylobacteriu...   133   7e-30 
UniRef100_B9BA87 Dihydrofolate reductase n=3 Tax=Burkholderia mu...   133   7e-30 
UniRef100_A4ABY4 Dihydrofolate reductase n=1 Tax=Congregibacter ...   133   7e-30 
UniRef100_A3TMG5 Probable dihydrofolate reductase oxidoreductase...   133   7e-30 
UniRef100_UPI00016A6DB3 dihydrofolate reductase n=1 Tax=Burkhold...   132   1e-29 
UniRef100_Q473Z0 Dihydrofolate reductase n=1 Tax=Ralstonia eutro...   132   1e-29 
UniRef100_D3N350 Dihydrofolate reductase n=1 Tax=Burkholderia sp...   132   1e-29 
UniRef100_C2YR77 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   132   1e-29 
UniRef100_B9Z6Q0 Dihydrofolate reductase n=1 Tax=Lutiella nitrof...   132   1e-29 
UniRef100_UPI00016A3836 dihydrofolate reductase n=1 Tax=Burkhold...   132   2e-29 
UniRef100_Q39IC3 Dihydrofolate reductase n=1 Tax=Burkholderia sp...   132   2e-29 
UniRef100_Q1LK80 Dihydrofolate reductase n=1 Tax=Cupriavidus met...   132   2e-29 
UniRef100_C6J4X9 Dihydrofolate reductase n=1 Tax=Paenibacillus s...   132   2e-29 
UniRef100_C2PEK5 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   132   2e-29 
UniRef100_Q88CP8 Dihydrofolate reductase n=1 Tax=Pseudomonas put...   131   2e-29 
UniRef100_C5DAR3 Dihydrofolate reductase n=1 Tax=Geobacillus sp....   131   2e-29 
UniRef100_A9ADR8 Dihydrofolate reductase n=2 Tax=Burkholderia mu...   131   2e-29 
UniRef100_D5R6D4 Dihydrofolate reductase n=1 Tax=Clostridium len...   131   2e-29 
UniRef100_C2XTJ8 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   131   2e-29 
UniRef100_C2SJJ2 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   131   2e-29 
UniRef100_UPI000038402E COG0262: Dihydrofolate reductase n=1 Tax...   131   3e-29 
UniRef100_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus s...   131   3e-29 
UniRef100_B8IF21 Dihydrofolate reductase region n=1 Tax=Methylob...   131   3e-29 
UniRef100_B1YHM1 Dihydrofolate reductase n=1 Tax=Exiguobacterium...   131   3e-29 
UniRef100_A9W645 Dihydrofolate reductase n=1 Tax=Methylobacteriu...   131   3e-29 
UniRef100_A1AXR7 Dihydrofolate reductase n=1 Tax=Candidatus Ruth...   131   3e-29 
UniRef100_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pi...   130   4e-29 
UniRef100_A5WAG5 Dihydrofolate reductase n=1 Tax=Pseudomonas put...   130   4e-29 
UniRef100_A4JCL0 Dihydrofolate reductase n=1 Tax=Burkholderia vi...   130   4e-29 
UniRef100_A0K5Q8 Dihydrofolate reductase n=1 Tax=Burkholderia ce...   130   4e-29 
UniRef100_D5H463 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   130   4e-29 
UniRef100_B5BLW0 Dihydrofolate reductase n=9 Tax=Bacilli RepID=B...   130   4e-29 
UniRef100_UPI000038356A COG0262: Dihydrofolate reductase n=1 Tax...   130   5e-29 
UniRef100_Q0BH56 Dihydrofolate reductase n=1 Tax=Burkholderia am...   130   5e-29 
UniRef100_B3PIV8 Dihydrofolate reductase n=1 Tax=Cellvibrio japo...   130   5e-29 
UniRef100_B1JXV6 Dihydrofolate reductase n=1 Tax=Burkholderia ce...   130   5e-29 
UniRef100_B0KN86 Dihydrofolate reductase n=1 Tax=Pseudomonas put...   130   5e-29 
UniRef100_C2Z7I5 Dihydrofolate reductase n=2 Tax=Bacillus cereus...   130   5e-29 
UniRef100_Q39RF9 Dihydrofolate reductase n=1 Tax=Geobacter metal...   130   6e-29 
UniRef100_Q2IYG6 Dihydrofolate reductase n=1 Tax=Rhodopseudomona...   130   6e-29 
UniRef100_B1YV70 Dihydrofolate reductase n=1 Tax=Burkholderia am...   130   6e-29 
UniRef100_B1FJ18 Dihydrofolate reductase n=1 Tax=Burkholderia am...   130   6e-29 
UniRef100_C6XT74 Dihydrofolate reductase n=1 Tax=Pedobacter hepa...   129   1e-28 
UniRef100_B0UDD2 Dihydrofolate reductase n=1 Tax=Methylobacteriu...   129   1e-28 
UniRef100_C3W7H6 Dihydrofolate reductase n=2 Tax=Staphylococcus ...   129   1e-28 
UniRef100_C2W7N0 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   129   1e-28 
UniRef100_A2WBN5 Dihydrofolate reductase n=1 Tax=Burkholderia do...   129   1e-28 
UniRef100_A2VRV2 Dihydrofolate reductase n=1 Tax=Burkholderia ce...   129   1e-28 
UniRef100_B4EAM3 Dihydrofolate reductase n=1 Tax=Burkholderia ce...   128   2e-28 
UniRef100_B1Y5E0 Dihydrofolate reductase n=1 Tax=Leptothrix chol...   128   2e-28 
UniRef100_B0T4Y7 Dihydrofolate reductase n=1 Tax=Caulobacter sp....   128   2e-28 
UniRef100_A1KAF8 FolA protein n=1 Tax=Azoarcus sp. BH72 RepID=A1...   128   2e-28 
UniRef100_A6CH84 Dihydrofolate reductase n=1 Tax=Bacillus sp. SG...   128   2e-28 
UniRef100_Q2Y7L3 Dihydrofolate reductase n=1 Tax=Nitrosospira mu...   128   2e-28 
UniRef100_Q1BXZ1 Dihydrofolate reductase n=1 Tax=Burkholderia ce...   128   2e-28 
UniRef100_B1J2N5 Dihydrofolate reductase n=1 Tax=Pseudomonas put...   128   2e-28 
UniRef100_Q2B1Y2 Dihydrofolate reductase n=1 Tax=Bacillus sp. NR...   128   2e-28 
UniRef100_D6L006 Dihydrofolate reductase n=1 Tax=Simonsiella mue...   128   2e-28 
UniRef100_D5WAH3 Dihydrofolate reductase n=1 Tax=Burkholderia sp...   128   2e-28 
UniRef100_A8TM77 Dihydrofolate reductase n=1 Tax=alpha proteobac...   128   2e-28 
UniRef100_UPI00016A4F70 dihydrofolate reductase n=1 Tax=Burkhold...   127   3e-28 
UniRef100_Q2SXY8 Dihydrofolate reductase n=1 Tax=Burkholderia th...   127   3e-28 
UniRef100_A9IW81 Dihydrofolate reductase n=1 Tax=Bartonella trib...   127   3e-28 
UniRef100_B1T1L1 Dihydrofolate reductase n=1 Tax=Burkholderia am...   127   3e-28 
UniRef100_A0PBE3 Dihydrofolate reductase n=1 Tax=Photobacterium ...   127   3e-28 
UniRef100_Q65IB5 DfrA n=1 Tax=Bacillus licheniformis ATCC 14580 ...   127   4e-28 
UniRef100_Q5P234 Dihydrofolate reductase n=1 Tax=Aromatoleum aro...   127   4e-28 
UniRef100_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fer...   127   4e-28 
UniRef100_C0ZI90 Dihydrofolate reductase n=1 Tax=Brevibacillus b...   127   4e-28 
UniRef100_A7HVX5 Dihydrofolate reductase n=1 Tax=Parvibaculum la...   127   4e-28 
UniRef100_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesi...   127   4e-28 
UniRef100_C6QQX0 Dihydrofolate reductase n=2 Tax=Geobacillus Rep...   127   4e-28 
UniRef100_B2I6E9 Dihydrofolate reductase n=2 Tax=Xylella fastidi...   127   5e-28 
UniRef100_Q3R9N2 Dihydrofolate reductase n=1 Tax=Xylella fastidi...   127   5e-28 
UniRef100_D4DN27 Dihydrofolate reductase n=1 Tax=Neisseria elong...   127   5e-28 
UniRef100_C6ARN7 Dihydrofolate reductase n=1 Tax=Rhizobium legum...   126   7e-28 
UniRef100_B9M6P8 Dihydrofolate reductase n=1 Tax=Geobacter sp. F...   126   7e-28 
UniRef100_B5ZWE4 Dihydrofolate reductase n=1 Tax=Rhizobium legum...   126   7e-28 
UniRef100_A6UB22 Dihydrofolate reductase n=1 Tax=Sinorhizobium m...   126   7e-28 
UniRef100_B5WVB7 Dihydrofolate reductase n=1 Tax=Burkholderia sp...   126   7e-28 
UniRef100_D3FZ31 Dihydrofolate reductase n=1 Tax=Bacillus pseudo...   126   9e-28 
UniRef100_C8SLZ0 Dihydrofolate reductase n=1 Tax=Mesorhizobium o...   126   9e-28 
UniRef100_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylop...   125   1e-27 
UniRef100_Q2K6G9 Dihydrofolate reductase protein n=1 Tax=Rhizobi...   125   1e-27 
UniRef100_Q1QUE0 Dihydrofolate reductase n=1 Tax=Chromohalobacte...   125   1e-27 
UniRef100_D4G8G5 Dihydrofolate reductase n=1 Tax=Candidatus Ries...   125   1e-27 
UniRef100_D7N4S5 Dihydrofolate reductase n=1 Tax=Neisseria sp. o...   125   1e-27 
UniRef100_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobac...   125   1e-27 
UniRef100_B3PTQ3 Dihydrofolate reductase protein n=2 Tax=Rhizobi...   125   1e-27 
UniRef100_A4CPT6 Dihydrofolate reductase n=1 Tax=Robiginitalea b...   125   1e-27 
UniRef100_Q05GI2 Putative trimethoprim resistance dihydrofolate ...   125   1e-27 
UniRef100_Q21NW4 Dihydrofolate reductase n=1 Tax=Saccharophagus ...   125   2e-27 
UniRef100_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium...   124   3e-27 
UniRef100_Q1ME83 Putative dihydrofolate reductase n=1 Tax=Rhizob...   124   3e-27 
UniRef100_A5GBA2 Dihydrofolate reductase n=1 Tax=Geobacter urani...   124   3e-27 
UniRef100_D5X0X7 Dihydrofolate reductase n=1 Tax=Thiomonas inter...   124   3e-27 
UniRef100_Q9PB14 Dihydrofolate reductase type III n=1 Tax=Xylell...   124   4e-27 
UniRef100_Q3BX85 Dihydrofolate reductase n=1 Tax=Xanthomonas cam...   124   4e-27 
UniRef100_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xant...   124   4e-27 
UniRef100_C3MEC3 Dihydrofolate reductase n=1 Tax=Rhizobium sp. N...   124   4e-27 
UniRef100_C5V5U0 Dihydrofolate reductase n=1 Tax=Gallionella cap...   124   4e-27 
UniRef100_Q98KI7 Dihydrofolate reductase n=1 Tax=Mesorhizobium l...   123   6e-27 
UniRef100_A4INY0 Dihydrofolate reductase n=2 Tax=Geobacillus Rep...   123   6e-27 
UniRef100_B0U3I9 Dihydrofolate reductase n=3 Tax=Xylella fastidi...   123   6e-27 
UniRef100_D6CT04 Dihydrofolate reductase type 3 n=1 Tax=Thiomona...   123   6e-27 
UniRef100_B4W5U5 Dihydrofolate reductase n=1 Tax=Brevundimonas s...   123   6e-27 
UniRef100_Q92NQ7 Probable dihydrofolate reductase n=1 Tax=Sinorh...   123   7e-27 
UniRef100_Q0C500 Dihydrofolate reductase n=1 Tax=Hyphomonas nept...   123   7e-27 
UniRef100_B9JGK8 Dihydrofolate reductase protein n=1 Tax=Agrobac...   123   7e-27 
UniRef100_B0MUX5 Putative uncharacterized protein n=1 Tax=Alisti...   122   1e-26 
UniRef100_A4B9F5 Dihydrofolate reductase n=1 Tax=Reinekea blande...   122   1e-26 
UniRef100_UPI000190802D dihydrofolate reductase protein n=1 Tax=...   122   1e-26 
UniRef100_UPI0001907CE2 dihydrofolate reductase protein n=1 Tax=...   122   1e-26 
UniRef100_A1ZDK5 Dihydrofolate reductase n=1 Tax=Microscilla mar...   122   1e-26 
UniRef100_Q5KZ26 Dihydrofolate reductase n=1 Tax=Geobacillus kau...   122   2e-26 
UniRef100_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacte...   122   2e-26 
UniRef100_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter n...   122   2e-26 
UniRef100_Q71YE2 Dihydrofolate reductase n=3 Tax=root RepID=Q71Y...   122   2e-26 
UniRef100_D2MH00 Dihydrofolate reductase n=1 Tax=Rhodopseudomona...   122   2e-26 
UniRef100_C8JS20 Dihydrofolate reductase n=9 Tax=Listeria monocy...   122   2e-26 
UniRef100_C9RST4 Dihydrofolate reductase n=2 Tax=Geobacillus Rep...   122   2e-26 
UniRef100_D2NUZ8 Putative uncharacterized protein n=2 Tax=Lister...   121   2e-26 
UniRef100_B3QEZ8 Dihydrofolate reductase n=2 Tax=Rhodopseudomona...   121   2e-26 
UniRef100_B2JF42 Dihydrofolate reductase n=1 Tax=Burkholderia ph...   121   2e-26 
UniRef100_Q1VWN8 Dihydrofolate reductase n=1 Tax=Psychroflexus t...   121   2e-26 
UniRef100_D7D6N2 Dihydrofolate reductase n=1 Tax=Geobacillus sp....   121   2e-26 
UniRef100_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas s...   121   2e-26 
UniRef100_C5SJ39 Dihydrofolate reductase n=1 Tax=Asticcacaulis e...   121   2e-26 
UniRef100_A1UTA4 Dihydrofolate reductase n=1 Tax=Bartonella baci...   121   3e-26 
UniRef100_D1D7V4 Dihydrofolate reductase n=3 Tax=Neisseria gonor...   121   3e-26 
UniRef100_D0WDI7 Dihydrofolate reductase n=1 Tax=Neisseria lacta...   121   3e-26 
UniRef100_C6S8Z8 Dihydrofolate reductase n=1 Tax=Neisseria menin...   120   4e-26 
UniRef100_B8DDM9 Dihydrofolate reductase n=2 Tax=Listeria monocy...   120   4e-26 
UniRef100_D6H5J1 Dihydrofolate reductase FolA n=2 Tax=Neisseria ...   120   4e-26 
UniRef100_C1PFX1 Dihydrofolate reductase n=1 Tax=Bacillus coagul...   120   4e-26 
UniRef100_Q134B2 Dihydrofolate reductase n=1 Tax=Rhodopseudomona...   120   5e-26 
UniRef100_C6AEH4 Dihydrofolate reductase FolA n=1 Tax=Bartonella...   120   5e-26 
UniRef100_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax para...   120   5e-26 
UniRef100_B4RNR3 FolA n=1 Tax=Neisseria gonorrhoeae NCCP11945 Re...   120   5e-26 
UniRef100_A9M313 Dihydrofolate reductase n=2 Tax=Neisseria menin...   120   5e-26 
UniRef100_A4SVT6 Dihydrofolate reductase n=1 Tax=Polynucleobacte...   120   5e-26 
UniRef100_D6V2P9 Dihydrofolate reductase n=1 Tax=Afipia sp. 1NLS...   120   5e-26 
UniRef100_Q5F669 Dihydrofolate reductase n=6 Tax=Neisseria gonor...   120   5e-26 
UniRef100_A3UE72 Dihydrofolate reductase n=1 Tax=Oceanicaulis al...   120   5e-26 
UniRef100_C9X2U0 Dihydrofolate reductase n=1 Tax=Neisseria menin...   120   6e-26 
UniRef100_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltic...   120   6e-26 
UniRef100_D4W574 Dihydrofolate reductase n=1 Tax=Turicibacter sp...   120   6e-26 
UniRef100_D4SVP4 Dihydrofolate reductase type III n=1 Tax=Xantho...   120   6e-26 
UniRef100_D1DYB7 Dihydrofolate reductase n=2 Tax=Neisseria gonor...   120   6e-26 
UniRef100_C0YTZ2 Possible dihydrofolate reductase type I involve...   120   6e-26 
UniRef100_Q4UR36 Dihydrofolate reductase type III n=2 Tax=Xantho...   119   8e-26 
UniRef100_D2UFT3 Probable dihydrofolate reductase protein n=1 Ta...   119   8e-26 
UniRef100_D1EHM6 Dihydrofolate reductase n=3 Tax=Neisseria gonor...   119   8e-26 
UniRef100_C2S379 Dihydrofolate reductase n=1 Tax=Bacillus cereus...   119   8e-26 
UniRef100_P04174 Dihydrofolate reductase n=1 Tax=Neisseria gonor...   119   8e-26 
UniRef100_D0ME22 Dihydrofolate reductase n=1 Tax=Rhodothermus ma...   119   1e-25 
UniRef100_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mob...   119   1e-25 
UniRef100_B6INW3 Dihydrofolate reductase n=1 Tax=Rhodospirillum ...   119   1e-25 
UniRef100_D3HPI7 Dihydrofolate reductase FolA n=2 Tax=Legionella...   119   1e-25 
UniRef100_Q9K168 Dihydrofolate reductase n=1 Tax=Neisseria menin...   119   1e-25 
UniRef100_Q9JSQ9 Dihydrofolate reductase n=2 Tax=Neisseria menin...   119   1e-25 
UniRef100_C1D068 Putative dihydrofolate reductase (Tetrahydrofol...   118   2e-25 
UniRef100_B0RUI6 Dihydrofolate reductase , probable n=1 Tax=Xant...   118   2e-25 
UniRef100_A2SN57 Dihydrofolate reductase n=1 Tax=Methylibium pet...   118   2e-25 
UniRef100_A9D3J2 Probable dihydrofolate reductase protein n=1 Ta...   118   2e-25 
UniRef100_Q5X875 Dihydrofolate reductase FolA n=1 Tax=Legionella...   118   2e-25 
UniRef100_A1KVY2 Dihydrofolate reductase n=1 Tax=Neisseria menin...   118   2e-25 
UniRef100_Q92AD5 Lin1987 protein n=1 Tax=Listeria innocua RepID=...   117   3e-25 
UniRef100_C6WWY5 Dihydrofolate reductase n=1 Tax=Methylotenera m...   117   3e-25 
UniRef100_B4RGA7 Dihydrofolate reductase n=1 Tax=Phenylobacteriu...   117   3e-25 
UniRef100_D4T5W7 Dihydrofolate reductase type III n=1 Tax=Xantho...   117   3e-25 
UniRef100_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris...   117   3e-25 
UniRef100_A3J0E0 Dihydrofolate reductase n=1 Tax=Flavobacteria b...   117   3e-25 
UniRef100_Q5WZM8 Dihydrofolate reductase FolA n=1 Tax=Legionella...   117   4e-25 
UniRef100_A7Z5T2 DfrA n=1 Tax=Bacillus amyloliquefaciens FZB42 R...   117   4e-25 
UniRef100_A2SHH1 Dihydrofolate reductase n=1 Tax=Methylibium pet...   117   4e-25 
UniRef100_Q57426 Dihydrofolate reductase n=2 Tax=Bacillales RepI...   117   4e-25 
UniRef100_C4GG99 Putative uncharacterized protein n=1 Tax=Kingel...   117   4e-25 
UniRef100_Q54277 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   117   4e-25 
UniRef100_Q8PP44 Dihydrofolate reductase type III n=1 Tax=Xantho...   117   5e-25 
UniRef100_Q5ZYR2 Dihydrofolate reductase n=1 Tax=Legionella pneu...   117   5e-25 
UniRef100_D3PT29 Dihydrofolate reductase n=1 Tax=Meiothermus rub...   117   5e-25 
UniRef100_D3NQH5 Dihydrofolate reductase n=1 Tax=Azospirillum sp...   117   5e-25 
UniRef100_Q74FN5 Dihydrofolate reductase n=1 Tax=Geobacter sulfu...   116   7e-25 
UniRef100_D7NBT0 Dihydrofolate reductase n=1 Tax=Prevotella oris...   116   7e-25 
UniRef100_C6QE80 Dihydrofolate reductase n=1 Tax=Hyphomicrobium ...   116   7e-25 
UniRef100_Q18HG9 Dihydrofolate reductase n=1 Tax=Haloquadratum w...   116   7e-25 
UniRef100_Q9UWQ4 Dihydrofolate reductase n=1 Tax=Haloferax volca...   116   7e-25 
UniRef100_C6X2F4 Dihydrofolate reductase n=1 Tax=Flavobacteriace...   116   9e-25 
UniRef100_A0AJX9 DfrA protein n=1 Tax=Listeria welshimeri serova...   116   9e-25 
UniRef100_D7AFP8 Dihydrofolate reductase n=1 Tax=Geobacter sulfu...   116   9e-25 
UniRef100_D0W3P7 Dihydrofolate reductase n=1 Tax=Neisseria ciner...   116   9e-25 
UniRef100_D4GXT3 Dihydrofolate reductase n=1 Tax=Haloferax volca...   116   9e-25 
UniRef100_B9LR90 Dihydrofolate reductase region n=1 Tax=Halorubr...   115   1e-24 
UniRef100_D5T7T8 Dihydrofolate reductase n=2 Tax=Legionella pneu...   115   2e-24 
UniRef100_A2TSC5 Dihydrofolate reductase n=1 Tax=Dokdonia dongha...   115   2e-24 
UniRef100_Q6FZ92 Dihydrofolate reductase n=1 Tax=Bartonella quin...   115   2e-24 
UniRef100_A3ZN23 FolA, dihydrofolate reductase n=1 Tax=Blastopir...   115   2e-24 
UniRef100_Q89G37 Dihydrofolate reductase n=1 Tax=Bradyrhizobium ...   114   3e-24 
UniRef100_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin...   114   3e-24 
UniRef100_B8KU40 Dihydrofolate reductase n=1 Tax=gamma proteobac...   114   3e-24 
UniRef100_Q9RR65 Dihydrofolate reductase n=1 Tax=Deinococcus rad...   114   3e-24 
UniRef100_Q6G2S9 Dihydrofolate reductase n=1 Tax=Bartonella hens...   114   3e-24 
UniRef100_C8N678 Dihydrofolate reductase n=1 Tax=Cardiobacterium...   114   3e-24 
UniRef100_A6G6A1 Dihydrofolate reductase n=1 Tax=Plesiocystis pa...   114   3e-24 
UniRef100_UPI0001CC0CAC dihydrofolate reductase n=1 Tax=Xanthomo...   114   4e-24 
UniRef100_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula stale...   114   4e-24 
UniRef100_B6JB68 Dihydrofolate reductase n=1 Tax=Oligotropha car...   114   4e-24 
UniRef100_UPI0001DBA57A UPI0001DBA57A related cluster n=1 Tax=un...   113   6e-24 
UniRef100_UPI0001850D12 DfrA n=1 Tax=Bacillus coahuilensis m4-4 ...   113   6e-24 
UniRef100_UPI0001692AB5 dihydrofolate reductase type III n=1 Tax...   113   6e-24 
UniRef100_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mul...   113   6e-24 
UniRef100_A6M379 Dihydrofolate reductase n=1 Tax=Clostridium bei...   113   6e-24 
UniRef100_A0NVK6 Probable dihydrofolate reductase protein n=1 Ta...   113   6e-24 
UniRef100_D5ESJ0 Dihydrofolate reductase n=1 Tax=Prevotella rumi...   112   1e-23 
UniRef100_D3UPH5 FolA protein n=1 Tax=Listeria seeligeri serovar...   112   1e-23 
UniRef100_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula ma...   112   1e-23 
UniRef100_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accu...   112   1e-23 
UniRef100_B9KKD1 Dihydrofolate reductase n=1 Tax=Rhodobacter sph...   112   1e-23 
UniRef100_B5EIA1 Dihydrofolate reductase region n=1 Tax=Geobacte...   112   1e-23 
UniRef100_D7JDP8 Dihydrofolate reductase n=1 Tax=Bacteroidetes o...   112   1e-23 
UniRef100_C6ML22 Dihydrofolate reductase n=1 Tax=Geobacter sp. M...   112   1e-23 
UniRef100_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidat...   112   2e-23 
UniRef100_D1BJ51 Dihydrofolate reductase n=1 Tax=Sanguibacter ke...   112   2e-23 
UniRef100_A0LY20 Dihydrofolate reductase n=1 Tax=Gramella forset...   112   2e-23 
UniRef100_C7P1M2 Dihydrofolate reductase n=1 Tax=Halomicrobium m...   112   2e-23 
UniRef100_Q211Y1 Dihydrofolate reductase n=1 Tax=Rhodopseudomona...   111   2e-23 
UniRef100_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium per...   111   2e-23 
UniRef100_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroc...   111   2e-23 
UniRef100_B2SPT0 Dihydrofolate reductase n=3 Tax=Xanthomonas ory...   111   2e-23 
UniRef100_Q3SQ37 Dihydrofolate reductase n=1 Tax=Nitrobacter win...   111   3e-23 
UniRef100_D5CN50 Dihydrofolate reductase n=1 Tax=Sideroxydans li...   111   3e-23 
UniRef100_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fer...   111   3e-23 
UniRef100_A6SX85 Dihydrofolate reductase n=1 Tax=Janthinobacteri...   111   3e-23 
UniRef100_A3PLD0 Dihydrofolate reductase n=1 Tax=Rhodobacter sph...   111   3e-23 
UniRef100_D7DQC1 Dihydrofolate reductase n=1 Tax=Methylotenera s...   111   3e-23 
UniRef100_C5REZ9 Dihydrofolate reductase n=1 Tax=Clostridium cel...   111   3e-23 
UniRef100_B9CRZ3 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   111   3e-23 
UniRef100_B1B802 Dihydrofolate reductase n=1 Tax=Clostridium bot...   111   3e-23 
UniRef100_B9JXQ3 Dihydrofolate reductase n=1 Tax=Agrobacterium v...   110   5e-23 
UniRef100_A0PY39 Dihydrofolate reductase n=1 Tax=Clostridium nov...   110   5e-23 
UniRef100_D4SCG9 Dihydrofolate reductase n=1 Tax=Aeromicrobium m...   110   5e-23 
UniRef100_A0Q4H0 Dihydrofolate reductase type I n=2 Tax=Francise...   110   5e-23 
UniRef100_UPI0001CBF90A dihydrofolate reductase n=1 Tax=Xanthomo...   110   6e-23 
UniRef100_A7IF75 Dihydrofolate reductase n=1 Tax=Xanthobacter au...   110   6e-23 
UniRef100_D1W8T2 Dihydrofolate reductase n=1 Tax=Prevotella bucc...   110   6e-23 
UniRef100_C6YSX5 Dihydrofolate reductase n=1 Tax=Francisella phi...   110   6e-23 
UniRef100_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopis...   109   8e-23 
UniRef100_A7JFU6 Dihydrofolate reductase type I n=1 Tax=Francise...   109   8e-23 
UniRef100_UPI0001855309 dihydrofolate reductase n=1 Tax=Francise...   109   1e-22 
UniRef100_Q47IJ5 Dihydrofolate reductase n=1 Tax=Dechloromonas a...   109   1e-22 
UniRef100_D4Z3E5 Dihydrofolate reductase n=1 Tax=Sphingobium jap...   109   1e-22 
UniRef100_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muc...   109   1e-22 
UniRef100_B0U102 Dihydrofolate reductase n=1 Tax=Francisella phi...   109   1e-22 
UniRef100_A7N9R3 Dihydrofolate reductase n=1 Tax=Francisella tul...   109   1e-22 
UniRef100_A7JK21 Dihydrofolate reductase type I n=1 Tax=Francise...   109   1e-22 
UniRef100_B2SDZ8 Dihydrofolate reductase n=7 Tax=Francisella tul...   109   1e-22 
UniRef100_Q7MTB4 Dihydrofolate reductase n=1 Tax=Porphyromonas g...   108   1e-22 
UniRef100_Q12CI7 Dihydrofolate reductase n=1 Tax=Polaromonas sp....   108   1e-22 
UniRef100_C6GT27 Dihydrofolate reductase n=1 Tax=Streptococcus s...   108   1e-22 
UniRef100_A0Z2N0 Dihydrofolate reductase n=1 Tax=marine gamma pr...   108   1e-22 
UniRef100_A0NJB2 Dihydropholate reductase n=1 Tax=Oenococcus oen...   108   1e-22 
UniRef100_UPI0001DBDB57 Dihydrofolate reductase n=1 Tax=Staphylo...   108   2e-22 
UniRef100_Q8EQG1 Dihydrofolate reductase n=1 Tax=Oceanobacillus ...   108   2e-22 
UniRef100_Q3J0X0 Dihydrofolate reductase n=1 Tax=Rhodobacter sph...   108   2e-22 
UniRef100_Q0AN20 Dihydrofolate reductase n=1 Tax=Maricaulis mari...   108   2e-22 
UniRef100_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni...   108   2e-22 
UniRef100_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium ...   108   2e-22 
UniRef100_C7ZW41 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   108   2e-22 
UniRef100_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloa...   108   2e-22 
UniRef100_C3RMT4 Dihydrofolate reductase n=2 Tax=Bacteria RepID=...   108   2e-22 
UniRef100_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp...   108   2e-22 
UniRef100_Q07PL3 Dihydrofolate reductase n=1 Tax=Rhodopseudomona...   108   2e-22 
UniRef100_C5QSH4 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   108   2e-22 
UniRef100_Q0BNU0 Dihydrofolate reductase n=3 Tax=Francisella tul...   108   2e-22 
UniRef100_A2U3M8 Dihydrofolate reductase n=1 Tax=Polaribacter sp...   108   2e-22 
UniRef100_A4WQT7 Dihydrofolate reductase n=1 Tax=Rhodobacter sph...   107   3e-22 
UniRef100_A1VQZ7 Dihydrofolate reductase n=1 Tax=Polaromonas nap...   107   3e-22 
UniRef100_B7X1J0 Dihydrofolate reductase n=1 Tax=Comamonas testo...   107   3e-22 
UniRef100_B1C3H4 Putative uncharacterized protein n=1 Tax=Clostr...   107   3e-22 
UniRef100_A7YRM5 Dihydrofolate reductase n=1 Tax=Francisella tul...   107   3e-22 
UniRef100_D3SQY4 Dihydrofolate reductase n=1 Tax=Natrialba magad...   107   3e-22 
UniRef100_Q21U57 Dihydrofolate reductase n=1 Tax=Rhodoferax ferr...   107   4e-22 
UniRef100_Q1H2G1 Dihydrofolate reductase n=1 Tax=Methylobacillus...   107   4e-22 
UniRef100_Q2S5H3 Dihydrofolate reductase n=2 Tax=Salinibacter ru...   107   4e-22 
UniRef100_D2PSR9 Dihydrofolate reductase n=1 Tax=Kribbella flavi...   107   4e-22 
UniRef100_A9CIC8 Dihydrofolate reductase n=1 Tax=Agrobacterium t...   107   4e-22 
UniRef100_A3WU80 Dihydrofolate reductase region n=1 Tax=Nitrobac...   107   4e-22 
UniRef100_UPI0001DBDB56 Dihydrofolate reductase n=1 Tax=Staphylo...   107   5e-22 
UniRef100_Q2G376 Dihydrofolate reductase n=1 Tax=Novosphingobium...   107   5e-22 
UniRef100_D2N753 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   107   5e-22 
UniRef100_A8HYP1 Dihydrofolate reductase n=1 Tax=Azorhizobium ca...   107   5e-22 
UniRef100_D3IEM7 Dihydrofolate reductase n=1 Tax=Prevotella sp. ...   107   5e-22 
UniRef100_D1W222 Dihydrofolate reductase n=1 Tax=Prevotella timo...   107   5e-22 
UniRef100_Q5HFZ7 Dihydrofolate reductase n=51 Tax=Staphylococcus...   107   5e-22 
UniRef100_C8MB12 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   107   5e-22 
UniRef100_C5Q023 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   107   5e-22 
UniRef100_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=B...   107   5e-22 
UniRef100_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminoco...   106   7e-22 
UniRef100_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucom...   106   7e-22 
UniRef100_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xe...   106   7e-22 
UniRef100_D7A7D6 Dihydrofolate reductase n=1 Tax=Starkeya novell...   106   7e-22 
UniRef100_D3A2N3 Dihydrofolate reductase n=1 Tax=Neisseria subfl...   106   7e-22 
UniRef100_C9LK50 Dihydrofolate reductase n=1 Tax=Prevotella tann...   106   7e-22 
UniRef100_A9DJM5 Dihydrofolate reductase type I; trimethoprim re...   106   7e-22 
UniRef100_A5P9U6 Phosphoribosylaminoimidazole carboxylase ATPase...   106   7e-22 
UniRef100_A3VSC3 FolA, dihydrofolate reductase n=1 Tax=Parvularc...   106   7e-22 
UniRef100_Q1QJT9 Dihydrofolate reductase n=1 Tax=Nitrobacter ham...   106   9e-22 
UniRef100_Q1GQK3 Dihydrofolate reductase n=1 Tax=Sphingopyxis al...   106   9e-22 
UniRef100_D6LXR8 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   106   9e-22 
UniRef100_D3I1E7 Dihydrofolate reductase n=1 Tax=Prevotella bucc...   106   9e-22 
UniRef100_C0WTJ8 Dihydrofolate reductase n=1 Tax=Lactobacillus b...   106   9e-22 
UniRef100_D3QD07 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   105   1e-21 
UniRef100_A4G3Z7 Dihydrofolate reductase n=1 Tax=Herminiimonas a...   105   1e-21 
UniRef100_B0NUF6 Putative uncharacterized protein n=1 Tax=Bacter...   105   1e-21 
UniRef100_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp....   105   1e-21 
UniRef100_Q5HPB1 Dihydrofolate reductase n=6 Tax=Staphylococcus ...   105   1e-21 
UniRef100_UPI0001B561B5 putative dihydrofolate reductase n=1 Tax...   105   2e-21 
UniRef100_Q6X968 Trimethoprim-resistant dihydrofolate reductase ...   105   2e-21 
UniRef100_D6VE97 Dihydrofolate reductase n=1 Tax=Alicycliphilus ...   105   2e-21 
UniRef100_D0J2N2 Dihydrofolate reductase region n=1 Tax=Comamona...   105   2e-21 
UniRef100_C5T5W4 Dihydrofolate reductase n=1 Tax=Acidovorax dela...   105   2e-21 
UniRef100_C5QX46 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   105   2e-21 
UniRef100_C2BZA8 Dihydrofolate reductase n=1 Tax=Listeria grayi ...   105   2e-21 
UniRef100_B3JMT6 Putative uncharacterized protein n=1 Tax=Bacter...   105   2e-21 
UniRef100_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena t...   105   2e-21 
UniRef100_C1V7D7 Dihydrofolate reductase n=1 Tax=Halogeometricum...   105   2e-21 
UniRef100_P13955 Dihydrofolate reductase type 1 from Tn4003 n=7 ...   105   2e-21 
UniRef100_UPI0001B4F0B6 putative dihydrofolate reductase n=1 Tax...   105   2e-21 
UniRef100_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutch...   105   2e-21 
UniRef100_C6XC58 Dihydrofolate reductase n=1 Tax=Methylovorus sp...   105   2e-21 
UniRef100_C6E4H2 Dihydrofolate reductase n=1 Tax=Geobacter sp. M...   105   2e-21 
UniRef100_B2ICT5 Dihydrofolate reductase n=1 Tax=Beijerinckia in...   105   2e-21 
UniRef100_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas u...   105   2e-21 
UniRef100_C2M0L1 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   105   2e-21 
UniRef100_C2D4L3 Dihydrofolate reductase n=1 Tax=Lactobacillus b...   105   2e-21 
UniRef100_A6ERV0 Dihydrofolate reductase n=1 Tax=unidentified eu...   105   2e-21 
UniRef100_UPI000197A994 dihydrofolate reductase n=1 Tax=Staphylo...   104   3e-21 
UniRef100_Q4L6D6 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   104   3e-21 
UniRef100_D4H815 Dihydrofolate reductase n=1 Tax=Denitrovibrio a...   104   3e-21 
UniRef100_B3ER85 Putative uncharacterized protein n=1 Tax=Candid...   104   3e-21 
UniRef100_C0XLT5 Dihydrofolate reductase n=1 Tax=Lactobacillus h...   104   3e-21 
UniRef100_A7V261 Putative uncharacterized protein n=1 Tax=Bacter...   104   3e-21 
UniRef100_A4EZL4 Dihydrofolate reductase n=1 Tax=Roseobacter sp....   104   3e-21 
UniRef100_Q3IQP3 Dihydrofolate reductase n=1 Tax=Natronomonas ph...   104   3e-21 
UniRef100_Q0TV23 Dihydrofolate reductase n=1 Tax=Clostridium per...   104   4e-21 
UniRef100_B2RMI4 Probable dihydrofolate reductase n=1 Tax=Porphy...   104   4e-21 
UniRef100_D2EZC7 Dihydrofolate reductase n=1 Tax=Bacteroides sp....   104   4e-21 
UniRef100_C5UZN8 Dihydrofolate reductase n=1 Tax=Clostridium bot...   104   4e-21 
UniRef100_C2M8M4 Dihydrofolate reductase n=1 Tax=Capnocytophaga ...   104   4e-21 
UniRef100_B5D2C4 Putative uncharacterized protein n=1 Tax=Bacter...   104   4e-21 
UniRef100_B1RH66 Dihydrofolate reductase n=1 Tax=Clostridium per...   104   4e-21 
UniRef100_Q6G9D5 Dihydrofolate reductase n=4 Tax=Staphylococcus ...   104   4e-21 
UniRef100_UPI000197B05C hypothetical protein BACCOPRO_02426 n=1 ...   103   5e-21 
UniRef100_Q26HU7 Dihydrofolate reductase n=1 Tax=Flavobacteria b...   103   5e-21 
UniRef100_D6KQV3 Dihydrofolate reductase n=1 Tax=Veillonella sp....   103   5e-21 
UniRef100_Q1GFV5 Dihydrofolate reductase n=1 Tax=Ruegeria sp. TM...   103   6e-21 
UniRef100_D2UM47 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   103   6e-21 
UniRef100_C5VR52 Dihydrofolate reductase n=1 Tax=Clostridium bot...   103   6e-21 
UniRef100_C7M6R2 Dihydrofolate reductase n=1 Tax=Capnocytophaga ...   103   8e-21 
UniRef100_B2V0W4 Dihydrofolate reductase n=1 Tax=Clostridium bot...   103   8e-21 
UniRef100_A6GWG8 Dihydrofolate reductase n=1 Tax=Flavobacterium ...   103   8e-21 
UniRef100_C2KUX7 Possible dihydrofolate reductase n=1 Tax=Oribac...   103   8e-21 
UniRef100_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp....   103   8e-21 
UniRef100_A3XKR2 Dihydrofolate reductase n=1 Tax=Leeuwenhoekiell...   103   8e-21 
UniRef100_A3WEP6 Dihydrofolate reductase n=1 Tax=Erythrobacter s...   103   8e-21 
UniRef100_UPI0001BC7A4E dihydrofolate reductase n=1 Tax=Bacteroi...   102   1e-20 
UniRef100_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilu...   102   1e-20 
UniRef100_B9DNX8 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   102   1e-20 
UniRef100_D1BNV5 Dihydrofolate reductase region n=2 Tax=Veillone...   102   1e-20 
UniRef100_C9Y9Z4 Dihydrofolate reductase n=2 Tax=cellular organi...   102   1e-20 
UniRef100_C3QWY6 Dihydrofolate reductase n=3 Tax=Bacteroides Rep...   102   1e-20 
UniRef100_B1QY68 Dihydrofolate reductase n=2 Tax=Clostridium but...   102   1e-20 
UniRef100_Q97EV2 Dihydrofolate reductase n=1 Tax=Clostridium ace...   102   1e-20 
UniRef100_Q6AFI1 Dihydrofolate reductase n=1 Tax=Leifsonia xyli ...   102   1e-20 
UniRef100_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter suc...   102   1e-20 
UniRef100_A9BMQ5 Dihydrofolate reductase n=2 Tax=cellular organi...   102   1e-20 
UniRef100_Q1YJ87 Putative dihydrofolate reductase n=1 Tax=Aurant...   102   1e-20 
UniRef100_C9KVV0 Dihydrofolate reductase n=1 Tax=Bacteroides fin...   102   1e-20 
UniRef100_Q8XPC1 Probable dihydrofolate reductase n=1 Tax=Clostr...   102   2e-20 
UniRef100_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carb...   102   2e-20 
UniRef100_Q0SEI0 Dihydrofolate reductase n=1 Tax=Rhodococcus jos...   102   2e-20 
UniRef100_C1B0L0 Dihydrofolate reductase n=1 Tax=Rhodococcus opa...   102   2e-20 
UniRef100_A5VCW5 Dihydrofolate reductase n=1 Tax=Sphingomonas wi...   102   2e-20 
UniRef100_C8P8Q5 Dihydrofolate reductase n=1 Tax=Lactobacillus a...   102   2e-20 
UniRef100_C2H4X4 Dihydrofolate reductase n=7 Tax=Enterococcus fa...   102   2e-20 
UniRef100_B4D395 Dihydrofolate reductase region n=1 Tax=Chthonio...   102   2e-20 
UniRef100_B1BTC7 Dihydrofolate reductase n=1 Tax=Clostridium per...   102   2e-20 
UniRef100_B1BI35 Dihydrofolate reductase n=1 Tax=Clostridium per...   102   2e-20 
UniRef100_UPI0001DB59AA UPI0001DB59AA related cluster n=1 Tax=un...   101   2e-20 
UniRef100_C0ZMB2 Dihydrofolate reductase n=1 Tax=Rhodococcus ery...   101   2e-20 
UniRef100_B1MD46 Dihydrofolate reductase DfrA n=1 Tax=Mycobacter...   101   2e-20 
UniRef100_C4FNN3 Putative uncharacterized protein n=1 Tax=Veillo...   101   2e-20 
UniRef100_C2DCR4 Dihydrofolate reductase n=2 Tax=Enterococcus fa...   101   2e-20 
UniRef100_C0VI23 Dihydrofolate reductase n=2 Tax=Acinetobacter R...   101   2e-20 
UniRef100_B1V2Z1 Dihydrofolate reductase n=1 Tax=Clostridium per...   101   2e-20 
UniRef100_Q49XN7 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   101   3e-20 
UniRef100_B8HHJ9 Dihydrofolate reductase n=1 Tax=Arthrobacter ch...   101   3e-20 
UniRef100_B2TR57 Dihydrofolate reductase n=1 Tax=Clostridium bot...   101   3e-20 
UniRef100_C7WAB9 Dihydrofolate reductase n=3 Tax=Enterococcus fa...   101   3e-20 
UniRef100_C7VVQ6 Dihydrofolate reductase n=1 Tax=Enterococcus fa...   101   3e-20 
UniRef100_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemoly...   101   3e-20 
UniRef100_C3JX49 Dihydrofolate reductase n=1 Tax=Rhodococcus ery...   101   3e-20 
UniRef100_C3JBM5 Dihydrofolate reductase n=1 Tax=Porphyromonas e...   101   3e-20 
UniRef100_C6VQJ3 Dihydrofolate reductase n=3 Tax=Lactobacillus p...   101   3e-20 
UniRef100_C2ESE4 Dihydrofolate reductase n=1 Tax=Lactobacillus v...   101   3e-20 
UniRef100_Q834R2 Dihydrofolate reductase n=11 Tax=Enterococcus R...   101   3e-20 
UniRef100_B7AD53 Putative uncharacterized protein n=1 Tax=Bacter...   101   3e-20 
UniRef100_B1RS99 Dihydrofolate reductase n=1 Tax=Clostridium per...   101   3e-20 
UniRef100_B1R855 Dihydrofolate reductase n=1 Tax=Clostridium per...   101   3e-20 
UniRef100_D6Y175 Dihydrofolate reductase n=1 Tax=Bacillus seleni...   100   4e-20 
UniRef100_D3LM00 Dihydrofolate reductase n=1 Tax=Micrococcus lut...   100   4e-20 
UniRef100_C0BQ92 Putative uncharacterized protein n=1 Tax=Bifido...   100   4e-20 
UniRef100_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candida...   100   5e-20 
UniRef100_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp...   100   5e-20 
UniRef100_D5PXE6 Dihydrofolate reductase n=1 Tax=Rhodococcus equ...   100   5e-20 
UniRef100_C9LPL0 Dihydrofolate reductase n=1 Tax=Dialister invis...   100   5e-20 
UniRef100_C6ZDI7 Dihydrofolate reductase n=1 Tax=Staphylococcus ...   100   5e-20 
UniRef100_B1MYC2 Dihydrofolate reductase n=1 Tax=Leuconostoc cit...   100   7e-20 
UniRef100_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira ...   100   7e-20 
UniRef100_C9M099 Dihydrofolate reductase n=1 Tax=Lactobacillus h...   100   7e-20 
UniRef100_C7D9E1 Dihydrofolate reductase n=1 Tax=Thalassiobium s...   100   7e-20 
UniRef100_C4FSY3 Putative uncharacterized protein n=1 Tax=Catone...   100   7e-20 
UniRef100_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium...   100   7e-20 
UniRef100_A5ZJU5 Putative uncharacterized protein n=1 Tax=Bacter...   100   7e-20 
UniRef100_A6WGF8 Dihydrofolate reductase n=1 Tax=Kineococcus rad...   100   9e-20 
UniRef100_D1YQG2 Dihydrofolate reductase n=1 Tax=Veillonella par...   100   9e-20 
UniRef100_C9AP80 Dihydrofolate reductase n=2 Tax=Enterococcus fa...   100   9e-20 
UniRef100_C2JK83 Dihydrofolate reductase n=1 Tax=Enterococcus fa...   100   9e-20 
UniRef100_D5BKS2 Dihydrofolate reductase n=1 Tax=Zunongwangia pr...    99   1e-19 
UniRef100_C1C8G2 Dihydrofolate reductase n=1 Tax=Streptococcus p...    99   1e-19 
UniRef100_UPI0001B540B5 Dihydrofolate reductase n=1 Tax=Streptom...    99   1e-19 
UniRef100_UPI000185CE55 dihydrofolate reductase n=1 Tax=Capnocyt...    99   1e-19 
UniRef100_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidat...    99   1e-19 
UniRef100_C5CC92 Dihydrofolate reductase n=1 Tax=Micrococcus lut...    99   1e-19 
UniRef100_C4L1C8 Dihydrofolate reductase region n=1 Tax=Exiguoba...    99   1e-19 
UniRef100_A1A0D7 Dihydrofolate reductase n=2 Tax=Bifidobacterium...    99   1e-19 
UniRef100_O85263 Dihydrofolate reductase n=1 Tax=Streptococcus p...    99   1e-19 
UniRef100_D1NHG3 Dihydrofolate reductase n=1 Tax=Haemophilus inf...    99   1e-19 
UniRef100_D0WS26 Dihydrofolate reductase n=1 Tax=Actinomyces sp....    99   1e-19 
UniRef100_B0NHQ4 Putative uncharacterized protein n=1 Tax=Clostr...    99   1e-19 
UniRef100_A4BZZ7 Dihydrofolate reductase type I n=1 Tax=Polariba...    99   1e-19 
UniRef100_D0JBB8 Dihydrofolate reductase n=1 Tax=Blattabacterium...    99   2e-19 
UniRef100_A8YUW1 Dihydrofolate reductase n=1 Tax=Lactobacillus h...    99   2e-19 
UniRef100_D5EIU9 Dihydrofolate reductase n=1 Tax=Coraliomargarit...    99   2e-19 
UniRef100_C0BFU4 Dihydrofolate reductase n=1 Tax=Flavobacteria b...    99   2e-19 
UniRef100_B8ZX83 Dihydrofolate reductase type A22 n=1 Tax=uncult...    99   2e-19 
UniRef100_A8UEB2 Dihydrofolate reductase n=1 Tax=Flavobacteriale...    99   2e-19 
UniRef100_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stell...    99   2e-19 
UniRef100_UPI0001874368 dihydrofolate reductase n=1 Tax=Coryneba...    98   3e-19 
UniRef100_A1R8Y8 Dihydrofolate reductase n=1 Tax=Arthrobacter au...    98   3e-19 
UniRef100_D6L4Q0 Dihydrofolate reductase n=1 Tax=Parascardovia d...    98   3e-19 
UniRef100_C7WP69 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    98   3e-19 
UniRef100_A5MWQ4 Dihydrofolate reductase n=2 Tax=Streptococcus p...    98   3e-19 
UniRef100_D0J8Z9 Dihydrofolate reductase n=1 Tax=Blattabacterium...    98   3e-19 
UniRef100_B8EN62 Dihydrofolate reductase n=1 Tax=Methylocella si...    98   3e-19 
UniRef100_Q9F6Y7 Dihydrofolate reductase n=1 Tax=Streptococcus p...    98   3e-19 
UniRef100_D4BQZ4 Dihydrofolate reductase n=1 Tax=Bifidobacterium...    98   3e-19 
UniRef100_D3LVS8 Dihydrofolate reductase n=1 Tax=Megasphaera gen...    98   3e-19 
UniRef100_C4WAC0 Dihydrofolate reductase n=1 Tax=Staphylococcus ...    98   3e-19 
UniRef100_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus...    97   4e-19 
UniRef100_C1CLS0 Dihydrofolate reductase n=1 Tax=Streptococcus p...    97   4e-19 
UniRef100_Q9S6K9 Dihydrofolate reductase n=1 Tax=Streptococcus p...    97   4e-19 
UniRef100_D7IY94 Dihydrofolate reductase n=1 Tax=Bacteroides sp....    97   4e-19 
UniRef100_D5QQC2 Dihydrofolate reductase region n=1 Tax=Methylos...    97   4e-19 
UniRef100_D3IGA1 Dihydrofolate reductase n=1 Tax=Prevotella sp. ...    97   4e-19 
UniRef100_C3QI18 Dihydrofolate reductase n=5 Tax=Bacteroides Rep...    97   4e-19 
UniRef100_A3TYY0 Dihydrofolate reductase n=1 Tax=Oceanicola bats...    97   4e-19 
UniRef100_Q54801 Dihydrofolate reductase n=7 Tax=Streptococcus p...    97   4e-19 
UniRef100_D3HAA3 Dihydrofolate reductase n=1 Tax=Streptococcus m...    97   6e-19 
UniRef100_D1AI85 Dihydrofolate reductase region n=1 Tax=Sebaldel...    97   6e-19 
UniRef100_B9MG01 Dihydrofolate reductase n=1 Tax=Acidovorax ebre...    97   6e-19 
UniRef100_Q04JH7 Dihydrofolate reductase n=3 Tax=Streptococcus p...    97   6e-19 
UniRef100_Q701L3 Trimethoprim-resistance dihydrofolate reductase...    97   6e-19 
UniRef100_A6L1Q7 Dihydrofolate reductase n=2 Tax=Bacteroides vul...    97   6e-19 
UniRef100_D1NV40 Dihydrofolate reductase n=1 Tax=Bifidobacterium...    97   6e-19 
UniRef100_B7QY66 Dihydrofolate reductase n=1 Tax=Ruegeria sp. R1...    97   6e-19 
UniRef100_B6XVP3 Putative uncharacterized protein n=1 Tax=Bifido...    97   6e-19 
UniRef100_C3Q5Q3 Dihydrofolate reductase n=4 Tax=Bacteroides Rep...    97   6e-19 
UniRef100_Q701L5 Trimethoprim-resistance dihydrofolate reductase...    97   6e-19 
UniRef100_A5M941 Dihydrofolate reductase n=1 Tax=Streptococcus p...    97   6e-19 
UniRef100_A5LCY0 Dihydrofolate reductase n=1 Tax=Streptococcus p...    97   6e-19 
UniRef100_Q03F97 Dihydrofolate reductase n=1 Tax=Pediococcus pen...    97   7e-19 
UniRef100_A1W5A2 Dihydrofolate reductase n=1 Tax=Acidovorax sp. ...    97   7e-19 
UniRef100_Q9S6K8 Dihydrofolate reductase n=1 Tax=Streptococcus p...    97   7e-19 
UniRef100_Q1NE43 Dihydrofolate reductase n=1 Tax=Sphingomonas sp...    97   7e-19 
UniRef100_D5T4G3 Putative uncharacterized protein n=1 Tax=Leucon...    97   7e-19 
UniRef100_D0SPX6 Dihydrofolate reductase n=1 Tax=Acinetobacter j...    97   7e-19 
UniRef100_C3X6T6 Dihydrofolate reductase n=1 Tax=Oxalobacter for...    97   7e-19 
UniRef100_A9E266 Dihydrofolate reductase n=1 Tax=Oceanibulbus in...    97   7e-19 
UniRef100_A3UB42 Dihydrofolate reductase n=1 Tax=Croceibacter at...    97   7e-19 
UniRef100_A1TM51 Dihydrofolate reductase n=1 Tax=Acidovorax citr...    96   1e-18 
UniRef100_O85260 Dihydrofolate reductase n=1 Tax=Streptococcus p...    96   1e-18 
UniRef100_C6Z510 Dihydrofolate reductase n=1 Tax=Bacteroides sp....    96   1e-18 
UniRef100_C6IMX4 Dihydrofolate reductase n=2 Tax=Bacteroides Rep...    96   1e-18 
UniRef100_C1CSJ1 Dihydrofolate reductase n=3 Tax=Streptococcus R...    96   1e-18 
UniRef100_Q2N685 Dihydrofolate reductase n=1 Tax=Erythrobacter l...    96   1e-18 
UniRef100_Q4LB96 Dfr23 protein n=1 Tax=Klebsiella pneumoniae Rep...    96   1e-18 
UniRef100_D5UD89 Dihydrofolate reductase n=1 Tax=Cellulomonas fl...    96   1e-18 
UniRef100_C2HA90 Dihydrofolate reductase n=3 Tax=Enterococcus fa...    96   1e-18 
UniRef100_B6B7G6 Dihydrofolate reductase n=1 Tax=Rhodobacterales...    96   1e-18 
UniRef100_D3B6I5 Dihydrofolate reductase n=1 Tax=Polysphondylium...    96   1e-18 
UniRef100_UPI0001B46120 dihydrofolate reductase n=1 Tax=Mycobact...    96   2e-18 
UniRef100_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula ...    96   2e-18 
UniRef100_A9WNH1 Dihydrofolate reductase n=1 Tax=Renibacterium s...    96   2e-18 
UniRef100_Q9F6Y4 Dihydrofolate reductase n=1 Tax=Streptococcus p...    96   2e-18 
UniRef100_D7IBT8 Dihydrofolate reductase n=1 Tax=Bacteroides sp....    96   2e-18 
UniRef100_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium ...    96   2e-18 
UniRef100_C9BCK2 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    96   2e-18 
UniRef100_C2EF51 Dihydrofolate reductase n=1 Tax=Lactobacillus s...    96   2e-18 
UniRef100_UPI0001B49BAA dihydrofolate reductase n=1 Tax=Bacteroi...    95   2e-18 
UniRef100_UPI0001976330 dihydrofolate reductase n=1 Tax=Bifidoba...    95   2e-18 
UniRef100_Q168V7 Dihydrofolate reductase n=1 Tax=Roseobacter den...    95   2e-18 
UniRef100_Q04B28 Dihydrofolate reductase n=2 Tax=Lactobacillus d...    95   2e-18 
UniRef100_D2Q8R3 DfrA Dihydrofolate reductase n=2 Tax=Bifidobact...    95   2e-18 
UniRef100_B9EC23 Dihydrofolate reductase n=1 Tax=Macrococcus cas...    95   2e-18 
UniRef100_D6JVM1 Putative uncharacterized protein n=1 Tax=Acinet...    95   2e-18 
UniRef100_A7ADB9 Putative uncharacterized protein n=1 Tax=Paraba...    95   2e-18 
UniRef100_D3B2M2 Putative uncharacterized protein n=1 Tax=Polysp...    95   2e-18 
UniRef100_A0JZC8 Dihydrofolate reductase n=1 Tax=Arthrobacter sp...    95   3e-18 
UniRef100_Q3CZU7 Dihydrofolate reductase n=8 Tax=Streptococcus a...    95   3e-18 
UniRef100_Q2MJU3 Dihydrofolate reductase n=1 Tax=Klebsiella pneu...    95   3e-18 
UniRef100_O85258 Dihydrofolate reductase n=1 Tax=Streptococcus p...    95   3e-18 
UniRef100_D4TWE1 Dihydrofolate reductase n=1 Tax=Actinomyces odo...    95   3e-18 
UniRef100_D1SRX0 Dihydrofolate reductase region n=1 Tax=Acidovor...    95   3e-18 
UniRef100_Q03Y56 Dihydrofolate reductase n=1 Tax=Leuconostoc mes...    94   4e-18 
UniRef100_D0L1A6 Dihydrofolate reductase n=1 Tax=Halothiobacillu...    94   4e-18 
UniRef100_C4Z3U6 Dihydrofolate reductase n=1 Tax=Eubacterium eli...    94   4e-18 
UniRef100_A1WMP6 Dihydrofolate reductase n=1 Tax=Verminephrobact...    94   4e-18 
UniRef100_Q9F6Y6 Dihydrofolate reductase n=1 Tax=Streptococcus p...    94   4e-18 
UniRef100_B5E6L4 Dihydrofolate reductase n=2 Tax=Streptococcus p...    94   4e-18 
UniRef100_C2GVD7 Dihydrofolate reductase n=1 Tax=Bifidobacterium...    94   4e-18 
UniRef100_C2EXZ6 Dihydrofolate reductase n=2 Tax=Lactobacillus r...    94   4e-18 
UniRef100_B7VEV8 Dihydrofolate reductase n=4 Tax=Streptococcus R...    94   4e-18 
UniRef100_B7BFY3 Putative uncharacterized protein n=1 Tax=Paraba...    94   4e-18 
UniRef100_UPI0001DA2A35 UPI0001DA2A35 related cluster n=1 Tax=un...    94   5e-18 
UniRef100_A5EPD1 Dihydrofolate reductase n=1 Tax=Bradyrhizobium ...    94   5e-18 
UniRef100_D0GJF3 Dihydrofolate reductase n=1 Tax=Leptotrichia go...    94   5e-18 
UniRef100_B3DQJ7 Dihydrofolate reductase n=4 Tax=Bifidobacterium...    94   5e-18 
UniRef100_B0BKZ8 Dihydrofolate reductase n=6 Tax=Bacteria RepID=...    94   5e-18 
UniRef100_A3VMD7 Dihydrofolate reductase n=1 Tax=Rhodobacterales...    94   5e-18 
UniRef100_Q1WU16 Dihydrofolate reductase n=1 Tax=Lactobacillus s...    94   6e-18 
UniRef100_C7MA29 Dihydrofolate reductase n=1 Tax=Brachybacterium...    94   6e-18 
UniRef100_B7GUQ6 Dihydrofolate reductase n=1 Tax=Bifidobacterium...    94   6e-18 
UniRef100_D5PJI4 Dihydrofolate reductase n=1 Tax=Mycobacterium p...    94   6e-18 
UniRef100_C5J9C4 Dihydrofolate reductase n=1 Tax=uncultured bact...    94   6e-18 
UniRef100_C2KKL3 Dihydrofolate reductase n=1 Tax=Leuconostoc mes...    94   6e-18 
UniRef100_A9ELD3 Dihydrofolate reductase n=1 Tax=Phaeobacter gal...    94   6e-18 
UniRef100_UPI0001968E2D hypothetical protein BACCELL_01017 n=1 T...    93   8e-18 
UniRef100_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptob...    93   8e-18 
UniRef100_Q6JA79 Dhfr n=2 Tax=Salmonella enterica RepID=Q6JA79_S...    93   8e-18 
UniRef100_Q6J2S1 Dihydrofolate reductase n=1 Tax=Streptococcus p...    93   8e-18 
UniRef100_D5BRR6 Dihydrofolate reductase n=1 Tax=Candidatus Puni...    93   8e-18 
UniRef100_D4THT4 Dihydrofolate reductase n=1 Tax=Cylindrospermop...    93   8e-18 
UniRef100_D3MS19 Dihydrofolate reductase n=1 Tax=Peptostreptococ...    93   8e-18 
UniRef100_D0S5D0 Dihydrofolate reductase n=1 Tax=Acinetobacter c...    93   8e-18 
UniRef100_D0AEL6 Dihydrofolate reductase n=5 Tax=Enterococcus fa...    93   8e-18 
UniRef100_C9BJS9 Dihydrofolate reductase n=9 Tax=Enterococcus fa...    93   8e-18 
UniRef100_C9B6C7 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    93   8e-18 
UniRef100_C6IAB8 Dihydrofolate reductase n=1 Tax=Bacteroides sp....    93   8e-18 
UniRef100_A5VJL0 Dihydrofolate reductase n=5 Tax=Lactobacillus r...    93   8e-18 
UniRef100_B2ZF14 Dihydrofolate reductase n=1 Tax=Escherichia col...    93   8e-18 
UniRef100_A9FZV8 Dihydrofolate reductase n=1 Tax=Phaeobacter gal...    93   8e-18 
UniRef100_A5LUC1 Dihydrofolate reductase n=2 Tax=Streptococcus p...    93   8e-18 
UniRef100_Q03S94 Dihydrofolate reductase n=1 Tax=Lactobacillus b...    93   1e-17 
UniRef100_A5MZB6 DfrD n=2 Tax=Clostridium kluyveri RepID=A5MZB6_...    93   1e-17 
UniRef100_A4YZC2 Dihydrofolate reductase n=1 Tax=Bradyrhizobium ...    93   1e-17 
UniRef100_Q6J2S2 Dihydrofolate reductase n=1 Tax=Streptococcus p...    93   1e-17 
UniRef100_B2IR89 Dihydrofolate reductase n=3 Tax=Streptococcus p...    93   1e-17 
UniRef100_A9QNV7 Tri n=1 Tax=Salmonella enterica subsp. enterica...    93   1e-17 
UniRef100_A7LS80 Putative uncharacterized protein n=1 Tax=Bacter...    93   1e-17 
UniRef100_Q79DQ2 DfrA12 n=32 Tax=Bacteria RepID=Q79DQ2_ECOLX           93   1e-17 
UniRef100_Q6FER8 Dihydrofolate reductase n=1 Tax=Acinetobacter s...    92   1e-17 
UniRef100_D7BML3 Dihydrofolate reductase n=1 Tax=Arcanobacterium...    92   1e-17 
UniRef100_C9D258 Dihydrofolate reductase n=1 Tax=Silicibacter sp...    92   1e-17 
UniRef100_C0BM31 Dihydrofolate reductase n=1 Tax=Flavobacteria b...    92   1e-17 
UniRef100_B7VEV4 Dihydrofolate reductase n=1 Tax=Streptococcus p...    92   1e-17 
UniRef100_B1SCG8 Putative uncharacterized protein n=1 Tax=Strept...    92   1e-17 
UniRef100_Q5YPL6 Putative dihydrofolate reductase n=1 Tax=Nocard...    92   2e-17 
UniRef100_Q03LN2 Dihydrofolate reductase n=1 Tax=Streptococcus t...    92   2e-17 
UniRef100_C7NFY1 Dihydrofolate reductase n=1 Tax=Kytococcus sede...    92   2e-17 
UniRef100_C7N8V9 Dihydrofolate reductase region n=1 Tax=Leptotri...    92   2e-17 
UniRef100_A0QVS0 Dihydrofolate reductase n=1 Tax=Mycobacterium s...    92   2e-17 
UniRef100_D6GQY5 Dihydrofolate reductase n=1 Tax=Filifactor aloc...    92   2e-17 
UniRef100_D2EL04 Dihydrofolate reductase n=1 Tax=Pediococcus aci...    92   2e-17 
UniRef100_D0CAK1 Dihydrofolate reductase n=1 Tax=Acinetobacter b...    92   2e-17 
UniRef100_C5RLN8 Dihydrofolate reductase region n=1 Tax=Clostrid...    92   2e-17 
UniRef100_C4VQ22 Dihydrofolate reductase n=1 Tax=Lactobacillus g...    92   2e-17 
UniRef100_Q9CBW1 Dihydrofolate reductase n=2 Tax=Mycobacterium l...    92   2e-17 
UniRef100_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmon...    92   2e-17 
UniRef100_Q5L9L5 Putative dihydrofolate reductase n=1 Tax=Bacter...    92   2e-17 
UniRef100_D3HDY9 Dihydrofolate reductase n=1 Tax=Streptococcus g...    92   2e-17 
UniRef100_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate re...    92   2e-17 
UniRef100_Q5R1L9 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    92   2e-17 
UniRef100_D7DVX3 Dihydrofolate reductase region n=1 Tax='Nostoc ...    92   2e-17 
UniRef100_D6ZW36 Dihydrofolate reductase n=1 Tax=Bifidobacterium...    92   2e-17 
UniRef100_D1JUP5 Dihydrofolate reductase n=2 Tax=Bacteroides Rep...    92   2e-17 
UniRef100_B2I3A1 Dihydrofolate reductase n=3 Tax=Acinetobacter b...    92   2e-17 
UniRef100_A3M1W8 Dihydrofolate reductase n=5 Tax=Acinetobacter R...    92   2e-17 
UniRef100_C0XC57 Possible dihydrofolate reductase n=1 Tax=Lactob...    92   2e-17 
UniRef100_B7VEV3 Dihydrofolate reductase n=1 Tax=Streptococcus p...    92   2e-17 
UniRef100_B7VEV2 Dihydrofolate reductase n=1 Tax=Streptococcus p...    92   2e-17 
UniRef100_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubact...    92   2e-17 
UniRef100_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lit...    92   2e-17 
UniRef100_A5LL59 Dihydrofolate reductase n=2 Tax=Streptococcus p...    92   2e-17 
UniRef100_P15093 Dihydrofolate reductase n=2 Tax=Haloferax volca...    92   2e-17 
UniRef100_UPI0001AEF9DA dihydrofolate reductase n=1 Tax=Acinetob...    91   3e-17 
UniRef100_Q5M0S6 Dihydrofolate reductase n=1 Tax=Streptococcus t...    91   3e-17 
UniRef100_Q044A0 Dihydrofolate reductase n=2 Tax=Lactobacillus g...    91   3e-17 
UniRef100_C1CFF4 Dihydrofolate reductase n=1 Tax=Streptococcus p...    91   3e-17 
UniRef100_Q46718 Dihydrofolate reductase type Ib n=1 Tax=Escheri...    91   3e-17 
UniRef100_O85261 Dihydrofolate reductase n=1 Tax=Streptococcus p...    91   3e-17 
UniRef100_D5LHB0 Dihydrofolate reductase n=2 Tax=Enterobacter cl...    91   3e-17 
UniRef100_C9PZE0 Dihydrofolate reductase n=1 Tax=Prevotella sp. ...    91   3e-17 
UniRef100_C4FGJ0 Putative uncharacterized protein n=1 Tax=Bifido...    91   3e-17 
UniRef100_C3XD45 Dihydrofolate reductase n=1 Tax=Oxalobacter for...    91   3e-17 
UniRef100_C2LUY3 Dihydrofolate reductase n=1 Tax=Streptococcus s...    91   3e-17 
UniRef100_B7VEW1 Dihydrofolate reductase n=1 Tax=Streptococcus v...    91   3e-17 
UniRef100_B7VEV1 Dihydrofolate reductase n=1 Tax=Streptococcus p...    91   3e-17 
UniRef100_A0A1K1 Dihydrofolate reductase n=1 Tax=Acinetobacter b...    91   3e-17 
UniRef100_Q5M5B2 Dihydrofolate reductase n=1 Tax=Streptococcus t...    91   4e-17 
UniRef100_C0QWN0 Dihydrofolate reductase n=1 Tax=Brachyspira hyo...    91   4e-17 
UniRef100_Q9F6Y8 Dihydrofolate reductase n=1 Tax=Streptococcus p...    91   4e-17 
UniRef100_B7VEV5 Dihydrofolate reductase n=1 Tax=Streptococcus p...    91   4e-17 
UniRef100_Q93MZ2 Dihydrofolate reductase n=3 Tax=Gammaproteobact...    91   4e-17 
UniRef100_B3CJ29 Putative uncharacterized protein n=1 Tax=Bacter...    91   4e-17 
UniRef100_B6SCG1 Dihydrofolate reductase n=2 Tax=Enterobacteriac...    91   4e-17 
UniRef100_Q38WX9 Dihydrofolate reductase n=1 Tax=Lactobacillus s...    91   5e-17 
UniRef100_D4TRH7 Dihydrofolate reductase n=1 Tax=Raphidiopsis br...    91   5e-17 
UniRef100_D2EQ41 Dihydrofolate reductase n=1 Tax=Streptococcus s...    91   5e-17 
UniRef100_D0SSE8 Dihydrofolate reductase n=1 Tax=Acinetobacter l...    91   5e-17 
UniRef100_C4F8V0 Putative uncharacterized protein n=1 Tax=Collin...    91   5e-17 
UniRef100_C1JZF9 Dihydrofolate reductase type 12 n=1 Tax=Escheri...    91   5e-17 
UniRef100_B7VES3 Dihydrofolate reductase n=1 Tax=Aeromonas hydro...    91   5e-17 
UniRef100_A4ATU1 DfrA n=1 Tax=Flavobacteriales bacterium HTCC217...    91   5e-17 
UniRef100_Q59408 Dihydrofolate reductase type A13 n=1 Tax=Escher...    91   5e-17 
UniRef100_D2B6Z2 Dihydrofolate reductase n=1 Tax=Streptosporangi...    90   7e-17 
UniRef100_D5V858 Dihydrofolate reductase n=1 Tax=Moraxella catar...    90   7e-17 
UniRef100_C7X688 Dihydrofolate reductase n=4 Tax=Bacteroidales R...    90   7e-17 
UniRef100_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobact...    90   7e-17 
UniRef100_A3X8B1 Dihydrofolate reductase n=1 Tax=Roseobacter sp....    90   7e-17 
UniRef100_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    90   7e-17 
UniRef100_UPI000190698B putative dihydrofolate reductase n=1 Tax...    90   9e-17 
UniRef100_Q6NIF3 Putative folate reductase n=1 Tax=Corynebacteri...    90   9e-17 
UniRef100_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia ca...    90   9e-17 
UniRef100_B8HD50 Dihydrofolate reductase n=1 Tax=Arthrobacter ch...    90   9e-17 
UniRef100_B1ICZ1 Dihydrofolate reductase n=1 Tax=Streptococcus p...    90   9e-17 
UniRef100_D5UM99 Dihydrofolate reductase n=1 Tax=Tsukamurella pa...    90   9e-17 
UniRef100_D4FU60 Dihydrofolate reductase n=1 Tax=Streptococcus o...    90   9e-17 
UniRef100_C2HC06 Dihydrofolate reductase n=4 Tax=Enterococcus fa...    90   9e-17 
UniRef100_B9YC91 Putative uncharacterized protein n=1 Tax=Holdem...    90   9e-17 
UniRef100_B7VEW2 Dihydrofolate reductase n=1 Tax=Streptococcus s...    90   9e-17 
UniRef100_A7Y2S5 Dihydrofolate reductase n=4 Tax=Bacteria RepID=...    90   9e-17 
UniRef100_A4AHI2 Dihydrofolate reductase n=1 Tax=marine actinoba...    90   9e-17 
UniRef100_B1LRU7 Dihydrofolate reductase type 5 n=6 Tax=Proteoba...    90   9e-17 
UniRef100_Q5WDS2 Dihydrofolate reductase n=1 Tax=Bacillus clausi...    89   1e-16 
UniRef100_A0PQG8 Dihydrofolate reductase DfrA n=2 Tax=Mycobacter...    89   1e-16 
UniRef100_Q6J2R9 Dihydrofolate reductase n=1 Tax=Streptococcus p...    89   1e-16 
UniRef100_Q46750 Dihydrofolate reductase type Ib n=1 Tax=Escheri...    89   1e-16 
UniRef100_C9AME4 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    89   1e-16 
UniRef100_C6RT36 Dihydrofolate reductase n=1 Tax=Acinetobacter r...    89   1e-16 
UniRef100_C2EMP9 Dihydrofolate reductase n=1 Tax=Lactobacillus u...    89   1e-16 
UniRef100_B2GC42 Dihydrofolate reductase n=3 Tax=Lactobacillus f...    89   1e-16 
UniRef100_B2DMN7 Dihydrofolate reductase n=2 Tax=Streptococcus p...    89   1e-16 
UniRef100_A7B8R9 Putative uncharacterized protein n=1 Tax=Actino...    89   1e-16 
UniRef100_D3PJE0 Dihydrofolate reductase n=1 Tax=Lepeophtheirus ...    89   1e-16 
UniRef100_P11731 Dihydrofolate reductase type 5 n=13 Tax=Bacteri...    89   1e-16 
UniRef100_Q1BA63 Dihydrofolate reductase n=2 Tax=Mycobacterium R...    89   2e-16 
UniRef100_C6SQW5 Putative dihydrofolate reductase n=2 Tax=Strept...    89   2e-16 
UniRef100_Q9ZIF9 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    89   2e-16 
UniRef100_Q6J2S0 Dihydrofolate reductase n=1 Tax=Streptococcus p...    89   2e-16 
UniRef100_Q0G0R9 Dihydrofolate reductase n=1 Tax=Fulvimarina pel...    89   2e-16 
UniRef100_C9BIV0 Dihydrofolate reductase n=2 Tax=Enterococcus fa...    89   2e-16 
UniRef100_B6B1Z6 Dihydrofolate reductase n=1 Tax=Rhodobacterales...    89   2e-16 
UniRef100_B1S133 Dihydrofolate reductase n=1 Tax=Streptococcus p...    89   2e-16 
UniRef100_UPI0001AF6F7C putative dihydrofolate reductase n=1 Tax...    89   2e-16 
UniRef100_A3PYA9 Dihydrofolate reductase n=1 Tax=Mycobacterium s...    89   2e-16 
UniRef100_Q9X6S2 Dihydrofolate reductase n=1 Tax=Streptococcus p...    89   2e-16 
UniRef100_Q9F6Y9 Dihydrofolate reductase n=1 Tax=Streptococcus p...    89   2e-16 
UniRef100_Q8GL82 Dihydrofolate reductase n=1 Tax=uncultured bact...    89   2e-16 
UniRef100_Q1G0X6 Dihydrofolate reductase type V (Fragment) n=1 T...    89   2e-16 
UniRef100_D0T6N5 Dihydrofolate reductase n=1 Tax=Acinetobacter r...    89   2e-16 
UniRef100_B8X1A3 Dihydrofolate reductase n=1 Tax=Escherichia col...    89   2e-16 
UniRef100_A0JC99 Dihydrofolate reductase n=6 Tax=Bacteria RepID=...    89   2e-16 
UniRef100_D0LBL1 Dihydrofolate reductase region n=1 Tax=Gordonia...    88   3e-16 
UniRef100_B2GI60 Dihydrofolate reductase n=1 Tax=Kocuria rhizoph...    88   3e-16 
UniRef100_D4QI32 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    88   3e-16 
UniRef100_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berg...    88   3e-16 
UniRef100_A6BHY1 Putative uncharacterized protein n=1 Tax=Dorea ...    88   3e-16 
UniRef100_O81395 Thymidylate synthase n=1 Tax=Zea mays RepID=DRT...    88   3e-16 
UniRef100_UPI0001B5A211 DfrA n=1 Tax=Mycobacterium avium subsp. ...    88   3e-16 
UniRef100_Q27Q94 Dihydrofolate reductase n=1 Tax=Salmonella ente...    88   3e-16 
UniRef100_B7VEV7 Dihydrofolate reductase n=1 Tax=Streptococcus o...    88   3e-16 
UniRef100_A8UAT9 Dihydrofolate reductase n=1 Tax=Carnobacterium ...    88   3e-16 
UniRef100_B3FJX9 Dihydrofolate reductase n=1 Tax=Pseudomonas pha...    88   3e-16 
UniRef100_Q3ZEI9 Dihydrofolate reductase n=2 Tax=Gammaproteobact...    87   5e-16 
UniRef100_D4FDC5 Dihydrofolate reductase n=1 Tax=Lactobacillus c...    87   5e-16 
UniRef100_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copr...    87   5e-16 
UniRef100_C8NE93 Dihydrofolate reductase n=1 Tax=Granulicatella ...    87   5e-16 
UniRef100_A7VDR2 Putative uncharacterized protein n=1 Tax=Clostr...    87   5e-16 
UniRef100_A0QIU0 Dihydrofolate reductase n=1 Tax=Mycobacterium a...    87   6e-16 
UniRef100_Q5QQ10 Dihydrofolate reductase n=1 Tax=Salmonella ente...    87   6e-16 
UniRef100_D5NW46 Dihydrofolate reductase n=1 Tax=Corynebacterium...    87   6e-16 
UniRef100_D0RTH9 Dihydrofolate reductase n=1 Tax=Streptococcus s...    87   6e-16 
UniRef100_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=...    87   6e-16 
UniRef100_C3PEY4 Dihydrofolate reductase n=1 Tax=Corynebacterium...    87   8e-16 
UniRef100_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azob...    87   8e-16 
UniRef100_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thurin...    87   8e-16 
UniRef100_D6ZMC1 Dihydrofolate reductase n=1 Tax=Streptococcus p...    87   8e-16 
UniRef100_B0G3K8 Putative uncharacterized protein n=1 Tax=Dorea ...    87   8e-16 
UniRef100_P0A547 Dihydrofolate reductase n=18 Tax=Mycobacterium ...    87   8e-16 
UniRef100_A2VL99 Dihydrofolate reductase dfrA (Tetrahydrofolate ...    87   8e-16 
UniRef100_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitri...    86   1e-15 
UniRef100_D0HC54 Dihydrofolate reductase n=1 Tax=Vibrio mimicus ...    86   1e-15 
UniRef100_C9B4R3 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    86   1e-15 
UniRef100_A4E6S4 Putative uncharacterized protein n=1 Tax=Collin...    86   1e-15 
UniRef100_P78218 Dihydrofolate reductase type 15 n=8 Tax=Gammapr...    86   1e-15 
UniRef100_Q05762 Thymidylate synthase n=1 Tax=Arabidopsis thalia...    86   1e-15 
UniRef100_Q73VZ3 DfrA n=1 Tax=Mycobacterium avium subsp. paratub...    86   1e-15 
UniRef100_A8AXC0 Dihydrofolate reductase n=1 Tax=Streptococcus g...    86   1e-15 
UniRef100_O30463 Dihydrofolate reductase n=1 Tax=Mycobacterium a...    86   1e-15 
UniRef100_D6JDN7 Dihydrofolate reductase n=1 Tax=Escherichia col...    86   1e-15 
UniRef100_D1XVW4 Dihydrofolate reductase n=1 Tax=Prevotella bivi...    86   1e-15 
UniRef100_C9BQH3 Dihydrofolate reductase n=11 Tax=Enterococcus f...    86   1e-15 
UniRef100_C7XHU5 Dihydrofolate reductase n=1 Tax=Lactobacillus c...    86   1e-15 
UniRef100_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella param...    86   1e-15 
UniRef100_C2KBD3 Dihydrofolate reductase n=2 Tax=Lactobacillus c...    86   1e-15 
UniRef100_C2HNZ8 Dihydrofolate reductase n=2 Tax=Lactobacillus a...    86   1e-15 
UniRef100_C2E963 Dihydrofolate reductase n=1 Tax=Lactobacillus r...    86   1e-15 
UniRef100_B7VEW8 Dihydrofolate reductase (Fragment) n=1 Tax=Stre...    86   1e-15 
UniRef100_D7L1V0 Dihydrofolate reductase-thymidylate synthase n=...    86   1e-15 
UniRef100_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cel...    86   2e-15 
UniRef100_Q8NS39 DIHYDROFOLATE REDUCTASE n=2 Tax=Corynebacterium...    86   2e-15 
UniRef100_D4QQP8 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    86   2e-15 
UniRef100_D1MX72 Dihydrofolate reductase n=1 Tax=Moritella japon...    86   2e-15 
UniRef100_D0SD19 Dihydrofolate reductase n=1 Tax=Acinetobacter j...    86   2e-15 
UniRef100_D0DF62 Dihydrofolate reductase n=1 Tax=Lactobacillus c...    86   2e-15 
UniRef100_C9A4K2 Dihydrofolate reductase n=3 Tax=Enterococcus ca...    86   2e-15 
UniRef100_Q18J41 Dihydrofolate reductase n=1 Tax=Haloquadratum w...    86   2e-15 
UniRef100_UPI000196B285 hypothetical protein CATMIT_00683 n=1 Ta...    85   2e-15 
UniRef100_Q6YQS9 Dihydrofolate reductase n=1 Tax=Onion yellows p...    85   2e-15 
UniRef100_D5H317 Dihydrofolate reductase n=1 Tax=Lactobacillus c...    85   2e-15 
UniRef100_A4TCI8 Dihydrofolate reductase n=1 Tax=Mycobacterium g...    85   2e-15 
UniRef100_Q52T92 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...    85   2e-15 
UniRef100_Q0ZB28 Dihydrofolate reductase n=2 Tax=Salmonella ente...    85   2e-15 
UniRef100_B9WSE4 Dihydrofolate reductase n=1 Tax=Streptococcus s...    85   2e-15 
UniRef100_Q1RPN7 Dihydrofolate reductase n=2 Tax=Enterobacteriac...    85   2e-15 
UniRef100_A6QKP0 Dihydrofolate reductase n=1 Tax=Onion yellows p...    85   2e-15 
UniRef100_C5Y2E9 Putative uncharacterized protein Sb05g016730 n=...    85   2e-15 
UniRef100_Q2NJ47 Dihydrofolate reductase n=1 Tax=Aster yellows w...    85   3e-15 
UniRef100_C8WCM1 Dihydrofolate reductase region n=1 Tax=Zymomona...    85   3e-15 
UniRef100_A4VUL2 Dihydrofolate reductase n=5 Tax=Streptococcus s...    85   3e-15 
UniRef100_D4YDX3 Dihydrofolate reductase n=1 Tax=Aerococcus viri...    85   3e-15 
UniRef100_D4SLH8 Dihydrofolate reductase n=1 Tax=Enterococcus fa...    85   3e-15 
UniRef100_D4RYZ1 Dihydrofolate reductase n=1 Tax=Butyrivibrio cr...    85   3e-15 
UniRef100_B0NCI3 Putative uncharacterized protein n=1 Tax=Clostr...    85   3e-15 
UniRef100_A5Z9U9 Putative uncharacterized protein n=1 Tax=Eubact...    85   3e-15 
UniRef100_B6UD82 Bifunctional dihydrofolate reductase-thymidylat...    85   3e-15 
UniRef100_Q7NHQ9 Dihydrofolate reductase n=1 Tax=Gloeobacter vio...    84   4e-15 
UniRef100_B1VI97 Putative uncharacterized protein n=1 Tax=Coryne...    84   4e-15 
UniRef100_D6S016 Dihydrofolate reductase n=1 Tax=Gardnerella vag...    84   4e-15 
UniRef100_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostr...    84   4e-15 
UniRef100_C5VBQ6 Dihydrofolate reductase n=2 Tax=Corynebacterium...    84   4e-15 
UniRef100_Q05763 Thymidylate synthase n=1 Tax=Arabidopsis thalia...    84   4e-15 
UniRef100_A3CMV0 Dihydrofolate reductase, putative n=1 Tax=Strep...    84   5e-15 
UniRef100_D5S7H5 Dihydrofolate reductase n=1 Tax=Streptococcus p...    84   5e-15 
UniRef100_D4C7R7 Dihydrofolate reductase n=1 Tax=Clostridium sp....    84   5e-15 
UniRef100_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix ...    84   5e-15 
UniRef100_C2E718 Possible dihydrofolate reductase n=1 Tax=Lactob...    84   5e-15 
UniRef100_C0VZ67 Possible dihydrofolate reductase n=1 Tax=Actino...    84   5e-15 
UniRef100_D7MEC7 Predicted protein n=1 Tax=Arabidopsis lyrata su...    84   5e-15 
UniRef100_D6DI29 Dihydrofolate reductase n=1 Tax=Clostridium cf....    84   7e-15 
UniRef100_D0R3K8 DfrA protein n=1 Tax=Lactobacillus johnsonii FI...    83   8e-15 
UniRef100_D7GCN2 Dihydrofolate reductase n=1 Tax=Propionibacteri...    83   8e-15 
UniRef100_D6KTS2 Dihydrofolate reductase n=1 Tax=Scardovia inopi...    83   8e-15 
UniRef100_D5U4M6 Dihydrofolate reductase n=1 Tax=Brachyspira mur...    83   8e-15 
UniRef100_D0BJR3 Dihydrofolate reductase n=1 Tax=Granulicatella ...    83   8e-15 
UniRef100_C8NW56 Dihydrofolate reductase n=1 Tax=Corynebacterium...    83   8e-15 
UniRef100_C6R9E0 Dihydrofolate reductase n=1 Tax=Corynebacterium...    83   8e-15 
UniRef100_C6R3D3 Dihydrofolate reductase n=1 Tax=Rothia mucilagi...    83   8e-15 
UniRef100_Q9RNJ3 Dihydrofolate reductase typeIII n=1 Tax=Zymomon...    83   1e-14 
UniRef100_Q14P23 Putative dihydrofolate reductase oxidoreductase...    83   1e-14 
UniRef100_C8NN76 Dihydrofolate reductase n=2 Tax=Corynebacterium...    83   1e-14 
UniRef100_C0B955 Putative uncharacterized protein n=1 Tax=Coproc...    83   1e-14 
UniRef100_B7VEW7 Dihydrofolate reductase (Fragment) n=1 Tax=Stre...    83   1e-14 
UniRef100_A7B732 Putative uncharacterized protein n=1 Tax=Rumino...    83   1e-14 
UniRef100_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured mari...    83   1e-14 
UniRef100_B9LSX5 Dihydrofolate reductase region n=1 Tax=Halorubr...    83   1e-14 
UniRef100_UPI0000DD9E97 Os12g0446900 n=1 Tax=Oryza sativa Japoni...    82   1e-14 
UniRef100_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea v...    82   1e-14 
UniRef100_C7ENF1 Dihydrofolate reductase n=8 Tax=Bacteria RepID=...    82   1e-14 
UniRef100_D6HM33 Dihydrofolate reductase n=1 Tax=Erysipelotricha...    82   1e-14 
UniRef100_C6N576 Truncated dihydrofolate reductase n=1 Tax=Legio...    82   1e-14 
UniRef100_C5J9C0 Dihydrofolate reductase (Fragment) n=2 Tax=uncu...    82   1e-14 
UniRef100_A6P1N6 Putative uncharacterized protein n=1 Tax=Bacter...    82   1e-14 
UniRef100_Q39687 Dihydrofolate reductase-thymidylate synthetase ...    82   1e-14 
UniRef100_B9GCZ3 Putative uncharacterized protein n=1 Tax=Oryza ...    82   1e-14 
UniRef100_C7P3D4 Dihydrofolate reductase region n=1 Tax=Halomicr...    82   1e-14 
UniRef100_P45350 Thymidylate synthase n=1 Tax=Daucus carota RepI...    82   1e-14 
UniRef100_Q74IU4 Dihydrofolate reductase n=1 Tax=Lactobacillus j...    82   2e-14 
UniRef100_A1T7P5 Dihydrofolate reductase n=1 Tax=Mycobacterium v...    82   2e-14 
UniRef100_B8YG26 DhfR n=1 Tax=Vibrio splendidus RepID=B8YG26_VIBSP     82   2e-14 
UniRef100_B7VPW7 Dihydrofolate reductase type I (Trimethoprim re...    82   2e-14 
UniRef100_C9MLK6 Dihydrofolate reductase n=1 Tax=Prevotella vero...    82   2e-14 
UniRef100_C5ENL5 Putative uncharacterized protein n=1 Tax=Clostr...    82   2e-14 
UniRef100_C0WF10 Dihydrofolate reductase n=1 Tax=Corynebacterium...    82   2e-14 
UniRef100_C0BY08 Putative uncharacterized protein n=1 Tax=Clostr...    82   2e-14 
UniRef100_Q9Z488 Trimethoprim resistant dihydrofolate reductase ...    81   3e-14 
UniRef100_C8PUX4 Dihydrofolate reductase n=1 Tax=Enhydrobacter a...    81   3e-14 
UniRef100_B6FSV0 Putative uncharacterized protein n=1 Tax=Clostr...    81   3e-14 
UniRef100_Q934B2 Dehydrofolate reductase n=5 Tax=Gammaproteobact...    81   3e-14 
UniRef100_B9H0T4 Dihydrofolate reductase-thymidylate synthase n=...    81   3e-14 
UniRef100_B4M4D4 GJ10259 n=1 Tax=Drosophila virilis RepID=B4M4D4...    81   3e-14 
UniRef100_Q2QRX6 Thymidylate synthase n=3 Tax=Oryza sativa RepID...    81   3e-14 
UniRef100_UPI0001926A4C PREDICTED: similar to Dihydrofolate redu...    81   4e-14 
UniRef100_UPI00005845B8 PREDICTED: similar to Dihydrofolate redu...    81   4e-14 
UniRef100_D3K2Q6 Dihydrofolate reductase n=1 Tax=Escherichia col...    81   4e-14 
UniRef100_C0CXS5 Putative uncharacterized protein n=1 Tax=Clostr...    81   4e-14 
UniRef100_B7VEW6 Dihydrofolate reductase (Fragment) n=1 Tax=Stre...    81   4e-14 
UniRef100_B7VEQ0 Dihydrofolate reductase n=1 Tax=Aeromonas hydro...    81   4e-14 
UniRef100_D0NVQ6 Putative uncharacterized protein n=1 Tax=Phytop...    81   4e-14 
UniRef100_Q4JX60 FolA protein n=1 Tax=Corynebacterium jeikeium K...    80   6e-14 
UniRef100_Q5D6X1 Dihydrofolate reductase n=1 Tax=Escherichia col...    80   6e-14 
UniRef100_D1LUJ3 Dihydrofolate reductase n=2 Tax=Proteobacteria ...    80   6e-14 
UniRef100_C2BQ09 Dihydrofolate reductase n=1 Tax=Corynebacterium...    80   6e-14 
UniRef100_A8IDB7 Dihydrofolate reductase n=1 Tax=Citrobacter kos...    80   6e-14 
UniRef100_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentisph...    80   6e-14 
UniRef100_A2TJ31 Dihydrofolatereductase n=1 Tax=Salmonella enter...    80   6e-14 
UniRef100_Q8L6F0 Dihydrofolate reductase-thymidylate synthase n=...    80   6e-14 
UniRef100_Q2R481 Bifunctional dihydrofolate reductase-thymidylat...    80   6e-14 
UniRef100_B9GAQ2 Putative uncharacterized protein n=1 Tax=Oryza ...    80   6e-14 
UniRef100_B8BKI9 Putative uncharacterized protein n=1 Tax=Oryza ...    80   6e-14 
UniRef100_B7FQJ9 Predicted protein (Fragment) n=1 Tax=Phaeodacty...    80   6e-14 
UniRef100_A4RXM1 Predicted protein n=1 Tax=Ostreococcus lucimari...    80   6e-14 
UniRef100_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemens...    80   6e-14 
UniRef100_B4JFC4 GH19291 n=1 Tax=Drosophila grimshawi RepID=B4JF...    80   6e-14 
UniRef100_D2NRG7 Dihydrofolate reductase n=1 Tax=Rothia mucilagi...    80   7e-14 
UniRef100_D6Z918 Dihydrofolate reductase region n=1 Tax=Segnilip...    80   7e-14 
UniRef100_D3I4M7 Dihydrofolate reductase n=1 Tax=Prevotella mela...    80   7e-14 
UniRef100_D0RB21 Dihydrofolate reductase (Fragment) n=1 Tax=uncu...    80   7e-14 
UniRef100_C7Y041 Dihydrofolate reductase n=4 Tax=Lactobacillus j...    80   7e-14 
UniRef100_C5VHR0 Dihydrofolate reductase n=1 Tax=Prevotella mela...    80   7e-14 
UniRef100_B2ZNP4 Dihydrofolate reductase n=3 Tax=Gammaproteobact...    80   7e-14 
UniRef100_B2CKK0 Dihydrofolate reductase (Fragment) n=1 Tax=Kleb...    80   7e-14 
UniRef100_A8JD96 Predicted protein n=1 Tax=Chlamydomonas reinhar...    80   7e-14 
UniRef100_B4K681 GI23507 n=1 Tax=Drosophila mojavensis RepID=B4K...    80   7e-14 
UniRef100_UPI000151B033 hypothetical protein PGUG_03856 n=1 Tax=...    80   9e-14 
UniRef100_D5V6S5 Dihydrofolate reductase region n=1 Tax=Arcobact...    80   9e-14 
UniRef100_B9R0F3 Dihydrofolate reductase n=1 Tax=Labrenzia alexa...    80   9e-14 
UniRef100_A9QKP8 DfrA1 n=1 Tax=Escherichia coli RepID=A9QKP8_ECOLX     80   9e-14 
UniRef100_A5DKQ5 Putative uncharacterized protein n=1 Tax=Meyero...    80   9e-14 
UniRef100_Q1Q8B1 Dihydrofolate reductase n=1 Tax=Psychrobacter c...    79   1e-13 
UniRef100_A4W0V4 Dihydrofolate reductase n=1 Tax=Streptococcus s...    79   1e-13 
UniRef100_C2GIH4 Dihydrofolate reductase n=1 Tax=Corynebacterium...    79   1e-13 
UniRef100_B9H4E4 Dihydrofolate reductase-thymidylate synthase n=...    79   1e-13 
UniRef100_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escheric...    79   1e-13 
UniRef100_Q4U1X9 Dihydrofolate reductase type I n=1 Tax=Escheric...    79   2e-13 
UniRef100_D5SAQ1 Dihydrofolate reductase n=1 Tax=Rothia dentocar...    79   2e-13 
UniRef100_D4HQU4 Dihydrofolate reductase n=1 Tax=Klebsiella pneu...    79   2e-13 
UniRef100_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus c...    79   2e-13 
UniRef100_C7S9T5 Dihydrofolate reductase type VII n=1 Tax=Escher...    79   2e-13 
UniRef100_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium sap...    79   2e-13 
UniRef100_B8ZX77 Dihydrofolate reductase n=1 Tax=uncultured bact...    79   2e-13 
UniRef100_B1VCG5 DfrA17 protein n=5 Tax=Enterobacteriaceae RepID...    79   2e-13 
UniRef100_A8RRN5 Putative uncharacterized protein n=1 Tax=Clostr...    79   2e-13 
UniRef100_Q7BPP7 DHFRXVII n=18 Tax=Bacteria RepID=Q7BPP7_ECOLX         79   2e-13 
UniRef100_B9R7Y4 Bifunctional dihydrofolate reductase-thymidylat...    79   2e-13 
UniRef100_B3RI81 Putative uncharacterized protein n=1 Tax=Tricho...    79   2e-13 
UniRef100_C4LHD2 Bifunctional dihydrofolate reductase-thymidylat...    79   2e-13 
UniRef100_C6JD56 Dihydrofolate reductase n=1 Tax=Ruminococcus sp...    79   2e-13 
UniRef100_B0M928 Putative uncharacterized protein n=1 Tax=Anaero...    79   2e-13 
UniRef100_B0BL08 Dihydrofolate reductase n=1 Tax=Escherichia col...    79   2e-13 
UniRef100_A9RXS0 Predicted protein n=1 Tax=Physcomitrella patens...    79   2e-13 
UniRef100_Q59487 Dihydrofolate reductase n=1 Tax=Lactococcus lac...    79   2e-13 
UniRef100_Q0GGS3 Dihydrofolate reductase n=2 Tax=Enterobacteriac...    78   3e-13 
UniRef100_D6ZHY5 Possible dihydrofolate reductase n=1 Tax=Mobilu...    78   3e-13 
UniRef100_C4VL55 Dihydrofolate reductase n=4 Tax=Lactobacillus j...    78   3e-13 
UniRef100_C2KQT3 Possible dihydrofolate reductase n=2 Tax=Mobilu...    78   3e-13 
UniRef100_C1KAQ6 Dihydrofolate reductase n=1 Tax=Escherichia col...    78   3e-13 
UniRef100_C0XQ92 Dihydrofolate reductase n=1 Tax=Corynebacterium...    78   3e-13 
UniRef100_C0VSW2 Dihydrofolate reductase n=1 Tax=Corynebacterium...    78   3e-13 
UniRef100_B6EA32 Trimethoprim-resistant dihydrofolate reductase ...    78   3e-13 
UniRef100_Q6BTR6 DEHA2C16456p n=1 Tax=Debaryomyces hansenii RepI...    78   3e-13 
UniRef100_D5GLH9 Whole genome shotgun sequence assembly, scaffol...    78   3e-13 
UniRef100_Q02Z24 Dihydrofolate reductase n=1 Tax=Lactococcus lac...    78   4e-13 
UniRef100_Q4W864 Dihydrofolate reductase n=1 Tax=Escherichia col...    78   4e-13 
UniRef100_Q75QQ9 Dihydrofolate reductase 1 n=5 Tax=Gammaproteoba...    78   4e-13 
UniRef100_B8YG21 DhfR n=1 Tax=Vibrio splendidus RepID=B8YG21_VIBSP     78   4e-13 
UniRef100_Q79IE7 DHFRI n=32 Tax=Bacteria RepID=Q79IE7_ECOLX            78   4e-13 
UniRef100_UPI0001985464 PREDICTED: similar to Bifunctional dihyd...    77   5e-13 
UniRef100_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penet...    77   5e-13 
UniRef100_Q9RM44 Dihydrofolate reductase type1 n=3 Tax=Gammaprot...    77   5e-13 
UniRef100_A2RKW6 DfrA protein n=2 Tax=Lactococcus lactis subsp. ...    77   5e-13 
UniRef100_D6CJT7 Dihydrofolate reductase n=1 Tax=uncultured bact...    77   5e-13 
UniRef100_C8RVX9 Dihydrofolate reductase n=1 Tax=Corynebacterium...    77   5e-13 
UniRef100_B9H4E7 Dihydrofolate reductase-thymidylate synthase n=...    77   5e-13 
UniRef100_Q5V3R2 Dihydrofolate reductase 1 n=1 Tax=Haloarcula ma...    77   5e-13 
UniRef100_P00382 Dihydrofolate reductase type 1 n=53 Tax=root Re...    77   5e-13 
UniRef100_B3QZX1 Dihydrofolate reductase n=1 Tax=Candidatus Phyt...    77   6e-13 
UniRef100_O85802 Trimethoprim resistant dihydrofolate reductase ...    77   6e-13 
UniRef100_D7PM74 Dihydrofolate reductase type I n=2 Tax=Proteoba...    77   6e-13 
UniRef100_C3VC48 Dihydrofolate reductase n=1 Tax=Escherichia col...    77   6e-13 
UniRef100_Q01FK1 Bifunctional dihydrofolate reductase-thymidylat...    77   6e-13 
UniRef100_D2BQQ1 Dihydrofolate reductase n=1 Tax=Lactococcus lac...    77   8e-13 
UniRef100_Q937I9 Dihydrofolate reductase n=1 Tax=Escherichia col...    77   8e-13 
UniRef100_Q8GL46 Dihydrofolate reductase n=1 Tax=Shigella sonnei...    77   8e-13 
UniRef100_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mul...    77   8e-13 
UniRef100_Q0FG98 Dihydrofolate reductase n=1 Tax=Rhodobacterales...    77   8e-13 
UniRef100_D4YUF7 Dihydrofolate reductase n=1 Tax=Lactobacillus a...    77   8e-13 
UniRef100_D4LPD3 Dihydrofolate reductase n=1 Tax=Ruminococcus sp...    77   8e-13 
UniRef100_B9VQ79 Dihydrofolate reductase n=1 Tax=Escherichia col...    77   8e-13 
UniRef100_Q96V60 Dihydrofolate reductase (Fragment) n=1 Tax=Pneu...    77   8e-13 
UniRef100_Q4FQ49 Dihydrofolate reductase n=1 Tax=Psychrobacter a...    76   1e-12 
UniRef100_C3JYD2 Putative dihydrofolate reductase n=1 Tax=Pseudo...    76   1e-12 
UniRef100_Q5R1L6 Dihydrofolate reductase n=1 Tax=Escherichia col...    76   1e-12 
UniRef100_Q5DUC2 Trimethoprim-resistant dihydrofolate reductase ...    76   1e-12 
UniRef100_D6PYN7 DfrA14 (Fragment) n=1 Tax=Pantoea agglomerans R...    76   1e-12 
UniRef100_B8X162 Dihydrofolate reductase-like protein n=1 Tax=Es...    76   1e-12 
UniRef100_B6GC06 Putative uncharacterized protein n=1 Tax=Collin...    76   1e-12 
UniRef100_P27422 Dihydrofolate reductase type 7 n=10 Tax=Bacteri...    76   1e-12 
UniRef100_Q6ARI5 Probable dihydrofolate reductase, type VII n=1 ...    76   1e-12 
UniRef100_A5WHY1 Dihydrofolate reductase n=1 Tax=Psychrobacter s...    76   1e-12 
UniRef100_D7GU12 Dihydrofolate reductase n=1 Tax=unclassified Cl...    76   1e-12 
UniRef100_B5MBT2 Trimethoprim insensitive dihydrofolate reductas...    76   1e-12 
UniRef100_P51820 Thymidylate synthase n=1 Tax=Glycine max RepID=...    76   1e-12 
UniRef100_C9LBU3 Dihydrofolate reductase n=1 Tax=Blautia hanseni...    75   2e-12 
UniRef100_C0W934 Possible dihydrofolate reductase n=1 Tax=Actino...    75   2e-12 
UniRef100_B8ZX76 Dihydrofolate reductase protein n=1 Tax=uncultu...    75   2e-12 
UniRef100_B8Y6B2 Dihydrofolate reductase type 1 n=3 Tax=Moraxell...    75   2e-12 
UniRef100_B5CSF3 Putative uncharacterized protein n=1 Tax=Rumino...    75   2e-12 
UniRef100_P16184 Dihydrofolate reductase n=2 Tax=Pneumocystis ca...    75   2e-12 
UniRef100_C9XIG7 Dihydrofolate reductase region n=2 Tax=Clostrid...    75   2e-12 
UniRef100_B1V8Y8 Dihydrofolate reductase n=1 Tax=Candidatus Phyt...    75   2e-12 
UniRef100_D7RF77 Dihydrofolate reductase n=1 Tax=Acinetobacter b...    75   2e-12 
UniRef100_A5ZQQ0 Putative uncharacterized protein n=1 Tax=Rumino...    75   2e-12 
UniRef100_D0N806 Bifunctional dihydrofolate reductase-thymidylat...    75   2e-12 
UniRef100_UPI0001982DBD PREDICTED: similar to Bifunctional dihyd...    75   3e-12 
UniRef100_B1ZSC9 Dihydrofolate reductase region n=1 Tax=Opitutus...    75   3e-12 
UniRef100_Q937J0 Dihydrofolate reductase n=1 Tax=Escherichia col...    75   3e-12 
UniRef100_D4M6M6 Dihydrofolate reductase n=1 Tax=Ruminococcus to...    75   3e-12 
UniRef100_D7U4L1 Whole genome shotgun sequence of line PN40024, ...    75   3e-12 
UniRef100_C7TCF0 Dihydrofolate reductase n=1 Tax=Lactobacillus r...    74   4e-12 
UniRef100_C4Z7Z2 Dihydrofolate reductase n=3 Tax=Eubacterium rec...    74   4e-12 
UniRef100_D4J9X4 Dihydrofolate reductase n=1 Tax=Coprococcus cat...    74   4e-12 
UniRef100_B5QPD0 Dihydrofolate reductase n=1 Tax=Lactobacillus r...    74   4e-12 
UniRef100_P00381 Dihydrofolate reductase n=3 Tax=Lactobacillus R...    74   4e-12 
UniRef100_C5ENL6 Putative uncharacterized protein n=1 Tax=Clostr...    74   5e-12 
UniRef100_C2CM84 Dihydrofolate reductase n=1 Tax=Corynebacterium...    74   5e-12 
UniRef100_Q0MQM2 Dihydrofolate reductase n=4 Tax=Bacteria RepID=...    74   5e-12 
UniRef100_B0FMU4 Dihydrofolate reductase type I n=1 Tax=Klebsiel...    74   5e-12 
UniRef100_B9RH79 Bifunctional dihydrofolate reductase-thymidylat...    74   5e-12 
UniRef100_Q2XPQ8 DfrA n=1 Tax=Escherichia coli RepID=Q2XPQ8_ECOLX      74   7e-12 
UniRef100_D6SVW2 Dihydrofolate reductase n=1 Tax=Gardnerella vag...    74   7e-12 
UniRef100_C4GBY0 Putative uncharacterized protein n=1 Tax=Shuttl...    74   7e-12 
UniRef100_B0FMU6 Dihydrofolate reductase 1 n=2 Tax=Enterobacteri...    74   7e-12 
UniRef100_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubact...    74   7e-12 
UniRef100_A5KQ22 Putative uncharacterized protein n=1 Tax=Rumino...    74   7e-12 
UniRef100_Q96V61 Dihydrofolate reductase (Fragment) n=1 Tax=Pneu...    74   7e-12 
UniRef100_UPI0001CBA782 PREDICTED: dihydrofolate reductase-like ...    73   9e-12 
UniRef100_D4IZ19 Dihydrofolate reductase n=1 Tax=Butyrivibrio fi...    73   9e-12 
UniRef100_C8ZZ85 Dihydrofolate reductase n=1 Tax=Enterococcus ga...    73   9e-12 
UniRef100_C0CJ33 Putative uncharacterized protein n=1 Tax=Blauti...    73   9e-12 
UniRef100_Q8SDF8 PHIKZ004 n=1 Tax=Pseudomonas phage phiKZ RepID=...    73   9e-12 
UniRef100_C5WG30 Dihydrofolate reductase n=1 Tax=Streptococcus d...    73   1e-11 
UniRef100_C4Z104 Dihydrofolate reductase n=1 Tax=Eubacterium eli...    73   1e-11 
UniRef100_D4LWB7 Dihydrofolate reductase n=1 Tax=Ruminococcus ob...    73   1e-11 
UniRef100_A8RRN4 Putative uncharacterized protein n=1 Tax=Clostr...    73   1e-11 
UniRef100_UPI000186EC32 Dihydrofolate reductase, putative n=1 Ta...    72   1e-11 
UniRef100_UPI00003C069E PREDICTED: similar to Dihydrofolate redu...    72   1e-11 
UniRef100_B4U362 Dihydrofolate reductase DhfR n=1 Tax=Streptococ...    72   1e-11 
UniRef100_D4MKF0 Dihydrofolate reductase n=1 Tax=Eubacterium sir...    72   1e-11 
UniRef100_C0FVW5 Putative uncharacterized protein n=1 Tax=Rosebu...    72   1e-11 
UniRef100_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma man...    72   1e-11 
UniRef100_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis vires...    72   1e-11 
UniRef100_P95524 Dihydrofolate reductase type 6 n=1 Tax=Proteus ...    72   1e-11 
UniRef100_UPI000194E247 PREDICTED: dihydrofolate reductase n=1 T...    72   2e-11 
UniRef100_B9DU71 Dihydrofolate reductase n=1 Tax=Streptococcus u...    72   2e-11 
UniRef100_Q9F4H6 Dihydrofolate reductase n=2 Tax=Gammaproteobact...    72   2e-11 
UniRef100_Q5NDM0 Dihydrofolate reductase type 17 n=2 Tax=Enterob...    72   2e-11 
UniRef100_D4KTZ5 Dihydrofolate reductase n=1 Tax=Roseburia intes...    72   2e-11 
UniRef100_C6LEJ1 Dihydrofolate reductase n=1 Tax=Bryantella form...    72   2e-11 
UniRef100_C5TDF8 Dihydrofolate reductase region n=2 Tax=Zymomona...    72   2e-11 
UniRef100_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvim...    72   2e-11 
UniRef100_C1MMA6 Bifunctional dihydrofolate reductase-thymidylat...    72   2e-11 
UniRef100_Q5CPQ4 Dihydrofolate reductase-thymidylate synthase (F...    72   2e-11 
UniRef100_Q27551 Bifunctional dihydrofolate reductase-thymidylat...    72   2e-11 
UniRef100_D3R1R3 Dihydrofolate reductase n=1 Tax=Clostridiales g...    72   3e-11 
UniRef100_D6T0J1 Dihydrofolate reductase n=1 Tax=Gardnerella vag...    72   3e-11 
UniRef100_D0RB76 Dihydrofolate reductase n=1 Tax=Escherichia col...    72   3e-11 
UniRef100_Q68KG9 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    72   3e-11 
UniRef100_A0EQ09 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EQ0...    72   3e-11 
UniRef100_A0EPY9 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPY...    72   3e-11 
UniRef100_Q9Z7E7 Dihydrofolate Reductase n=1 Tax=Chlamydophila p...    71   3e-11 
UniRef100_D0ZZS5 Dihydrofolate reductase n=1 Tax=Chlamydophila p...    71   3e-11 
UniRef100_Q9UUP5 DHFR n=1 Tax=Pneumocystis jirovecii RepID=Q9UUP...    71   3e-11 
UniRef100_Q68KH6 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    71   3e-11 
UniRef100_Q68KH4 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    71   3e-11 
UniRef100_C7SAR2 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    71   3e-11 
UniRef100_A0SIB6 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    71   3e-11 
UniRef100_A0EPY3 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPY...    71   3e-11 
UniRef100_A0EPY1 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPY...    71   3e-11 
UniRef100_A0EPX5 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPX...    71   3e-11 
UniRef100_A0EPX1 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPX...    71   3e-11 
UniRef100_A0EPW5 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPW...    71   3e-11 
UniRef100_Q6A762 Dihydrofolate reductase n=1 Tax=Propionibacteri...    71   4e-11 
UniRef100_D1YEK5 Dihydrofolate reductase n=1 Tax=Propionibacteri...    71   4e-11 
UniRef100_C4G1L6 Putative uncharacterized protein n=1 Tax=Abiotr...    71   4e-11 
UniRef100_D4MVJ7 Dihydrofolate reductase n=2 Tax=Clostridiales R...    71   4e-11 
UniRef100_C3Z0P2 Putative uncharacterized protein n=1 Tax=Branch...    71   4e-11 
UniRef100_B6AE97 Thymidylate synthase family protein n=1 Tax=Cry...    71   4e-11 
UniRef100_Q96V94 Dihydrofolate reductase (Fragment) n=1 Tax=Pneu...    71   4e-11 
UniRef100_Q68KH7 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    71   4e-11 
UniRef100_B2AX68 Predicted CDS Pa_7_9500 n=1 Tax=Podospora anser...    71   4e-11 
UniRef100_A0EQ14 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EQ1...    71   4e-11 
UniRef100_A0EQ07 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EQ0...    71   4e-11 
UniRef100_A0EPY5 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPY...    71   4e-11 
UniRef100_UPI00017450E9 dihydrofolate reductase type III n=1 Tax...    70   6e-11 
UniRef100_D2RA19 Dihydrofolate reductase n=1 Tax=Gardnerella vag...    70   6e-11 
UniRef100_D4H976 Dihydrofolate reductase n=3 Tax=Propionibacteri...    70   6e-11 
UniRef100_C9MUF3 Dihydrofolate reductase n=1 Tax=Leptotrichia ho...    70   6e-11 
UniRef100_C7G683 Dihydrofolate reductase n=2 Tax=Roseburia intes...    70   6e-11 
UniRef100_A7SCT0 Predicted protein n=1 Tax=Nematostella vectensi...    70   6e-11 
UniRef100_B9WKH7 Dihydrofolate reductase, putative n=1 Tax=Candi...    70   6e-11 
UniRef100_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraur...    70   6e-11 
UniRef100_Q9PJC7 Dihydrofolate reductase n=1 Tax=Chlamydia murid...    70   7e-11 
UniRef100_C0M9R5 Dihydrofolate reductase n=1 Tax=Streptococcus e...    70   7e-11 
UniRef100_C5IWK1 Dihydrofolate reductase n=3 Tax=Gammaproteobact...    70   7e-11 
UniRef100_B7AQR6 Putative uncharacterized protein n=1 Tax=Bacter...    70   7e-11 
UniRef100_B5YMV7 Possible thymidylate synthase (Fragment) n=1 Ta...    70   7e-11 
UniRef100_Q68KI2 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    70   7e-11 
UniRef100_A0SIB5 Dihydrofolate reductase (Fragment) n=1 Tax=Pneu...    70   7e-11 
UniRef100_A0EPX9 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPX...    70   7e-11 
UniRef100_O62583 Dihydrofolate reductase n=1 Tax=Encephalitozoon...    70   7e-11 
UniRef100_UPI00015B4DEB PREDICTED: similar to conserved hypothet...    70   1e-10 
UniRef100_A3DES9 Dihydrofolate reductase n=3 Tax=Clostridium the...    70   1e-10 
UniRef100_Q68KH3 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    70   1e-10 
UniRef100_Q68KH0 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    70   1e-10 
UniRef100_Q5A5E0 Putative uncharacterized protein CaJ7.0360 n=1 ...    70   1e-10 
UniRef100_P22906 Dihydrofolate reductase n=1 Tax=Candida albican...    70   1e-10 
UniRef100_P0ABQ7 Dihydrofolate reductase type 8 n=2 Tax=Enteroba...    70   1e-10 
UniRef100_UPI0001D42926 Chain A, crystal structure of Dhfr n=1 T...    69   1e-10 
UniRef100_D4JS19 Dihydrofolate reductase n=1 Tax=Eubacterium sir...    69   1e-10 
UniRef100_D0QXI5 Dihydrofolate reductase n=1 Tax=Vibrio cholerae...    69   1e-10 
UniRef100_C7HSC0 Dihydrofolate reductase n=1 Tax=Anaerococcus va...    69   1e-10 
UniRef100_Q27552 Bifunctional dihydrofolate reductase-thymidylat...    69   1e-10 
UniRef100_B4GFC1 GL22182 n=1 Tax=Drosophila persimilis RepID=B4G...    69   1e-10 
UniRef100_A8XF85 Putative uncharacterized protein n=1 Tax=Caenor...    69   1e-10 
UniRef100_Q68KI1 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    69   1e-10 
UniRef100_Q68KH1 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    69   1e-10 
UniRef100_A0SIB4 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    69   1e-10 
UniRef100_Q256K1 Dihydrofolate reductase n=1 Tax=Chlamydophila f...    69   2e-10 
UniRef100_Q6ZXJ4 Dihydrofolate reductase type V n=1 Tax=Morganel...    69   2e-10 
UniRef100_D7LBE8 Predicted protein n=1 Tax=Arabidopsis lyrata su...    69   2e-10 
UniRef100_Q296C6 GA13324 n=1 Tax=Drosophila pseudoobscura pseudo...    69   2e-10 
UniRef100_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum...    69   2e-10 
UniRef100_A0SIB3 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    69   2e-10 
UniRef100_A0EPX3 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPX...    69   2e-10 
UniRef100_C8WAC3 Dihydrofolate reductase region n=1 Tax=Atopobiu...    69   2e-10 
UniRef100_D5HGI0 Dihydrofolate reductase n=1 Tax=Coprococcus sp....    69   2e-10 
UniRef100_D4S4K2 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi...    69   2e-10 
UniRef100_C5F5P0 Dihydrofolate reductase n=1 Tax=Lactobacillus p...    69   2e-10 
UniRef100_Q6B327 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    69   2e-10 
UniRef100_Q68KH2 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    69   2e-10 
UniRef100_UPI000023ED61 hypothetical protein FG07210.1 n=1 Tax=G...    68   3e-10 
UniRef100_B0X4N3 Dihydrofolate reductase n=1 Tax=Culex quinquefa...    68   3e-10 
UniRef100_Q6F181 Dihydrofolate reductase n=1 Tax=Mesoplasma flor...    68   4e-10 
UniRef100_B0JFA3 Dihydrofolate reductase n=2 Tax=uncultured bact...    68   4e-10 
UniRef100_Q68KH9 Dihydrofolate reductase n=1 Tax=Pneumocystis ji...    68   4e-10 
UniRef100_C5MGL9 Dihydrofolate reductase n=1 Tax=Candida tropica...    68   4e-10 
UniRef100_A0EPZ9 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPZ...    68   4e-10 
UniRef100_P28019 Dihydrofolate reductase n=1 Tax=Aedes albopictu...    68   4e-10 
UniRef100_C0MEW3 Dihydrofolate reductase n=1 Tax=Steptococcus eq...    67   5e-10 
UniRef100_D3AQZ1 Dihydrofolate reductase n=1 Tax=Clostridium hat...    67   5e-10 
UniRef100_B2G4X5 Dihydrofolate reductase n=1 Tax=uncultured bact...    67   5e-10 
UniRef100_Q172I3 Putative uncharacterized protein n=1 Tax=Aedes ...    67   5e-10 
UniRef100_A0EPW7 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPW...    67   5e-10 
UniRef100_P09503 Viral dihydrofolate reductase n=1 Tax=Herpesvir...    67   5e-10 
UniRef100_P07382 Thymidylate synthase n=2 Tax=Leishmania major R...    67   5e-10 
UniRef100_B3WE88 Dihydrofolate reductase n=2 Tax=Lactobacillus c...    67   6e-10 
UniRef100_C2BF28 Possible dihydrofolate reductase n=1 Tax=Anaero...    67   6e-10 
UniRef100_C0EV19 Putative uncharacterized protein n=1 Tax=Eubact...    67   6e-10 
UniRef100_B6WB26 Putative uncharacterized protein n=1 Tax=Anaero...    67   6e-10 
UniRef100_B5ARG6 FolA n=1 Tax=Chlamydophila psittaci RepID=B5ARG...    67   6e-10 
UniRef100_C1E6F7 Bifunctional dihydrofolate reductase-thymidylat...    67   6e-10 
UniRef100_B4QX21 GD19106 n=1 Tax=Drosophila simulans RepID=B4QX2...    67   6e-10 
UniRef100_B4NBB6 GK11864 n=1 Tax=Drosophila willistoni RepID=B4N...    67   6e-10 
UniRef100_B4IBU7 GM15163 n=1 Tax=Drosophila sechellia RepID=B4IB...    67   6e-10 
UniRef100_B4PQL2 GE24403 n=1 Tax=Drosophila yakuba RepID=B4PQL2_...    67   8e-10 
UniRef100_UPI0001742C79 Dihydrofolate reductase n=1 Tax=candidat...    66   1e-09 
UniRef100_Q48U24 Dihydrofolate reductase n=1 Tax=Streptococcus p...    66   1e-09 
UniRef100_Q47FU1 Dihydrofolate reductase region n=1 Tax=Dechloro...    66   1e-09 
UniRef100_C4PPZ8 Dihydrofolate reductase n=1 Tax=Chlamydia trach...    66   1e-09 
UniRef100_Q9EXQ6 Dihydrofolate reductase n=1 Tax=Campylobacter j...    66   1e-09 
UniRef100_C4PNC2 Dihydrofolate reductase n=12 Tax=Chlamydia trac...    66   1e-09 
UniRef100_D3AQZ3 Dihydrofolate reductase (Fragment) n=1 Tax=Clos...    66   1e-09 
UniRef100_Q54LA0 Dihydrofolate reductase n=1 Tax=Dictyostelium d...    66   1e-09 
UniRef100_C4QXY7 Putative uncharacterized protein n=1 Tax=Pichia...    66   1e-09 
UniRef100_A5E6H1 Dihydrofolate reductase n=1 Tax=Lodderomyces el...    66   1e-09 
UniRef100_P17719 Dihydrofolate reductase n=1 Tax=Drosophila mela...    66   1e-09 
UniRef100_Q9A091 Putative dihydrofolate reductase n=1 Tax=Strept...    66   1e-09 
UniRef100_B5XL01 Dihydrofolate reductase n=5 Tax=Streptococcus p...    66   1e-09 
UniRef100_D6S8Q9 Possible dihydrofolate reductase n=1 Tax=Finego...    66   1e-09 
UniRef100_C2FFQ7 Dihydrofolate reductase n=1 Tax=Lactobacillus p...    66   1e-09 
UniRef100_Q96V99 Dihydrofolate reductase (Fragment) n=1 Tax=Pneu...    66   1e-09 
UniRef100_A3LSL9 Dihydrofolate reductase n=1 Tax=Scheffersomyces...    66   1e-09 
UniRef100_A0EPX7 DHFR n=1 Tax=Pneumocystis jirovecii RepID=A0EPX...    66   1e-09 
UniRef100_P16126 Thymidylate synthase n=1 Tax=Leishmania amazone...    66   1e-09 
UniRef100_A7ASX7 Dihydrofolate reductase/thymidylate synthase n=...    65   2e-09 
UniRef100_UPI000180BE94 PREDICTED: similar to GA13324-PA n=1 Tax...    65   2e-09 
UniRef100_Q48ZB1 Dihydrofolate reductase n=1 Tax=Streptococcus p...    65   2e-09 
UniRef100_Q9SIK4 Putative dihydrofolate reductase-thymidylate sy...    65   2e-09 
UniRef100_Q7Z0Z9 Dihydrofolate reductase/thymidilate synthase n=...    65   2e-09 
UniRef100_Q93341 Putative dihydrofolate reductase n=1 Tax=Caenor...    65   2e-09 
UniRef100_Q1J743 Dihydrofolate reductase n=1 Tax=Streptococcus p...    65   2e-09 
UniRef100_Q8MQV3 Dihydrofolate reductase/thymidylate synthase n=...    65   2e-09 
UniRef100_Q8MQV1 Dhfr-ts n=1 Tax=Leishmania chagasi RepID=Q8MQV1...    65   2e-09 
UniRef100_B3M2T2 GF18503 n=1 Tax=Drosophila ananassae RepID=B3M2...    65   2e-09 
UniRef100_Q9DSS3 Dihydrofolate reductase n=1 Tax=Saimiriine herp...    65   3e-09 
UniRef100_B0B8I7 Dihydrofolate reductase n=2 Tax=Chlamydia trach...    65   3e-09 
UniRef100_B9CJY4 Dihydrofolate reductase n=1 Tax=Atopobium rimae...    65   3e-09 
UniRef100_B5U9U8 Dihydrofolate reductase-thymidylate synthase n=...    65   3e-09 
UniRef100_A4H4P8 Dihydrofolate reductase-thymidylate synthase n=...    65   3e-09 
UniRef100_Q5L4P0 Dihydrofolate reductase n=1 Tax=Chlamydophila a...    64   4e-09 
UniRef100_A8SSS6 Putative uncharacterized protein n=1 Tax=Coproc...    64   5e-09 
UniRef100_Q22KR8 Bifunctional dihydrofolate reductase-thymidylat...    64   5e-09 
UniRef100_Q821E3 Dihydrofolate reductase n=1 Tax=Chlamydophila c...    64   7e-09 
UniRef100_B5U212 Putative uncharacterized protein n=1 Tax=uncult...    64   7e-09 
UniRef100_Q8MXB8 Dihydrofolate reductase-thymidylate synthase n=...    64   7e-09 
UniRef100_Q8MXB7 Dihydrofolate reductase-thymidylate synthase n=...    64   7e-09 
UniRef100_Q8MTJ0 Dihydrofolate reductase n=1 Tax=Haematobia irri...    64   7e-09 
UniRef100_C7YNN0 Predicted protein n=1 Tax=Nectria haematococca ...    64   7e-09 
UniRef100_Q8P1D0 Putative dihydrofolate reductase n=1 Tax=Strept...    63   9e-09 
UniRef100_Q07801 Dihydrofolate reductase n=2 Tax=Filobasidiella ...    63   9e-09 
UniRef100_C5DXQ4 ZYRO0F06930p n=1 Tax=Zygosaccharomyces rouxii C...    63   9e-09 
UniRef100_C4XYS3 Putative uncharacterized protein n=1 Tax=Clavis...    63   9e-09 
UniRef100_UPI00004A6135 PREDICTED: similar to Dihydrofolate redu...    63   1e-08 
UniRef100_A2RF19 Dihydrofolate reductase n=2 Tax=Streptococcus p...    63   1e-08 
UniRef100_C6YJR8 Dehydrofolate reductase n=4 Tax=Vibrio RepID=C6...    63   1e-08 
UniRef100_Q75BZ5 ACR124Wp n=1 Tax=Eremothecium gossypii RepID=Q7...    63   1e-08 
UniRef100_D2XB64 Bifunctional dihydrofolate reductase-thymidylat...    62   2e-08 
UniRef100_D3FFQ3 Bifunctional protein including dihydrofolate re...    62   2e-08 
UniRef100_D3TND9 Dihydrofolate reductase n=1 Tax=Glossina morsit...    62   2e-08 
UniRef100_B3P134 GG17010 n=1 Tax=Drosophila erecta RepID=B3P134_...    62   2e-08 
UniRef100_Q920D2 Dihydrofolate reductase n=2 Tax=Rattus norvegic...    62   2e-08 
UniRef100_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyp...    62   2e-08 
UniRef100_A6TJ05 Putative dihydrofolate reductase n=1 Tax=Klebsi...    62   2e-08 
UniRef100_C2CJZ1 Possible dihydrofolate reductase n=1 Tax=Anaero...    62   2e-08 
UniRef100_B0BLI5 CM0216.390.nc protein n=1 Tax=Lotus japonicus R...    62   2e-08 
UniRef100_Q2EZ44 Dihydrofolate reductase (Fragment) n=1 Tax=Cryp...    62   2e-08 
UniRef100_P00375 Dihydrofolate reductase n=2 Tax=Mus musculus Re...    62   2e-08 
UniRef100_UPI00016EA14C UPI00016EA14C related cluster n=1 Tax=Ta...    62   3e-08 
UniRef100_A3RKL3 Dihydrofolate reductase n=3 Tax=Gallus gallus R...    62   3e-08 
UniRef100_Q4T3D4 Chromosome undetermined SCAF10097, whole genome...    61   3e-08 
UniRef100_B0S098 Dihydrofolate reductase n=1 Tax=Finegoldia magn...    61   3e-08 
UniRef100_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi...    61   3e-08 
UniRef100_A9VA22 Predicted protein n=1 Tax=Monosiga brevicollis ...    61   3e-08 
UniRef100_C7GWF0 Dfr1p n=1 Tax=Saccharomyces cerevisiae JAY291 R...    61   3e-08 
UniRef100_P07807 Dihydrofolate reductase n=4 Tax=Saccharomyces c...    61   3e-08 
UniRef100_Q98Q32 Dihydrofolate reductase n=1 Tax=Mycoplasma pulm...    61   3e-08 
UniRef100_C3KIX5 Dihydrofolate reductase n=1 Tax=Anoplopoma fimb...    61   5e-08 
UniRef100_Q2MH30 Dihydrofolate reductase n=3 Tax=Cricetulus gris...    61   5e-08 
UniRef100_D3TQQ1 Dihydrofolate reductase n=1 Tax=Glossina morsit...    61   5e-08 
UniRef100_B0X1Y0 Dihydrofolate reductase n=1 Tax=Culex quinquefa...    61   5e-08 
UniRef100_Q6CRP4 KLLA0D07458p n=1 Tax=Kluyveromyces lactis RepID...    61   5e-08 
UniRef100_A7TKP4 Putative uncharacterized protein n=1 Tax=Vander...    61   5e-08 
UniRef100_A6ZP76 Dihydrofolate reductase n=1 Tax=Saccharomyces c...    61   5e-08 
UniRef100_UPI0001D369F3 UPI0001D369F3 related cluster n=1 Tax=un...    60   6e-08 
UniRef100_D2TF54 Bifunctional dihydrofolate reductase-thymidylat...    60   6e-08 
UniRef100_C7REN4 Dihydrofolate reductase region n=1 Tax=Anaeroco...    60   6e-08 
UniRef100_A8RBH0 Putative uncharacterized protein n=1 Tax=Eubact...    60   6e-08 
UniRef100_Q6TNI3 Dihydrofolate reductase (Fragment) n=1 Tax=Cryp...    60   6e-08 
UniRef100_Q6FPH0 Strain CBS138 chromosome J complete sequence n=...    60   6e-08 
UniRef100_UPI000006EBF1 PREDICTED: hypothetical protein XP_00234...    60   8e-08 
UniRef100_D3VZW1 Dihydrofolate reductase-thymidylate synthase n=...    60   8e-08 
UniRef100_D1Z6W1 Whole genome shotgun sequence assembly, scaffol...    60   8e-08 
UniRef100_B6K009 Dihydrofolate reductase n=1 Tax=Schizosaccharom...    60   8e-08 
UniRef100_P04753 Dihydrofolate reductase n=2 Tax=Cricetinae RepI...    60   8e-08 
UniRef100_P00374 Dihydrofolate reductase n=3 Tax=Homo sapiens Re...    60   8e-08 
UniRef100_UPI000180BE95 PREDICTED: similar to GJ10259 n=1 Tax=Ci...    60   1e-07 
UniRef100_UPI00006A1B50 Dihydrofolate reductase (EC 1.5.1.3). n=...    60   1e-07 
UniRef100_A9NG26 Dihydrofolate reductase n=1 Tax=Acholeplasma la...    60   1e-07 
UniRef100_D4XWL1 Dihydrofolate reductase n=1 Tax=Mycoplasma alli...    60   1e-07 
UniRef100_D4L9U2 Dihydrofolate reductase n=1 Tax=Ruminococcus sp...    60   1e-07 
UniRef100_A8QGA9 Dihydrofolate reductase family protein n=2 Tax=...    60   1e-07 
UniRef100_P00378 Dihydrofolate reductase n=1 Tax=Gallus gallus R...    60   1e-07 
UniRef100_UPI000155F6CA PREDICTED: similar to Dihydrofolate redu...    59   1e-07 
UniRef100_Q78EH1 Dihydrofolate reductase n=1 Tax=Cricetulus sp. ...    59   1e-07 
UniRef100_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphok...    59   1e-07 
UniRef100_Q6TNI4 Dihydrofolate reductase (Fragment) n=2 Tax=Cryp...    59   1e-07 
UniRef100_P00377 Dihydrofolate reductase n=1 Tax=Sus scrofa RepI...    59   1e-07 
UniRef100_P00376 Dihydrofolate reductase n=1 Tax=Bos taurus RepI...    59   1e-07 
UniRef100_Q4A320 Bifunctional dihydrofolate reductase-thymidylat...    59   2e-07 
UniRef100_D0LYN1 Dihydrofolate reductase n=1 Tax=Haliangium ochr...    59   2e-07 
UniRef100_Q3V4E4 Trimethoprim resistant dihydrofolate reductase ...    59   2e-07 
UniRef100_C8PAU8 Dihydrofolate reductase n=1 Tax=Lactobacillus i...    59   2e-07 
UniRef100_B8Y1M6 Dihydrofolate reductase n=2 Tax=Enterobacteriac...    59   2e-07 
UniRef100_Q9GNB4 Dihydrofolate reductase-thymidylate synthase (F...    59   2e-07 
UniRef100_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylat...    59   2e-07 
UniRef100_Q5PZ13 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    59   2e-07 
UniRef100_Q8I1R6 Bifunctional dihydrofolate reductase-thymidylat...    59   2e-07 
UniRef100_A7UD79 Dihydrofolate reductase-thymidylate synthase n=...    59   2e-07 
UniRef100_UPI0001D36058 UPI0001D36058 related cluster n=1 Tax=un...    59   2e-07 
UniRef100_UPI0001CC35A2 dihydrofolate reductase n=1 Tax=Pseudomo...    59   2e-07 
UniRef100_UPI0000DC887A UPI0000DC887A related cluster n=1 Tax=un...    59   2e-07 
UniRef100_Q6KIQ5 Dihydrofolate reductase n=1 Tax=Mycoplasma mobi...    59   2e-07 
UniRef100_Q9GNC9 Dihydrofolate reductase-thymidylate synthase (F...    59   2e-07 
UniRef100_Q9GNC7 Dihydrofolate reductase-thymidylate synthase (F...    59   2e-07 
UniRef100_D3W856 Dihydrofolate reductase-thymidylate synthase (F...    59   2e-07 
UniRef100_D3W854 Dihydrofolate reductase-thymidylate synthase (F...    59   2e-07 
UniRef100_D3W853 Dihydrofolate reductase-thymidylate synthase (F...    59   2e-07 
UniRef100_P13922 Thymidylate synthase n=2 Tax=Plasmodium falcipa...    59   2e-07 
UniRef100_C0R3V1 Dihydrofolate reductase n=3 Tax=Wolbachia RepID...    58   3e-07 
UniRef100_Q6WIE5 Dihydrofolate reductase n=1 Tax=Vibrio phage KV...    58   3e-07 
UniRef100_Q9GTX1 Dihydrofolate reductase-thymidylate synthase (F...    58   3e-07 
UniRef100_Q9GNB5 Dihydrofolate reductase-thymidylate synthase (F...    58   3e-07 
UniRef100_Q9GNB0 Dihydrofolate reductase-thymidylate synthase (F...    58   3e-07 
UniRef100_Q9GN27 Dihydrofolate reductase-thymidylate synthase (F...    58   3e-07 
UniRef100_Q6TNI5 Dihydrofolate reductase (Fragment) n=1 Tax=Cryp...    58   3e-07 
UniRef100_D3VZW0 Dihydrofolate reductase-thymidylate synthase n=...    58   3e-07 
UniRef100_D3VZV9 Dihydrofolate reductase-thymidylate synthase (F...    58   3e-07 
UniRef100_D3VZV8 Dihydrofolate reductase-thymidylate synthase (F...    58   3e-07 
UniRef100_Q98TR9 Dihydrofolate reductase (Fragment) n=1 Tax=Dani...    58   4e-07 
UniRef100_Q6IQS4 Dihydrofolate reductase n=1 Tax=Danio rerio Rep...    58   4e-07 
UniRef100_A2BGQ1 Dihydrofolate reductase n=1 Tax=Danio rerio Rep...    58   4e-07 
UniRef100_Q8L2S3 Dihydrofolate redutase (Fragment) n=2 Tax=Bacte...    58   4e-07 
UniRef100_Q95US9 Dihydrofolate reductase/thymidylate synthase n=...    58   4e-07 
UniRef100_Q7Q0L5 AGAP010278-PA n=1 Tax=Anopheles gambiae RepID=Q...    58   4e-07 
UniRef100_UPI0001D5EA6F UPI0001D5EA6F related cluster n=1 Tax=un...    57   5e-07 
UniRef100_UPI0000D8F453 PREDICTED: similar to dihydrofolate redu...    57   5e-07 
UniRef100_Q963S7 Dihydrofolate reductase-thymidylate synthetase ...    57   5e-07 
UniRef100_Q4YWH2 Bifunctional dihydrofolate reductase-thymidylat...    57   5e-07 
UniRef100_C2D6N3 Possible dihydrofolate reductase n=1 Tax=Atopob...    57   7e-07 
UniRef100_Q9U0F2 Dihydrofolate reductase-thymidylate synthase (F...    57   7e-07 
UniRef100_C9DIG7 Dihydrofolate reductase (Fragment) n=1 Tax=Toxo...    57   7e-07 
UniRef100_P47470 Dihydrofolate reductase n=1 Tax=Mycoplasma geni...    57   7e-07 
UniRef100_Q07422 Thymidylate synthase n=4 Tax=Toxoplasma gondii ...    57   7e-07 
UniRef100_Q5PZ25 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    57   9e-07 
UniRef100_UPI0000363A36 UPI0000363A36 related cluster n=1 Tax=Ta...    56   1e-06 
UniRef100_A9JPH5 Dihydrofolate reductase-like protein n=1 Tax=Re...    56   1e-06 
UniRef100_Q4A612 Dihydrofolate reductase n=1 Tax=Mycoplasma syno...    56   1e-06 
UniRef100_A8GUE9 Dihydrofolate reductase n=2 Tax=Rickettsia bell...    56   1e-06 
UniRef100_B2D9J8 Dihydrofolate reductase n=1 Tax=Ureaplasma parv...    56   1e-06 
UniRef100_Q5U543 LOC495375 protein n=1 Tax=Xenopus laevis RepID=...    56   1e-06 
UniRef100_C5LQI2 Dihydrofolate reductase-thymidylate synthase, p...    56   1e-06 
UniRef100_B3TLD5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    56   1e-06 
UniRef100_UPI0001D55F17 UPI0001D55F17 related cluster n=1 Tax=un...    55   2e-06 
UniRef100_UPI0001D388A4 UPI0001D388A4 related cluster n=1 Tax=un...    55   2e-06 
UniRef100_UPI00017B5371 UPI00017B5371 related cluster n=1 Tax=Te...    55   2e-06 
UniRef100_B1RX87 Dihydrofolate reductase n=4 Tax=Ureaplasma urea...    55   2e-06 
UniRef100_Q9U0F3 Dihydrofolate reductase-thymidylate synthase (F...    55   2e-06 
UniRef100_Q00NX8 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_C5KZ80 Dihydrofolate reductase/thymidilate synthase, p...    55   2e-06 
UniRef100_C5DEY6 KLTH0D10802p n=1 Tax=Lachancea thermotolerans C...    55   2e-06 
UniRef100_P78028 Dihydrofolate reductase n=1 Tax=Mycoplasma pneu...    55   2e-06 
UniRef100_B5XG28 Dihydrofolate reductase n=1 Tax=Salmo salar Rep...    55   2e-06 
UniRef100_B1RW45 Dihydrofolate reductase n=1 Tax=Ureaplasma parv...    55   2e-06 
UniRef100_Q5U9I7 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_Q5U9H0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_Q5U9G9 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_Q5U9G6 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_Q4JCR7 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_Q4JCR5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   2e-06 
UniRef100_Q4JCR0 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    55   2e-06 
UniRef100_D3VZW2 Dihydrofolate reductase-thymidylate synthase (F...    55   2e-06 
UniRef100_D2CLX9 Dihydrofolate reductase-thymidylate synthase (F...    55   2e-06 
UniRef100_C4YTZ8 Putative uncharacterized protein n=1 Tax=Candid...    55   2e-06 
UniRef100_Q23695 Thymidylate synthase n=1 Tax=Crithidia fascicul...    55   2e-06 
UniRef100_UPI00016E0919 UPI00016E0919 related cluster n=1 Tax=Ta...    55   3e-06 
UniRef100_UPI00004BEDB7 UPI00004BEDB7 related cluster n=1 Tax=Ca...    55   3e-06 
UniRef100_Q4SM73 Chromosome 13 SCAF14555, whole genome shotgun s...    55   3e-06 
UniRef100_Q95NY4 Dihydrofolate reductase-thymidylate synthetase ...    55   3e-06 
UniRef100_O77455 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    55   3e-06 
UniRef100_Q7RW41 Putative uncharacterized protein n=1 Tax=Neuros...    55   3e-06 
UniRef100_B2WH77 Dihydrofolate reductase n=1 Tax=Pyrenophora tri...    55   3e-06 
UniRef100_A7ETZ6 Putative uncharacterized protein n=1 Tax=Sclero...    55   3e-06 
UniRef100_Q9PR30 Dihydrofolate reductase n=6 Tax=Ureaplasma parv...    55   3e-06 
UniRef100_Q27713 Thymidylate synthase n=1 Tax=Plasmodium berghei...    55   3e-06 
UniRef100_UPI0001D5DFF0 UPI0001D5DFF0 related cluster n=1 Tax=un...    54   4e-06 
UniRef100_UPI0001554317 PREDICTED: similar to dihydrofolate redu...    54   4e-06 
UniRef100_B2DA24 Dihydrofolate reductase n=5 Tax=Ureaplasma urea...    54   4e-06 
UniRef100_Q8I9L4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   4e-06 
UniRef100_Q8I9L0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   4e-06 
UniRef100_D3JL96 Dihydrofolate reductase-thymidylate synthase (F...    54   4e-06 
UniRef100_Q86ZU9 Dihydrofolate reductase n=1 Tax=Coprinopsis cin...    54   4e-06 
UniRef100_Q7NB76 Segregation and condensation protein A n=2 Tax=...    54   4e-06 
UniRef100_D3FI96 Bifunctional protein including Segregation and ...    54   6e-06 
UniRef100_B9K7R0 Dihydrofolate reductase n=1 Tax=Thermotoga neap...    54   6e-06 
UniRef100_B5ZAU6 Dihydrofolate reductase n=11 Tax=Ureaplasma ure...    54   6e-06 
UniRef100_A6LKQ9 Dihydrofolate reductase region n=1 Tax=Thermosi...    54   6e-06 
UniRef100_Q8I9L3 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_Q8I9L1 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_Q00NX3 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_Q00NX0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_O76975 Dihydrofolate reductase-thymidylate synthase (F...    54   6e-06 
UniRef100_D3X766 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_D3X764 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_D3X762 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_D3X758 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   6e-06 
UniRef100_Q4P9N0 Putative uncharacterized protein n=1 Tax=Ustila...    54   6e-06 
UniRef100_Q53D67 JM3 n=1 Tax=Macaca fuscata rhadinovirus RepID=Q...    54   7e-06 
UniRef100_B3CLN4 Dihydrofolate reductase n=2 Tax=Wolbachia endos...    54   7e-06 
UniRef100_Q6KGF0 Putative dihydrofolate reductase n=1 Tax=Entero...    54   7e-06 
UniRef100_Q9U0F4 Dihydrofolate reductase-thymidylate synthase (F...    54   7e-06 
UniRef100_Q9U0F1 Dihydrofolate reductase-thymidylate synthase (F...    54   7e-06 
UniRef100_Q9U0F0 Dihydrofolate reductase-thymidylate synthase (F...    54   7e-06 
UniRef100_Q9U0E9 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q9U0E8 Dihydrofolate reductase-thymidylate synthase (F...    54   7e-06 
UniRef100_Q9U0E7 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    54   7e-06 
UniRef100_Q9TW60 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    54   7e-06 
UniRef100_Q963S8 Dihydrofolate reductase-thymidylate synthetase ...    54   7e-06 
UniRef100_Q95NX3 Dihydrofolate reductase-thymidylate synthetase ...    54   7e-06 
UniRef100_Q95NI3 Dihydrofolate reductase-thymidylate synthetase ...    54   7e-06 
UniRef100_Q8T5T9 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_Q5U9I3 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9I1 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9I0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9H8 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9H7 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9H6 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9H3 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q5U9G8 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_Q19PC0 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_Q19PB8 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_Q19N46 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_Q19N45 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_Q19N43 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_D2CLY0 Dihydrofolate reductase-thymidylate synthase (F...    54   7e-06 
UniRef100_D2CLX6 Dihydrofolate reductase-thymidylate synthase (F...    54   7e-06 
UniRef100_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_C3RUA8 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_C3RUA7 Dihydrofolate reductase-thymidylate synthase n=...    54   7e-06 
UniRef100_A7T5F9 Predicted protein (Fragment) n=1 Tax=Nematostel...    54   7e-06 
UniRef100_A6XHU0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    54   7e-06 
UniRef100_A5K620 Bifunctional dihydrofolate reductase-thymidylat...    54   7e-06 
UniRef100_Q27793 Thymidylate synthase n=2 Tax=Trypanosoma cruzi ...    54   7e-06 
UniRef100_O02604 Thymidylate synthase n=1 Tax=Plasmodium vivax R...    54   7e-06 
UniRef100_UPI00005A0635 PREDICTED: similar to Dihydrofolate redu...    53   9e-06 
UniRef100_UPI0000E20814 PREDICTED: similar to Chain  , Dihydrofo...    53   9e-06 
UniRef100_B5X910 Dihydrofolate reductase n=1 Tax=Salmo salar Rep...    53   9e-06 
UniRef100_Q73GQ2 Dihydrofolate reductase n=1 Tax=Wolbachia endos...    53   9e-06 
UniRef100_Q9TVU7 Dihydrofolate reductase (Fragment) n=3 Tax=Plas...    53   9e-06 
UniRef100_Q9TVP1 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q9TVN4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q95NT2 Dihydrofolate reductase-thymidylate synthetase ...    53   9e-06 
UniRef100_Q95NS0 Dihydrofolate reductase-thymidylate synthetase ...    53   9e-06 
UniRef100_Q8T5T8 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylat...    53   9e-06 
UniRef100_Q5U9I8 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q5U9H5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q5U9H4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q5U9H1 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q4JCR6 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q4JCR4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   9e-06 
UniRef100_Q19N44 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_Q19N42 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_Q19N40 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_D2CLX8 Dihydrofolate reductase-thymidylate synthase (F...    53   9e-06 
UniRef100_D2CLX7 Dihydrofolate reductase-thymidylate synthase (F...    53   9e-06 
UniRef100_D2CLX5 Dihydrofolate reductase-thymidylate synthase (F...    53   9e-06 
UniRef100_D2CLW8 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_D2CLW6 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_D2CLW4 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_C3RUB1 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_C3RUA6 Dihydrofolate reductase-thymidylate synthase n=...    53   9e-06 
UniRef100_A6XHT6 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    53   9e-06 
UniRef100_Q96UP7 Dihydrofolate reductase (Fragment) n=1 Tax=Pneu...    53   9e-06 
UniRef100_B0CPS0 Predicted protein n=1 Tax=Laccaria bicolor S238...    53   9e-06 
UniRef100_P20712 Thymidylate synthase n=1 Tax=Plasmodium chabaud...    53   9e-06 
UniRef100_UPI0001CE23C8 PREDICTED: dihydrofolate reductase-like ...    53   1e-05 
UniRef100_D5E6F5 Dihydrofolate reductase n=1 Tax=Mycoplasma croc...    53   1e-05 
UniRef100_Q8I9M0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   1e-05 
UniRef100_Q5U9I4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   1e-05 
UniRef100_D3JLA6 Dihydrofolate reductase-thymidylate synthase (F...    53   1e-05 
UniRef100_C7AC74 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    53   1e-05 
UniRef100_D3TTX0 Dihydrofolate reductase n=1 Tax=Epizootic haema...    52   2e-05 
UniRef100_C5CHN8 FolA n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID...    52   2e-05 
UniRef100_B7IG96 Dihydrofolate reductase n=1 Tax=Thermosipho afr...    52   2e-05 
UniRef100_Q9U0F5 Dihydrofolate reductase-thymidylate synthase (F...    52   2e-05 
UniRef100_Q8I9L5 Dihydrofolate reductase (Fragment) n=3 Tax=Plas...    52   2e-05 
UniRef100_Q5U9G7 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NY6 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NY3 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NY2 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NX5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NX2 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NW8 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NW7 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X765 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X760 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X759 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X756 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X755 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X754 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_B2BY17 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_B2BY16 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    52   2e-05 
UniRef100_B2BY14 Dihydrofolate reductase (Fragment) n=4 Tax=Plas...    52   2e-05 
UniRef100_Q7RGH7 Thymidylate synthase, putative n=1 Tax=Plasmodi...    52   2e-05 
UniRef100_Q582G3 Dihydrofolate reductase-thymidylate synthase n=...    52   2e-05 
UniRef100_Q19PB9 Dihydrofolate reductase-thymidylate synthase n=...    52   2e-05 
UniRef100_Q00NY5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NY0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q00NW5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_D3X769 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    52   2e-05 
UniRef100_D3X757 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_C9ZTK8 Dihydrofolate reductase-thymidylate synthase n=...    52   2e-05 
UniRef100_B2BY25 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_B2BY23 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    52   2e-05 
UniRef100_B2BY18 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   2e-05 
UniRef100_Q27783 Thymidylate synthase n=1 Tax=Trypanosoma brucei...    52   2e-05 
UniRef100_A9JPH0 Dihydrofolate reductase-like protein n=1 Tax=Re...    52   3e-05 
UniRef100_D2K048 Dihydrofolate reductase n=1 Tax=Staphylococcus ...    52   3e-05 
UniRef100_C5H7L7 Dihydrofolate reductase n=1 Tax=Enterobacteria ...    52   3e-05 
UniRef100_Q4XXZ2 Bifunctional dihydrofolate reductase-thymidylat...    52   3e-05 
UniRef100_Q19N41 Dihydrofolate reductase-thymidylate synthase n=...    52   3e-05 
UniRef100_Q00NX4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   3e-05 
UniRef100_Q00NW9 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   3e-05 
UniRef100_D6WRE9 Putative uncharacterized protein n=1 Tax=Tribol...    52   3e-05 
UniRef100_D2CLX4 Dihydrofolate reductase-thymidylate synthase (F...    52   3e-05 
UniRef100_D2CLX2 Dihydrofolate reductase-thymidylate synthase (F...    52   3e-05 
UniRef100_D2CLX1 Dihydrofolate reductase-thymidylate synthase (F...    52   3e-05 
UniRef100_D2CLW9 Dihydrofolate reductase-thymidylate synthase n=...    52   3e-05 
UniRef100_B2BY21 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   3e-05 
UniRef100_B2BY20 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    52   3e-05 
UniRef100_Q0U312 Putative uncharacterized protein n=1 Tax=Phaeos...    52   3e-05 
UniRef100_P22573 Viral dihydrofolate reductase n=2 Tax=Saimiriin...    52   3e-05 
UniRef100_C1JLF0 Dihydrofolate reductase n=1 Tax=Oryctolagus cun...    51   4e-05 
UniRef100_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi Rep...    51   4e-05 
UniRef100_D2CLX0 Dihydrofolate reductase-thymidylate synthase (F...    51   4e-05 
UniRef100_B3L1J6 Bifunctional dihydrofolate reductase-thymidylat...    51   4e-05 
UniRef100_B2BY26 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    51   4e-05 
UniRef100_B2BY22 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    51   4e-05 
UniRef100_Q5EXQ5 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    51   5e-05 
UniRef100_D3X770 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    51   5e-05 
UniRef100_D3X768 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    51   5e-05 
UniRef100_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylat...    50   6e-05 
UniRef100_P27421 Viral dihydrofolate reductase n=1 Tax=Herpesvir...    50   8e-05 
UniRef100_D2CLX3 Dihydrofolate reductase-thymidylate synthase (F...    50   1e-04 
UniRef100_Q92JN3 Dihydrofolate reductase n=1 Tax=Rickettsia cono...    49   1e-04 
UniRef100_Q1LWC6 Novel protein similar to vertebrate dihydrofola...    49   2e-04 
UniRef100_A8GQG4 Dihydrofolate reductase n=2 Tax=Rickettsia rick...    49   2e-04 
UniRef100_A8N1E6 Dihydrofolate reductase n=1 Tax=Coprinopsis cin...    49   2e-04 
UniRef100_C3PM57 Dihydrofolate reductase n=2 Tax=spotted fever g...    49   2e-04 
UniRef100_A5KSY7 Bifunctional deaminase-reductase domain protein...    49   2e-04 
UniRef100_Q5EXQ6 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    49   2e-04 
UniRef100_Q04515 Dihydrofolate reductase type A10 n=4 Tax=Gammap...    49   2e-04 
UniRef100_Q28J42 Dihydrofolate reductase n=1 Tax=Xenopus (Silura...    48   3e-04 
UniRef100_Q9WRU3 Dihydrofolate reductase n=1 Tax=Macaca mulatta ...    48   3e-04 
UniRef100_Q9J2M7 DHFR n=1 Tax=Rhesus monkey rhadinovirus H26-95 ...    48   3e-04 
UniRef100_B7XJG7 Putative uncharacterized protein n=1 Tax=Entero...    48   3e-04 
UniRef100_A8Q785 Putative uncharacterized protein n=1 Tax=Malass...    48   3e-04 
UniRef100_Q6J3S1 Dihydrofolate reductase n=1 Tax=Escherichia col...    48   4e-04 
UniRef100_C0F8J6 Dihydrofolate reductase n=1 Tax=Wolbachia endos...    48   4e-04 
UniRef100_A7XFK8 Frd dihydrofolate reductase n=1 Tax=Enterobacte...    48   4e-04 
UniRef100_Q0IJY2 Dihydrofolate reductase-thymidylate synthase n=...    48   4e-04 
UniRef100_A8C2U7 Dihydrofolate reductase-thymidylate synthase n=...    48   4e-04 
UniRef100_A8C2U6 Dihydrofolate reductase-thymidylate synthase n=...    48   4e-04 
UniRef100_A8C2U4 Dihydrofolate reductase-thymidylate synthase n=...    48   4e-04 
UniRef100_A8C2U2 Dihydrofolate reductase-thymidylate synthase n=...    48   4e-04 
UniRef100_Q2HRC6 ORF2 n=1 Tax=Human herpesvirus 8 type P (isolat...    47   5e-04 
UniRef100_O40919 ORF 02 n=1 Tax=Human herpesvirus 8 RepID=O40919...    47   5e-04 
UniRef100_A6QKT3 Dihydrofolate reductase n=1 Tax=Onion yellows p...    47   5e-04 
UniRef100_C4MZ60 Dihydrofolate reductase n=1 Tax=Enterobacteria ...    47   5e-04 
UniRef100_B3KV46 cDNA FLJ16119 fis, clone ASTRO2018540, highly s...    47   5e-04 
UniRef100_P36591 Dihydrofolate reductase n=1 Tax=Schizosaccharom...    47   5e-04 
UniRef100_P46103 Thymidylate synthase (Fragment) n=1 Tax=Plasmod...    47   5e-04 
UniRef100_UPI0000E1FE09 PREDICTED: dihydrofolate reductase-like ...    47   7e-04 
UniRef100_Q86XF0 Dihydrofolate reductase-like protein 1 n=3 Tax=...    47   7e-04 
UniRef100_P90486 ORF 2 n=2 Tax=Human herpesvirus 8 RepID=P90486_...    47   9e-04 
UniRef100_Q4XAU7 Putative uncharacterized protein (Fragment) n=1...    47   9e-04 
UniRef100_Q0PW64 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    47   9e-04 
UniRef100_Q9BK95 Dihydrofolate reductase (Fragment) n=1 Tax=Cryp...    46   0.002 
UniRef100_A8C565 Dihydrofolate reductase-thymidylate synthase (F...    46   0.002 
UniRef100_A8C556 Dihydrofolate reductase-thymidylate synthase (F...    46   0.002 
UniRef100_A8C544 Dihydrofolate reductase-thymidylate synthase (F...    46   0.002 
UniRef100_A8C541 Dihydrofolate reductase-thymidylate synthase (F...    46   0.002 
UniRef100_A7HNA2 Dihydrofolate reductase region n=1 Tax=Fervidob...    45   0.002 
UniRef100_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilat...    45   0.002 
UniRef100_A8C562 Dihydrofolate reductase-thymidylate synthase (F...    45   0.002 
UniRef100_A6WBG8 Bifunctional deaminase-reductase domain protein...    45   0.003 
UniRef100_Q0PW61 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_Q00NX7 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_D3KYV5 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    45   0.003 
UniRef100_D3KYV3 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    45   0.003 
UniRef100_D3KYV0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_A8D9U9 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_A8D9G1 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_A8D9E6 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_D2E8H0 ORF119 n=1 Tax=Anguillid herpesvirus 1 RepID=D2...    45   0.003 
UniRef100_Q8LL90 Bifunctional dihydrofolate reductase-thymidylat...    45   0.003 
UniRef100_Q27762 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_D3KYV2 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_D3KYV1 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    45   0.003 
UniRef100_D3KYU9 Dihydrofolate reductase (Fragment) n=2 Tax=Plas...    45   0.003 
UniRef100_A8C549 Dihydrofolate reductase-thymidylate synthase (F...    45   0.003 
UniRef100_A8C546 Dihydrofolate reductase-thymidylate synthase (F...    45   0.003 
UniRef100_Q60034 Dihydrofolate reductase n=1 Tax=Thermotoga mari...    45   0.003 
UniRef100_A9BEP7 Dihydrofolate reductase region n=1 Tax=Petrotog...    44   0.004 
UniRef100_C5J9B6 Dihydrofolate reductase n=1 Tax=uncultured bact...    44   0.004 
UniRef100_Q27763 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    44   0.004 
UniRef100_A3KCU6 Dihydrofolate reductase-thymidylate synthase (F...    44   0.004 
UniRef100_P75478 Segregation and condensation protein A n=1 Tax=...    44   0.004 
UniRef100_D3AKI3 Dihydrofolate reductase (Fragment) n=1 Tax=Clos...    44   0.006 
UniRef100_Q7Y426 Dihydrofolate reductase n=1 Tax=Enterobacteria ...    44   0.007 
UniRef100_A8D9P0 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    44   0.007 
UniRef100_A7LM88 Dihydrofolate reductase-thymidylate synthase (F...    43   0.010 
UniRef100_C1IUN8 DfrA19 n=1 Tax=Enterobacter cloacae RepID=C1IUN...    43   0.013 
UniRef100_Q00NY4 Dihydrofolate reductase (Fragment) n=1 Tax=Plas...    42   0.017 
UniRef100_UPI0001B44834 dihydrofolate reductase n=1 Tax=Listeria...    42   0.022 
UniRef100_Q9L6G3 Dihydrofolate reductase (Fragment) n=1 Tax=Lact...    42   0.022 
UniRef100_C5B3V4 Putative dihydrofolate reductase n=1 Tax=Methyl...    42   0.028 
UniRef100_Q8KQF2 Dihydrofolate reductase n=1 Tax=Methylobacteriu...    42   0.028 
UniRef100_B1LBF1 Dihydrofolate reductase-like protein n=1 Tax=Th...    41   0.037 
UniRef100_Q09Q25 DfrA19 n=3 Tax=Enterobacteriaceae RepID=Q09Q25_...    41   0.037 
UniRef100_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylat...    41   0.037 
UniRef100_B4DM58 cDNA FLJ51500, highly similar to Dihydrofolate ...    41   0.037 
UniRef100_B0QTU6 Dihydrofolate reductase n=1 Tax=Haemophilus par...    41   0.048 
UniRef100_B8BYC4 Putative uncharacterized protein n=1 Tax=Thalas...    40   0.063 
UniRef100_Q7Y267 Frd n=1 Tax=Enterobacteria phage RB69 RepID=Q7Y...    40   0.063 
UniRef100_Q56BY6 Frd dihydrofolate reductase n=1 Tax=Enterobacte...    40   0.063 
UniRef100_B2G4X4 Dihydrofolate reductase n=1 Tax=uncultured bact...    40   0.082 
UniRef100_D5JFA1 Frd dihydrofolate reductase n=1 Tax=Klebsiella ...    40   0.082 
UniRef100_Q8MW00 Bifunctional dihydrofolate reductase-thymidylat...    40   0.082 

>UniRef100_A1A797 Dihydrofolate reductase n=5 Tax=Escherichia
           RepID=A1A797_ECOK1
          Length = 204

 Score =  333 bits (855), Expect = 3e-90
 Identities = 159/159 (100%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 46  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 105

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 106 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 165

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 166 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 204



>UniRef100_P0ABQ5 Dihydrofolate reductase n=48
           Tax=Enterobacteriaceae RepID=DYR_ECOL6
          Length = 159

 Score =  333 bits (855), Expect = 3e-90
 Identities = 159/159 (100%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_A7ZHE1 Dihydrofolate reductase n=1 Tax=Escherichia coli
           E24377A RepID=A7ZHE1_ECO24
          Length = 159

 Score =  332 bits (852), Expect = 6e-90
 Identities = 158/159 (99%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP+IMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPMIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_C3TR67 Dihydrofolate reductase type I; trimethoprim
           resistance n=1 Tax=Escherichia coli RepID=C3TR67_ECOLX
          Length = 159

 Score =  332 bits (852), Expect = 6e-90
 Identities = 158/159 (99%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV+
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVD 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_D3H430 Dihydrofolate reductase n=1 Tax=Escherichia coli
           042 RepID=D3H430_ECO44
          Length = 159

 Score =  330 bits (847), Expect = 2e-89
 Identities = 158/159 (99%), Positives = 158/159 (99%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL KAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLAKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_Q8Z9J9 Dihydrofolate reductase type I n=3 Tax=Salmonella
           enterica subsp. enterica serovar Typhi
           RepID=Q8Z9J9_SALTI
          Length = 159

 Score =  328 bits (842), Expect = 9e-89
 Identities = 155/159 (97%), Positives = 157/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           I+SSQPGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  IISSQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_B4T6L3 Dihydrofolate reductase n=24 Tax=Salmonella
           enterica RepID=B4T6L3_SALNS
          Length = 159

 Score =  328 bits (841), Expect = 1e-88
 Identities = 154/159 (96%), Positives = 157/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_C3TR68 Dihydrofolate reductase type I; trimethoprim
           resistance n=13 Tax=Escherichia coli RepID=C3TR68_ECOLX
          Length = 159

 Score =  328 bits (841), Expect = 1e-88
 Identities = 158/159 (99%), Positives = 158/159 (99%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHT ESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTRESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_D2TGF3 Dihydrofolate reductase n=1 Tax=Citrobacter
           rodentium ICC168 RepID=D2TGF3_CITRI
          Length = 159

 Score =  327 bits (838), Expect = 3e-88
 Identities = 153/159 (96%), Positives = 157/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_B1EML8 Dihydrofolate reductase n=1 Tax=Escherichia
           albertii TW07627 RepID=B1EML8_9ESCH
          Length = 196

 Score =  327 bits (838), Expect = 3e-88
 Identities = 154/159 (96%), Positives = 158/159 (99%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 38  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 97

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQ GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA+VE
Sbjct: 98  VISSQSGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDADVE 157

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 158 GDTHFPDYDPDDWESVFSEFHDADAQNSHSYCFEILERR 196



>UniRef100_B4A3Q1 Dihydrofolate reductase n=1 Tax=Salmonella
           enterica subsp. enterica serovar Newport str. SL317
           RepID=B4A3Q1_SALNE
          Length = 159

 Score =  327 bits (837), Expect = 3e-88
 Identities = 153/159 (96%), Positives = 156/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMEN MPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENTMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_Q32K48 Dihydrofolate reductase type I n=1 Tax=Shigella
           dysenteriae Sd197 RepID=Q32K48_SHIDS
          Length = 159

 Score =  326 bits (836), Expect = 4e-88
 Identities = 156/159 (98%), Positives = 158/159 (99%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGR+TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRYTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL KAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLAKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEP+DWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPNDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_B5BL24 Dihydrofolate reductase type I n=2 Tax=Salmonella
           enterica subsp. enterica serovar Paratyphi A
           RepID=B5BL24_SALPK
          Length = 159

 Score =  326 bits (836), Expect = 4e-88
 Identities = 153/159 (96%), Positives = 156/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WV SVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVQWVNSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_A8ALQ3 Putative uncharacterized protein n=1
           Tax=Citrobacter koseri ATCC BAA-895 RepID=A8ALQ3_CITK8
          Length = 159

 Score =  326 bits (836), Expect = 4e-88
 Identities = 153/159 (96%), Positives = 156/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDAD QNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADEQNSHSYCFEILERR 159



>UniRef100_P31073 Dihydrofolate reductase n=3 Tax=Citrobacter
           RepID=DYR_CITFR
          Length = 159

 Score =  326 bits (835), Expect = 6e-88
 Identities = 153/159 (96%), Positives = 157/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKPGTDDRVQWVKSVDEAIAACGDEPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_A9MQG5 Putative uncharacterized protein n=1
           Tax=Salmonella enterica subsp. arizonae serovar
           62:z4,z23:-- RepID=A9MQG5_SALAR
          Length = 159

 Score =  325 bits (833), Expect = 1e-87
 Identities = 153/159 (96%), Positives = 156/159 (98%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQ GTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQSGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_D2Z9N8 Putative uncharacterized protein n=1
           Tax=Enterobacter cancerogenus ATCC 35316
           RepID=D2Z9N8_9ENTR
          Length = 159

 Score =  316 bits (809), Expect = 6e-85
 Identities = 149/159 (93%), Positives = 154/159 (96%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKR TLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRTTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WVKSVDEAIAACGD  EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVEWVKSVDEAIAACGDAEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_D5CH31 Dihydrofolate reductase n=1 Tax=Enterobacter
           cloacae subsp. cloacae ATCC 13047 RepID=D5CH31_ENTCC
          Length = 159

 Score =  314 bits (804), Expect = 2e-84
 Identities = 148/159 (93%), Positives = 154/159 (96%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKR TLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRTTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRV WVKSVDEAIAACG+  EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDDRVEWVKSVDEAIAACGNAEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_C4X343 Trimethoprim resistance dihydrofolate reductase
           n=3 Tax=Klebsiella pneumoniae RepID=C4X343_KLEPN
          Length = 159

 Score =  313 bits (802), Expect = 4e-84
 Identities = 147/159 (92%), Positives = 155/159 (97%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_A4W6F4 Dihydrofolate reductase n=1 Tax=Enterobacter sp.
           638 RepID=A4W6F4_ENT38
          Length = 159

 Score =  312 bits (799), Expect = 9e-84
 Identities = 146/159 (91%), Positives = 153/159 (96%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKR TLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRTTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTD RV WVKSVD+AIAACGD  EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSQPGTDSRVEWVKSVDDAIAACGDAEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFE+LERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEVLERR 159



>UniRef100_B5Y1Z7 Dihydrofolate reductase n=3 Tax=Klebsiella
           RepID=B5Y1Z7_KLEP3
          Length = 159

 Score =  311 bits (797), Expect = 1e-83
 Identities = 146/159 (91%), Positives = 154/159 (96%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVYEQFLPKA KLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYEQFLPKAHKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_P31074 Dihydrofolate reductase n=1 Tax=Enterobacter
           aerogenes RepID=DYR_ENTAE
          Length = 159

 Score =  311 bits (797), Expect = 1e-83
 Identities = 146/159 (91%), Positives = 154/159 (96%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWDLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WVKSVDEAIAACGD  EIMVIGGGRVYEQFLPKA KLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVKSVDEAIAACGDAEEIMVIGGGRVYEQFLPKAHKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_C8TBI7 Dihydrofolate reductase n=1 Tax=Klebsiella
           pneumoniae subsp. rhinoscleromatis ATCC 13884
           RepID=C8TBI7_KLEPR
          Length = 159

 Score =  306 bits (784), Expect = 5e-82
 Identities = 145/159 (91%), Positives = 153/159 (96%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+ G+DDRV WV SV+EAIAACGDV EIMVIGGG VYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKLGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGWVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_P27498 Dihydrofolate reductase n=1 Tax=Klebsiella
           aerogenes RepID=DYR_KLEAE
          Length = 159

 Score =  303 bits (777), Expect = 3e-81
 Identities = 142/159 (89%), Positives = 152/159 (95%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAAL VDRVIGMENAMPWNL  DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159



>UniRef100_C9XVK4 Dihydrofolate reductase n=2 Tax=Cronobacter
           RepID=C9XVK4_CROTZ
          Length = 176

 Score =  302 bits (774), Expect = 7e-81
 Identities = 140/159 (88%), Positives = 152/159 (95%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR TWESIGRPLPGRKNI
Sbjct: 18  MISLIAALAVDRVIGMENAMPWDLPADLAWFKRNTLNKPVIMGRLTWESIGRPLPGRKNI 77

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LSS+PG DDRV WV+SV+EA+ ACGD  E+MVIGGGRVYEQFLP+AQ+LYLTHIDAEVE
Sbjct: 78  VLSSRPGDDDRVVWVRSVEEALQACGDAEEVMVIGGGRVYEQFLPRAQRLYLTHIDAEVE 137

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+SVFSEFHDAD +NSHSYCFEILERR
Sbjct: 138 GDTHFPDYEPDEWQSVFSEFHDADEKNSHSYCFEILERR 176



>UniRef100_C4UXT8 Dihydrofolate reductase n=1 Tax=Yersinia rohdei
           ATCC 43380 RepID=C4UXT8_YERRO
          Length = 160

 Score =  282 bits (722), Expect = 7e-75
 Identities = 130/159 (81%), Positives = 145/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DR+IGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRIIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRVTW  S+DEA+A  GDV E+MV+GGGRVY+QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGTDDRVTWATSIDEALALAGDVEEVMVMGGGRVYKQFLDRAHRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADEANSHSYCFEILERR 160



>UniRef100_C4U0S2 Dihydrofolate reductase n=1 Tax=Yersinia
           kristensenii ATCC 33638 RepID=C4U0S2_YERKR
          Length = 160

 Score =  281 bits (720), Expect = 1e-74
 Identities = 130/159 (81%), Positives = 145/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRVTW  S+D+A+A  GDV E+MV+GGGRVY+QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGTDDRVTWATSIDDALALAGDVAEVMVMGGGRVYKQFLDRANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADEANSHSYCFEILERR 160



>UniRef100_C4SIW8 Dihydrofolate reductase n=1 Tax=Yersinia
           frederiksenii ATCC 33641 RepID=C4SIW8_YERFR
          Length = 160

 Score =  281 bits (718), Expect = 2e-74
 Identities = 130/159 (81%), Positives = 144/159 (90%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPG DDRVTW  S+DEA+A  GDV E+MV+GGGRVY+QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGVDDRVTWANSIDEALALAGDVEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADEVNSHSYCFEILERR 160



>UniRef100_C4RWF7 Dihydrofolate reductase n=1 Tax=Yersinia
           bercovieri ATCC 43970 RepID=C4RWF7_YERBE
          Length = 160

 Score =  279 bits (714), Expect = 6e-74
 Identities = 129/159 (81%), Positives = 143/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRVTW  S+DEA++  GD  E+MV+GGGRVY QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGTDDRVTWATSIDEALSFAGDAQEVMVMGGGRVYNQFLDRANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADEANSHSYCFEILERR 160



>UniRef100_D2BWQ4 Dihydrofolate reductase n=1 Tax=Dickeya dadantii
           Ech586 RepID=D2BWQ4_DICD5
          Length = 160

 Score =  279 bits (713), Expect = 8e-74
 Identities = 130/159 (81%), Positives = 146/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR+T+ SIGRPLPGR NI
Sbjct: 2   VISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRNTFRSIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPG D+RVTWV S+D A+AA GDV E+MVIGGG +Y+Q LP+A +LYLTHIDAEVE
Sbjct: 62  VVSSQPGDDERVTWVTSLDAALAAAGDVEEVMVIGGGCIYQQMLPQAGRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W S FSEFHDAD QNSHSYCFEIL+RR
Sbjct: 122 GDTHFPDYEPDEWVSTFSEFHDADEQNSHSYCFEILDRR 160



>UniRef100_C6C9F9 Dihydrofolate reductase n=1 Tax=Dickeya dadantii
           Ech703 RepID=C6C9F9_DICDC
          Length = 165

 Score =  278 bits (711), Expect = 1e-73
 Identities = 128/159 (80%), Positives = 144/159 (90%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIG ENAMPW+LPADLAWFKRNTLNKPVIMGRHT+ SIG+PLPGR NI
Sbjct: 2   MISLIAALAVDRVIGKENAMPWHLPADLAWFKRNTLNKPVIMGRHTYRSIGKPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPG D+RV W  S+DEA+ A GDV E+MVIGGG+VY+Q LPKA +LYLTHIDAEVE
Sbjct: 62  VVSSQPGDDERVIWAASLDEALLAAGDVEEVMVIGGGKVYQQMLPKAGRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFP+YEPD+W S+FSEFHDAD  NSHSYCFEIL+RR
Sbjct: 122 GDTHFPEYEPDEWVSIFSEFHDADEHNSHSYCFEILDRR 160



>UniRef100_C8QA90 Dihydrofolate reductase n=1 Tax=Pantoea sp. At-9b
           RepID=C8QA90_9ENTR
          Length = 160

 Score =  278 bits (710), Expect = 2e-73
 Identities = 128/159 (80%), Positives = 144/159 (90%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALA DR+IGMENAMPWNLPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 1   MISLIAALAADRIIGMENAMPWNLPADLAWFKRNTLNKPVIMGRLTFESIGRPLPGRLNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG  D VTWV S+++A+ A GD  E+MVIGGGR+YEQ LP+A +LYLTHIDAEVE
Sbjct: 61  VVSSKPGNHDGVTWVTSLEDAVNAAGDAEEVMVIGGGRIYEQMLPRADRLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FPDYEPD+W+S FSEFHDADAQNSHSYCFEIL+RR
Sbjct: 121 GDTQFPDYEPDEWQSTFSEFHDADAQNSHSYCFEILDRR 159



>UniRef100_A4TQE3 Dihydrofolate reductase n=24 Tax=Yersinia
           RepID=A4TQE3_YERPP
          Length = 160

 Score =  277 bits (709), Expect = 2e-73
 Identities = 128/159 (80%), Positives = 145/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTD+RVTW  S++EA+A  G+  E+MV+GGGRVY+QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WESVFSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERR 160



>UniRef100_UPI0001A4292B dihydrofolate reductase n=1
           Tax=Pectobacterium carotovorum subsp. brasiliensis
           PBR1692 RepID=UPI0001A4292B
          Length = 160

 Score =  277 bits (708), Expect = 3e-73
 Identities = 127/159 (79%), Positives = 146/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKP+IMGR+T+ SIG+PLPGR NI
Sbjct: 2   VISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPIIMGRNTFRSIGQPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S+ PG DDRVTWV S+D A+AA GDV E+MVIGGG +Y+Q L +A +LYLTHIDAEVE
Sbjct: 62  VVSNHPGDDDRVTWVSSLDAALAAAGDVEEVMVIGGGSIYQQMLAQANRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+SVFSEFHDAD +NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWQSVFSEFHDADERNSHSYCFEILERR 160



>UniRef100_C4SD95 Dihydrofolate reductase n=1 Tax=Yersinia
           mollaretii ATCC 43969 RepID=C4SD95_YERMO
          Length = 160

 Score =  276 bits (707), Expect = 4e-73
 Identities = 128/159 (80%), Positives = 142/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQ GTDDRVTW  S+DEA++  GD  E+MV+GGGRVY QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQSGTDDRVTWATSIDEALSLAGDAEEVMVMGGGRVYNQFLDRANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADEANSHSYCFEILERR 160



>UniRef100_C4U9J8 Dihydrofolate reductase n=1 Tax=Yersinia aldovae
           ATCC 35236 RepID=C4U9J8_YERAL
          Length = 160

 Score =  276 bits (706), Expect = 5e-73
 Identities = 126/159 (79%), Positives = 143/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DR+IGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRIIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPGTDDRVTW  S+++A+   GD  E+MV+GGGRVY+QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGTDDRVTWASSIEQALTLAGDTEEVMVMGGGRVYKQFLGRANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADNANSHSYCFEILERR 160



>UniRef100_D0KML9 Dihydrofolate reductase n=1 Tax=Pectobacterium
           wasabiae WPP163 RepID=D0KML9_PECWW
          Length = 160

 Score =  276 bits (705), Expect = 7e-73
 Identities = 125/159 (78%), Positives = 146/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKP+IMGR+T+ SI +PLPGR N+
Sbjct: 2   VISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPIIMGRNTFRSISQPLPGRLNV 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S+ PG DDRVTWV S+D A+AA G+V E+MVIGGG +Y+Q LP+A +LYLTHIDAEVE
Sbjct: 62  VVSNHPGDDDRVTWVSSLDAALAAAGEVEEVMVIGGGSIYQQMLPQANRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+SVFSEFHDAD +NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWQSVFSEFHDADERNSHSYCFEILERR 160



>UniRef100_C4T7L5 Dihydrofolate reductase n=1 Tax=Yersinia
           intermedia ATCC 29909 RepID=C4T7L5_YERIN
          Length = 160

 Score =  276 bits (705), Expect = 7e-73
 Identities = 127/159 (79%), Positives = 143/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQP  D+RVTW  S++EA++  GDV E+MV+GGGRVY+QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPSADERVTWATSIEEALSFAGDVEEVMVMGGGRVYKQFLARANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWESTFSEFHDADEANSHSYCFEILERR 160



>UniRef100_C6DEZ2 Dihydrofolate reductase n=1 Tax=Pectobacterium
           carotovorum subsp. carotovorum PC1 RepID=C6DEZ2_PECCP
          Length = 160

 Score =  275 bits (704), Expect = 9e-73
 Identities = 126/159 (79%), Positives = 146/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKP+IMGR+T+ SIG+PLPGR NI
Sbjct: 2   VISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPIIMGRNTFRSIGQPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S+ PG DDRVTWV S+D A+AA G+V E+MVIGGG +Y+Q L +A +LYLTHIDAEVE
Sbjct: 62  VVSNHPGDDDRVTWVSSLDAALAAAGEVEEVMVIGGGSIYQQMLAQANRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+SVFSEFHDAD +NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWQSVFSEFHDADERNSHSYCFEILERR 160



>UniRef100_UPI000190DAB1 dihydrofolate reductase n=1 Tax=Salmonella
           enterica subsp. enterica serovar Typhi str. E01-6750
           RepID=UPI000190DAB1
          Length = 133

 Score =  274 bits (701), Expect = 2e-72
 Identities = 128/133 (96%), Positives = 131/133 (98%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV+MGRHTWESIGRPLPGRKNII+S
Sbjct: 1   MIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNIIIS 60

Query: 64  SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123
           SQPGTDDRV WVKSVDEAIAACGD PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT
Sbjct: 61  SQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 120

Query: 124 HFPDYEPDDWESV 136
           HFPDYEPDDWESV
Sbjct: 121 HFPDYEPDDWESV 133



>UniRef100_Q6D0D5 Dihydrofolate reductase n=1 Tax=Pectobacterium
           atrosepticum RepID=Q6D0D5_ERWCT
          Length = 160

 Score =  274 bits (701), Expect = 2e-72
 Identities = 126/159 (79%), Positives = 146/159 (91%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKP+IMGR+T+ SIG+PLPGR NI
Sbjct: 2   VISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPIIMGRNTFRSIGQPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S+ PG D+RVTWV S+D A+AA G+V E+MVIGGG VY+Q L +A +LYLTHIDAEVE
Sbjct: 62  VVSNHPGDDERVTWVSSLDAALAAAGEVEEVMVIGGGSVYQQMLSQANRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+SVFSEFHDAD +NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWQSVFSEFHDADERNSHSYCFEILERR 160



>UniRef100_C6CJ62 Dihydrofolate reductase n=1 Tax=Dickeya zeae
           Ech1591 RepID=C6CJ62_DICZE
          Length = 160

 Score =  271 bits (693), Expect = 2e-71
 Identities = 126/159 (79%), Positives = 144/159 (90%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR+T+ +IGRPLPGR NI
Sbjct: 2   VISLIAALAVDRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRNTFRAIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPG D+RVTWV S+  A+AA  DV E+MVIGGG +Y+Q LP+A +LYLTHIDAEVE
Sbjct: 62  VVSSQPGDDERVTWVTSLAAALAAASDVDEVMVIGGGSIYQQMLPQAGRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W S FSEFHDAD +NSHSYCFEIL+RR
Sbjct: 122 GDTHFPDYEPDEWVSTFSEFHDADDKNSHSYCFEILDRR 160



>UniRef100_D4DXA7 Dihydrofolate reductase n=1 Tax=Serratia odorifera
           DSM 4582 RepID=D4DXA7_SEROD
          Length = 160

 Score =  271 bits (693), Expect = 2e-71
 Identities = 126/159 (79%), Positives = 142/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LSS+ G +  VTW  S+DEA+AA GDV E+MV+GGGR+Y QFL +A ++YLTHIDAEV 
Sbjct: 62  VLSSRAGVETGVTWATSLDEALAAAGDVEEVMVMGGGRIYSQFLARANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WE+ FSEFHDAD QNSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWETSFSEFHDADEQNSHSYCFEILERR 160



>UniRef100_C4ULN4 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri
           ATCC 29473 RepID=C4ULN4_YERRU
          Length = 160

 Score =  271 bits (692), Expect = 2e-71
 Identities = 124/159 (77%), Positives = 141/159 (88%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SSQPG D RV+W  S+DEA+A  G+V E+MV+GGG VY QFL +A ++YLTHIDAEV 
Sbjct: 62  VISSQPGADSRVSWATSIDEALALAGEVEEVMVMGGGHVYSQFLDRAHRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WE+ FSEFHDAD  NSHSYCFE+LERR
Sbjct: 122 GDTHFPDYEPDEWETSFSEFHDADEANSHSYCFEVLERR 160



>UniRef100_D2T4F9 FolA protein n=2 Tax=Erwinia pyrifoliae
           RepID=D2T4F9_ERWP6
          Length = 172

 Score =  270 bits (690), Expect = 4e-71
 Identities = 122/159 (76%), Positives = 143/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALA DRVIGMENAMPW+LPADLAWFK++TLNKPVIMGR TWESIGRPLPGR NI
Sbjct: 14  MISLIAALAADRVIGMENAMPWHLPADLAWFKKHTLNKPVIMGRRTWESIGRPLPGRLNI 73

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S Q G  + VTWV ++++A+ A G+V E+MVIGGGR+YEQ LP+A +LYLTHIDAEVE
Sbjct: 74  VISRQKGVAEGVTWVTTIEDALKAAGEVQELMVIGGGRIYEQLLPQADRLYLTHIDAEVE 133

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+S FSEFHDAD +NSHS+CFEIL+RR
Sbjct: 134 GDTHFPDYEPDEWQSTFSEFHDADEKNSHSFCFEILDRR 172



>UniRef100_A8G9N6 Dihydrofolate reductase n=1 Tax=Serratia
           proteamaculans 568 RepID=A8G9N6_SERP5
          Length = 160

 Score =  270 bits (689), Expect = 5e-71
 Identities = 126/159 (79%), Positives = 140/159 (88%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LSS+ GTD  VTW  S+DEA+AA GDV E+MVIGGGR+Y QFL +A ++YLTHIDAEV 
Sbjct: 62  VLSSRAGTDAGVTWATSIDEALAAAGDVEEVMVIGGGRIYSQFLARANRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD HFPDYEPD+WE+ FSEFHDAD  NSHSYCFEILE R
Sbjct: 122 GDAHFPDYEPDEWETSFSEFHDADEVNSHSYCFEILEHR 160



>UniRef100_D1RWX7 Dihydrofolate reductase n=1 Tax=Serratia odorifera
           4Rx13 RepID=D1RWX7_SEROD
          Length = 160

 Score =  270 bits (689), Expect = 5e-71
 Identities = 125/159 (78%), Positives = 142/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRHNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LSS+PG++  VTW  S+DEA+AA GDV E+MV+GGG +Y QFL +A ++YLTHIDAEV 
Sbjct: 62  VLSSRPGSETGVTWATSLDEALAAAGDVEEVMVMGGGHIYTQFLARADRMYLTHIDAEVG 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+WE+ FSEFHDAD  NSHSYCFEILERR
Sbjct: 122 GDTHFPDYEPDEWETSFSEFHDADELNSHSYCFEILERR 160



>UniRef100_D4GJN7 FolA n=1 Tax=Pantoea ananatis LMG 20103
           RepID=D4GJN7_PANAM
          Length = 171

 Score =  269 bits (688), Expect = 6e-71
 Identities = 126/159 (79%), Positives = 142/159 (89%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALA DR+IGMENAMPW+LPADLAWFKRNTL KPVIMGR T+ESIGRPLPGR NI
Sbjct: 12  MISLIAALAADRIIGMENAMPWDLPADLAWFKRNTLKKPVIMGRLTFESIGRPLPGRLNI 71

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+ + VTWV S+D+AI+A G+  EIMVIGGGR+YEQ L +A +LYLTHIDAEVE
Sbjct: 72  VVSSKPGSAEGVTWVTSLDDAISAAGEAEEIMVIGGGRIYEQMLARADRLYLTHIDAEVE 131

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FPDYEPD+W S FSEFHDAD QNSHSYCFEILERR
Sbjct: 132 GDTQFPDYEPDEWHSTFSEFHDADEQNSHSYCFEILERR 170



>UniRef100_A1JJF1 Dihydrofolate reductase n=1 Tax=Yersinia
           enterocolitica subsp. enterocolitica 8081
           RepID=A1JJF1_YERE8
          Length = 153

 Score =  269 bits (687), Expect = 8e-71
 Identities = 122/151 (80%), Positives = 136/151 (90%)

Query: 9   AVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGT 68
           A DRVIGMENAMPW+LPADLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI++SSQPGT
Sbjct: 3   AADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGT 62

Query: 69  DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDY 128
           DDRVTW  S+D+A+A  GD  E+MV+GGGRVY+QFL +A ++YLTHIDAEV GDTHFPDY
Sbjct: 63  DDRVTWATSIDDALALAGDAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDY 122

Query: 129 EPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EPD+WES FSEFHDAD  NSHSYCFEILERR
Sbjct: 123 EPDEWESTFSEFHDADEANSHSYCFEILERR 153



>UniRef100_Q7N8W0 Dihydrofolate reductase n=1 Tax=Photorhabdus
           luminescens subsp. laumondii RepID=Q7N8W0_PHOLL
          Length = 161

 Score =  268 bits (686), Expect = 1e-70
 Identities = 122/158 (77%), Positives = 141/158 (89%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAALA+DRVIGMEN MPWNLP DLAWFKRNTLNKPVIMGR T+ESIG PLPGR NI+
Sbjct: 3   ISLIAALAMDRVIGMENKMPWNLPGDLAWFKRNTLNKPVIMGRVTYESIGHPLPGRLNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS+QPG D+RVTWV SVDEA+A  GD  E+MV+GGG+VY+QF+ +A ++YLTHIDAEV G
Sbjct: 63  LSNQPGNDERVTWVSSVDEALAVAGDAEEVMVMGGGKVYDQFISRASRMYLTHIDAEVIG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DTHFPDYEPD+W+S F+E+HDAD  NSHSYCFEIL+RR
Sbjct: 123 DTHFPDYEPDEWDSEFTEYHDADELNSHSYCFEILQRR 160



>UniRef100_D3VCQ8 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Xenorhabdus nematophila ATCC 19061
           RepID=D3VCQ8_XENNA
          Length = 161

 Score =  268 bits (686), Expect = 1e-70
 Identities = 121/158 (76%), Positives = 141/158 (89%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A+DRVIGMENAMPW LP DLAWFKRNTL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   ISLIAAMAMDRVIGMENAMPWTLPGDLAWFKRNTLGKPVVMGRVTYESIGRPLPGRLNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           +SSQP +DD+VTWV S++ A+AA GDV EIMV+GGG++YEQF+P A ++YLTHIDAEV G
Sbjct: 63  ISSQPASDDQVTWVNSIEAALAAAGDVEEIMVMGGGKIYEQFIPLASRMYLTHIDAEVIG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DTHFPDYEPD+W SVF+E+HDAD  NSH YCFEILERR
Sbjct: 123 DTHFPDYEPDEWNSVFTEYHDADENNSHGYCFEILERR 160



>UniRef100_D4I0G8 Dihydrofolate reductase n=2 Tax=Erwinia amylovora
           RepID=D4I0G8_ERWAC
          Length = 172

 Score =  268 bits (685), Expect = 1e-70
 Identities = 122/159 (76%), Positives = 141/159 (88%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALA DRVIGMENAMPW+LPADLAWFK+ TLNKPVIMGR TWESIGRPLPGR NI
Sbjct: 14  MISLIAALAADRVIGMENAMPWHLPADLAWFKKQTLNKPVIMGRRTWESIGRPLPGRLNI 73

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S Q G  + VTWV ++++A+ A G+V E+MVIGGG VYEQ LP+A +LYLTHIDAEVE
Sbjct: 74  VISRQKGVAEGVTWVTTIEDALKAAGEVQELMVIGGGHVYEQLLPQADRLYLTHIDAEVE 133

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+S FSEFHDAD +NSHS+CFEIL+RR
Sbjct: 134 GDTHFPDYEPDEWQSTFSEFHDADEKNSHSFCFEILDRR 172



>UniRef100_B2VGQ7 Dihydrofolate reductase n=1 Tax=Erwinia
           tasmaniensis RepID=B2VGQ7_ERWT9
          Length = 160

 Score =  268 bits (685), Expect = 1e-70
 Identities = 121/159 (76%), Positives = 141/159 (88%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALA DRVIGMENAMPW+LPADLAWFK++TLNKPVIMGR TWESIGRPLPGR NI
Sbjct: 2   MISLIAALAADRVIGMENAMPWHLPADLAWFKKHTLNKPVIMGRRTWESIGRPLPGRLNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S Q G  + V WV  +++A++A G+V E+MVIGGGR+YEQ LP+A +LYLTHIDAEVE
Sbjct: 62  VISRQKGEAEGVVWVTGIEDALSAAGEVEELMVIGGGRIYEQMLPRADRLYLTHIDAEVE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPD+W+S FSEFHDAD  NSHS+CFEIL+RR
Sbjct: 122 GDTHFPDYEPDEWQSTFSEFHDADENNSHSFCFEILDRR 160



>UniRef100_D3V2G6 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Xenorhabdus bovienii SS-2004
           RepID=D3V2G6_XENBS
          Length = 161

 Score =  263 bits (673), Expect = 4e-69
 Identities = 119/158 (75%), Positives = 139/158 (87%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A+DRVIGMENAMPW LP DLAWFKRNTL K V+MGR T+ESIGRPLPGR NI+
Sbjct: 3   ISLIAAMAMDRVIGMENAMPWTLPGDLAWFKRNTLGKSVVMGRVTYESIGRPLPGRLNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           +SSQP  DD VTWV++++EA+AA GDV EIMV+GGG++YEQF+P A ++YLTHIDAEV G
Sbjct: 63  ISSQPARDDSVTWVRTIEEALAAAGDVDEIMVMGGGKIYEQFIPLAHRMYLTHIDAEVIG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DTHFPDY PD+W SVF+E+HDAD  NSH YCFEILERR
Sbjct: 123 DTHFPDYAPDEWNSVFTEYHDADEHNSHGYCFEILERR 160



>UniRef100_C7BKH0 Dihydrofolate reductase n=1 Tax=Photorhabdus
           asymbiotica subsp. asymbiotica ATCC 43949
           RepID=C7BKH0_PHOAA
          Length = 161

 Score =  262 bits (670), Expect = 8e-69
 Identities = 119/158 (75%), Positives = 139/158 (87%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAALA+DR+IGM+  MPWNLP DLAWFKRNTLNKPVIMGR T+ESIGRPLPGR NI+
Sbjct: 3   ISLIAALAMDRIIGMDKTMPWNLPGDLAWFKRNTLNKPVIMGRVTYESIGRPLPGRLNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS+QPG D+RVTWV SVDEA+   GD  EIMVIGGG++Y+QF+  A ++YLTHIDAEV G
Sbjct: 63  LSNQPGDDERVTWVSSVDEALVVAGDAEEIMVIGGGKIYDQFISLANRMYLTHIDAEVIG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT+FPDYEPD+W+S F+E+HDAD  NSHSYCFEIL+RR
Sbjct: 123 DTYFPDYEPDEWDSEFTEYHDADELNSHSYCFEILQRR 160



>UniRef100_Q2NVX9 Dihydrofolate reductase n=1 Tax=Sodalis
           glossinidius str. 'morsitans' RepID=Q2NVX9_SODGM
          Length = 161

 Score =  260 bits (665), Expect = 3e-68
 Identities = 121/159 (76%), Positives = 141/159 (88%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALAVDRVIGMEN MPW+L ADLAWFKRNTLNKPVIMGR T+ESIG+PLPGR+NI
Sbjct: 2   IISLIAALAVDRVIGMENTMPWHLSADLAWFKRNTLNKPVIMGRRTFESIGKPLPGRQNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LSS PG +D VTWV +  +A+AA G+V E+MVIGGG+VYE FLP+A +LYLTHIDAEV+
Sbjct: 62  VLSSHPGDNDAVTWVTTPAQALAAAGEVVEVMVIGGGKVYETFLPQAGRLYLTHIDAEVD 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FPDYEPD+W S FS FHDAD +N+HSYCFEIL+RR
Sbjct: 122 GDTWFPDYEPDEWRSTFSAFHDADEKNTHSYCFEILDRR 160



>UniRef100_B4F2I5 Dihydrofolate reductase n=2 Tax=Proteus mirabilis
           RepID=B4F2I5_PROMH
          Length = 161

 Score =  257 bits (657), Expect = 3e-67
 Identities = 121/158 (76%), Positives = 135/158 (85%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAALA DR+IGME AMPW LP DLAWFK+NTLNKPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   ISLIAALAADRIIGMEKAMPWTLPGDLAWFKKNTLNKPVIMGRVTYESIGRPLPNRLNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LSSQPG DD V WVKSV+EA+ A  +  EIMVIGGG+VYEQFLP A KLYLTHIDAEV G
Sbjct: 63  LSSQPGNDDNVVWVKSVEEALQAAENNDEIMVIGGGKVYEQFLPMANKLYLTHIDAEVIG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FPDYEPD+W+S F E+H+AD  NSH+YCFEIL+RR
Sbjct: 123 DTTFPDYEPDEWDSTFMEYHEADENNSHNYCFEILKRR 160



>UniRef100_C0AT60 Putative uncharacterized protein n=1 Tax=Proteus
           penneri ATCC 35198 RepID=C0AT60_9ENTR
          Length = 161

 Score =  255 bits (651), Expect = 1e-66
 Identities = 120/158 (75%), Positives = 135/158 (85%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAALA+DR+IGME AMPW LP DLAWFK+NTLNKPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   ISLIAALAMDRIIGMEKAMPWTLPGDLAWFKKNTLNKPVIMGRVTYESIGRPLPNRLNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LSSQPGTD  V WVKSV+EA+ A  +  EIMVIGGG+VYEQFLP A  LYLTHIDAEV G
Sbjct: 63  LSSQPGTDSEVVWVKSVEEALQAAENHDEIMVIGGGKVYEQFLPMANTLYLTHIDAEVIG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FPDYEPD+W+S F E+H+AD  NSH+YCFEIL+RR
Sbjct: 123 DTTFPDYEPDEWDSTFMEYHEADENNSHNYCFEILKRR 160



>UniRef100_D4BWU0 Dihydrofolate reductase n=1 Tax=Providencia
           rettgeri DSM 1131 RepID=D4BWU0_PRORE
          Length = 164

 Score =  249 bits (635), Expect = 9e-65
 Identities = 116/161 (72%), Positives = 137/161 (85%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A+D+VIGME AMPWNLP DLAWFKRNTLNKPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   ISLIAAMAIDQVIGMEKAMPWNLPGDLAWFKRNTLNKPVIMGRVTYESIGRPLPQRVNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LSS PGTD  V WV S++EA+AA     +V E+MVIGGG+VY+QFLP A KLYLTH+DAE
Sbjct: 63  LSSAPGTDSDVIWVTSIEEALAAAQAIENVEEVMVIGGGKVYQQFLPLANKLYLTHVDAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V GDTHFP YEPD+W+S+F+E+H+AD  N+H YCFEIL +R
Sbjct: 123 VIGDTHFPAYEPDEWDSIFTEYHEADENNTHGYCFEILTKR 163



>UniRef100_D0ZC43 Dihydrofolate reductase n=1 Tax=Edwardsiella tarda
           EIB202 RepID=D0ZC43_EDWTE
          Length = 160

 Score =  248 bits (633), Expect = 2e-64
 Identities = 110/159 (69%), Positives = 136/159 (85%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAAL+ DRVIG++NAMPW+LPADLAWFKRNTL KPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALSADRVIGLDNAMPWHLPADLAWFKRNTLAKPVIMGRKTYESIGRPLPGRHNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S + G DDRVTWV +   A+ A  +  E+M+IGGG +Y QFLP+A +LYLTH+DA+V 
Sbjct: 62  VISRRAGCDDRVTWVTTPQAALEAAAEAQEVMIIGGGSIYSQFLPQASRLYLTHVDADVA 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT+FPDY PD+W++ FSEFHDAD+ NSH+YCFEIL+RR
Sbjct: 122 GDTYFPDYAPDEWQTCFSEFHDADSDNSHAYCFEILDRR 160



>UniRef100_C5B7N8 Dihydrofolate reductase, putative n=1
           Tax=Edwardsiella ictaluri 93-146 RepID=C5B7N8_EDWI9
          Length = 160

 Score =  247 bits (631), Expect = 3e-64
 Identities = 110/159 (69%), Positives = 137/159 (86%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAAL+ DRVIG++NAMPW+L ADLAWFKRNTL KPVIMGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALSADRVIGLDNAMPWHLSADLAWFKRNTLAKPVIMGRKTYESIGRPLPGRHNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S Q G DDRV+WV + + A+ A  D  E+M+IGGG +YEQFLP+A +LYLTH+DA+V 
Sbjct: 62  VISRQAGCDDRVSWVATPEAALTAAADADEVMIIGGGTLYEQFLPQASRLYLTHVDADVA 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT+FPDY PD+W++ FSEFH+AD+ NSH+YCFEIL+RR
Sbjct: 122 GDTYFPDYAPDEWQTCFSEFHEADSDNSHAYCFEILDRR 160



>UniRef100_B2PX52 Putative uncharacterized protein n=1
           Tax=Providencia stuartii ATCC 25827 RepID=B2PX52_PROST
          Length = 167

 Score =  245 bits (626), Expect = 1e-63
 Identities = 115/164 (70%), Positives = 137/164 (83%), Gaps = 6/164 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A+D+VIGME AMPW+LP DLAWFKRNTLNKPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   ISLIAAMAIDQVIGMEKAMPWHLPGDLAWFKRNTLNKPVIMGRVTYESIGRPLPQRVNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           LSS+PG+D  V WV SV+EA+AA        D  E++VIGGG+VY+QFLP A KLYLTH+
Sbjct: 63  LSSKPGSDKNVIWVSSVEEALAAAKQTKTGSDDDEVIVIGGGKVYQQFLPLANKLYLTHV 122

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DAEV GDTHFP YEPD+W+S+F+E+H+AD  NSH YCFEIL +R
Sbjct: 123 DAEVIGDTHFPIYEPDEWDSIFTEYHEADENNSHGYCFEILTKR 166



>UniRef100_D1P1H8 Putative uncharacterized protein n=1
           Tax=Providencia rustigianii DSM 4541 RepID=D1P1H8_9ENTR
          Length = 164

 Score =  244 bits (624), Expect = 2e-63
 Identities = 116/161 (72%), Positives = 135/161 (83%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A D+VIGMENAMPWNLP DLAWFKR TLNKPVIMGR T+E++GRPLP R NI+
Sbjct: 3   ISLIAAMAFDQVIGMENAMPWNLPGDLAWFKRQTLNKPVIMGRVTYEALGRPLPQRVNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDV---PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LSSQ GTD  V WVKSV+EA+ A   V    EIMVIGGG+VY+QFLP A KLYLTH+DAE
Sbjct: 63  LSSQAGTDAGVIWVKSVEEALEAAKAVEGCDEIMVIGGGKVYQQFLPMANKLYLTHVDAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V GDTHFP YEPD+W+S+F+E+H+AD  NSH +CFE+L RR
Sbjct: 123 VIGDTHFPAYEPDEWDSIFTEYHEADENNSHGFCFEVLTRR 163



>UniRef100_D4F219 Dihydrofolate reductase n=1 Tax=Edwardsiella tarda
           ATCC 23685 RepID=D4F219_EDWTA
          Length = 160

 Score =  244 bits (622), Expect = 3e-63
 Identities = 112/158 (70%), Positives = 130/158 (82%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAAL+ DRVIGMENAMPW+LPADLAWFKRNTL KPV+MGR T+ESIGRPLPGR NI
Sbjct: 2   IISLIAALSADRVIGMENAMPWHLPADLAWFKRNTLAKPVVMGRKTYESIGRPLPGRHNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LS Q G DDRVTWV +   A+AA     E+M+IGGG +Y  FLP A +LYLTH+DA+V 
Sbjct: 62  VLSHQVGQDDRVTWVSTPQAALAAAAGADEVMIIGGGTIYRHFLPLASRLYLTHVDADVA 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FPDY  D+W++ FSEFHDAD  NSH YCFEILER
Sbjct: 122 GDTYFPDYASDEWQTRFSEFHDADEDNSHPYCFEILER 159



>UniRef100_B6XFY1 Putative uncharacterized protein n=1
           Tax=Providencia alcalifaciens DSM 30120
           RepID=B6XFY1_9ENTR
          Length = 164

 Score =  240 bits (612), Expect = 4e-62
 Identities = 113/161 (70%), Positives = 134/161 (83%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A D+VIGMENAMPWNLP DLAWFKR TLNKPVIMGR T+E++GRPLP R NI+
Sbjct: 3   ISLIAAMAFDQVIGMENAMPWNLPGDLAWFKRQTLNKPVIMGRVTYEALGRPLPQRVNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDV---PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LSSQ GT+  V WVKS++EA+ A   V    EIMVIGGG+VY+QFLP A KLYLTH+DAE
Sbjct: 63  LSSQAGTETGVIWVKSIEEALEAAKAVEGADEIMVIGGGKVYQQFLPLANKLYLTHVDAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V GDTHFP YEPD+W+S+F+E+H+AD  NSH +C E+L RR
Sbjct: 123 VIGDTHFPAYEPDEWDSIFTEYHEADEANSHGFCIEVLTRR 163



>UniRef100_D2U2B2 Dihydrofolate reductase n=1 Tax=Arsenophonus
           nasoniae RepID=D2U2B2_9ENTR
          Length = 180

 Score =  239 bits (611), Expect = 5e-62
 Identities = 112/159 (70%), Positives = 137/159 (86%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A D+VIG+EN MPW L  DLAWFKRNTLNKPVIMGR T+E+IG+PLP R NII
Sbjct: 21  ISLIAAMAADQVIGLENNMPWVLSGDLAWFKRNTLNKPVIMGRITYEAIGKPLPQRLNII 80

Query: 62  LSSQPGTDDR-VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           LS    ++D+ V WV SVDEA+AA G+V EIM+IGGG++YE FLP+A +LYLTH+DAEV 
Sbjct: 81  LSQTHSSNDKGVVWVNSVDEALAAAGEVEEIMIIGGGKIYELFLPQANRLYLTHVDAEVI 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT+FP YEPD+W+SVF+E+H+AD +NSH+YCFEILERR
Sbjct: 141 GDTYFPAYEPDEWDSVFTEYHEADEKNSHNYCFEILERR 179



>UniRef100_A0KNL5 Dihydrofolate reductase n=1 Tax=Aeromonas
           hydrophila subsp. hydrophila ATCC 7966
           RepID=A0KNL5_AERHH
          Length = 163

 Score =  191 bits (484), Expect = 3e-47
 Identities = 96/162 (59%), Positives = 118/162 (72%), Gaps = 3/162 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A DRVIG++N MPW+LPADLA FKR TL KPV+MGR T+ESIGRPLPGR+N+
Sbjct: 2   MISMIAAMAHDRVIGLDNQMPWHLPADLAHFKRVTLGKPVLMGRKTFESIGRPLPGRRNL 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S  P    D V  + SVD A+A  A  DV E+MVIGGG +Y Q LP+A +LYLT ID 
Sbjct: 62  VISRNPDYRADGVEVIDSVDAALALLAGSDVAELMVIGGGHLYGQLLPRADRLYLTRIDL 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            VEGDT FP ++  DW  +  E H  D +N HSYCFE  +RR
Sbjct: 122 AVEGDTRFPAFDEGDWSCIERESHQPDEKNPHSYCFETWQRR 163



>UniRef100_C4K6P5 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Candidatus Hamiltonella defensa 5AT
           (Acyrthosiphon pisum) RepID=C4K6P5_HAMD5
          Length = 161

 Score =  186 bits (471), Expect = 9e-46
 Identities = 85/158 (53%), Positives = 115/158 (72%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+A +RVIG+ N MPW+LP D AWFK+NTL+KPVIMGR T++S+GR LPGR NI
Sbjct: 2   IISLIAAMAQNRVIGLNNKMPWHLPLDFAWFKKNTLHKPVIMGRKTFDSLGRALPGRMNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ Q      V  V S+++A+ A  D PE+MVIGG  +Y QFLP+A +LYLT +   ++
Sbjct: 62  VMTRQGIASPGVIGVSSMEKALKAAQDAPEVMVIGGAEIYRQFLPQANRLYLTEVLKNIQ 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP+YE   WE VF E H  D  + +S+ F+IL R
Sbjct: 122 GDTYFPEYEQQQWEMVFQESHSPDNSHLYSFSFQILHR 159



>UniRef100_C9QCG5 Dihydrofolate reductase n=1 Tax=Vibrio orientalis
           CIP 102891 RepID=C9QCG5_VIBOR
          Length = 160

 Score =  183 bits (465), Expect = 5e-45
 Identities = 87/159 (54%), Positives = 122/159 (76%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A DRVIG++N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR+NI
Sbjct: 2   IISMIAAMAQDRVIGIDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRQNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V S++EA+ A G+V E+M+IGGG +Y+  LPKA KLY+THI+AE+
Sbjct: 62  VISRDASLVIEGVTTVTSIEEALTAAGEVEEVMIIGGGTIYQACLPKANKLYVTHIEAEI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            GDT FP +  D+++  ++E + AD +N++   F +LER
Sbjct: 122 NGDTQFPAW-GDEFKETYAEAYAADEKNAYDMRFVVLER 159



>UniRef100_A4SJJ4 Dihydrofolate reductase n=1 Tax=Aeromonas
           salmonicida subsp. salmonicida A449 RepID=A4SJJ4_AERS4
          Length = 164

 Score =  182 bits (463), Expect = 8e-45
 Identities = 94/162 (58%), Positives = 116/162 (71%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A DRVIG++N MPW+LPADLA FKR TL KPV+MGR T+ESIGRPLPGR+N++
Sbjct: 3   ISMIAAMAHDRVIGLDNQMPWHLPADLAHFKRVTLGKPVLMGRKTFESIGRPLPGRRNLV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEA---IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S  P    D V  V SV+ A   +A  G+V E+MVIGGG +Y Q LP+A  LYLT ID 
Sbjct: 63  ISRNPDYRADGVEVVDSVEAALMLLANAGNVDELMVIGGGHLYGQLLPQANSLYLTRIDL 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            V GDT FP +E D+W  V  E H+ D +N H YCFE  +RR
Sbjct: 123 AVAGDTCFPAFEEDEWHCVEREPHEPDEKNPHPYCFETWQRR 164



>UniRef100_A5L1A1 Dihydrofolate reductase n=1 Tax=Vibrionales
           bacterium SWAT-3 RepID=A5L1A1_9GAMM
          Length = 159

 Score =  182 bits (461), Expect = 1e-44
 Identities = 87/159 (54%), Positives = 120/159 (75%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG +N MPW+LPAD AWFKR+T+ KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   IISMIAAMANNRVIGKDNQMPWHLPADFAWFKRSTMGKPVVMGRKTYDSIGRPLPGRLNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S     + + VT V S+++A+    DV E+M+IGGG +YE  LPKA KLYLT+ID +V
Sbjct: 62  VISRDASLEIEGVTTVTSIEKALELVSDVEEVMIIGGGSIYETCLPKADKLYLTYIDFDV 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  + W+  F++ + AD +N H+  F ILER
Sbjct: 122 DGDTQFPDW-GEGWKQSFNDTYQADEKNKHNMEFVILER 159




 Score =  181 bits (460), Expect = 2e-44
 Identities = 0/159 (0%), Positives = 0/159 (0%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILER 158



>UniRef100_A3UY31 Dihydrofolate reductase n=1 Tax=Vibrio splendidus
           12B01 RepID=A3UY31_VIBSP
          Length = 159

 Score =  181 bits (460), Expect = 2e-44
 Identities = 85/159 (53%), Positives = 120/159 (75%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG +N MPW+LPAD AWFKR+T+ KPV+MGR T++SIGRPLPGR N+
Sbjct: 2   IISMIAAMANNRVIGKDNQMPWHLPADFAWFKRSTMGKPVVMGRKTYDSIGRPLPGRLNV 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S     + + VT V S+++A+    DV E+M+IGGG +YE  LPKA KLYLT+ID +V
Sbjct: 62  VISRDESLEIEGVTTVTSIEKALELVSDVDEVMIIGGGSIYESCLPKANKLYLTYIDFDV 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  + W+  F++ + AD +N H+  F +LER
Sbjct: 122 DGDTQFPDW-GEGWKQSFNDTYQADEKNKHNMEFVVLER 159



>UniRef100_Q70YQ6 Dihydrofolate reductase n=1 Tax=Moritella profunda
           RepID=Q70YQ6_MORPR
          Length = 162

 Score =  181 bits (458), Expect = 3e-44
 Identities = 87/159 (54%), Positives = 118/159 (74%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S+IAALA +RVIG++N MPW+LPA+L  FKR TL KP++MGR+T+ESIGRPLPGR NI
Sbjct: 2   IVSMIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +LS Q     + VT V ++++A+ A GDV E+M+IGG  +Y Q L  A +LYLTHI+   
Sbjct: 62  VLSRQTDYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQCLAAADRLYLTHIELTT 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT FPDYE  +W+ +  E + AD +N H+Y F +LER
Sbjct: 122 EGDTWFPDYEQYNWQEIEHESYAADDKNPHNYRFSLLER 160



>UniRef100_C9NN44 Dihydrofolate reductase n=1 Tax=Vibrio
           coralliilyticus ATCC BAA-450 RepID=C9NN44_9VIBR
          Length = 161

 Score =  181 bits (458), Expect = 3e-44
 Identities = 89/160 (55%), Positives = 121/160 (75%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A DRVIG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR+NI
Sbjct: 2   IISMIAAMAKDRVIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRQNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V S+D+AI A GDV E+M+IGGG +Y+  LP+A KLY+T+IDA++
Sbjct: 62  VISRDANLAIEDVTTVTSIDDAIKAAGDVEEVMIIGGGAIYKACLPQADKLYVTYIDAQI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP +  D ++   SE + AD +N++   F +LER+
Sbjct: 122 EGDTQFPSW-GDMFKESHSENYAADEKNAYDMRFVVLERQ 160



>UniRef100_B8KEM2 Dihydrofolate reductase n=1 Tax=Vibrio
           parahaemolyticus 16 RepID=B8KEM2_VIBPA
          Length = 161

 Score =  180 bits (457), Expect = 4e-44
 Identities = 88/159 (55%), Positives = 120/159 (75%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A DR+IG +N MPW+LPAD AWFKR T+ KPV+MGR T++SIGRPLPGR+NI
Sbjct: 2   IISMIAAMANDRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYDSIGRPLPGRENI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S     T D VT V S+D+A+ A G+V E+M+IGGG +Y   LP A KLY+THIDA V
Sbjct: 62  VISRDASLTIDGVTTVTSIDDALKAAGNVDEVMIIGGGAIYAACLPLANKLYVTHIDACV 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+   ++E  +SE   AD +N+++  F +LE+
Sbjct: 122 DGDTQFPDWGA-EFEECYSETFTADEKNAYNMRFVVLEK 159



>UniRef100_B7VID9 Dihydrofolate reductase n=2 Tax=Vibrio
           RepID=B7VID9_VIBSL
          Length = 159

 Score =  180 bits (457), Expect = 4e-44
 Identities = 85/159 (53%), Positives = 119/159 (74%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG +N MPW+LPAD AWFKR+T+ KPV+MGR T++SIGRPLPGR N+
Sbjct: 2   IISMIAAMANNRVIGKDNQMPWHLPADFAWFKRSTMGKPVVMGRKTYDSIGRPLPGRLNV 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S     +   VT V S+++A+    DV E+M+IGGG +YE  LPKA KLYLT+ID +V
Sbjct: 62  VISRDESLEIGGVTTVTSIEKALELVSDVDEVMIIGGGSIYESCLPKANKLYLTYIDFDV 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  + W+  F++ + AD +N H+  F +LER
Sbjct: 122 DGDTQFPDW-GEGWKQSFNDTYQADEKNKHNMEFVVLER 159



>UniRef100_Q6LV44 Putative Dihydrofolate reductase n=1
           Tax=Photobacterium profundum RepID=Q6LV44_PHOPR
          Length = 220

 Score =  180 bits (456), Expect = 5e-44
 Identities = 89/158 (56%), Positives = 117/158 (74%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A DRVIG +NAMPW+LPAD AWFK++TL KP++MGR T+ESIGRPLPGR NI+
Sbjct: 59  ISMIAAMAKDRVIGKDNAMPWHLPADFAWFKKSTLGKPIVMGRKTFESIGRPLPGRLNIV 118

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S  P  + + VT V  ++ A  A GD+ E+MVIGGG +YE  LP A +LYLT ID +V+
Sbjct: 119 ISRNPEFSVEGVTVVADIEAAKHAAGDIGELMVIGGGSIYEACLPSADRLYLTFIDLDVD 178

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FPD+  + W   ++E + AD +N+H   F ILER
Sbjct: 179 GDTCFPDW-GEGWIKSYTEHYSADEKNAHDMQFVILER 215



>UniRef100_Q1Z4P4 Putative Dihydrofolate reductase n=1
           Tax=Photobacterium profundum 3TCK RepID=Q1Z4P4_PHOPR
          Length = 164

 Score =  180 bits (456), Expect = 5e-44
 Identities = 87/158 (55%), Positives = 117/158 (74%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A DRVIG +NAMPW+LPAD AWFK++TL KP++MGR T+ESIGRPLPGR NI+
Sbjct: 3   ISMIAAMAKDRVIGKDNAMPWHLPADFAWFKKSTLGKPIVMGRKTFESIGRPLPGRLNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S  P  + + VT V  ++ A  A GD+ E+M+IGGG +YE  LP A +LYLT ID +V+
Sbjct: 63  ISRNPAFSVEGVTVVADIEAAKHAAGDIEELMIIGGGSIYEACLPSADRLYLTFIDLDVD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FPD+  D W   ++E + +D +N+H   F IL+R
Sbjct: 123 GDTCFPDW-GDGWIKSYTEHYSSDEKNAHDMQFVILDR 159



>UniRef100_D1MX71 Dihydrofolate reductase n=1 Tax=Moritella
           yayanosii RepID=D1MX71_9GAMM
          Length = 158

 Score =  179 bits (455), Expect = 7e-44
 Identities = 86/156 (55%), Positives = 115/156 (73%), Gaps = 1/156 (0%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAALA +RVIG++N MPW+LPA+L  FKR TL KP++MGR+T+ESIGRPLPGR NI+LS
Sbjct: 1   MIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNIVLS 60

Query: 64  SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
            Q     + VT V ++++A+ A GDV E+M+IGG  +Y Q+L  A +LYLTHI+  +EGD
Sbjct: 61  RQTDYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQYLAAADRLYLTHIELTIEGD 120

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T FPDYE   W+ +  E + AD +N H Y F +LER
Sbjct: 121 TWFPDYEQYHWQEIEHESYAADDKNPHDYRFSLLER 156



>UniRef100_Q5R038 Dihydrofolate reductase n=1 Tax=Idiomarina
           loihiensis RepID=Q5R038_IDILO
          Length = 166

 Score =  179 bits (453), Expect = 1e-43
 Identities = 86/162 (53%), Positives = 118/162 (72%), Gaps = 5/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+
Sbjct: 3   ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62

Query: 62  LSSQ----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           LS +       D +V WV  V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ 
Sbjct: 63  LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122

Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158
            VEGDT+FPDY +  DW+ +  +   AD +NSH++   I +R
Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164



>UniRef100_A6VM90 Dihydrofolate reductase n=1 Tax=Actinobacillus
           succinogenes 130Z RepID=A6VM90_ACTSZ
          Length = 160

 Score =  178 bits (452), Expect = 1e-43
 Identities = 86/159 (54%), Positives = 111/159 (69%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           + SLI A   ++VIG +N MPW+LPADLAWF+RNT  KPVIMGR T+ESIGRPLP R NI
Sbjct: 2   LFSLIVAATKNQVIGKDNQMPWHLPADLAWFRRNTTGKPVIMGRKTFESIGRPLPKRMNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LS +P   + V W  S++ A+    D  EIM+IGGG +++Q+LPKA KLYLT I AE+E
Sbjct: 62  VLSRRPFEHEGVIWKDSLESAVDFVQDFDEIMLIGGGELFKQYLPKADKLYLTQIQAEIE 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP+   ++WE    E H AD  N++   F IL R+
Sbjct: 122 GDTFFPELNWNEWEIEHEERHSADENNAYDLRFLILRRK 160



>UniRef100_Q1ZLZ5 Putative Dihydrofolate reductase n=1
           Tax=Photobacterium angustum S14 RepID=Q1ZLZ5_PHOAS
          Length = 160

 Score =  178 bits (451), Expect = 2e-43
 Identities = 88/158 (55%), Positives = 116/158 (73%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A DRVIG ENAMPW+LPAD AWFK+ TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   ISMIAAMAHDRVIGKENAMPWHLPADFAWFKQCTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++  P    + +T V  ++ AI A GDV E+M+IGGG +Y+  LP+A  LYLT IDA + 
Sbjct: 63  ITRNPEFHGEGITVVSDIEAAIQAAGDVEEVMIIGGGSIYQACLPQANCLYLTFIDANLN 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP++  + W  V SE + AD +N+++  F +LER
Sbjct: 123 GDTRFPEW-GEGWHQVKSEHYTADEKNAYAMDFTVLER 159



>UniRef100_Q3LT92 FolA n=2 Tax=Vibrio harveyi RepID=Q3LT92_VIBHA
          Length = 159

 Score =  177 bits (449), Expect = 3e-43
 Identities = 83/159 (52%), Positives = 120/159 (75%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR NI
Sbjct: 2   IISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V S+++A+   G+V E+M+IGGG +Y   LP A KLY+THI+AE+
Sbjct: 62  VISRDASLSIEGVTTVTSIEQALEIAGEVEEVMIIGGGAIYAACLPMANKLYVTHIEAEI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT FPD+  ++++  +SE + AD +N+++  F +LE+
Sbjct: 122 EGDTQFPDW-GNEFKETYSEAYQADEKNAYNMRFTVLEK 159



>UniRef100_D0X9A9 Dihydrofolate reductase n=1 Tax=Vibrio harveyi
           1DA3 RepID=D0X9A9_VIBHA
          Length = 159

 Score =  177 bits (449), Expect = 3e-43
 Identities = 84/159 (52%), Positives = 119/159 (74%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR NI
Sbjct: 2   IISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V S+++A+   G+V E+M+IGGG +Y   LP A KLY+THI+AE+
Sbjct: 62  VISRDASLSIEGVTTVTSIEQALEVAGEVEEVMIIGGGAIYAACLPMANKLYVTHIEAEI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+   +++  +SE + AD +N++S  F ILE+
Sbjct: 122 DGDTQFPDW-GTEFKETYSEAYQADEKNAYSMRFTILEK 159



>UniRef100_D0WT35 Dihydrofolate reductase n=2 Tax=Vibrio
           alginolyticus RepID=D0WT35_VIBAL
          Length = 159

 Score =  177 bits (449), Expect = 3e-43
 Identities = 83/159 (52%), Positives = 119/159 (74%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR NI
Sbjct: 2   IISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V S+++A+   GDV E+M+IGGG +Y   LP A KLY+THI+A +
Sbjct: 62  VISRDETLKIEGVTTVTSIEQALEVAGDVEEVMIIGGGAIYTTCLPMANKLYVTHIEAAI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  D+++  +SE + AD +N+++  F +LE+
Sbjct: 122 DGDTQFPDW-GDEFKETYSEMYQADEKNAYNMRFTVLEK 159



>UniRef100_A6F6E6 Putative Dihydrofolate reductase n=1 Tax=Moritella
           sp. PE36 RepID=A6F6E6_9GAMM
          Length = 158

 Score =  177 bits (449), Expect = 3e-43
 Identities = 86/156 (55%), Positives = 114/156 (73%), Gaps = 1/156 (0%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAALA +RVIG++N MPW+LPA+L  FKR TL KP++MGR+T+ESIGRPLPGR NI+LS
Sbjct: 1   MIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNIVLS 60

Query: 64  SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
            Q     + VT V ++++A+ A GDV E+M+IGG  +Y Q L  A +LYLTHI+   EGD
Sbjct: 61  RQADYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQCLAAADRLYLTHIELTTEGD 120

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T FPDYE  +W+ +  E + AD +N H Y F +LER
Sbjct: 121 TWFPDYEQYNWQEIEHESYAADDKNPHDYHFSLLER 156



>UniRef100_A6B5Q2 Dihydrofolate reductase n=2 Tax=Vibrio
           parahaemolyticus RepID=A6B5Q2_VIBPA
          Length = 160

 Score =  177 bits (449), Expect = 3e-43
 Identities = 87/160 (54%), Positives = 120/160 (75%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG +N MPW+LPAD AWFKR T+ KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   IISMIAAMADNRVIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYDSIGRPLPGRLNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V SV++A+ A GDV E+M+IGGG +Y   L  A KLY+THIDA V
Sbjct: 62  VISRDESLSIEGVTTVTSVEKALEAAGDVEEVMIIGGGAIYASCLAMANKLYVTHIDAVV 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FPD+  ++++  +SE + AD +N+++  F ILE++
Sbjct: 122 EGDTQFPDW-GNEFKETYSETYQADEKNAYNMRFTILEKQ 160



>UniRef100_D1MX70 Dihydrofolate reductase n=1 Tax=Photobacterium
           profundum SS9 RepID=D1MX70_PHOPR
          Length = 160

 Score =  177 bits (448), Expect = 4e-43
 Identities = 87/156 (55%), Positives = 115/156 (73%), Gaps = 2/156 (1%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAA+A DRVIG +NAMPW+LPAD AWFK++TL KP++MGR T+ESIGRPLPGR NI++S
Sbjct: 1   MIAAMAKDRVIGKDNAMPWHLPADFAWFKKSTLGKPIVMGRKTFESIGRPLPGRLNIVIS 60

Query: 64  SQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
             P  + + VT V  ++ A  A GD+ E+MVIGGG +YE  LP A +LYLT ID +V+GD
Sbjct: 61  RNPEFSVEGVTVVADIEAAKHAAGDIGELMVIGGGSIYEACLPSADRLYLTFIDLDVDGD 120

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T FPD+  + W   ++E + AD +N+H   F ILER
Sbjct: 121 TCFPDW-GEGWIKSYTEHYSADEKNAHDMQFVILER 155



>UniRef100_Q0EWL5 Dihydrofolate reductase n=1 Tax=Mariprofundus
           ferrooxydans PV-1 RepID=Q0EWL5_9PROT
          Length = 166

 Score =  176 bits (447), Expect = 6e-43
 Identities = 85/159 (53%), Positives = 111/159 (69%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SLI A+  +R+IG  NA+PW LPAD+AWF++NT+ KP++MGR T +SIGRPLPGR N+
Sbjct: 6   LVSLIWAMDHNRLIGCNNALPWQLPADMAWFRKNTMGKPILMGRKTHDSIGRPLPGRTNL 65

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ILS Q     D  T V ++D A+AA  D  EIMV+GG  +Y   LP A +LY+T IDAE 
Sbjct: 66  ILSRQQDLHIDGCTVVDNLDSAVAAVADASEIMVMGGAEIYALLLPHADRLYITEIDAEF 125

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP ++   W +V SE H AD +N+H Y F ILER
Sbjct: 126 EGDAWFPAFDRSAWHTVSSESHPADERNAHPYTFTILER 164



>UniRef100_C9P2R4 Dihydrofolate reductase n=1 Tax=Vibrio
           metschnikovii CIP 69.14 RepID=C9P2R4_VIBME
          Length = 166

 Score =  176 bits (447), Expect = 6e-43
 Identities = 88/159 (55%), Positives = 116/159 (72%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG +N MPW+LPAD AWFKR T+ KPVIMGR T++SIGRPLPGR NI
Sbjct: 2   IISMIAAMANERVIGKDNQMPWHLPADFAWFKRCTIGKPVIMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  P    D V  V S+D A+   G VPE+M+IGGG +Y + LP+A KLY+T IDA+ 
Sbjct: 62  VISRDPELVIDGVDVVSSLDAALLKAGAVPEVMIIGGGSIYTECLPQADKLYITLIDAQF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            GDTHFP++   +W   + E + AD +N++S  F ILER
Sbjct: 122 IGDTHFPNW-GTNWHECYREHYSADDKNAYSMDFIILER 159



>UniRef100_Q2BZR8 Putative Dihydrofolate reductase n=1
           Tax=Photobacterium sp. SKA34 RepID=Q2BZR8_9GAMM
          Length = 160

 Score =  176 bits (446), Expect = 7e-43
 Identities = 87/158 (55%), Positives = 117/158 (74%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A DRVIG ENAMPW+LPAD AWFK+ TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   ISMIAAMAHDRVIGKENAMPWHLPADFAWFKQCTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++  P    + +T V+ ++ A  A GDV E+M+IGGG +Y+  LP+A  LYLT IDA ++
Sbjct: 63  ITRNPEFHAEGITVVRDIEAAKQAAGDVEELMIIGGGSIYQACLPQATCLYLTFIDANLD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP++  + W  V SE + AD +N+++  F +LER
Sbjct: 123 GDTRFPEW-GEGWHQVSSEHYTADEKNAYAMDFMVLER 159



>UniRef100_D0GU26 Dihydrofolate reductase n=1 Tax=Vibrio mimicus
           MB-451 RepID=D0GU26_VIBMI
          Length = 160

 Score =  176 bits (445), Expect = 1e-42
 Identities = 87/160 (54%), Positives = 115/160 (71%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A +R+IG +N MPW+LPAD AWFKR TL KPVIMGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMAENRIIGKDNQMPWHLPADFAWFKRCTLGKPVIMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       D V  V S+D A+A  G+V EIM+IGGG +Y   LP A KLY+T I+AE+
Sbjct: 62  VISRDESLQIDGVDVVTSIDAALAKAGEVDEIMIIGGGSLYAACLPMANKLYITEINAEL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP +   DW+  + E + AD +N+++  F I ER+
Sbjct: 122 DGDTQFPAW-GSDWQECYREHYPADEKNTYAMDFVIFERK 160



>UniRef100_D0M2N3 Dihydrofolate reductase n=1 Tax=Vibrio sp. Ex25
           RepID=D0M2N3_VIBSE
          Length = 159

 Score =  175 bits (444), Expect = 1e-42
 Identities = 83/159 (52%), Positives = 118/159 (74%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR NI
Sbjct: 2   IISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT V S+++A+   GDV E+M+IGGG +Y   LP A KLY+THI+A +
Sbjct: 62  VISRDETLKIEGVTTVTSIEQALDVAGDVEEVMIIGGGAIYAACLPMANKLYVTHIEAAI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  D ++  +SE + AD +N+++  F +LE+
Sbjct: 122 DGDTQFPDW-GDQFKETYSETYQADEKNAYNMRFTVLEK 159



>UniRef100_D2YUL8 Dihydrofolate reductase n=1 Tax=Vibrio mimicus
           VM573 RepID=D2YUL8_VIBMI
          Length = 160

 Score =  175 bits (444), Expect = 1e-42
 Identities = 87/160 (54%), Positives = 115/160 (71%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A +R+IG +N MPW+LPAD AWFKR TL KPVIMGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTLGKPVIMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       D V  V S+D A+A  G+V EIM+IGGG +Y   LP A KLY+T I+AE+
Sbjct: 62  VISRDESLQIDGVDVVASIDAALAKAGEVDEIMIIGGGSLYAACLPMANKLYITEINAEL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP +   DW+  + E + AD +N+++  F I ER+
Sbjct: 122 DGDTQFPAW-GSDWQECYREHYPADEKNTYAMDFVIFERK 160



>UniRef100_A8T8F4 GTPase ObgE n=1 Tax=Vibrio sp. AND4
           RepID=A8T8F4_9VIBR
          Length = 159

 Score =  175 bits (444), Expect = 1e-42
 Identities = 83/159 (52%), Positives = 120/159 (75%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR NI
Sbjct: 2   IISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNI 61

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  Q  + + VT V S+++A+   G V E+M+IGGG +Y   LP+  KLY+THI+A++
Sbjct: 62  VISRDQSLSIEGVTTVMSIEQALEVAGQVEEVMIIGGGAIYTACLPRVNKLYITHIEAKI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT FPD+   +++  +SE + AD +N+++  F ILE+
Sbjct: 122 EGDTQFPDW-GGEFKETYSEVYPADEKNAYNMRFTILEK 159



>UniRef100_A3WNK2 Dihydrofolate reductase n=1 Tax=Idiomarina baltica
           OS145 RepID=A3WNK2_9GAMM
          Length = 166

 Score =  175 bits (444), Expect = 1e-42
 Identities = 81/162 (50%), Positives = 118/162 (72%), Gaps = 5/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+IAA+A +RVIG +NAMPW++P +L +FK+ TL KP++MGR T+ES+GRPLPGRKNI+
Sbjct: 3   VSMIAAMANNRVIGKDNAMPWHIPNELQYFKKVTLGKPIVMGRRTFESLGRPLPGRKNIV 62

Query: 62  LSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           L+SQP      D+ V WV +VD+A AA GD  E+M+IGGG++YE F P   +LY+T I+ 
Sbjct: 63  LTSQPDRHQDPDNGVIWVANVDQAFAAAGDAEELMIIGGGKIYELFFPYCDRLYVTEIEL 122

Query: 118 EVEGDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILER 158
           +VEGDT+FPDY+    W+ +  +F  A      +Y  ++L++
Sbjct: 123 DVEGDTYFPDYQKAHSWQELKRQFVAASDDQVPAYTIKVLDK 164



>UniRef100_C9PMD9 Dihydrofolate reductase n=1 Tax=Pasteurella
           dagmatis ATCC 43325 RepID=C9PMD9_9PAST
          Length = 161

 Score =  175 bits (443), Expect = 2e-42
 Identities = 84/157 (53%), Positives = 109/157 (69%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A+  +RVIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+L
Sbjct: 4   SLIVAITKNRVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRVNIVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S QP   + +TW  S++ A+    D PEIM+IGGG +++Q+L KA KLYLT I  E+EGD
Sbjct: 64  SHQPYEHEGITWKSSLESAVDFVKDSPEIMLIGGGELFKQYLSKADKLYLTEIQTELEGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T+FP+   D+W     E   +D  N +   F IL R+
Sbjct: 124 TYFPEIMWDEWTIEHDELRKSDENNPYDCRFLILRRK 160



>UniRef100_D0IJU2 Dihydrofolate reductase n=1 Tax=Vibrio sp. RC586
           RepID=D0IJU2_9VIBR
          Length = 160

 Score =  174 bits (442), Expect = 2e-42
 Identities = 87/160 (54%), Positives = 115/160 (71%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A +R+IG +N MPW+LPAD AWFKR TL KPVIMGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTLGKPVIMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       D V  V S+D A+A  G+V EIM+IGGG +Y   LP A KLY+T I+AE+
Sbjct: 62  VISRDESLLIDGVDLVASIDAALAKAGEVDEIMIIGGGSLYAACLPMANKLYITEINAEL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP +   DW+  + E + AD +N+++  F I ER+
Sbjct: 122 DGDTQFPAW-GSDWQECYREHYPADEKNTYAMDFVIFERK 160



>UniRef100_Q65RE5 FolA protein n=1 Tax=Mannheimia succiniciproducens
           MBEL55E RepID=Q65RE5_MANSM
          Length = 161

 Score =  174 bits (441), Expect = 3e-42
 Identities = 84/158 (53%), Positives = 108/158 (68%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A   + VIG +N MPW+LPADL WFK NTL KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   LSLIVAATKNHVIGKDNQMPWHLPADLKWFKENTLGKPVIMGRKTFESIGRPLPKRVNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS  P   + V W +S++ A+    D  EIM+IGGG+++EQ+L +A KLY T I  E+EG
Sbjct: 63  LSRHPFEHEGVIWKESLESAVDFLKDSAEIMLIGGGQLFEQYLSQADKLYFTEIQTELEG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP    D+WE  + E+  AD  N++   F ILER+
Sbjct: 123 DTFFPAINTDEWEISYEEYRPADENNAYDLRFLILERK 160



>UniRef100_A5UDH5 Dihydrofolate reductase n=3 Tax=Haemophilus
           influenzae RepID=A5UDH5_HAEIE
          Length = 160

 Score =  174 bits (441), Expect = 3e-42
 Identities = 85/157 (54%), Positives = 108/157 (68%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A  ++ VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+L
Sbjct: 4   SLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S Q    D V W  S++ A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++GD
Sbjct: 64  SRQLFEHDGVVWKGSLESAVDFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 124 TFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160



>UniRef100_A4N7X6 ATP-dependent RNA helicase n=3 Tax=Haemophilus
           influenzae RepID=A4N7X6_HAEIN
          Length = 160

 Score =  174 bits (441), Expect = 3e-42
 Identities = 85/157 (54%), Positives = 108/157 (68%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A  ++ VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+L
Sbjct: 4   SLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S Q    D V W  S++ A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++GD
Sbjct: 64  SRQLFEHDGVVWKGSLESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 124 TFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160



>UniRef100_A6AS75 Dihydrofolate reductase n=1 Tax=Vibrio harveyi
           HY01 RepID=A6AS75_VIBHA
          Length = 159

 Score =  174 bits (440), Expect = 4e-42
 Identities = 83/158 (52%), Positives = 118/158 (74%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A +R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   ISMIAAMADNRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYESIGRPLPGRLNIV 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       + VT V S+++A+   G+V E+M+IGGG +Y   LP A KLY+THI+A++E
Sbjct: 63  ISRDASLFIEGVTTVTSIEQALEVAGEVEEVMIIGGGAIYAACLPMANKLYVTHIEAKIE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FPD+  ++++  +SE + AD +N ++  F ILE+
Sbjct: 123 GDTQFPDW-GNEFKETYSEAYQADEKNVYNMRFTILEK 159



>UniRef100_Q4QM09 Dihydrofolate reductase n=1 Tax=Haemophilus
           influenzae 86-028NP RepID=Q4QM09_HAEI8
          Length = 160

 Score =  172 bits (437), Expect = 8e-42
 Identities = 84/157 (53%), Positives = 108/157 (68%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A+ ++ VIG +N MPW+LPADLAWF++ T  KPVIMGR T+ESIGRPLP R NI+L
Sbjct: 4   SLIVAITLNNVIGKDNQMPWHLPADLAWFRQKTTGKPVIMGRKTFESIGRPLPKRTNIVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S Q    + V W  S + A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++GD
Sbjct: 64  SRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T FP    ++WE  F E+  ADAQN +   F IL R+
Sbjct: 124 TFFPQLNWEEWEIEFDEYRKADAQNRYDCRFLILTRK 160



>UniRef100_Q9CJU8 FolA n=1 Tax=Pasteurella multocida
           RepID=Q9CJU8_PASMU
          Length = 164

 Score =  172 bits (436), Expect = 1e-41
 Identities = 82/156 (52%), Positives = 108/156 (69%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A+  + VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R N++L
Sbjct: 4   SLIVAMTKNHVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNLVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S QP   + V W  S++ A+    D PEI++IGGG +++Q+L KA KLYLT I  E+EGD
Sbjct: 64  SRQPYLHEGVIWQNSLESAVDFVKDSPEILLIGGGELFKQYLHKADKLYLTEIQTELEGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T FP+    DW+  +  +H AD +N +   F IL R
Sbjct: 124 TFFPEIVWQDWQIEYEAWHQADEKNPYDCRFLILSR 159



>UniRef100_D4EE88 Dihydrofolate reductase n=1 Tax=Aggregatibacter
           actinomycetemcomitans D7S-1 RepID=D4EE88_AGGAC
          Length = 161

 Score =  172 bits (436), Expect = 1e-41
 Identities = 82/158 (51%), Positives = 110/158 (69%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  + VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   LSLIVAMTKNHVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS QP   D + W  S++ A+    D  EIM+IGGG++++Q+LP+A +LYLT I  E++G
Sbjct: 63  LSRQPFVHDGIIWKDSLESAVDFVIDSDEIMLIGGGQLFKQYLPQATRLYLTEIQTELDG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP  + D W   F ++  AD QN +   F IL R+
Sbjct: 123 DTFFPPIDWDHWHIEFEQYRPADEQNPYDCRFLILVRK 160



>UniRef100_C9R6T6 Putative uncharacterized protein n=1
           Tax=Aggregatibacter actinomycetemcomitans D11S-1
           RepID=C9R6T6_AGGAD
          Length = 161

 Score =  172 bits (435), Expect = 1e-41
 Identities = 82/158 (51%), Positives = 110/158 (69%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  + VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   LSLIVAMTKNHVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS QP   D + W  S++ A+    D  EIM+IGGG++++Q+LP+A +LYLT I  E+EG
Sbjct: 63  LSRQPFVHDGIIWKDSLESAVDFVIDSDEIMLIGGGQLFKQYLPQATRLYLTEIQTELEG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP  + + W   F ++  AD QN +   F IL R+
Sbjct: 123 DTFFPPIDWNHWNIEFEQYRPADEQNPYDCRFMILVRK 160



>UniRef100_D2YI02 Dihydrofolate reductase n=1 Tax=Vibrio mimicus
           VM603 RepID=D2YI02_VIBMI
          Length = 160

 Score =  172 bits (435), Expect = 1e-41
 Identities = 85/160 (53%), Positives = 113/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A +R+IG +N MPW+LPAD AWFKR TL KPVIMGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMAENRIIGKDNQMPWHLPADFAWFKRCTLGKPVIMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       D V  V S+D A+A  G+V E+M+IGGG +Y   LP   KLY+T I+AE+
Sbjct: 62  VISRDESLQIDGVDVVASIDAALAKAGEVDEVMIIGGGSLYAACLPMVNKLYITEINAEL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP +   DW+  + E   AD +N+++  F I ER+
Sbjct: 122 DGDTQFPAW-GSDWQECYREHCPADEKNTYAMDFVIFERK 160



>UniRef100_P43791 Dihydrofolate reductase n=8 Tax=Haemophilus
           influenzae RepID=DYR_HAEIN
          Length = 160

 Score =  172 bits (435), Expect = 1e-41
 Identities = 84/157 (53%), Positives = 107/157 (68%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A  ++ VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+L
Sbjct: 4   SLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S Q    + V W  S + A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++GD
Sbjct: 64  SRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 124 TFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160



>UniRef100_Q7MP89 Dihydrofolate reductase n=1 Tax=Vibrio vulnificus
           YJ016 RepID=Q7MP89_VIBVY
          Length = 162

 Score =  171 bits (434), Expect = 2e-41
 Identities = 84/159 (52%), Positives = 111/159 (69%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A  R+IG +N MPW+LPAD AWFKR T+ KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   IISMIAAMAKQRIIGKDNQMPWHLPADFAWFKRCTMGKPVVMGRKTYDSIGRPLPGRLNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT   S+  A+A  GD  E+M+IGGG +Y + LPKA KLYLT IDA +
Sbjct: 62  VISRDESLVIEGVTMANSIAHALALAGDADEVMIIGGGSIYAECLPKADKLYLTFIDATI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  + W     E + AD +N ++  F ILER
Sbjct: 122 DGDTQFPDW-GEQWCESHREHYSADEKNRYAMDFVILER 159



>UniRef100_Q8DEC9 Dihydrofolate reductase n=1 Tax=Vibrio vulnificus
           RepID=Q8DEC9_VIBVU
          Length = 162

 Score =  171 bits (433), Expect = 2e-41
 Identities = 83/159 (52%), Positives = 111/159 (69%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A  R+IG +N MPW+LPAD AWFKR T+ KP++MGR T++SIGRPLPGR NI
Sbjct: 2   IISMIAAMAKQRIIGKDNQMPWHLPADFAWFKRCTMGKPIVMGRKTYDSIGRPLPGRLNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + VT   S+  A+A  GD  E+M+IGGG +Y + LPKA KLYLT IDA +
Sbjct: 62  VISRDESLVIEGVTMANSIAHALALAGDADEVMIIGGGSIYAECLPKADKLYLTFIDATI 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  + W     E + AD +N ++  F ILER
Sbjct: 122 DGDTQFPDW-GEQWCESHREHYSADEKNRYAMDFVILER 159



>UniRef100_Q5E867 Dihydrofolate reductase n=1 Tax=Vibrio fischeri
           ES114 RepID=Q5E867_VIBF1
          Length = 155

 Score =  171 bits (432), Expect = 3e-41
 Identities = 82/156 (52%), Positives = 110/156 (70%), Gaps = 2/156 (1%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAA+A +R+IG++N MPW+LPAD AWFK+ T+ KP++MGR T+ESIGRPLPGR NI+LS
Sbjct: 1   MIAAMAKNRIIGIDNQMPWHLPADFAWFKKCTMGKPIVMGRKTYESIGRPLPGRLNIVLS 60

Query: 64  SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
                  D VT V S++EA  A GD+ E+M+IGGG +Y+  L  A KLYLT IDA++ GD
Sbjct: 61  RDANLQIDGVTCVTSIEEAKQAAGDIEELMIIGGGSIYQACLSDADKLYLTFIDADINGD 120

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T FPD+  + W    SE +  D +N +   F +LER
Sbjct: 121 TQFPDW-GEGWNQTHSETYSKDEKNQYDMEFVVLER 155



>UniRef100_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia
           cicadellinicola str. Hc (Homalodisca coagulata)
           RepID=Q1LSS4_BAUCH
          Length = 165

 Score =  171 bits (432), Expect = 3e-41
 Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+ VDR+IG++N MPW+L  DL WFK++T NKPVIMGR T+++I +PL GR NI
Sbjct: 2   IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61

Query: 61  ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS    P  D  + WV +  +A+ A G+V E+MVIGG ++Y  F+ +A +LYLTHID  
Sbjct: 62  VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           ++GDT FP Y  + W   F ++H+   +N   Y FEILER
Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161



>UniRef100_C4L9L7 Dihydrofolate reductase n=1 Tax=Tolumonas auensis
           DSM 9187 RepID=C4L9L7_TOLAT
          Length = 163

 Score =  171 bits (432), Expect = 3e-41
 Identities = 89/159 (55%), Positives = 112/159 (70%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A+A  RVIG  N MPW+LPADL  FKR TL KPVIMGR T+ESIGRPLPGR+N++
Sbjct: 3   ISLIVAMAQHRVIGRGNQMPWHLPADLRHFKRVTLGKPVIMGRKTFESIGRPLPGRRNLV 62

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           ++ +     D V  V S+D A+A  GD  E+M+IGGG++Y + LP A +LYLTHID  V 
Sbjct: 63  ITRNSDWQADGVESVNSLDAALALVGDEAEVMIIGGGQLYREALPLAHRLYLTHIDLTVN 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + DT FPDY    W++V  E H AD +N ++Y FE LER
Sbjct: 123 DADTWFPDYSVCRWQTVAEEMHCADEKNPYNYRFETLER 161



>UniRef100_A6D791 Dihydrofolate reductase n=1 Tax=Vibrio shilonii
           AK1 RepID=A6D791_9VIBR
          Length = 159

 Score =  171 bits (432), Expect = 3e-41
 Identities = 86/159 (54%), Positives = 116/159 (72%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG +N MPW+LPAD  WFK+ T+ KPVIMGR T+ESIGRPLPGR+NI
Sbjct: 2   IISMIAAMADNRVIGKDNQMPWHLPADFIWFKKCTMGKPVIMGRKTYESIGRPLPGRQNI 61

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S +     D V  V S+++A++   DV E M+IGGG  YE  +P A KLYLT+IDA V
Sbjct: 62  VVSRNSELCIDGVETVTSLEQALSLVSDVEEAMIIGGGSFYEHCMPMANKLYLTYIDANV 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FPD+  + W+ V +E + AD +N++   F ILER
Sbjct: 122 DGDTRFPDW-GEGWKQVHNEQYQADEKNAYDMQFVILER 159



>UniRef100_C6APV3 Dihydrofolate reductase n=1 Tax=Aggregatibacter
           aphrophilus NJ8700 RepID=C6APV3_AGGAN
          Length = 161

 Score =  170 bits (431), Expect = 4e-41
 Identities = 82/158 (51%), Positives = 109/158 (68%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  +RVIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   LSLIVAMTKNRVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS QP   D V W  S++ A+    D  EIM+IGGG+++ ++L KA +LYLT I  E++G
Sbjct: 63  LSRQPFEHDGVIWKDSLESAVDFVRDSKEIMLIGGGQLFNEYLSKADRLYLTEIQTELDG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP    D+W   F ++  AD QN +   F IL ++
Sbjct: 123 DTFFPSINWDEWFIEFEQYRPADEQNPYDCRFLILLKK 160



>UniRef100_B5FGG3 Dihydrofolate reductase n=1 Tax=Vibrio fischeri
           MJ11 RepID=B5FGG3_VIBFM
          Length = 155

 Score =  170 bits (431), Expect = 4e-41
 Identities = 82/156 (52%), Positives = 111/156 (71%), Gaps = 2/156 (1%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAA+A +R+IG++N MPW+LPAD AWFKR T+ KP++MGR T+ESIGR LPGR NI+LS
Sbjct: 1   MIAAMAKNRIIGIDNQMPWHLPADFAWFKRCTMGKPIVMGRKTYESIGRSLPGRLNIVLS 60

Query: 64  SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
                  D VT V S++EA  A GD+ E+M+IGGG +Y+  L  A KLYLT IDA+++GD
Sbjct: 61  RDANLQIDGVTCVTSIEEAKQAAGDIEELMIIGGGSIYQACLADADKLYLTFIDADIKGD 120

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T FPD+  + W+   SE +  D +N +   F +LER
Sbjct: 121 TQFPDW-GEGWDQTHSEMYPKDEKNQYDMEFVVLER 155



>UniRef100_D0I8H5 Dihydrofolate reductase n=1 Tax=Grimontia hollisae
           CIP 101886 RepID=D0I8H5_VIBHO
          Length = 160

 Score =  170 bits (430), Expect = 5e-41
 Identities = 88/158 (55%), Positives = 112/158 (70%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A  RVIG +NAMPW+LPAD AWFK+NTL KPVIMGR T+ESIGRPLPGR+NI+
Sbjct: 3   ISMIAAMAKGRVIGKDNAMPWHLPADFAWFKQNTLGKPVIMGRKTYESIGRPLPGRRNIV 62

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S  +    + V    S+D AIA  G V E ++IGGG +Y   LP+A KLYLT IDA++E
Sbjct: 63  ISRDESWAAEGVESATSIDAAIALAGAVEEAVIIGGGAIYTACLPRADKLYLTFIDADIE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FPD+  + W  V      AD +N ++  F +LER
Sbjct: 123 GDTCFPDW-GEGWLEVQKTAFVADEKNRYNMEFVVLER 159



>UniRef100_D7HDE4 Dihydrofolate reductase n=1 Tax=Vibrio cholerae
           RC385 RepID=D7HDE4_VIBCH
          Length = 165

 Score =  169 bits (428), Expect = 9e-41
 Identities = 84/160 (52%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDTHFP++   DW     E + AD +N++   F I ER+
Sbjct: 122 EGDTHFPEW-GSDWLERSREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_A6Y0I5 Dihydrofolate reductase n=3 Tax=Vibrio cholerae
           RepID=A6Y0I5_VIBCH
          Length = 165

 Score =  169 bits (428), Expect = 9e-41
 Identities = 84/160 (52%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW   F E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERFREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_A6A7Q6 Dihydrofolate reductase n=1 Tax=Vibrio cholerae
           MZO-2 RepID=A6A7Q6_VIBCH
          Length = 165

 Score =  169 bits (428), Expect = 9e-41
 Identities = 84/160 (52%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDASLQIEGVDVVTSIEAALAIAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW   F E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERFREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_A4NZZ8 Dihydrofolate reductase n=1 Tax=Haemophilus
           influenzae 22.4-21 RepID=A4NZZ8_HAEIN
          Length = 160

 Score =  169 bits (428), Expect = 9e-41
 Identities = 82/157 (52%), Positives = 107/157 (68%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           SLI A  ++ VIG +N +PW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+L
Sbjct: 4   SLIVATTLNSVIGKDNQIPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVL 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           S Q    + V W  S + A+    D  EIM++GGG +++Q+LPKA KLYLT I  E++GD
Sbjct: 64  SRQLFEHEGVIWKDSFESAVNFVRDFDEIMLLGGGELFKQYLPKADKLYLTQIQTELDGD 123

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 124 TFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160



>UniRef100_A2PXK6 Dihydrofolate reductase n=1 Tax=Vibrio cholerae
           MZO-3 RepID=A2PXK6_VIBCH
          Length = 165

 Score =  169 bits (427), Expect = 1e-40
 Identities = 84/160 (52%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDVSLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW   F E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERFREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_C9P9B7 Dihydrofolate reductase n=1 Tax=Vibrio furnissii
           CIP 102972 RepID=C9P9B7_VIBFU
          Length = 159

 Score =  167 bits (423), Expect = 3e-40
 Identities = 81/159 (50%), Positives = 112/159 (70%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +R+IG +N MPW+LPAD  WFKR T+ KPV+MGR T++SIGRPLPGR+NI
Sbjct: 2   IISMIAAMASNRIIGKDNQMPWHLPADFVWFKRCTMGKPVVMGRKTYQSIGRPLPGRQNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       D V  V S+D A+   G   E+M+IGGG +Y + LP+A KLY+T IDA++
Sbjct: 62  VISRDASLVIDGVDVVTSIDAALDKAGAADEVMIIGGGSIYTECLPRAGKLYITLIDADL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FP +   +W+    E +DAD +N +   F ILER
Sbjct: 122 DGDTQFPAWGA-EWQETHREHYDADEKNQYDMDFVILER 159



>UniRef100_C2IN22 Dihydrofolate reductase n=1 Tax=Vibrio cholerae
           TMA 21 RepID=C2IN22_VIBCH
          Length = 165

 Score =  167 bits (423), Expect = 3e-40
 Identities = 83/160 (51%), Positives = 111/160 (69%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I  ++
Sbjct: 62  VISRDVSLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHTKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW   F E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERFREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_A2PC61 Dihydrofolate reductase n=2 Tax=Vibrio cholerae
           RepID=A2PC61_VIBCH
          Length = 165

 Score =  166 bits (420), Expect = 8e-40
 Identities = 83/160 (51%), Positives = 111/160 (69%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW     E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERSREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_D0HUH5 Dihydrofolate reductase n=1 Tax=Vibrio cholerae CT
           5369-93 RepID=D0HUH5_VIBCH
          Length = 165

 Score =  166 bits (419), Expect = 1e-39
 Identities = 83/160 (51%), Positives = 111/160 (69%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVLMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW     E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERSREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_C9Q1P5 Dihydrofolate reductase n=1 Tax=Vibrio sp. RC341
           RepID=C9Q1P5_9VIBR
          Length = 160

 Score =  165 bits (418), Expect = 1e-39
 Identities = 83/160 (51%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I+A+A +R+IG +N MPW+LPAD AWFKR TL KPVIMGR T++SIGRPLPGR NI
Sbjct: 2   MISMISAMADNRIIGKDNQMPWHLPADFAWFKRCTLGKPVIMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       D V  V S+D A+A  G V E+M+IGGG +Y   LP A KLY+T I A +
Sbjct: 62  VISRDENLQIDGVDVVTSIDAALAKAGAVDEVMIIGGGSLYAACLPIANKLYITEIRANL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP++   +W+    E + AD +N+++  F I ER+
Sbjct: 122 DGDTQFPEW-GSEWQEGAREHYPADEKNAYAMDFVIFERQ 160



>UniRef100_A5F8P5 Dihydrofolate reductase n=15 Tax=Vibrio cholerae
           RepID=A5F8P5_VIBC3
          Length = 165

 Score =  165 bits (417), Expect = 2e-39
 Identities = 82/160 (51%), Positives = 111/160 (69%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       + V  V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP++   DW     E + AD +N++   F I ER+
Sbjct: 122 DGDTQFPEW-GSDWLERSREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_A4C912 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Pseudoalteromonas tunicata D2
           RepID=A4C912_9GAMM
          Length = 157

 Score =  164 bits (415), Expect = 3e-39
 Identities = 79/152 (51%), Positives = 108/152 (71%), Gaps = 2/152 (1%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAA+A +R+IG  N MPW+LPADL  FK+ TL KPV+MGR T+ESIGRPLPGRKNI++S
Sbjct: 1   MIAAMANNRIIGQNNQMPWHLPADLQHFKKVTLGKPVVMGRKTFESIGRPLPGRKNIVIS 60

Query: 64  -SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
            +     + +  V + +EAI   G++ E+M+IGGG +Y+ FLP+ Q+LYLT I+ E +GD
Sbjct: 61  RNTEFYAEGIFVVSTPEEAIEIAGEIDELMIIGGGHIYDVFLPRCQRLYLTFIELETDGD 120

Query: 123 THFPDYEP-DDWESVFSEFHDADAQNSHSYCF 153
           T FPDYE    W+ + SE H +D  N + Y F
Sbjct: 121 TQFPDYEKVGPWQVISSEKHQSDKSNPYDYTF 152



>UniRef100_P12833 Dihydrofolate reductase type 3 n=1 Tax=Salmonella
           enterica subsp. enterica serovar Typhimurium
           RepID=DYR3_SALTY
          Length = 162

 Score =  164 bits (415), Expect = 3e-39
 Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA + +IG +N +PW+LPADL  FK  TL KPV+MGR T+ESIGRPLPGR+N+
Sbjct: 2   LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  P    + V    S+D A+A   D  E M+IGGG++Y + LP+A +LYLT+IDA++
Sbjct: 62  VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDTHFPDY    W+ +    H AD +NS++  F  L R+
Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161



>UniRef100_A6AHG6 Dihydrofolate reductase n=1 Tax=Vibrio cholerae
           623-39 RepID=A6AHG6_VIBCH
          Length = 165

 Score =  163 bits (412), Expect = 6e-39
 Identities = 82/160 (51%), Positives = 110/160 (68%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+A  R+IG +N MPW+LPAD AWFKR TL KPV+MGR T++SIGRPLPGR NI
Sbjct: 2   MISMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       +    V S++ A+A  G+V E+M+IGGG +Y   LP A KLY+T I A++
Sbjct: 62  VISRDVSLQIEGGDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAKL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP++   DW     E + AD +N++   F I ER+
Sbjct: 122 EGDTQFPEW-GSDWLERSREHYPADEKNAYGMDFVIFERQ 160



>UniRef100_Q47VL9 Dihydrofolate reductase n=1 Tax=Colwellia
           psychrerythraea 34H RepID=Q47VL9_COLP3
          Length = 170

 Score =  162 bits (411), Expect = 8e-39
 Identities = 82/165 (49%), Positives = 112/165 (67%), Gaps = 7/165 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S+I A A + +IG +N MPW+LPADLA+FK+ TL KP+IMGR T+ESIGRPLPGR+NI
Sbjct: 3   ILSMIVATADNNIIGKDNDMPWHLPADLAYFKKVTLGKPIIMGRKTFESIGRPLPGRRNI 62

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIA------ACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++S  +    + +  V SV++A+A            EIMVIGGG +Y   LPKA +LY+T
Sbjct: 63  VISRDEHYQAEGIDSVTSVEQALALVDGSDGIEGAEEIMVIGGGAIYAHCLPKADRLYIT 122

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           HI A ++GDT FP+YE   WE V SE  ++D +N H   F + ER
Sbjct: 123 HIKAAIDGDTKFPNYEDGSWEKVSSELRESDEKNIHQLDFCVYER 167



>UniRef100_Q1ZCG4 Dihydrofolate reductase n=1 Tax=Psychromonas sp.
           CNPT3 RepID=Q1ZCG4_9GAMM
          Length = 162

 Score =  162 bits (410), Expect = 1e-38
 Identities = 82/159 (51%), Positives = 112/159 (70%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+IAA+A DRVIG++N MPW+LPADLA+FK+ TL KPVIMGR T++SIG PLPGR+NI+
Sbjct: 3   ISMIAAMAADRVIGLDNKMPWHLPADLAFFKKVTLGKPVIMGRKTYQSIGFPLPGRQNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           LS       + V  V+S+ +A+A   D  E+M+IGG  +YE++L +   LYLT I+ +V 
Sbjct: 63  LSRDTTLRIEGVVCVQSMTQALALVEDATEVMIIGGASLYEKYLEQVDCLYLTFIELKVA 122

Query: 121 GDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FPDYE    W+ V  + H  D +N ++Y F   ER
Sbjct: 123 GDTYFPDYEKQGSWKEVARDVHLKDTKNGYNYQFVTFER 161



>UniRef100_D0KZ69 Dihydrofolate reductase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KZ69_HALNC
          Length = 177

 Score =  160 bits (406), Expect = 3e-38
 Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AAL  ++VIG  NA+PW+LPADL  FK+ T+ KP+IMGR T++SIGRPLPGRKNI+
Sbjct: 3   IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           +S  P    D VT V S+D A+ A    PE+MVIGG  +Y QFLP+A +LY T +   + 
Sbjct: 63  ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GD  FP Y   DW  V  E H ADA N   Y F   +R
Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161



>UniRef100_B6EL46 Dihydrofolate reductase type 3 n=1 Tax=Aliivibrio
           salmonicida LFI1238 RepID=B6EL46_ALISL
          Length = 173

 Score =  160 bits (406), Expect = 3e-38
 Identities = 83/172 (48%), Positives = 110/172 (63%), Gaps = 16/172 (9%)

Query: 2   ISLIAALAVD--------------RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTW 47
           IS+IAA+A +              R+IG  N MPW+LPAD AWFK+ T+ KP++MGR T+
Sbjct: 3   ISMIAAMANNGKIDKSCNLSNSQSRIIGKNNQMPWHLPADFAWFKQCTMGKPIVMGRKTY 62

Query: 48  ESIGRPLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPK 106
           ESIGRPLPGR NI+LS       + VT V S+DEA    GD+ E+M+IGGG +Y+  LP 
Sbjct: 63  ESIGRPLPGRLNIVLSRDASLKIEGVTCVTSIDEAKQVAGDIEELMIIGGGSIYQACLPD 122

Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           A  LYLT IDA+++GDT FPD+  + W    SE +  D +N +   F +LER
Sbjct: 123 ADTLYLTFIDADIDGDTQFPDW-GEGWNQTHSEMYLKDEKNQYDMEFVVLER 173



>UniRef100_B0UV15 Dihydrofolate reductase n=2 Tax=Histophilus somni
           RepID=B0UV15_HAES2
          Length = 161

 Score =  160 bits (406), Expect = 3e-38
 Identities = 77/159 (48%), Positives = 108/159 (67%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  + VIG  N MPW+LPADLAWF++NT  KP+IMGR T+ESIGRPLP R NI+
Sbjct: 3   LSIIVAMTKNHVIGKNNQMPWHLPADLAWFRQNTGGKPIIMGRKTFESIGRPLPNRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           LS  P   D + W  ++  A+    +   EIM+IGGG +++Q+LP+A KLYLT I  E+E
Sbjct: 63  LSRSPYEHDGIIWKDNLQSAVDFVRENHHEIMLIGGGELFKQYLPQANKLYLTEIQTELE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP++   +W+  F +   AD +N ++  F IL R+
Sbjct: 123 GDTFFPEFNWQEWQIEFEQQRPADEKNPYACRFLILNRK 161



>UniRef100_C7R934 Dihydrofolate reductase n=1 Tax=Kangiella
           koreensis DSM 16069 RepID=C7R934_KANKD
          Length = 171

 Score =  159 bits (403), Expect = 7e-38
 Identities = 81/163 (49%), Positives = 106/163 (65%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISL+ A+A DRVIG +N MPW+LPADL  FK  TL KPVIMGR T ESIG  LPGR NI
Sbjct: 6   IISLVVAMANDRVIGKDNQMPWHLPADLKHFKAVTLGKPVIMGRKTHESIGMVLPGRHNI 65

Query: 61  ILSSQPG-----TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           I+S  P       ++R   V S+++A  A G+  E+M+IGG  +Y Q + +A KLYLT I
Sbjct: 66  IISRNPDYRSQFHNERCQVVTSLEQAFEAAGEAQEVMIIGGSNIYHQMIDQADKLYLTFI 125

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           D + +GD HFPD+   +W+ V  + H  D +N + Y F  LER
Sbjct: 126 DLDTDGDAHFPDWTHLEWKEVSRDKHQPDEKNPYHYQFVELER 168



>UniRef100_A1S9H0 Dihydrofolate reductase n=1 Tax=Shewanella
           amazonensis SB2B RepID=A1S9H0_SHEAM
          Length = 160

 Score =  159 bits (401), Expect = 1e-37
 Identities = 78/144 (54%), Positives = 105/144 (72%), Gaps = 1/144 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNQMPWHLPEDLKHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q   + + ++ V S +EA+A  GD  E++VIGGG++Y+  + +A KLYLT I  EVE
Sbjct: 63  ISRQSDYSHEGISLVSSFEEAVALAGDCEELVVIGGGQLYQTLISQADKLYLTEIALEVE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDAD 144
           GDTHFP ++   WE+V S  H +D
Sbjct: 123 GDTHFPAWDDGSWETVESTEHVSD 146



>UniRef100_A0Y6E2 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Alteromonadales bacterium TW-7
           RepID=A0Y6E2_9GAMM
          Length = 163

 Score =  158 bits (400), Expect = 2e-37
 Identities = 86/161 (53%), Positives = 113/161 (70%), Gaps = 8/161 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS+IAA+A +RVIG++N MPW+LPADL  FK  T  KPVIMGR T+ESIGRPLPGR+NI
Sbjct: 2   IISMIAAMANNRVIGLDNKMPWHLPADLQHFKAVTTGKPVIMGRKTFESIGRPLPGRRNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAA----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I++    T+ +   +++V    AA    CG V E+M+IGGG VY+QFL +A++LYLT ID
Sbjct: 62  IITR--NTEYKAEGIETVTSPEAALSLVCG-VEEVMIIGGGNVYQQFLTQAERLYLTFID 118

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEIL 156
            +VEGDT FPDY+   +WE    +    D +N HSY F  L
Sbjct: 119 LDVEGDTQFPDYQAVANWEVKEEQVKLPDEKNKHSYKFVTL 159



>UniRef100_B8GN07 Dihydrofolate reductase n=1 Tax=Thioalkalivibrio
           sp. HL-EbGR7 RepID=B8GN07_THISH
          Length = 162

 Score =  157 bits (398), Expect = 3e-37
 Identities = 77/158 (48%), Positives = 107/158 (67%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  + +IG +N +PW+LPADLA+FKR T+  P++MGR TWESIGRPLPGR +I+
Sbjct: 3   LSLIVAVDRNNLIGRDNQLPWHLPADLAFFKRTTMGAPMLMGRKTWESIGRPLPGRTSIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++  P    +    V S++E IAA GD PE+ VIGG +++   LP A +LYLT ID   E
Sbjct: 63  ITRDPDYRAEGARVVHSIEEGIAAAGDAPELFVIGGAKLFVDTLPLADRLYLTRIDHAFE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP+   D W  +  E H+ D +N+++Y F  LER
Sbjct: 123 GDTWFPEI-GDAWREITREEHEPDEKNAYAYAFITLER 159



>UniRef100_C0N5C2 Dihydrofolate reductase n=1 Tax=Methylophaga
           thiooxidans DMS010 RepID=C0N5C2_9GAMM
          Length = 163

 Score =  157 bits (398), Expect = 3e-37
 Identities = 76/158 (48%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++I A+   R+IG EN +PW L ADL +F+R T+ KP+IMGR T ESIGRPLPGR+NI+
Sbjct: 3   IAIIVAMDEQRLIGRENDLPWKLSADLQYFRRTTMGKPIIMGRSTHESIGRPLPGRQNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q     D    V S++ A+A C D  E+MV+GG  +Y+Q LP A  LYLT + A + 
Sbjct: 63  LTKQQDYQADGCEVVNSIEAAMALCSDAEEMMVMGGASLYQQLLPLADTLYLTRVHASLT 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP++   DW  + SE H AD  N   Y F+  +R
Sbjct: 123 GDTWFPEWSEQDWMLISSEDHQADENNEFDYSFQCYQR 160



>UniRef100_UPI0000E0ED99 Dihydrofolate reductase n=1
           Tax=Rhodobacterales bacterium HTCC2255
           RepID=UPI0000E0ED99
          Length = 169

 Score =  156 bits (394), Expect = 8e-37
 Identities = 78/160 (48%), Positives = 106/160 (66%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++I A+A +R+IG +N MPW+LPADL  FKR T+ KPV+MGR T+ESIG+ LPGR NI+
Sbjct: 9   LAIIVAMAHNRIIGADNDMPWHLPADLQHFKRTTMGKPVVMGRKTYESIGKALPGRHNIV 68

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ P    +  + V SVDEA+A C    E+M+IGGG +Y   +   Q L+LT ID  V 
Sbjct: 69  ITTNPDYHLEDASVVYSVDEALALCAQEDEVMIIGGGSIYALLIEHTQTLHLTFIDKAVA 128

Query: 121 GDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FPD+ E   WE V  E H  D +N H Y F  L+R+
Sbjct: 129 GDTTFPDWTEYGQWEEVSREQHQRDEKNPHDYEFVTLQRQ 168



>UniRef100_Q2BL89 Dihydrofolate reductase n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BL89_9GAMM
          Length = 167

 Score =  156 bits (394), Expect = 8e-37
 Identities = 77/165 (46%), Positives = 112/165 (67%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++I A A +RVIG+ N +PW+LP DL +FK+ T+ KP+IMGR+T+ESIGRPLPGR NI+
Sbjct: 3   LAIIVAQAKNRVIGINNKLPWHLPEDLRYFKQVTMGKPIIMGRNTYESIGRPLPGRTNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEA------IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ Q     + V  V S++EA      IA    + E MVIGG ++YEQ L  AQ+LYLT 
Sbjct: 63  ITRQNDYAPEGVRVVNSLEEAVELAESIALINGIDEAMVIGGAQIYEQALASAQRLYLTE 122

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +DAE++GD  FP++E  +W  V  E   A+  N ++Y F +L+R+
Sbjct: 123 VDAEIDGDAWFPEFERQEWSEVGREDFSAEGPNPYNYSFIVLDRK 167



>UniRef100_Q15PF1 Dihydrofolate reductase n=1 Tax=Pseudoalteromonas
           atlantica T6c RepID=Q15PF1_PSEA6
          Length = 171

 Score =  155 bits (393), Expect = 1e-36
 Identities = 82/168 (48%), Positives = 109/168 (64%), Gaps = 11/168 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+++AA+A  RVIG+ N MPW++PADL  FKR TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 4   IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC------GDVP----EIMVIGGGRVYEQFLPKAQKL 110
           ++S         + V S ++AIA          +P    E+MVIGGG VY+ FLP A +L
Sbjct: 64  ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YLT ID +  GDT+FP+Y    W+ + SE +D D +N HSY F  L R
Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171



>UniRef100_A0L069 Dihydrofolate reductase n=1 Tax=Shewanella sp.
           ANA-3 RepID=A0L069_SHESA
          Length = 160

 Score =  155 bits (392), Expect = 1e-36
 Identities = 77/138 (55%), Positives = 101/138 (73%), Gaps = 1/138 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     + VT V S ++A  A GD  E++VIGGG++Y+Q LP+A +LYLT I+ EVE
Sbjct: 63  ISRQADLQIEGVTCVTSFEDAKLAAGDCEELVVIGGGQLYQQLLPQADRLYLTQINLEVE 122

Query: 121 GDTHFPDYEPDDWESVFS 138
           GDT FP ++ D W+   S
Sbjct: 123 GDTFFPAWDSDKWQETES 140



>UniRef100_Q07YJ3 Dihydrofolate reductase n=1 Tax=Shewanella
           frigidimarina NCIMB 400 RepID=Q07YJ3_SHEFN
          Length = 160

 Score =  155 bits (391), Expect = 2e-36
 Identities = 77/134 (57%), Positives = 99/134 (73%), Gaps = 1/134 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL+KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAMTLSKPVVMGRKTYESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       + VT VKS DEAI   GD  EI+VIGGG++Y+Q LP+A  LYLT ID +V+
Sbjct: 63  ISRNSQLSIEGVTCVKSFDEAITVAGDCEEIVVIGGGQLYQQLLPQADVLYLTLIDVDVD 122

Query: 121 GDTHFPDYEPDDWE 134
           GDT FP ++   W+
Sbjct: 123 GDTVFPAWDDGSWD 136



>UniRef100_Q0HS01 Dihydrofolate reductase n=1 Tax=Shewanella sp.
           MR-7 RepID=Q0HS01_SHESR
          Length = 160

 Score =  154 bits (389), Expect = 3e-36
 Identities = 77/138 (55%), Positives = 100/138 (72%), Gaps = 1/138 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     + VT V S ++A  A GD  E++VIGGG++Y+Q LP+A  LYLT I+ EVE
Sbjct: 63  ISRQADLQIEGVTCVTSFEDAKLAAGDCEELVVIGGGQLYQQLLPQADTLYLTQINLEVE 122

Query: 121 GDTHFPDYEPDDWESVFS 138
           GDT FP ++ D W+   S
Sbjct: 123 GDTFFPAWDSDKWQETES 140



>UniRef100_Q31I54 Dihydrofolate reductase n=1 Tax=Thiomicrospira
           crunogena XCL-2 RepID=Q31I54_THICR
          Length = 175

 Score =  154 bits (388), Expect = 4e-36
 Identities = 75/157 (47%), Positives = 110/157 (70%), Gaps = 4/157 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+   R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+
Sbjct: 14  ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73

Query: 61  ILSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     +     V  S +EA+ +C    EI+++GGG++Y Q +P A KLY+T +DAEV
Sbjct: 74  VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
            GDT FP++  D+W+ +  E+HD D +  H+Y FE +
Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDER--HAYAFEFV 168



>UniRef100_B1KGH4 Dihydrofolate reductase n=1 Tax=Shewanella woodyi
           ATCC 51908 RepID=B1KGH4_SHEWM
          Length = 160

 Score =  154 bits (388), Expect = 4e-36
 Identities = 74/133 (55%), Positives = 98/133 (73%), Gaps = 1/133 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LIAA+A +RVIG +N MPW+LP DL  FK  TL KP++MGR T++SIGRPLPGR NI+
Sbjct: 3   IALIAAMANNRVIGKDNQMPWHLPEDLRHFKAMTLGKPIVMGRKTFDSIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q G   + VT V S D A++A GD+ E++VIGGG++Y   L  A KLYLT I+ +V+
Sbjct: 63  ISRQEGLKIEGVTCVSSFDAAVSAAGDIEELVVIGGGQLYSATLALADKLYLTEINLDVD 122

Query: 121 GDTHFPDYEPDDW 133
           GDTHFP ++   W
Sbjct: 123 GDTHFPSWDDGSW 135



>UniRef100_A2V5V4 Dihydrofolate reductase region n=1 Tax=Shewanella
           putrefaciens 200 RepID=A2V5V4_SHEPU
          Length = 160

 Score =  153 bits (387), Expect = 5e-36
 Identities = 76/138 (55%), Positives = 100/138 (72%), Gaps = 1/138 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTYESIGRPLPGRHNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     D VT V S D A  A GD  E++V+GGG++Y + LP+A  LYLT I+ +VE
Sbjct: 63  ISRQANLVIDGVTCVTSFDAAKQAAGDCEELVVVGGGQLYTELLPQADILYLTQINLDVE 122

Query: 121 GDTHFPDYEPDDWESVFS 138
           GDT+FP+++  DW+   S
Sbjct: 123 GDTYFPEWDACDWQETES 140



>UniRef100_Q8K9Z8 Dihydrofolate reductase n=1 Tax=Buchnera
           aphidicola (Schizaphis graminum) RepID=DYR_BUCAP
          Length = 161

 Score =  153 bits (386), Expect = 7e-36
 Identities = 77/159 (48%), Positives = 106/159 (66%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           ISLI+A++ + VIG  N +PW LP DL WFK+NT++K +IMGR TWESI   PLP RKNI
Sbjct: 3   ISLISAISNNLVIGHNNKIPWYLPEDLKWFKKNTIHKDIIMGRLTWESILNHPLPMRKNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S +      V W  S+ +A+ +     EIMVIGG ++Y+Q L  A KLYLTH+D    
Sbjct: 63  VISHKEIIHKDVIWANSISKALLSTTYDKEIMVIGGSKIYKQMLFYATKLYLTHVDFNGI 122

Query: 121 GDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP Y+    W+++F + H  D  N +++CFEIL R
Sbjct: 123 GDTYFPQYKSCKFWKTIFRKQHFKDKNNPYNFCFEILSR 161



>UniRef100_Q0HLT7 Dihydrofolate reductase n=1 Tax=Shewanella sp.
           MR-4 RepID=Q0HLT7_SHESM
          Length = 160

 Score =  152 bits (385), Expect = 9e-36
 Identities = 76/138 (55%), Positives = 99/138 (71%), Gaps = 1/138 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     D VT V S ++A  A G+  E++VIGGG++Y+Q LP+A  LYLT I  +VE
Sbjct: 63  ISRQADLQIDGVTCVTSFEDAKLAAGECEELVVIGGGQLYQQLLPQADTLYLTQISLDVE 122

Query: 121 GDTHFPDYEPDDWESVFS 138
           GDT FP ++ D W+   S
Sbjct: 123 GDTFFPAWDSDKWQETES 140



>UniRef100_C5BMA4 Dihydrofolate reductase n=1 Tax=Teredinibacter
           turnerae T7901 RepID=C5BMA4_TERTT
          Length = 173

 Score =  152 bits (385), Expect = 9e-36
 Identities = 73/165 (44%), Positives = 110/165 (66%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+L+  +A + VIG +N +PW LP DLA+FKR T+  P++MGR T++SIGRPLPGR NI+
Sbjct: 9   IALVVGVAANGVIGRDNGLPWRLPKDLAYFKRVTMGHPIVMGRKTFDSIGRPLPGRTNIV 68

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++  P    + V    S+++A+    D      V +IMVIGG   Y Q LP+A +LYLT 
Sbjct: 69  VTRNPTWQAEGVDVCHSLEDALVLARDVATQTQVKQIMVIGGAEFYRQMLPQADRLYLTE 128

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + A+V GD +FP+++   W+ + +E H+AD+ N ++Y F +LERR
Sbjct: 129 VHADVVGDAYFPEFDRSRWQQLSAERHEADSGNPYAYSFLVLERR 173



>UniRef100_B0TUI5 Dihydrofolate reductase n=1 Tax=Shewanella
           halifaxensis HAW-EB4 RepID=B0TUI5_SHEHH
          Length = 160

 Score =  152 bits (384), Expect = 1e-35
 Identities = 77/151 (50%), Positives = 103/151 (68%), Gaps = 1/151 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNQMPWHLPEDLRHFKAMTLGKPVVMGRKTYESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     D VT V S  EA  A G+  E++V+GGG++YE  LP+A  LYLT I   V+
Sbjct: 63  ISRQTDLSIDGVTIVSSFAEAKIAAGECEELVVMGGGQLYEMLLPQADILYLTEIALTVD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
           GDT+FP+++   W+ V     + D Q  +S+
Sbjct: 123 GDTYFPEWDDGSWQEVSRNVAEDDKQLEYSF 153



>UniRef100_D6RUA1 Dihydrofolate reductase n=1 Tax=Shewanella
           benthica RepID=D6RUA1_9GAMM
          Length = 160

 Score =  152 bits (384), Expect = 1e-35
 Identities = 77/151 (50%), Positives = 103/151 (68%), Gaps = 1/151 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG  N MPW+LP DL  FK  TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKNNQMPWHLPEDLKHFKAMTLGKPIVMGRKTYESIGRALPGRLNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q G T   VT V S + A+AA G+  E++VIGGG++Y   L +A KLYLT I+ +V+
Sbjct: 63  ISRQQGLTIPGVTCVTSFESAVAAAGECEELVVIGGGQLYAALLSQADKLYLTEINLDVD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
           GDTHFP ++   W+ V  E    D    +S+
Sbjct: 123 GDTHFPQWDDGSWQRVSQETSINDKGVEYSF 153



>UniRef100_B4RZH2 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Alteromonas macleodii 'Deep ecotype'
           RepID=B4RZH2_ALTMD
          Length = 167

 Score =  151 bits (382), Expect = 2e-35
 Identities = 82/163 (50%), Positives = 106/163 (65%), Gaps = 6/163 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +R+IG++N MPW+LPADL  FK  TL K VIMGR T++SIGR LPGR NI+
Sbjct: 3   IAMIAAMAQNRIIGVDNDMPWHLPADLKHFKAITLGKAVIMGRKTYQSIGRALPGRPNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAI----AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +++         T V S + A+    A   D  EIM+IGGG +Y+ FL KA  LYLT+ID
Sbjct: 63  ITNNADYSLSDATVVDSPESALEVAKALSVDSDEIMIIGGGTIYQAFLDKADTLYLTYID 122

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILER 158
             V+GDT FPDYE    W  V  E +D D +N H+Y F  L R
Sbjct: 123 LSVDGDTQFPDYEAVGTWREVSREENDPDEKNKHAYTFVTLSR 165



>UniRef100_A8H0U7 Dihydrofolate reductase n=1 Tax=Shewanella
           pealeana ATCC 700345 RepID=A8H0U7_SHEPA
          Length = 160

 Score =  151 bits (382), Expect = 2e-35
 Identities = 77/151 (50%), Positives = 103/151 (68%), Gaps = 1/151 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNQMPWHLPEDLRHFKAMTLGKPVVMGRKTYESIGRPLPGRHNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     D VT V S +EA  A GD  E++V+GGG++YE  L +A  LYLT I+  VE
Sbjct: 63  ISRQDSLVIDGVTRVSSFEEAKIAAGDCDELVVMGGGQLYEMLLSQADILYLTEINLTVE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
           GDT+FP+++   W+ V  +    D    +S+
Sbjct: 123 GDTYFPEWDNGSWQEVSRDVAKNDKDVEYSF 153



>UniRef100_P57243 Dihydrofolate reductase n=3 Tax=Buchnera
           aphidicola (Acyrthosiphon pisum) RepID=DYR_BUCAI
          Length = 161

 Score =  151 bits (382), Expect = 2e-35
 Identities = 75/159 (47%), Positives = 108/159 (67%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           ISLIAA++ + VIG +N +PW LP DL WFK+ T+NK +IMGR TWESI + PLP RKNI
Sbjct: 3   ISLIAAISKNLVIGYKNKIPWYLPEDLKWFKQKTINKNIIMGRLTWESIKKKPLPMRKNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS     + + W  S+  AI +     EIM+IGG ++Y++ L  A KLYLTHID ++ 
Sbjct: 63  VISSNEIKQEGIIWADSISNAIISAQYNQEIMIIGGAKIYKEMLFYANKLYLTHIDIDIV 122

Query: 121 GDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP+Y+    W+++F + +  +  N ++Y FEIL R
Sbjct: 123 GDAYFPEYKLYPYWKTLFRKKNTKNKMNPYNYSFEILSR 161



>UniRef100_A3QB98 Dihydrofolate reductase n=1 Tax=Shewanella loihica
           PV-4 RepID=A3QB98_SHELP
          Length = 160

 Score =  151 bits (381), Expect = 3e-35
 Identities = 75/144 (52%), Positives = 103/144 (71%), Gaps = 1/144 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK+ TL KPV+MGR T+ESIGRPLPGR N++
Sbjct: 3   IAMIAAMANNRVIGKDNQMPWHLPEDLRHFKQMTLGKPVVMGRKTFESIGRPLPGRHNLV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     + VT V S ++A        E++VIGGG++Y + LP+A +LYLT I+ +VE
Sbjct: 63  VSRQEDLVIEGVTCVTSFEQAKELVQGCDELVVIGGGQLYAELLPQADRLYLTEINLDVE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDAD 144
           GDTHFPD++   W+ + SE H  D
Sbjct: 123 GDTHFPDWDDGSWQLLDSESHIND 146



>UniRef100_D1KC52 Dihydrofolate reductase n=1 Tax=uncultured SUP05
           cluster bacterium RepID=D1KC52_9GAMM
          Length = 161

 Score =  150 bits (380), Expect = 3e-35
 Identities = 73/158 (46%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW+LPADL +FK+ T  K V+MGR T+ESIGRPLP R+N+I
Sbjct: 3   LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A+    D  E+MV+GG   YEQ LP   +LY+T I+ E +
Sbjct: 63  VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP ++   +  V  E H AD +N H+Y F IL+R
Sbjct: 123 GDAHFPKFDRGKFSEVSRESHTADEKNQHTYHFTILDR 160



>UniRef100_UPI0001AEC2DE dihydrofolate reductase type I,
           trimethoprim resistance n=1 Tax=Alteromonas macleodii
           ATCC 27126 RepID=UPI0001AEC2DE
          Length = 165

 Score =  150 bits (379), Expect = 4e-35
 Identities = 84/164 (51%), Positives = 101/164 (61%), Gaps = 9/164 (5%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAA+A +R+IG +N MPW+LPADL  FK  TL K VIMGR T+ESIGR LPGR NI+++
Sbjct: 1   MIAAMAKNRIIGADNDMPWHLPADLKHFKAITLGKAVIMGRKTYESIGRALPGRPNIVIT 60

Query: 64  SQPGTD-DRVTWVKSVDEAI-------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S         T V S + AI       A   D  EIM+IGGG +Y+ FL     LYLTHI
Sbjct: 61  SNADYSLSDATVVDSPESAIEVAKALSAEHSDNDEIMIIGGGTIYQTFLDSTDTLYLTHI 120

Query: 116 DAEVEGDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILER 158
           D  V+GDT FPDYE    W  V  + HDAD +N H Y F  L R
Sbjct: 121 DLTVDGDTQFPDYEAAASWTEVSRDEHDADEKNPHPYTFVTLVR 164



>UniRef100_Q0ABL0 Dihydrofolate reductase n=1 Tax=Alkalilimnicola
           ehrlichii MLHE-1 RepID=Q0ABL0_ALHEH
          Length = 166

 Score =  150 bits (379), Expect = 4e-35
 Identities = 77/159 (48%), Positives = 103/159 (64%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LIAALA + VIG +N +PW +PADL  FK  T  +P+IMGR  +ESIGRPLPGR NI+
Sbjct: 7   ITLIAALADNGVIGRDNDLPWRIPADLKRFKARTQGRPLIMGRRNYESIGRPLPGRHNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ +     +  T V   + A+AA GDV E+MVIGG  +Y  FLP+A +L LT +  EV 
Sbjct: 67  LTRRRDWQAEGCTVVHDPEAALAAAGDVEEVMVIGGEEIYRLFLPRADRLELTRVHTEVP 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FPD +P DW+ V  +   ++  N     ++ LERR
Sbjct: 127 GDTFFPDIDPADWQVVAEQQPPSEETNDWPLTYQTLERR 165



>UniRef100_A9D6G1 Dihydrofolate reductase n=1 Tax=Shewanella
           benthica KT99 RepID=A9D6G1_9GAMM
          Length = 160

 Score =  150 bits (379), Expect = 4e-35
 Identities = 75/151 (49%), Positives = 103/151 (68%), Gaps = 1/151 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLKHFKAMTLGKPIVMGRKTYESIGRALPGRLNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q G     VT V S + A+AA G+  E++VIGGG++Y   L +A KLYLT I+ +V+
Sbjct: 63  ISRQQGLSIAGVTCVTSFESAVAAAGECEELVVIGGGQLYAALLSQADKLYLTEINLDVD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
           GDTHFP ++   W+ +  E    D    +S+
Sbjct: 123 GDTHFPRWDDGSWQRISQETSINDKGVEYSF 153



>UniRef100_Q8EB86 Dihydrofolate reductase n=1 Tax=Shewanella
           oneidensis RepID=Q8EB86_SHEON
          Length = 160

 Score =  150 bits (378), Expect = 6e-35
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 1/134 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     + VT V S + A    GD  E++VIGGG++Y+Q LP+A +LYLT I+ +V+
Sbjct: 63  ISRQADLQIEGVTCVTSFEAAKRVAGDCEELVVIGGGQLYKQLLPQADRLYLTQINLDVD 122

Query: 121 GDTHFPDYEPDDWE 134
           GDT FP +E ++W+
Sbjct: 123 GDTFFPAWEDNEWQ 136



>UniRef100_D6RUA3 Dihydrofolate reductase n=1 Tax=Shewanella
           benthica RepID=D6RUA3_9GAMM
          Length = 160

 Score =  150 bits (378), Expect = 6e-35
 Identities = 73/139 (52%), Positives = 99/139 (71%), Gaps = 1/139 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLKHFKAMTLGKPIVMGRKTYESIGRALPGRLNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q G     VT V S + A+AA G+  E++VIGGG++Y   L +A KLYLT I+ +V+
Sbjct: 63  ISRQEGLSIAGVTCVTSFESAVAAAGECEELVVIGGGQLYAALLSQADKLYLTEINLDVD 122

Query: 121 GDTHFPDYEPDDWESVFSE 139
           GDTHFP ++   W+ +  E
Sbjct: 123 GDTHFPRWDDGSWQRISQE 141



>UniRef100_D4XJC4 Dihydrofolate reductase n=1 Tax=Achromobacter
           piechaudii ATCC 43553 RepID=D4XJC4_9BURK
          Length = 160

 Score =  149 bits (377), Expect = 7e-35
 Identities = 76/158 (48%), Positives = 100/158 (63%), Gaps = 3/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A + +R IG +NA+PW LP DLA FKR+TL  P+IMGR TW+S+GRPLPGR NI+
Sbjct: 5   LTLIVAYSTNRAIGRDNALPWKLPGDLAHFKRSTLGHPIIMGRKTWDSLGRPLPGRANIV 64

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S  P  T    T V ++  AI ACGDV E  VIGG ++Y Q LP AQ++  T + A+VE
Sbjct: 65  ISRNPDFTAAGATVVPTLQAAIDACGDVAEAFVIGGAQIYAQALPLAQRVLATEVHADVE 124

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD  FP      W+ V  E     A+N + Y F   +R
Sbjct: 125 GDAFFPLLPSFQWKEVSRE--PQPAENGYDYAFVTYQR 160



>UniRef100_B0BPG8 Dihydrofolate reductase n=1 Tax=Actinobacillus
           pleuropneumoniae serovar 3 str. JL03 RepID=B0BPG8_ACTPJ
          Length = 162

 Score =  149 bits (376), Expect = 1e-34
 Identities = 79/161 (49%), Positives = 107/161 (66%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A  ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTLNHVIGKENRMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      +     ++  +A+       +  EIMVIGGG +++Q +P+A +LYLT I AE
Sbjct: 63  LSRSGFCVEGAYTAQNFAQAVELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGDT F +++  +W  V  ++ + D QN++   F ILER+
Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162



>UniRef100_D5C3K8 Dihydrofolate reductase n=1 Tax=Nitrosococcus
           halophilus Nc4 RepID=D5C3K8_NITHN
          Length = 173

 Score =  149 bits (376), Expect = 1e-34
 Identities = 75/163 (46%), Positives = 104/163 (63%), Gaps = 9/163 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS + A+   R+IG    +PW+L ADL +F+R T+ KP++MGR T ESIGRPLPGR NI
Sbjct: 2   IISFVVAMDDHRLIGANCRLPWHLSADLKYFRRLTMGKPILMGRGTHESIGRPLPGRHNI 61

Query: 61  ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +++ +     PG     T V SV+  + A G   E+MVIGG  +Y+Q  P+A ++YLT +
Sbjct: 62  VVTHKLHYKAPGC----TVVHSVEAGLQAAGKAEEVMVIGGASLYQQLFPQAHRIYLTLV 117

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                GDT FPD++P DW  V+ E HD D+QN + Y F  LER
Sbjct: 118 RGTFRGDTWFPDFDPADWAEVWREDHDPDSQNPYPYSFIRLER 160



>UniRef100_D6RUA2 Dihydrofolate reductase n=1 Tax=Shewanella
           benthica RepID=D6RUA2_9GAMM
          Length = 160

 Score =  148 bits (374), Expect = 2e-34
 Identities = 72/139 (51%), Positives = 98/139 (70%), Gaps = 1/139 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++I A+A +RVIG +N MPW+LP DL  FK  TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 3   IAMIVAMANNRVIGKDNKMPWHLPEDLKHFKAMTLGKPIVMGRKTYESIGRALPGRLNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q G     VT V S + A+AA G+  E++VIGGG++Y   L +A KLYLT I+ +V+
Sbjct: 63  ISRQEGLSIAGVTCVTSFESAVAAAGECEELVVIGGGQLYAALLSQADKLYLTEINLDVD 122

Query: 121 GDTHFPDYEPDDWESVFSE 139
           GDTHFP ++   W+ +  E
Sbjct: 123 GDTHFPRWDDGSWQRISQE 141



>UniRef100_D0U4K0 Dihydrofolate reductase n=1 Tax=uncultured SUP05
           cluster bacterium RepID=D0U4K0_9GAMM
          Length = 179

 Score =  148 bits (374), Expect = 2e-34
 Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW+LPADL +FK+ T  K V+MGR T+ESIGRPLP R+N+I
Sbjct: 21  LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A+    D  E+MV+GG   YEQ LP   +LY+T I+ E +
Sbjct: 81  VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP ++   +  V  E H AD +N ++Y F IL+R
Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178



>UniRef100_A1RMV3 Dihydrofolate reductase n=2 Tax=Shewanella
           RepID=A1RMV3_SHESW
          Length = 160

 Score =  148 bits (373), Expect = 2e-34
 Identities = 73/138 (52%), Positives = 99/138 (71%), Gaps = 1/138 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWYLPEDLKHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     + VT V S D A  A G+  E++++GGG++Y + LP+A  LYLT I+ +VE
Sbjct: 63  ISRQADLVIEGVTCVTSFDAAKQAAGECEELVIMGGGQLYRELLPQADILYLTQINLDVE 122

Query: 121 GDTHFPDYEPDDWESVFS 138
           GDT+FP+++  DW+   S
Sbjct: 123 GDTYFPEWDARDWQETES 140



>UniRef100_A3N0P3 Dihydrofolate reductase n=2 Tax=Actinobacillus
           pleuropneumoniae RepID=A3N0P3_ACTP2
          Length = 162

 Score =  147 bits (372), Expect = 3e-34
 Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A  ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      +     ++  +A        +  EIMVIGGG +++Q +P+A +LYLT I AE
Sbjct: 63  LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGDT F +++  +W  V  ++ + D QN++   F ILER+
Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162



>UniRef100_A7JRD3 Dihydrofolate reductase n=1 Tax=Mannheimia
           haemolytica PHL213 RepID=A7JRD3_PASHA
          Length = 164

 Score =  147 bits (372), Expect = 3e-34
 Identities = 76/161 (47%), Positives = 108/161 (67%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A  +++VIG +N MPW+LP DLAWF++NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISIIVARTINKVIGKDNQMPWHLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS    T +    V+S+++A+       +  EIM+IGGG +++Q LP A++LYLT I A+
Sbjct: 63  LSRSGFTVEGAYAVQSLEQAVELAKNFANTAEIMIIGGGELFKQALPLAERLYLTEIQAD 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGDT F +++  +W  V  ++ + D  N     F  LER+
Sbjct: 123 IEGDTFF-EFDEQNWALVEEKWSEIDENNPFRCRFMCLERK 162



>UniRef100_B0QU50 Dihydrofolate reductase n=1 Tax=Haemophilus
           parasuis 29755 RepID=B0QU50_HAEPR
          Length = 192

 Score =  147 bits (371), Expect = 4e-34
 Identities = 76/160 (47%), Positives = 106/160 (66%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A  +++VIG +NAMPW+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 30  ISVIVARTLNKVIGKDNAMPWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 89

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      D      S+++A+       +  EIM+IGGG +++Q +P A KLYLT I A 
Sbjct: 90  LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMIIGGGELFKQTMPFADKLYLTEIQAN 149

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT F +++   W+ +  ++ + D QNS+   F IL++
Sbjct: 150 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 188



>UniRef100_Q603S1 Dihydrofolate reductase n=1 Tax=Methylococcus
           capsulatus RepID=Q603S1_METCA
          Length = 172

 Score =  147 bits (370), Expect = 5e-34
 Identities = 79/158 (50%), Positives = 99/158 (62%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A+A +RVIG +NAMPW+L ADL  F+  TL KPV+MGR T ESIGR LPGR+NII
Sbjct: 7   ISLIVAMARNRVIGADNAMPWHLSADLKRFRALTLGKPVLMGRKTHESIGRVLPGRQNII 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+  P       T V  + E    C   PE+MVIGG  VYE  LP+A++LYLT ID +  
Sbjct: 67  LTRSPDFHAPGCTIVHDLGELATVCSGAPELMVIGGSAVYEALLPRARRLYLTLIDHDYP 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP++   DW  +  E    D      Y + +LER
Sbjct: 127 GDTYFPEFAAADWREISREDVRNDPDFPWPYSYLVLER 164



>UniRef100_C1DK10 Dihydrofolate reductase n=1 Tax=Azotobacter
           vinelandii DJ RepID=C1DK10_AZOVD
          Length = 171

 Score =  147 bits (370), Expect = 5e-34
 Identities = 76/164 (46%), Positives = 105/164 (64%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+A +  IG +N +PW+LPADL  FK +TL KPVIMGR TW+S+GRPLPGR N++
Sbjct: 8   LALIAAVAANGAIGRDNRLPWHLPADLRHFKASTLGKPVIMGRKTWDSLGRPLPGRLNLV 67

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S QPG   +      S+D A+             E+M+IGG ++Y + LP+A++LYLT 
Sbjct: 68  VSRQPGLVLEGAETFASLDAALTRADTWAREQGAGELMLIGGAQLYVESLPRAERLYLTR 127

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +D   +GD  FP + P DW  V  E H A AQ +  Y FE+ ER
Sbjct: 128 VDLAPQGDAFFPAWNPADWRLVSREEHPATAQ-APGYAFELWER 170



>UniRef100_B8EC01 Dihydrofolate reductase n=1 Tax=Shewanella baltica
           OS223 RepID=B8EC01_SHEB2
          Length = 160

 Score =  147 bits (370), Expect = 5e-34
 Identities = 78/140 (55%), Positives = 97/140 (69%), Gaps = 5/140 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG EN MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKENKMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S Q  TD   + VT V S D A  A G+  E++VIGGG++Y + LP A  LYLT I  E
Sbjct: 63  ISRQ--TDLVIEGVTCVTSFDAAKQAAGECEELVVIGGGQLYAELLPYADTLYLTQIKLE 120

Query: 119 VEGDTHFPDYEPDDWESVFS 138
           VEGDT FP ++   W+   S
Sbjct: 121 VEGDTFFPHWDDGTWKETES 140



>UniRef100_Q3JEI1 Dihydrofolate reductase n=2 Tax=Nitrosococcus
           oceani RepID=Q3JEI1_NITOC
          Length = 165

 Score =  147 bits (370), Expect = 5e-34
 Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A+  + +IG    +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI
Sbjct: 2   IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++  P       T V +V+  + A G+  E+ VIGG  +YEQ LP+A+++YLT +    
Sbjct: 62  VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FP ++P  W  V+ E +D D QN + Y F  LER
Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160



>UniRef100_A3D183 Dihydrofolate reductase n=1 Tax=Shewanella baltica
           OS155 RepID=A3D183_SHEB5
          Length = 160

 Score =  146 bits (368), Expect = 8e-34
 Identities = 78/140 (55%), Positives = 97/140 (69%), Gaps = 5/140 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG EN MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKENKMPWHLPEDLRHFKGMTLGKPVLMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S Q  TD   + VT V S D A  A G+  E++VIGGG++Y + LP A  LYLT I  E
Sbjct: 63  ISRQ--TDLVIEGVTCVTSFDAAKQAAGECEELVVIGGGQLYAELLPYADTLYLTQIKLE 120

Query: 119 VEGDTHFPDYEPDDWESVFS 138
           VEGDT FP ++   W+   S
Sbjct: 121 VEGDTFFPHWDDGTWKETES 140



>UniRef100_A3YH55 Dihydrofolate reductase n=1 Tax=Marinomonas sp.
           MED121 RepID=A3YH55_9GAMM
          Length = 171

 Score =  146 bits (368), Expect = 8e-34
 Identities = 76/168 (45%), Positives = 109/168 (64%), Gaps = 11/168 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI A+A + VIG+ N++PW+LP DL +FK+ T+ KP+IMGR T+ESIG+PLPGR+NI
Sbjct: 1   MLSLIVAMAQNHVIGINNSLPWHLPNDLKYFKKVTMGKPIIMGRKTYESIGKPLPGRRNI 60

Query: 61  ILSSQP-----GTDDRVTWVKSVD------EAIAACGDVPEIMVIGGGRVYEQFLPKAQK 109
           +++ Q      G +D +  V S+D      E+IA      E+MVIGG  +Y+Q L KA +
Sbjct: 61  VITRQDAYTGVGENDAIDVVSSLDQAIDLGESIALVEGHEEVMVIGGAEIYKQALLKADR 120

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           LY+TH+ A+VEGD +FP  +   +E V  E   A   N + Y F I +
Sbjct: 121 LYITHVLADVEGDAYFPQVDWTLYEEVGHEAFAASGHNPYDYRFSIYQ 168



>UniRef100_A6WK54 Dihydrofolate reductase n=2 Tax=Shewanella baltica
           RepID=A6WK54_SHEB8
          Length = 160

 Score =  145 bits (366), Expect = 1e-33
 Identities = 77/140 (55%), Positives = 97/140 (69%), Gaps = 5/140 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA++ +RVIG EN MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMSNNRVIGKENKMPWHLPEDLRHFKAMTLGKPVLMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S Q  TD   + VT V S D A  A G+  E++VIGGG++Y + LP A  LYLT I  E
Sbjct: 63  ISRQ--TDLVIEGVTCVTSFDAAKQAAGECEELVVIGGGQLYAELLPYADTLYLTQIKLE 120

Query: 119 VEGDTHFPDYEPDDWESVFS 138
           VEGDT FP ++   W+   S
Sbjct: 121 VEGDTFFPHWDDGTWKETES 140



>UniRef100_Q1MYJ4 Dihydrofolate reductase n=1 Tax=Bermanella
           marisrubri RepID=Q1MYJ4_9GAMM
          Length = 167

 Score =  145 bits (366), Expect = 1e-33
 Identities = 74/164 (45%), Positives = 105/164 (64%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+L+AA+A +R +G+ NA+PW+LP DL +FKR T  K +IMGR T+ESIGRPLP R NI+
Sbjct: 3   IALMAAMAENRTVGINNALPWHLPEDLKYFKRTTSGKAIIMGRKTYESIGRPLPNRTNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S  P    + V  V S+D+AI           + E+MVIGG  +YE  LPKA +LYLTH
Sbjct: 63  ISRNPNFQLEGVRIVSSLDDAIELAESVNEINGIDEVMVIGGAAIYELALPKADRLYLTH 122

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A+V GD  FP+ + + +  +  +   AD +N + Y F I +R
Sbjct: 123 VHADVHGDAFFPEVDFNQFTEISRDDFFADDKNPYDYSFVIYDR 166



>UniRef100_C8KWH5 Dihydrofolate reductase n=1 Tax=Actinobacillus
           minor 202 RepID=C8KWH5_9PAST
          Length = 160

 Score =  145 bits (366), Expect = 1e-33
 Identities = 74/161 (45%), Positives = 109/161 (67%), Gaps = 4/161 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A   + +IG ENAMPW+LP DLAWF++NT+ KPVIMGR T+ESIGR LP R NI
Sbjct: 1   MISLIVARTQNHIIGKENAMPWHLPKDLAWFRQNTVGKPVIMGRKTYESIGRLLPKRPNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAI---AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ILS    + +      ++++A+    +  +  EIM+IGGG +++Q LP A KLYLT I A
Sbjct: 61  ILSRSGFSVEGAYSANTLEQAVELAKSFANTDEIMIIGGGELFKQALPIANKLYLTEIQA 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +++GDT F +++ ++W+     + + DA+N++   F + ER
Sbjct: 121 DIDGDTLF-EFDEENWQLTQEIWSEKDAENAYDCRFMVFER 160



>UniRef100_A8FRU7 Dihydrofolate reductase n=1 Tax=Shewanella
           sediminis HAW-EB3 RepID=A8FRU7_SHESH
          Length = 160

 Score =  145 bits (365), Expect = 2e-33
 Identities = 73/139 (52%), Positives = 96/139 (69%), Gaps = 1/139 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KP++MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNQMPWHLPEDLKHFKAMTLGKPIVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     + VT V S + A    GD  E++VIGGG++Y   L +A KLYLT I+ +VE
Sbjct: 63  ISRQESLKIEGVTCVTSFEAAKEVAGDCEELVVIGGGQLYSSLLKEADKLYLTEINLDVE 122

Query: 121 GDTHFPDYEPDDWESVFSE 139
           GDT FP ++   WE +  E
Sbjct: 123 GDTFFPPWDDARWELLSKE 141



>UniRef100_C4WF14 Dihydrofolate reductase type 3 n=1
           Tax=Ochrobactrum intermedium LMG 3301 RepID=C4WF14_9RHIZ
          Length = 174

 Score =  145 bits (365), Expect = 2e-33
 Identities = 78/166 (46%), Positives = 107/166 (64%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S+I A A + VIG +N MPW L  DL  FK  TL KPVIMGR TWESIGRPLPGR NI
Sbjct: 7   IVSIIVAAAENGVIGRDNDMPWRLSTDLKRFKALTLGKPVIMGRRTWESIGRPLPGRPNI 66

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++   G   +  T V S+DEAI      AA     E+ VIGGG++Y Q LP A +++LT
Sbjct: 67  VVTRDKGFRAEGATTVGSLDEAIALGCKLAAEVGAEEVCVIGGGKIYAQALPLADRVHLT 126

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + AE++GDT FP+ +P+ W++V  E   A  ++SH   + + E+R
Sbjct: 127 RVLAEIDGDTRFPEIDPNLWQAVSQEDVPAGDKDSHPTRYFVYEKR 172



>UniRef100_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia
           persephone 'Hot96_1+Hot96_2' RepID=UPI0001698640
          Length = 158

 Score =  144 bits (364), Expect = 2e-33
 Identities = 71/145 (48%), Positives = 97/145 (66%), Gaps = 1/145 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  N MPW+LPADL  FK  T+ KP++MGR TWES+   LP R +I+++  P 
Sbjct: 1   MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60

Query: 68  T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              +  T V S+DEAIAA G+V EIMV+GGG  Y + LP+  ++YLT +DAE EGDT FP
Sbjct: 61  YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSY 151
           D +  +W     E H AD ++++ Y
Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPY 145



>UniRef100_A6W1R3 Dihydrofolate reductase n=1 Tax=Marinomonas sp.
           MWYL1 RepID=A6W1R3_MARMS
          Length = 169

 Score =  144 bits (363), Expect = 3e-33
 Identities = 68/165 (41%), Positives = 111/165 (67%), Gaps = 7/165 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI A++ +R IG+ N++PW+LP DL +FK+ T+ KP++MGR T+ESIG+PLPGR+NI
Sbjct: 1   MLSLIVAMSTNRTIGINNSLPWHLPNDLKYFKQATMGKPIVMGRKTFESIGKPLPGRRNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++S  P    + +  V ++++AI+   D+       E+MVIGG ++Y+  L +A +LY+T
Sbjct: 61  VISRDPTYQAEGIDVVTTLEDAISLGEDICLVNGQEEVMVIGGAQIYQLALERADRLYIT 120

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           H+DAEV+GD  FP+ +   +  +  E   A+  N + Y F + +R
Sbjct: 121 HVDAEVKGDAFFPEVDWPSFTLIGEEAFAAEGPNPYDYRFSVYQR 165



>UniRef100_A4Y040 Dihydrofolate reductase n=1 Tax=Pseudomonas
           mendocina ymp RepID=A4Y040_PSEMY
          Length = 176

 Score =  144 bits (363), Expect = 3e-33
 Identities = 80/165 (48%), Positives = 104/165 (63%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAALA +RVIG +N +PW+LPADL  FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 11  LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70

Query: 62  LSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G T +      +++EAI      A   D  E+M+IGG ++YE  L +A +LYLT 
Sbjct: 71  VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  E EGD  FP  +   W    S  H A A+    Y FE+ ERR
Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174



>UniRef100_A0Y9U0 Dihydrofolate reductase n=1 Tax=marine gamma
           proteobacterium HTCC2143 RepID=A0Y9U0_9GAMM
          Length = 175

 Score =  144 bits (363), Expect = 3e-33
 Identities = 75/165 (45%), Positives = 105/165 (63%), Gaps = 7/165 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I++I A+A +RVIG  N +PW LP DL +FK  T+ KPVIMGR T+ESIG+PLPGR NI
Sbjct: 8   VIAMIVAMAENRVIGRNNQLPWYLPGDLKYFKATTMGKPVIMGRKTYESIGKPLPGRANI 67

Query: 61  ILSSQPG-TDDRVTWVKSVDEA------IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       D V+ V S++EA      IA      EIMVIGG  +Y++FLP  ++LYLT
Sbjct: 68  VVTGNENYLADGVSVVHSIEEALKRARSIAMVDGAKEIMVIGGAELYKEFLPSIKRLYLT 127

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            I A V+GD  FP  +   W+ +  E  DA+  N ++Y F + +R
Sbjct: 128 KIHANVDGDACFPALDWRQWQELGREDFDAEGPNPYNYSFIVYQR 172



>UniRef100_Q89AV2 Dihydrofolate reductase n=1 Tax=Buchnera
           aphidicola str. Bp (Baizongia pistaciae) RepID=DYR_BUCBP
          Length = 164

 Score =  144 bits (363), Expect = 3e-33
 Identities = 71/160 (44%), Positives = 106/160 (66%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+
Sbjct: 3   ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q    +  V +V S+ +AI +     EIM+IGG  +Y Q L  A KLY+THI+  + 
Sbjct: 63  LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122

Query: 121 GDTHFPDYEPDDWESVFSE--FHDADAQNSHSYCFEILER 158
           GDT+FP Y+   W+ +F +        +NS    F+IL++
Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162



>UniRef100_Q7VUE2 Dihydrofolate reductase n=1 Tax=Bordetella
           pertussis RepID=Q7VUE2_BORPE
          Length = 167

 Score =  144 bits (362), Expect = 4e-33
 Identities = 74/159 (46%), Positives = 97/159 (61%), Gaps = 3/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SL+ A + +RVIG +NA+PW LP DLA FKR TL  P+IMGR+TWES+GRPLPGR NI
Sbjct: 8   LLSLVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNI 67

Query: 61  ILSSQPGTDDR-VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++  P  D      V S+  AI ACGD     VIGG ++Y Q LP AQ++  T + AE+
Sbjct: 68  VITRNPAYDAAGAVVVGSLAAAIQACGDAAVACVIGGAQIYAQALPLAQRVVATEVHAEI 127

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP      W    ++     A+N   Y F   ER
Sbjct: 128 EGDAFFPPLPAGQWRE--TQRAAQPAENGLRYDFVEYER 164



>UniRef100_Q3IFF7 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Pseudoalteromonas haloplanktis TAC125
           RepID=Q3IFF7_PSEHT
          Length = 155

 Score =  143 bits (361), Expect = 5e-33
 Identities = 77/151 (50%), Positives = 100/151 (66%), Gaps = 2/151 (1%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS-SQP 66
           +A +RVIG+ N MPW+LP DL  FK+ T  KPVIMGR T+ESIGRPLPGR+NII++ +  
Sbjct: 1   MANNRVIGLNNTMPWHLPGDLQHFKKVTTGKPVIMGRKTFESIGRPLPGRRNIIITRNSQ 60

Query: 67  GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                +  V + + A+    DV E+M+IGGG +Y+QFL  AQ+LYLT ID +VEGDT FP
Sbjct: 61  YQATGIEIVTTPEAALNLVTDVEEVMIIGGGNIYQQFLESAQRLYLTFIDLDVEGDTQFP 120

Query: 127 DYEPDDWESVFSEFH-DADAQNSHSYCFEIL 156
           DYE      V  E    AD +N +S+ F  L
Sbjct: 121 DYEKVATWQVKDEIQMAADEKNQYSHKFVTL 151



>UniRef100_A1U3D7 Dihydrofolate reductase n=1 Tax=Marinobacter
           aquaeolei VT8 RepID=A1U3D7_MARAV
          Length = 171

 Score =  143 bits (361), Expect = 5e-33
 Identities = 72/166 (43%), Positives = 103/166 (62%), Gaps = 12/166 (7%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+A +RVIG  N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++
Sbjct: 4   ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63

Query: 63  SSQP------GTDDRVT----WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           S  P      GT    +     VK+  +A    GD  E+M+IGGG++Y + LP   ++Y+
Sbjct: 64  SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGD--EVMIIGGGQIYAEALPMVDRIYI 121

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T + AEV+GD  FP+   D+WE +  E   A   N + Y F + +R
Sbjct: 122 TQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167



>UniRef100_UPI0001DAD9D5 UPI0001DAD9D5 related cluster n=1
           Tax=unknown RepID=UPI0001DAD9D5
          Length = 165

 Score =  143 bits (360), Expect = 7e-33
 Identities = 70/160 (43%), Positives = 103/160 (64%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I+ I A+   R+IG    +PW+LPADL +F+R T+ +P++MGR T E+IGRPLP R NI
Sbjct: 2   VIAFIVAMDEHRLIGANRRLPWHLPADLKYFRRMTMGRPMLMGRSTHEAIGRPLPRRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++   G      T V +V+  + A G+  EIMVIGG  +Y+Q LP+AQ++YLT +    
Sbjct: 62  VVTHNSGYKAPGCTVVHTVEAGLQAAGEAEEIMVIGGASLYQQLLPQAQRIYLTLVGGHF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP ++   W  V+ E H+ D QN + Y F  LER+
Sbjct: 122 QGDTWFPVFDSGAWVEVWREDHNPDPQNPYPYSFIRLERK 161



>UniRef100_Q7WP14 Dihydrofolate reductase n=1 Tax=Bordetella
           bronchiseptica RepID=Q7WP14_BORBR
          Length = 165

 Score =  143 bits (360), Expect = 7e-33
 Identities = 75/160 (46%), Positives = 99/160 (61%), Gaps = 5/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SL+ A + +RVIG +NA+PW LP DLA FKR TL  P+IMGR+TWES+GRPLPGR NI
Sbjct: 6   LLSLVVAYSTNRVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNI 65

Query: 61  ILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++  P  G    V  V S++ AI ACGD     VIGG ++Y Q LP AQ++  T + AE
Sbjct: 66  VITRNPAYGAAGAVV-VGSLNAAIQACGDAAVACVIGGAQIYAQALPLAQRVVATEVHAE 124

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGD  FP      W    ++     A+N   Y F   ER
Sbjct: 125 IEGDAFFPPLPAGQWRE--TQRAAQPAENGLRYDFVEYER 162



>UniRef100_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus
           Blochmannia pennsylvanicus str. BPEN RepID=Q494F1_BLOPB
          Length = 164

 Score =  142 bits (359), Expect = 9e-33
 Identities = 76/162 (46%), Positives = 107/162 (66%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAAL  + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL  R N
Sbjct: 2   IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61

Query: 60  IILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID-- 116
           I+LS +     + V   +++DEA++   D  E+MVIGG  +Y  FLP+AQ+LYLT+I   
Sbjct: 62  IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E++GD  FPDY+  +W+S+F+ F+           F ILER
Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163



>UniRef100_B8F4S8 Dihydrofolate reductase n=1 Tax=Haemophilus
           parasuis SH0165 RepID=B8F4S8_HAEPS
          Length = 165

 Score =  142 bits (359), Expect = 9e-33
 Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A  +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      D      S+++A+       +  EIM++GGG +++Q +P A KLYLT I A 
Sbjct: 63  LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT F +++   W+ +  ++ + D QNS+   F IL++
Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161



>UniRef100_A4VRN9 Dihydrofolate reductase n=1 Tax=Pseudomonas
           stutzeri A1501 RepID=A4VRN9_PSEU5
          Length = 246

 Score =  142 bits (359), Expect = 9e-33
 Identities = 75/165 (45%), Positives = 106/165 (64%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++IAALA   VIG +N MPW+LPADL  FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 83  LAMIAALAERHVIGRDNIMPWHLPADLRHFKAMTLGKPIIMGRKTWDSLGRPLPGRLNLV 142

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q     D       +D A+           V E+M+IGG ++Y Q L +AQ+LYLT 
Sbjct: 143 VSRQADLQLDGAETFTDLDAALVRAEQWAREQGVDELMLIGGAQLYAQALGQAQRLYLTR 202

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           IDA+ EGD  FP ++  +W+ + S+ H A+ + + +Y FE  +RR
Sbjct: 203 IDAQPEGDAFFPVFDEHEWQCIDSQPHPAEGE-APAYRFETWQRR 246



>UniRef100_Q7W1B0 Dihydrofolate reductase n=1 Tax=Bordetella
           parapertussis RepID=Q7W1B0_BORPA
          Length = 167

 Score =  142 bits (358), Expect = 1e-32
 Identities = 75/160 (46%), Positives = 98/160 (61%), Gaps = 5/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SL+ A + + VIG +NA+PW LP DLA FKR TL  P+IMGR+TWES+GRPLPGR NI
Sbjct: 8   LLSLVVAYSTNGVIGRDNALPWKLPGDLAHFKRTTLGHPIIMGRNTWESLGRPLPGRTNI 67

Query: 61  ILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++  P  G    V  V S+D AI ACGD     VIGG ++Y Q LP AQ++  T + AE
Sbjct: 68  VITRNPAYGAAGAVV-VGSLDAAIQACGDAAVACVIGGAQIYAQALPLAQRVVATEVHAE 126

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGD  FP      W    ++     A+N   Y F   ER
Sbjct: 127 IEGDAFFPPLPAGQWRE--TQRAAQPAENGLRYDFVEYER 164



>UniRef100_B5JTJ3 Dihydrofolate reductase n=1 Tax=gamma
           proteobacterium HTCC5015 RepID=B5JTJ3_9GAMM
          Length = 162

 Score =  142 bits (357), Expect = 2e-32
 Identities = 72/159 (45%), Positives = 101/159 (63%), Gaps = 4/159 (2%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +IAA A  RVIG  N +PW L ADL  FK  T+ KP++MGR TW+SIGRPLPGR N++++
Sbjct: 1   MIAATANRRVIGRNNTLPWRLSADLQHFKATTMGKPIVMGRKTWDSIGRPLPGRANVVVT 60

Query: 64  -SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
            +     + V  V S+D+A+A   D  +IM++GG ++Y+Q LP+A  L+LTHID ++EGD
Sbjct: 61  RNTEFKAEGVEVVHSLDDALALLSDQRDIMLMGGAQLYQQALPRADVLHLTHIDLDIEGD 120

Query: 123 THFPDYEPDDWESVFSEFHDADA---QNSHSYCFEILER 158
             FP+++   W     E H  +A   Q S  Y F   ER
Sbjct: 121 AFFPEWDDGSWTCTAEETHQQEAIGEQPSFQYRFCRYER 159



>UniRef100_A3JA79 Dihydrofolate reductase n=1 Tax=Marinobacter sp.
           ELB17 RepID=A3JA79_9ALTE
          Length = 171

 Score =  142 bits (357), Expect = 2e-32
 Identities = 69/164 (42%), Positives = 102/164 (62%), Gaps = 8/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+A +RVIG  N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++
Sbjct: 4   ALIVAMAQNRVIGRNNKLPWYLPGDLKYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63

Query: 63  S-----SQPGTDDRVTWVKSV---DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           S       P      T +++     EA A    + E+MVIGGG++Y + LP   ++Y+T 
Sbjct: 64  SRNEEWQAPAGITAATTLQAALKKAEAQAELDGIEEVMVIGGGQIYAEALPLVDRIYITL 123

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A VEGD +FP+   ++WE +  E   A   N ++Y F + +R
Sbjct: 124 VHANVEGDAYFPEVNWEEWEEIGREDFSASDNNPYNYSFVVYQR 167



>UniRef100_P11045 Dihydrofolate reductase n=1 Tax=Bacillus subtilis
           RepID=DYR_BACSU
          Length = 168

 Score =  142 bits (357), Expect = 2e-32
 Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    +IMGR T+ESIGRPLP RKNI
Sbjct: 1   MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S P ++    T V S+ + +  C    E  VIGG ++Y    P A +LY+T I  E 
Sbjct: 61  VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD HFP+++  +W+ V SE    D +N + Y F + E++
Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160



>UniRef100_UPI0001694629 Dihydrofolate reductase n=1
           Tax=Paenibacillus larvae subsp. larvae BRL-230010
           RepID=UPI0001694629
          Length = 161

 Score =  141 bits (356), Expect = 2e-32
 Identities = 72/160 (45%), Positives = 100/160 (62%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+S + A+   R IG+ N +PW+LP DL +FKR T+ K +IMGR T+ESIG+PLPGRKNI
Sbjct: 1   MLSYMLAMDRQRGIGVRNQLPWHLPEDLKYFKRVTMGKDIIMGRKTYESIGKPLPGRKNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           IL+   G   +  T V S  EA+A      E+ VIGG  ++    P+A +LY+T I+   
Sbjct: 61  ILTQNKGYRAEGCTVVHSPREALAV-SSTEEVFVIGGAEIFRLLWPRADRLYITRIEETF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FPD  P +W  + SE    D +N ++Y FE+ ER+
Sbjct: 120 EADTFFPDISPSEWVKISSEQGIKDERNPYTYYFEVYERK 159



>UniRef100_Q8Y0U7 Probable dihydrofolate reductase oxidoreductase
           protein n=1 Tax=Ralstonia solanacearum
           RepID=Q8Y0U7_RALSO
          Length = 167

 Score =  141 bits (356), Expect = 2e-32
 Identities = 73/163 (44%), Positives = 100/163 (61%), Gaps = 9/163 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG +N +PW LP DLA FKR T+  P++MGR T+ESIGRPLPGR+NI
Sbjct: 3   LLTLIVARARNGVIGRDNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYESIGRPLPGRRNI 62

Query: 61  ILS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +++     + PG +       S+++A   C  V +I +IGG ++Y   LP A +L +T I
Sbjct: 63  VVTRSAKLALPGCE----IAHSLEDAQRLCIGVEQIFLIGGAQLYADALPSADRLIVTEI 118

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DA+ EGD HFP  +P  W  V  E H A A N   Y F   ER
Sbjct: 119 DADFEGDAHFPAPDPAVWHEVARETHHAAAPNDFDYAFVTYER 161



>UniRef100_D5MV32 Dihydrofolate reductase n=1 Tax=Bacillus subtilis
           subsp. spizizenii ATCC 6633 RepID=D5MV32_BACSU
          Length = 168

 Score =  141 bits (356), Expect = 2e-32
 Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    +IMGR T+ESIGRPLP RKNI
Sbjct: 1   MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKVTSGHSIIMGRKTYESIGRPLPNRKNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S P ++    T V S+ + +  C    E  VIGG ++Y    P A +LY+T I  E 
Sbjct: 61  VVTSAPASEFPGCTVVSSLKDVLDICSGSEECFVIGGAQLYTALFPYADRLYMTKIHHEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD HFP+++  +W+ V SE    D +N + Y F + E++
Sbjct: 121 EGDRHFPEFDETNWKLVSSERGIKDEKNPYDYEFLVYEKK 160



>UniRef100_C5S0S9 Dihydrofolate reductase n=1 Tax=Actinobacillus
           minor NM305 RepID=C5S0S9_9PAST
          Length = 165

 Score =  141 bits (356), Expect = 2e-32
 Identities = 73/160 (45%), Positives = 107/160 (66%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A   + +IG ENAMPW+LP DLAWF++NT+ KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTQNHIIGKENAMPWHLPKDLAWFRQNTVGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAI---AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS    + +      ++++AI    +  +  EIM+IGGG +++Q LP A +LYLT I A+
Sbjct: 63  LSRAGFSVEGAYSANTLEQAIELARSFANTDEIMIIGGGELFKQALPIANRLYLTEIQAD 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           ++GDT F +++ ++W      + + DA+N++   F + ER
Sbjct: 123 IDGDTLF-EFDEENWRLTQDIWSEKDAENAYDCRFMVFER 161



>UniRef100_Q12K26 Dihydrofolate reductase n=1 Tax=Shewanella
           denitrificans OS217 RepID=Q12K26_SHEDO
          Length = 160

 Score =  141 bits (355), Expect = 3e-32
 Identities = 74/159 (46%), Positives = 103/159 (64%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNQMPWHLPEDLRHFKAMTLGKPVVMGRKTFESIGRPLPGRHNIV 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ Q     + V+ V S DEA    GD  E++V+GGG++Y + LP A+ +YLT I  +VE
Sbjct: 63  ITRQLDYAIEGVSCVSSFDEAKKIAGDCDELIVMGGGQLYAEILPFAEVMYLTLIKLDVE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP +   +W+   S+       +   Y F  L ++
Sbjct: 123 GDTFFPAWNEQEWQ--VSQTESVTNHDGLEYSFNTLVKK 159



>UniRef100_Q0VM07 Dihydrofolate reductase n=1 Tax=Alcanivorax
           borkumensis SK2 RepID=Q0VM07_ALCBS
          Length = 171

 Score =  141 bits (355), Expect = 3e-32
 Identities = 70/165 (42%), Positives = 101/165 (61%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A A + VIG  N +PW LP DL +FK+ T  KPVIMGR TWES+  PLPGR NI+
Sbjct: 7   LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ QP    +    V +VD+AI    +V       E +++GG  +Y   L + Q+LYLT 
Sbjct: 67  ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+Y+  +WE +  E   A+  N + Y F + ER+
Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171



>UniRef100_B4WYY5 Dihydrofolate reductase n=1 Tax=Alcanivorax sp.
           DG881 RepID=B4WYY5_9GAMM
          Length = 169

 Score =  141 bits (355), Expect = 3e-32
 Identities = 70/165 (42%), Positives = 102/165 (61%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A A + VIG  N +PW LP DL +FK+ T  KPVIMGR TWES+  PLPGR NI+
Sbjct: 5   LSMMVAKASNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 64

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ QP    +    V +V++AI   G+V       E +++GG  +Y   LP+ Q+LYLT 
Sbjct: 65  ITRQPDYLAEGAKVVTTVEDAITMAGNVAFIEGQEEAVIMGGAEIYALALPQTQRLYLTE 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+Y   +W+ +  E   A+  N + Y F + ER+
Sbjct: 125 VHAEVDGDTFFPEYATSEWKEIGREDFAAEGPNPYDYSFVVYERK 169



>UniRef100_B4SK37 Dihydrofolate reductase n=1 Tax=Stenotrophomonas
           maltophilia R551-3 RepID=B4SK37_STRM5
          Length = 163

 Score =  140 bits (354), Expect = 3e-32
 Identities = 76/161 (47%), Positives = 103/161 (63%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I AL  +R IG  NAMPW+LP D   FK  TL KP++MGR T ESIGR LPGR N++
Sbjct: 3   LSMIVALDRNRGIGQGNAMPWHLPDDFKHFKALTLGKPILMGRKTAESIGRVLPGRTNLV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+       + +  V S+DEA  IA      E+ +IGGG ++ Q L +A  LYLT +DAE
Sbjct: 63  LTRSGQVPFEGMRAVASLDEAKAIAEGEGASELCIIGGGEIFHQLLDQASDLYLTWVDAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V  DTHFP+ + DDW+ V SE H AD ++++++ F    RR
Sbjct: 123 VPADTHFPEVDADDWQEVSSEPHPADERHAYAFRFVHYVRR 163



>UniRef100_A6UYF3 Dihydrofolate reductase n=1 Tax=Pseudomonas
           aeruginosa PA7 RepID=A6UYF3_PSEA7
          Length = 168

 Score =  140 bits (354), Expect = 3e-32
 Identities = 73/165 (44%), Positives = 104/165 (63%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++IAAL  +R IG++N +PW LPADL  FK  TL KPVIMGR TW+S+GRPLPGR N++
Sbjct: 5   LAMIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLV 64

Query: 62  LSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S+D A+      A   D  E+M+IGG ++Y + LP+A++LYLT 
Sbjct: 65  VSRQAGLALEGAEVFASLDAALVRAEEWAQAEDADELMLIGGAQLYAEALPRAERLYLTR 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +    EGD  FP+ +   W  + S    A A ++ +Y FE+ ERR
Sbjct: 125 VGLAPEGDAFFPEIDDAGWR-LASSIEHAAADDAPAYAFEVWERR 168



>UniRef100_C6MAK4 Dihydrofolate reductase n=1 Tax=Neisseria sicca
           ATCC 29256 RepID=C6MAK4_NEISI
          Length = 162

 Score =  140 bits (354), Expect = 3e-32
 Identities = 70/154 (45%), Positives = 98/154 (63%), Gaps = 4/154 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I+LIAA A DR IG+ N MPW+LP D A+FK  TL+KPV+MGR TWES+ R PLPGR+NI
Sbjct: 4   ITLIAACAPDRCIGINNTMPWHLPEDFAFFKSYTLDKPVVMGRKTWESLPRKPLPGRRNI 63

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S Q     +    V S++EA+A C    E++++GG ++Y Q LP A  L +T +  +V
Sbjct: 64  VISRQADYPAEGAETVGSLEEALALCAAAEEVIIMGGAQIYAQALPLASDLRITEVALDV 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           +GD  FP++ P +W     E H   + N   Y F
Sbjct: 124 QGDAFFPEFSPSEWREAARETH--TSANGTGYAF 155



>UniRef100_Q9K7B6 Dihydrofolate reductase n=1 Tax=Bacillus
           halodurans RepID=Q9K7B6_BACHD
          Length = 163

 Score =  140 bits (353), Expect = 4e-32
 Identities = 73/160 (45%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+   R+IG EN +PW LPADLA FKR T    VIMGR T+ESIG+PLP R+N+
Sbjct: 1   MISFIVAMDKHRLIGKENDLPWRLPADLAHFKRVTSGHTVIMGRKTYESIGKPLPNRRNV 60

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ SQ  T + V  V S+DEAI       E  VIGG  +++ F P A ++Y+T+ID   
Sbjct: 61  VVTRSQAYTAEGVDIVHSIDEAIRLTEHENETFVIGGSELFKAFWPHADRMYVTYIDEVF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT+FP+ +  +WE V  E    D +N + + F + ER+
Sbjct: 121 DGDTYFPEIDGQEWELVSVEAGTIDEKNVYPHEFRVYERQ 160



>UniRef100_Q2W7P5 Dihydrofolate reductase n=1 Tax=Magnetospirillum
           magneticum AMB-1 RepID=Q2W7P5_MAGSA
          Length = 175

 Score =  140 bits (353), Expect = 4e-32
 Identities = 75/162 (46%), Positives = 102/162 (62%), Gaps = 9/162 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+
Sbjct: 17  VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACG----DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++ Q G   +      S+DEA+A       +  E+MVIGG  ++ + LP A++LYLT I 
Sbjct: 77  VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT FP +E   W  V    ++ D     ++ F IL+R
Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGDP----AFDFVILDR 174



>UniRef100_A9I779 FolA protein n=1 Tax=Bordetella petrii DSM 12804
           RepID=A9I779_BORPD
          Length = 178

 Score =  140 bits (353), Expect = 4e-32
 Identities = 71/163 (43%), Positives = 98/163 (60%), Gaps = 11/163 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A + +RVIG +N +PW LP DLA FKR TL  P+IMGR TWES+GRPLPGR N++
Sbjct: 21  LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80

Query: 62  LS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +S     + PG     T V ++  A+ ACGD P+  VIGG ++Y Q LP A ++  T + 
Sbjct: 81  ISRNLRYAAPG----ATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVH 136

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A VEGD  FP      W     +     A+N + Y F + ER+
Sbjct: 137 AHVEGDAFFPYLPSFAWREASRQ--PQPAENGYDYDFVVYERQ 177



>UniRef100_A9M656 Dihydrofolate reductase type 3 n=2 Tax=Brucella
           RepID=A9M656_BRUC2
          Length = 172

 Score =  140 bits (353), Expect = 4e-32
 Identities = 73/166 (43%), Positives = 107/166 (64%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A++ + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAVSENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S+++A+      AA G V EI VIGGG++Y Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + + +EGDT+FP+  P DW+ + SE   A  ++S+   + + ERR
Sbjct: 125 RVLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170



>UniRef100_B7S3D0 Dihydrofolate reductase n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7S3D0_9GAMM
          Length = 180

 Score =  140 bits (353), Expect = 4e-32
 Identities = 71/164 (43%), Positives = 101/164 (61%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++I A A + VIG  N +PW+LP DL +FKR T+ KP++MGR T+ESIGRPLPGR NI+
Sbjct: 17  LAVIVAAAQNGVIGRNNTLPWHLPEDLRYFKRTTMGKPIVMGRKTYESIGRPLPGRTNIV 76

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ S   + + V  V S+ +A++   DV       E+MVIGG  +Y   L  A +LYLT 
Sbjct: 77  VTRSSQWSAEGVNVVHSLGDALSLAQDVAANEGAQELMVIGGAEIYSTALLAADRLYLTE 136

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + AEVEGD + P  +   W  +  E H+A   N + Y F + ER
Sbjct: 137 VHAEVEGDAYLPQIDWTAWREISRERHEASENNPYGYSFVVFER 180



>UniRef100_A5VRE6 Dihydrofolate reductase n=1 Tax=Brucella ovis ATCC
           25840 RepID=A5VRE6_BRUO2
          Length = 172

 Score =  140 bits (352), Expect = 6e-32
 Identities = 73/166 (43%), Positives = 106/166 (63%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A + + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAASGNNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S+++A+      AA G V EI VIGGG++Y Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + + +EGDT+FP+  P DW+ + SE   A  ++S+   + + ERR
Sbjct: 125 RVLSVIEGDTYFPEINPQDWQLLLSEDVPAGDKDSYPTRYMLYERR 170



>UniRef100_D6RUA4 Dihydrofolate reductase n=1 Tax=Shewanella
           gelidimarina RepID=D6RUA4_9GAMM
          Length = 160

 Score =  140 bits (352), Expect = 6e-32
 Identities = 72/151 (47%), Positives = 99/151 (65%), Gaps = 1/151 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+A +RVIG +N MPW+LP DL  FK  TL KP++MGR T+ESIGRPLPGR NI+
Sbjct: 3   IAMIAAMANNRVIGKDNKMPWHLPEDLRHFKAVTLGKPIVMGRKTYESIGRPLPGRHNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S Q     D VT V   ++A  A GD  E++VIGGG++Y   L  +  LYLT I  +VE
Sbjct: 63  ISRQADLAIDGVTTVTCFEDAKLAAGDCEELVVIGGGQLYTSLLCLSDVLYLTEISLDVE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
           GDT+FP ++   W  +  +   +  Q  +S+
Sbjct: 123 GDTYFPHWDDGSWLEMSRDVAISGKQLEYSF 153



>UniRef100_D6LNG9 Dihydrofolate reductase n=1 Tax=Brucella sp. NVSL
           07-0026 RepID=D6LNG9_9RHIZ
          Length = 172

 Score =  140 bits (352), Expect = 6e-32
 Identities = 73/166 (43%), Positives = 106/166 (63%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A + + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S+++A+      AA G V EI VIGGG++Y Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYAQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + + +EGDT+FP+  P DW+ + SE   A  ++S+   + + ERR
Sbjct: 125 RVLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170



>UniRef100_D5VFQ9 Dihydrofolate reductase n=1 Tax=Caulobacter segnis
           ATCC 21756 RepID=D5VFQ9_CAUST
          Length = 171

 Score =  140 bits (352), Expect = 6e-32
 Identities = 75/165 (45%), Positives = 104/165 (63%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           ++++ A A + VIG +  +PW L +DLA FK NTL KP+IMGR TW+S+ R PLPGR N+
Sbjct: 6   LAIVVARAANGVIGRDGDLPWRLRSDLALFKANTLGKPIIMGRKTWDSLPRKPLPGRMNV 65

Query: 61  IL----SSQP-GTDDRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L    S +P G     TW+++V  A     D  V E+ VIGG  ++E  LPKA++LYLT
Sbjct: 66  VLTRDQSFEPDGAVACETWMEAVQMAKEQAADDGVDEVCVIGGRALFELALPKAKRLYLT 125

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + AEVEGD HFP ++   W  V  E H A   + H++ F +LER
Sbjct: 126 EVAAEVEGDVHFPAFDESAWTEVRREEHPAGDGDDHAFVFRVLER 170



>UniRef100_C5PXK6 Dihydrofolate reductase n=1 Tax=Sphingobacterium
           spiritivorum ATCC 33861 RepID=C5PXK6_9SPHI
          Length = 164

 Score =  140 bits (352), Expect = 6e-32
 Identities = 72/159 (45%), Positives = 98/159 (61%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +N MPW+LP D  +FK+NTL   VIMGR T+E+IG+ LP R+NI+
Sbjct: 6   ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S +Q      V    S+ EAI  C D  E+ VIGG  +YEQ LP A K+ LT +   +E
Sbjct: 66  ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP   P++W     E H AD +++  Y F+I  R+
Sbjct: 126 GDAVFPVLNPEEWALESEEKHFADDRHAFDYTFQIFNRK 164



>UniRef100_D1UG82 Dihydrofolate reductase n=1 Tax=Burkholderia sp.
           CCGE1001 RepID=D1UG82_9BURK
          Length = 166

 Score =  139 bits (351), Expect = 8e-32
 Identities = 76/165 (46%), Positives = 100/165 (60%), Gaps = 11/165 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P+IMGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++        G D   T    +DEA  +AA    PE  +IGG ++Y + L  A KL +T 
Sbjct: 64  VTRDATRRFQGCDAATT----LDEALKLAAQDQAPEAFLIGGAQLYVEGLRLADKLIVTE 119

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           I A+ +GD  FP  +PD+WE V  E H ADA N   Y F    R+
Sbjct: 120 ISADFQGDATFPAVDPDEWEEVAHETHRADAPNDFDYAFVTYRRK 164



>UniRef100_D0B8M8 Dihydrofolate reductase n=29 Tax=Brucella
           RepID=D0B8M8_BRUME
          Length = 172

 Score =  139 bits (351), Expect = 8e-32
 Identities = 73/166 (43%), Positives = 106/166 (63%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A + + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S+++A+      AA G V EI VIGGG++Y Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + + +EGDT+FP+  P DW+ + SE   A  ++S+   + + ERR
Sbjct: 125 RVLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170



>UniRef100_C0DS23 Putative uncharacterized protein n=1 Tax=Eikenella
           corrodens ATCC 23834 RepID=C0DS23_EIKCO
          Length = 166

 Score =  139 bits (351), Expect = 8e-32
 Identities = 69/146 (47%), Positives = 99/146 (67%), Gaps = 2/146 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I+LIAA+A +R IG  NAMPW++  D A+FKR TL KPV+MGR TW+S+ + PLPGR+NI
Sbjct: 4   ITLIAAVADNRCIGSGNAMPWHIAEDFAFFKRYTLGKPVVMGRKTWDSLPKKPLPGRRNI 63

Query: 61  ILSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ QP    + V    S+D A+A   DVPEI+++GG ++Y Q LP A  L LT +  ++
Sbjct: 64  VITRQPLWQAEGVERADSLDAALAVLADVPEIIIMGGAQIYAQALPLATDLRLTEVRLDI 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADA 145
           +GD  FP ++P +W+ V    H A A
Sbjct: 124 DGDAFFPAFDPAEWQEVERSSHTAAA 149



>UniRef100_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia
           endosymbiont of Glossina brevipalpis RepID=Q8D3H9_WIGBR
          Length = 162

 Score =  139 bits (350), Expect = 1e-31
 Identities = 70/159 (44%), Positives = 102/159 (64%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A + ++VIG +  +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL  R NI+
Sbjct: 3   ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62

Query: 62  LSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS          +   K+  +A+    +  E+M+IGG ++Y+ FLPKA KLYLT I+AE+
Sbjct: 63  LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            G+  FP Y    W   F ++ ++D +N +S  F I  +
Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161



>UniRef100_B8CSY0 Dihydrofolate reductase n=1 Tax=Shewanella
           piezotolerans WP3 RepID=B8CSY0_SHEPW
          Length = 152

 Score =  139 bits (350), Expect = 1e-31
 Identities = 70/145 (48%), Positives = 95/145 (65%), Gaps = 1/145 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  N MPW+LP DL  FK  TL KPV+MGR T+ESIGRPLPGR NI++S Q  
Sbjct: 1   MANNRVIGKNNKMPWHLPEDLRHFKALTLGKPVVMGRKTYESIGRPLPGRHNIVISRQAD 60

Query: 68  -TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              + VT V S ++A +A GD  E++++GGG++YE  L  +  LYLT I  +VEGDT+FP
Sbjct: 61  LCIEGVTTVTSFEDAKSAAGDCEELIIMGGGQLYETLLGISDILYLTEISLDVEGDTYFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSY 151
           D++   W  +       D Q  +S+
Sbjct: 121 DWDDGSWSEISRNVAKNDKQLEYSF 145



>UniRef100_D4FXU4 Dihydrofolate reductase n=1 Tax=Bacillus subtilis
           subsp. natto BEST195 RepID=D4FXU4_BACNA
          Length = 168

 Score =  139 bits (350), Expect = 1e-31
 Identities = 70/160 (43%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    +IMGR T+ESIGRPLP RKNI
Sbjct: 1   MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKVTSGHSIIMGRKTFESIGRPLPNRKNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S P ++    T V S+ + +  C    E  VIGG ++Y    P A +LY+T I  E 
Sbjct: 61  VVTSAPSSEFPGCTVVGSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD HFP ++  +W+ V SE    D +N + Y F + E++
Sbjct: 121 EGDRHFPKFDESNWKLVSSEQGIKDEKNPYDYEFLMYEKK 160



>UniRef100_C9T7B2 Dihydrofolate reductase n=2 Tax=Brucella ceti
           RepID=C9T7B2_9RHIZ
          Length = 172

 Score =  139 bits (350), Expect = 1e-31
 Identities = 72/166 (43%), Positives = 105/166 (63%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A + + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S+++A+A        G V EI VIGGG++Y Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEDALALARKFATEGGVDEICVIGGGQIYVQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + + +EGDT+FP+  P DW+ + SE   A  ++S+   + + ERR
Sbjct: 125 RVLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170



>UniRef100_C2FZ23 Dihydrofolate reductase n=1 Tax=Sphingobacterium
           spiritivorum ATCC 33300 RepID=C2FZ23_9SPHI
          Length = 164

 Score =  139 bits (350), Expect = 1e-31
 Identities = 71/159 (44%), Positives = 98/159 (61%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +N MPW+LP D  +FK+NTL   VIMGR T+E+IG+ LP R+NI+
Sbjct: 6   ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S +Q      V    S+ EAI  C D  E+ VIGG  +YEQ LP A K+ LT +   +E
Sbjct: 66  ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP   P++W     E H AD +++  Y F++  R+
Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164



>UniRef100_B4AKS8 Dihydrofolate reductase n=1 Tax=Bacillus pumilus
           ATCC 7061 RepID=B4AKS8_BACPU
          Length = 161

 Score =  139 bits (350), Expect = 1e-31
 Identities = 67/160 (41%), Positives = 103/160 (64%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A   DRVIG +N MPW+LPADLA+FK+ T    ++MGR T+ESIGR LP R+NI
Sbjct: 1   MISMIVATGKDRVIGQDNQMPWHLPADLAYFKKVTGGHTIVMGRKTFESIGRALPNRRNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L++    + +    V S+ + +A      E+ +IGG ++YE+ +P A +LY+THI    
Sbjct: 61  VLTTSSSFEAEGCEVVHSIADILAIGESETELFIIGGSKLYEEMMPYADRLYITHIHHAF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD +FPDY  ++W  V  +    D +N ++Y F + +++
Sbjct: 121 EGDRYFPDYNENEWTVVSRKKGHRDEKNPYNYEFVVYDKK 160



>UniRef100_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii
           RepID=A9KH09_COXBN
          Length = 161

 Score =  139 bits (350), Expect = 1e-31
 Identities = 69/160 (43%), Positives = 107/160 (66%), Gaps = 3/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I+LIAA+  +R+IG  N +PW+LPADLA FK  TL KP++MGR T++SIG+PLP R+NI
Sbjct: 2   IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ Q     +      S+D+A++A    PE+++IGG R++++ LPKA K+ LT I+   
Sbjct: 62  VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD +FP++   +W+      H+ D +N   Y F+ LE R
Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKN--PYPFQFLELR 159



>UniRef100_Q02U65 Dihydrofolate reductase n=3 Tax=Pseudomonas
           aeruginosa RepID=Q02U65_PSEAB
          Length = 168

 Score =  139 bits (350), Expect = 1e-31
 Identities = 74/165 (44%), Positives = 103/165 (62%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++IAAL  +R IG++N +PW LPADL  FK  TL KPVIMGR TW+S+GRPLPGR N++
Sbjct: 5   LAMIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLV 64

Query: 62  LSSQPGTD-DRVTWVKSVD------EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S+D      EA A   D  E+M+IGG ++Y + LP+A +LYLT 
Sbjct: 65  VSRQAGLALEGAEVFASLDAALARAEAWAQAEDADELMLIGGAQLYAEALPRAARLYLTR 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +    EGD  FP+ +   W  + S    A A ++ +Y FE+ ERR
Sbjct: 125 VGLAPEGDAFFPEIDGAAWR-LASSIEHAAADDAPAYAFEVWERR 168



>UniRef100_UPI0001AF545F dihydrofolate reductase n=1 Tax=Pseudomonas
           syringae pv. oryzae str. 1_6 RepID=UPI0001AF545F
          Length = 170

 Score =  139 bits (349), Expect = 1e-31
 Identities = 73/166 (43%), Positives = 107/166 (64%), Gaps = 12/166 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNLV 66

Query: 62  LSSQPGTDDRVTWVK---SVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S Q  TD ++   +   S+D A+           V E+M+IGG ++Y Q L +A +LYL
Sbjct: 67  VSRQ--TDLQLEGAEVFPSLDAAVVRAEQWAQEQGVDEVMLIGGAQLYAQGLAQADRLYL 124

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T +    EGD  FP+++   W ++ S   +A A +  +Y FE+ ER
Sbjct: 125 TRVALSPEGDAWFPEFDTTQW-ALVSNTENAAADDKPAYSFEVWER 169



>UniRef100_Q82WU4 Dihydrofolate reductase n=1 Tax=Nitrosomonas
           europaea RepID=Q82WU4_NITEU
          Length = 182

 Score =  139 bits (349), Expect = 1e-31
 Identities = 69/164 (42%), Positives = 105/164 (64%), Gaps = 11/164 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++AA++ +RVIG+ N +PW+LPADL  FK+ T  + V+MGR T++SIGRPLP R N++
Sbjct: 11  LAILAAVSANRVIGLNNTLPWHLPADLKHFKQLTTGQIVVMGRRTFDSIGRPLPDRTNVV 70

Query: 62  LS-----SQPGTDDRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           L+     +QPG    +    S+ E +   CGD  +I +IGG  +Y+Q LP  Q+LYLT I
Sbjct: 71  LTRQRHFNQPG----ILTAGSIQEVLEHFCGDDRQIFIIGGAEIYQQTLPFCQRLYLTEI 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             +  GDT FP+Y+ D+W  +  E H A   +   Y F +L+R+
Sbjct: 127 QQDFAGDTFFPEYDRDNWREISREMHQA-TDSGIEYHFVVLDRK 169



>UniRef100_Q4K492 Dihydrofolate reductase n=1 Tax=Pseudomonas
           fluorescens Pf-5 RepID=Q4K492_PSEF5
          Length = 170

 Score =  139 bits (349), Expect = 1e-31
 Identities = 73/165 (44%), Positives = 105/165 (63%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAALA +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAALAQNRVIGVDNSMPWHLPGDFKFFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S+  A+A   +        E+M+IGG ++Y Q L +A +LYLT 
Sbjct: 67  VSRQTGLMLEGAEVYPSLKAAVARAEEWALEQGANELMLIGGAQLYSQGLEQADRLYLTR 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +    EGD  FP+++   W+ V SE  +    +  +Y FE+ E+R
Sbjct: 127 VALSPEGDAWFPEFDEQQWKRV-SEVPNPAEGDKPAYSFEVWEKR 170



>UniRef100_Q11HI1 Dihydrofolate reductase n=1 Tax=Chelativorans sp.
           BNC1 RepID=Q11HI1_MESSB
          Length = 167

 Score =  139 bits (349), Expect = 1e-31
 Identities = 73/162 (45%), Positives = 102/162 (62%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+ A+A + VIG +  +PW L  DL  FK  T+ KP+IMGR TW+SIG+PLPGR+NI+
Sbjct: 3   LSLVVAVANNGVIGHQGDLPWRLSTDLKRFKAVTMGKPIIMGRKTWQSIGKPLPGRQNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S  P  T +      S+DEAIA  G    + EI VIGG  +Y Q L +A  L++TH++A
Sbjct: 63  ISRNPAFTAEGAYAAGSLDEAIALAGRQDGIEEICVIGGAEIYRQALSRADILHVTHVEA 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +VEGD  FP+ +P  W  V SE   A  ++ +   + I ERR
Sbjct: 123 DVEGDAVFPEIDPQVWRPVHSESVPAGEKDVYPTRYVIYERR 164



>UniRef100_B7V2R3 Dihydrofolate reductase n=1 Tax=Pseudomonas
           aeruginosa LESB58 RepID=B7V2R3_PSEA8
          Length = 168

 Score =  139 bits (349), Expect = 1e-31
 Identities = 75/165 (45%), Positives = 103/165 (62%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++IAAL  +R IG++N +PW LPADL  FK  TL KPVIMGR TW+S+GRPLPGR N++
Sbjct: 5   LAMIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLV 64

Query: 62  LSSQPGTD-DRVTWVKSVD------EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S+D      EA A   D  E+M+IGG ++Y + LP+A +LYLT 
Sbjct: 65  VSRQAGLALEGAEVFASLDAALARAEAWAQAEDADELMLIGGAQLYAEALPRAARLYLTR 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +    EGD  FP+ +   W    S  H A A ++ +Y FE+ ERR
Sbjct: 125 VGLAPEGDAFFPEIDGAAWRLASSIEHVA-ADDAPAYAFEVWERR 168



>UniRef100_A6WZV5 Dihydrofolate reductase n=1 Tax=Ochrobactrum
           anthropi ATCC 49188 RepID=A6WZV5_OCHA4
          Length = 174

 Score =  139 bits (349), Expect = 1e-31
 Identities = 76/166 (45%), Positives = 104/166 (62%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S+I A A + VIG +N MPW L  DL  FK  TL KPVIMGR TWESIGRPLPGR NI
Sbjct: 7   IVSIIVAAAENGVIGRDNDMPWRLSTDLKRFKALTLGKPVIMGRRTWESIGRPLPGRPNI 66

Query: 61  ILSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++   G   +  + + S++EAI      AA   V E+ VIGGG++Y Q LP A  ++LT
Sbjct: 67  VVTRDNGFQAEGASAIGSLEEAIALGQKLAADLGVGEVCVIGGGKIYAQALPLADHIHLT 126

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + AE++GDTHFP+ +   W  V  E   A  ++SH   + + E+R
Sbjct: 127 RVLAEIDGDTHFPEIDLQIWRVVSQEDVPAGDKDSHPTRYFVYEKR 172



>UniRef100_C6MH59 Dihydrofolate reductase n=1 Tax=Nitrosomonas sp.
           AL212 RepID=C6MH59_9PROT
          Length = 167

 Score =  139 bits (349), Expect = 1e-31
 Identities = 71/163 (43%), Positives = 108/163 (66%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A+A +RVIG  N +PW+LPADL  FK  T+ + ++MGR T+ESIGRPLPGR+NII
Sbjct: 6   LSILVAMAKNRVIGQNNQLPWHLPADLKHFKFLTMGQTIVMGRKTYESIGRPLPGRENII 65

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVP----EIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++ Q G D    T V S+++A+  C +      E  +IGG ++Y Q L   Q++Y+T I 
Sbjct: 66  ITRQSGYDVQGATVVNSLEDALLICEESSTINNESFIIGGEKLYRQTLDICQRMYITEIQ 125

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           ++ EGD  FP+++ ++WE +  + H +DAQ    Y F ILER+
Sbjct: 126 SDFEGDVVFPEFDRNNWEEIQRDKHISDAQ--IEYHFVILERK 166



>UniRef100_Q7VM78 Dihydrofolate reductase n=1 Tax=Haemophilus
           ducreyi RepID=Q7VM78_HAEDU
          Length = 161

 Score =  138 bits (348), Expect = 2e-31
 Identities = 77/159 (48%), Positives = 99/159 (62%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A   + VIG  N MPW+LP DL WF+  T++KP+IMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTKNHVIGRHNQMPWHLPRDLMWFREKTIDKPIIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS      D      S+ EAI  A      EIMVIGGG +++Q LP AQ+LYLT I+A++
Sbjct: 63  LSRTELKIDGAYTATSLAEAIELAKKFTAEEIMVIGGGELFKQALPLAQRLYLTEIEADI 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT+F  +   DW+ +  E  + D  N++   F   ER
Sbjct: 123 EGDTYFA-FNEQDWQLIRKESSEIDEHNNYVCHFMQFER 160



>UniRef100_D5DPX0 Dihydrofolate reductase n=1 Tax=Bacillus
           megaterium QM B1551 RepID=D5DPX0_BACMQ
          Length = 161

 Score =  138 bits (348), Expect = 2e-31
 Identities = 72/160 (45%), Positives = 102/160 (63%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A+  +R+IG EN +PW LP DL +FKR T +  +IMGR T+ESIGRPLP R+N+
Sbjct: 1   MISLIVAMDQNRLIGKENDLPWRLPEDLKYFKRITTSHTIIMGRKTFESIGRPLPNRENV 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +L+ Q     +  T + SV+E  A   +   E+ VIGG  +YEQ L  A +LY+THI+  
Sbjct: 61  VLTRQKDYQQEGATVIHSVEELEALDAEKKDELFVIGGATLYEQTLGVANRLYITHIEES 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGDTHFP  +  +W+ +  +    D +N ++Y F + ER
Sbjct: 121 FEGDTHFPAIDLSEWKVISKQQGIKDEKNPYTYYFTVYER 160



>UniRef100_D4ZGG4 Dihydrofolate reductase n=2 Tax=Shewanella
           violacea RepID=D4ZGG4_SHEVD
          Length = 152

 Score =  138 bits (348), Expect = 2e-31
 Identities = 68/133 (51%), Positives = 90/133 (67%), Gaps = 1/133 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG +N MPW+LP DL  FK  TL KP++MGR T++SIGR LPGR NI++S Q G
Sbjct: 1   MANNRVIGKDNQMPWHLPEDLKHFKAMTLGKPIVMGRKTYDSIGRALPGRLNIVISRQEG 60

Query: 68  TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                VT V S + A+ A G+  E++VIGGG++Y   L KA KLYLT I+ +V GDT FP
Sbjct: 61  LSIPGVTCVTSFEMAVEAAGECEELVVIGGGQLYASLLSKADKLYLTEINLDVAGDTFFP 120

Query: 127 DYEPDDWESVFSE 139
            ++   WE +  E
Sbjct: 121 QWDDGSWERISQE 133



>UniRef100_D1CYY5 Dihydrofolate reductase n=1 Tax=Brucella sp. 83/13
           RepID=D1CYY5_9RHIZ
          Length = 172

 Score =  138 bits (348), Expect = 2e-31
 Identities = 74/166 (44%), Positives = 105/166 (63%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A + + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S++ A+      AA G V EI VIGGG++Y Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEGALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + A VEGDT+FP+  P DW+ + SE   A  ++++   + + ERR
Sbjct: 125 RVLAVVEGDTYFPEINPQDWQLLSSEDVPAGDKDTYPTRYMLYERR 170



>UniRef100_Q2SA18 Dihydrofolate reductase n=1 Tax=Hahella chejuensis
           KCTC 2396 RepID=Q2SA18_HAHCH
          Length = 165

 Score =  138 bits (347), Expect = 2e-31
 Identities = 69/161 (42%), Positives = 102/161 (63%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A A +  IG+EN +PW L  DL +FK+ T+ KP+IMGR T++SIGRPLPGR NI
Sbjct: 4   VLSIVVARAENGAIGVENTLPWRLSNDLQYFKQVTMGKPIIMGRKTFDSIGRPLPGRTNI 63

Query: 61  ILS-SQPGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +++ ++    D V    S+DEA+  AA     E+M+IGG  +Y Q L  AQ++YLT +  
Sbjct: 64  VVTRNKDWRHDGVNVAHSLDEAVSLAAREQAEEVMLIGGAELYRQGLAAAQRVYLTEVKT 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            V+GD  FP+ +  DW     E H AD +N + + F + ER
Sbjct: 124 SVQGDAFFPELDLADWRETSRESHPADEKNQYPHDFVVFER 164



>UniRef100_D3E9M7 Dihydrofolate reductase n=1 Tax=Geobacillus sp.
           Y412MC10 RepID=D3E9M7_GEOS4
          Length = 162

 Score =  138 bits (347), Expect = 2e-31
 Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MIS+I A+  D+VIG+   MPW LP D+A+FK  TL+K ++MGR TW+S G +PLP RKN
Sbjct: 1   MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60

Query: 60  IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+       T+D+   +  ++ A+    +  E+MVIGG ++YE  LPKA +LY T ID
Sbjct: 61  IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              EGDT+FP+   D+W+ V       D +N ++Y F   ER+
Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162



>UniRef100_B2U8M3 Dihydrofolate reductase n=1 Tax=Ralstonia
           pickettii 12J RepID=B2U8M3_RALPJ
          Length = 167

 Score =  138 bits (347), Expect = 2e-31
 Identities = 71/163 (43%), Positives = 97/163 (59%), Gaps = 9/163 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG  N +PW LP DLA FKR T+  P++MGR T++SIGRPLPGR+NI
Sbjct: 3   ILTLIVARARNGVIGRNNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYDSIGRPLPGRRNI 62

Query: 61  ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +++       PG +       S+++A   C    +I +IGG ++Y   LP A +L +T I
Sbjct: 63  VVTRNAKLELPGCE----IAYSMEDAQRLCVGAEQIFLIGGAQLYADALPSADRLIVTEI 118

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DA+ EGD HFP  +P  W  V  E H A A N   Y F   ER
Sbjct: 119 DADFEGDAHFPAPDPKVWHEVSRETHHAAAPNDFDYAFVTYER 161



>UniRef100_D5NDB7 Dihydrofolate reductase n=1 Tax=Burkholderia sp.
           Ch1-1 RepID=D5NDB7_9BURK
          Length = 166

 Score =  138 bits (347), Expect = 2e-31
 Identities = 72/163 (44%), Positives = 100/163 (61%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P+IMGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++        G D   T  +++   +AA    PE  +IGG ++Y + L +A KL +T I 
Sbjct: 64  VTRNTTRRFQGCDTAATLQEAL--KLAAQDQAPEAFLIGGAQLYVEGLQQADKLIITEIS 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A+ EGD  FP+ +  +WE V  E H ADA N   Y F   +R+
Sbjct: 122 ADFEGDATFPELDETEWEEVAHETHRADAPNDFDYAFVTYKRK 164



>UniRef100_Q4ZM58 Dihydrofolate reductase n=1 Tax=Pseudomonas
           syringae pv. syringae B728a RepID=Q4ZM58_PSEU2
          Length = 170

 Score =  137 bits (346), Expect = 3e-31
 Identities = 72/166 (43%), Positives = 106/166 (63%), Gaps = 12/166 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNLV 66

Query: 62  LSSQPGTDDRVTWVK---SVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S Q  TD ++   +   S+D A+           V E+M+IGG ++Y Q LP+A +LYL
Sbjct: 67  VSRQ--TDLQLEGAEVFASLDAAVVRAEQWAQEQGVDEVMLIGGAQLYAQGLPQADRLYL 124

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T +    +GD  FP+++   W ++ S   +A      +Y FE+ ER
Sbjct: 125 TRVALSPDGDAWFPEFDTAQW-ALVSNTENAAVDGKPAYNFEVWER 169



>UniRef100_Q13VG2 Dihydrofolate reductase n=1 Tax=Burkholderia
           xenovorans LB400 RepID=Q13VG2_BURXL
          Length = 166

 Score =  137 bits (346), Expect = 3e-31
 Identities = 72/163 (44%), Positives = 100/163 (61%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P+IMGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++        G D   T  +++   +AA    PE  +IGG ++Y + L +A KL +T I 
Sbjct: 64  VTRDATRRFQGCDTAATLQEAL--KLAAQDQAPEAFLIGGAQLYVEGLRQADKLIITEIS 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A+ EGD  FP+ +  +WE V  E H ADA N   Y F   +R+
Sbjct: 122 ADFEGDATFPELDETEWEEVAHETHRADAPNDFDYAFVTYKRK 164



>UniRef100_D5DJI3 Dihydrofolate reductase n=1 Tax=Bacillus
           megaterium DSM319 RepID=D5DJI3_BACMD
          Length = 161

 Score =  137 bits (346), Expect = 3e-31
 Identities = 71/160 (44%), Positives = 101/160 (63%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A+  +R+IG EN +PW LP DL +FKR T +  ++MGR T+ESIGRPLP R+N+
Sbjct: 1   MISLIVAMDQNRLIGKENDLPWRLPEDLKYFKRITTSHTIVMGRKTFESIGRPLPNRENV 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +L+ Q     +  T + SV+E  A   +   E+ VIGG  +YEQ L  A +LY+THI+  
Sbjct: 61  VLTRQKDYQQEGATVIHSVEELEALDAEKEDELFVIGGATLYEQTLDVANRLYITHIEES 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGDTHFP  +  +W+ +  +    D +N + Y F + ER
Sbjct: 121 FEGDTHFPAIDLSEWKVISKQQGIKDEKNPYMYYFTVYER 160



>UniRef100_C6BF02 Dihydrofolate reductase n=1 Tax=Ralstonia
           pickettii 12D RepID=C6BF02_RALP1
          Length = 167

 Score =  137 bits (346), Expect = 3e-31
 Identities = 71/163 (43%), Positives = 97/163 (59%), Gaps = 9/163 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG  N +PW LP DLA FKR T+  P++MGR T++SIGRPLPGR+NI
Sbjct: 3   ILTLIVARARNGVIGRNNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYDSIGRPLPGRRNI 62

Query: 61  ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +++       PG +       S+++A   C    +I +IGG ++Y   LP A +L +T I
Sbjct: 63  VVTRNAKLELPGCE----IAYSMEDAQRLCVGAEQIFLIGGAQLYADALPSADRLIVTEI 118

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DA+ EGD HFP  +P  W  V  E H A A N   Y F   ER
Sbjct: 119 DADFEGDAHFPAPDPRVWREVSRETHHAAAPNDFDYAFVTYER 161



>UniRef100_B8GXW8 Dihydrofolate reductase n=2 Tax=Caulobacter
           vibrioides RepID=B8GXW8_CAUCN
          Length = 171

 Score =  137 bits (346), Expect = 3e-31
 Identities = 72/166 (43%), Positives = 101/166 (60%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           ++++ A A + VIG +  +PW L +DLA FK NTL KP+IMGR TW+S+ R PLPGR NI
Sbjct: 6   LAIVVARAANGVIGRDGDLPWRLKSDLALFKANTLFKPIIMGRKTWDSLPRKPLPGRTNI 65

Query: 61  ILSSQPGTDDR-----VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +LS     +        TW+++ + A     D    E+ VIGG  ++E  LPKA++LYLT
Sbjct: 66  VLSRDQSFEPEGAVACETWMEAFEIAREQAADDGADEVCVIGGSALFELALPKAKRLYLT 125

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + AEVEGD  FP ++   W  V  E H A   + H++ F +LERR
Sbjct: 126 EVAAEVEGDVRFPAFDESAWTEVRREAHPAGDGDDHAFVFRVLERR 171



>UniRef100_B7GI36 Dihydrofolate reductase n=1 Tax=Anoxybacillus
           flavithermus WK1 RepID=B7GI36_ANOFW
          Length = 162

 Score =  137 bits (346), Expect = 3e-31
 Identities = 73/160 (45%), Positives = 97/160 (60%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A+  +RVIG  N +PW+LPADLA+FKR T   P++MGR T+ SIGRPLPGR NI
Sbjct: 1   MISIIVAMDRNRVIGYNNTLPWHLPADLAYFKRVTFGHPIVMGRKTFASIGRPLPGRINI 60

Query: 61  ILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IL+      TD  V  + S+D           + VIGG +V+EQ +P A +LY+THIDA 
Sbjct: 61  ILTRDKTFSTDANVQVIHSIDNIRQIEQQYGHVFVIGGAQVFEQAMPLADRLYVTHIDAT 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT FP  +   W    ++    D +N + + F I ER
Sbjct: 121 FTGDTFFPPIDEKQWTLCTAQPGVQDEKNRYPHTFCIYER 160



>UniRef100_A8FEB8 Dihydrofolate reductase n=1 Tax=Bacillus pumilus
           SAFR-032 RepID=A8FEB8_BACP2
          Length = 161

 Score =  137 bits (346), Expect = 3e-31
 Identities = 67/160 (41%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A   DRVIG +N MPW+LPADLA+FK+ T    ++MGR T+ESIGR LP R+NI
Sbjct: 1   MISMIVATGKDRVIGQDNQMPWHLPADLAYFKKVTGGHTIVMGRKTYESIGRALPNRRNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L++    + +    V S+ + +A      E+ +IGG ++YE+ +P A +LY+THI    
Sbjct: 61  VLTTSSSFEAEGCEVVHSIADILAIGKGETELFIIGGSKLYEEMMPYADRLYITHIHHAF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD +FP Y+ + W  V  E    D +N ++Y F + +++
Sbjct: 121 EGDRYFPHYDENKWTVVSREKGHRDEKNPYNYEFVVYDKK 160



>UniRef100_A7GP91 Dihydrofolate reductase n=1 Tax=Bacillus
           cytotoxicus NVH 391-98 RepID=A7GP91_BACCN
          Length = 162

 Score =  137 bits (346), Expect = 3e-31
 Identities = 69/162 (42%), Positives = 103/162 (63%), Gaps = 5/162 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS + A+  +RVIG +N +PW+LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IISFMVAMDENRVIGKDNKLPWHLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTDDRVTWVK---SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++    TD  V   +   SV+E    C +  EI V GG ++YE FLP   KLY+T I  
Sbjct: 62  IVTR--NTDYYVEGCEIAHSVEEVFELCKNEEEIFVFGGAQIYELFLPYVDKLYITKIHH 119

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             EGDT FP+ +  +W+ VF E    D +N ++Y + I E++
Sbjct: 120 AFEGDTFFPEIDMKEWKEVFVEKGVTDEKNPYTYYYHIYEKK 161



>UniRef100_A3NBZ0 Dihydrofolate reductase n=1 Tax=Burkholderia
           pseudomallei 668 RepID=A3NBZ0_BURP6
          Length = 167

 Score =  137 bits (346), Expect = 3e-31
 Identities = 72/161 (44%), Positives = 100/161 (62%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+D+  A+AA     E  +IGG ++YE+ L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTVTSLDDALALAARDGAAEAFLIGGAQLYEEGLRHADKLIVTEIDQD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP+ +P  WE+V  + H A   N  +Y F +  RR
Sbjct: 124 FEGDASFPEPDPAQWEAVSRDAHRAAQPNDFTYAFVVYRRR 164



>UniRef100_B7IV73 Dihydrofolate reductase n=4 Tax=Bacillus cereus
           group RepID=B7IV73_BACC2
          Length = 162

 Score =  137 bits (346), Expect = 3e-31
 Identities = 64/160 (40%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHYAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D QN ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEIFVEKGLTDEQNPYTYYYHVYEKQ 161



>UniRef100_UPI0001BC9B3D dihydrofolate reductase n=2 Tax=Pseudomonas
           syringae group RepID=UPI0001BC9B3D
          Length = 170

 Score =  137 bits (345), Expect = 4e-31
 Identities = 72/166 (43%), Positives = 107/166 (64%), Gaps = 12/166 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNLV 66

Query: 62  LSSQPGTDDRVTWVK---SVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S Q  TD ++   +   S+D A+           V E+M+IGG ++Y Q LP+A +LYL
Sbjct: 67  VSRQ--TDLQLEGAEVFPSLDAAVVRAEQWAKEQGVDEVMLIGGAQLYAQGLPEADRLYL 124

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T +    +GD  FP+ +   W ++ S+  +A   +  +Y FE+ ER
Sbjct: 125 TRVALSPDGDAWFPEIDTAQW-ALVSDTENAAVDDKPAYNFEVWER 169



>UniRef100_B8I0T9 Dihydrofolate reductase region n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I0T9_CLOCE
          Length = 161

 Score =  137 bits (345), Expect = 4e-31
 Identities = 66/158 (41%), Positives = 99/158 (62%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A+  +  +G +N MPW +PAD A+FK+ T+ KPVIMGR T+ESIG+PLPGRKNI
Sbjct: 1   MISMIWAMGRNNALGCKNRMPWYIPADFAYFKKVTMGKPVIMGRKTFESIGKPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++   G D +   V +  E      +  E+ +IGG  +Y++FLP A +LY+T I+ E E
Sbjct: 61  VITRDTGYDPQGCIVVNSIEKAMEYTEEKEVFIIGGAEIYKEFLPIADRLYITLIEKEFE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            D  FP+ +   W+ +  E    D +N + Y + + ER
Sbjct: 121 ADAFFPEIDYSKWKQISCETGIKDEKNPYEYKWLVYER 158



>UniRef100_B2FPG1 Putative dihydrofolate reductase n=1
           Tax=Stenotrophomonas maltophilia K279a
           RepID=B2FPG1_STRMK
          Length = 163

 Score =  137 bits (345), Expect = 4e-31
 Identities = 75/161 (46%), Positives = 102/161 (63%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I AL  +R IG  NAMPW+LP D   FK  TL KP++MGR T ESIGR LPGR N++
Sbjct: 3   LSMIVALDRNRGIGQGNAMPWHLPDDFKHFKALTLGKPILMGRKTAESIGRVLPGRTNLV 62

Query: 62  LS-SQPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+ S     + +  V S+DEA  IA      E+ +IGGG ++ Q L +A  LYLT +DAE
Sbjct: 63  LTRSGQVPFEGMRAVASLDEAKTIAEGEGASELCIIGGGEIFHQLLDQASDLYLTWVDAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  DTHFP+ +  DW  V SE H AD ++++++ F    RR
Sbjct: 123 IPADTHFPEVDMQDWREVSSEPHPADERHAYAFRFAHYVRR 163



>UniRef100_Q1YUR3 FolA, dihydrofolate reductase n=1 Tax=gamma
           proteobacterium HTCC2207 RepID=Q1YUR3_9GAMM
          Length = 167

 Score =  137 bits (345), Expect = 4e-31
 Identities = 72/165 (43%), Positives = 104/165 (63%), Gaps = 9/165 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A++ + VIG  N +PW+LP DL +FK  T+ KP+IMGR T++SIGRPLPGR +I+
Sbjct: 3   VSLIVAVSRNGVIGQNNQLPWHLPGDLKYFKSVTMGKPLIMGRKTFDSIGRPLPGRTSIV 62

Query: 62  LSSQP-----GTDDRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++  P     G     T ++++  A  AC +  V EIMVIGG ++Y   LP A +LYLT 
Sbjct: 63  ITRDPEWHAEGVQIAQTLLQAMALAELACAEAGVDEIMVIGGEQIYRLTLPVADRLYLTE 122

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEVEGD  FP Y  + W  V  +    +  ++H Y + +LER+
Sbjct: 123 VQAEVEGDAFFPTYNLEQWHQVSEQL--PEKTDTHPYRYLVLERK 165



>UniRef100_D2LYG2 Dihydrofolate reductase n=1 Tax=Bacillus
           cellulosilyticus DSM 2522 RepID=D2LYG2_BACS4
          Length = 162

 Score =  137 bits (345), Expect = 4e-31
 Identities = 69/159 (43%), Positives = 102/159 (64%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA+  +R IG+   MPW+LP DL +FK+ T    V+MGR T+ESIGRPLP R+N+
Sbjct: 1   MISMIAAMGKNREIGLNGEMPWHLPNDLKFFKKTTSGHSVLMGRKTYESIGRPLPNRRNL 60

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ S+    D V  + S+D+         E  VIGG  +YEQ +P A++LY+T I+AE 
Sbjct: 61  VVTRSESFHADGVEVLHSLDDVKPLVNSEEEFFVIGGATLYEQLMPIAKRLYITSINAEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP  +  +W+ V SE    D +N + + F++ ER
Sbjct: 121 EADTYFPAIDEIEWKIVSSEKGIVDEKNKYEHTFQVFER 159



>UniRef100_C2PVF9 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           AH621 RepID=C2PVF9_BACCE
          Length = 162

 Score =  137 bits (345), Expect = 4e-31
 Identities = 64/160 (40%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW++P++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNKLPWHIPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++       +    V SV+E    C D  EI + GG ++Y+ FLP  +KLY+T I    
Sbjct: 62  IVTRNGDYHVEGCEVVHSVEEVFELCKDEEEIFIFGGAQIYDLFLPYVEKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+ +  DW+ VF E    D +N ++Y + I E++
Sbjct: 122 DGDTFFPEMDMTDWKEVFVEKGLTDEKNPYTYYYHIYEKQ 161



>UniRef100_A3RP92 Dihydrofolate reductase n=3 Tax=Ralstonia
           solanacearum RepID=A3RP92_RALSO
          Length = 167

 Score =  137 bits (345), Expect = 4e-31
 Identities = 70/159 (44%), Positives = 95/159 (59%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG +N +PW LP DLA FKR T+  P++MGR T+ESIGRPLPGR+NI
Sbjct: 3   LLTLIVARARNGVIGRDNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYESIGRPLPGRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++   G          S+++A   C  V +I +IGG ++Y   LP A +L +T IDA+ 
Sbjct: 63  VVTRNAGLALPGCEVAHSLEDAQRLCIGVEQIFLIGGAQLYADALPSADRLIVTEIDADF 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP  +P  W  V  E H A   N   Y F   ER
Sbjct: 123 EGDARFPAPDPAVWHEVARETHHAAPPNDFDYAFVTYER 161



>UniRef100_Q0K888 Dihydrofolate reductase n=1 Tax=Ralstonia eutropha
           H16 RepID=Q0K888_RALEH
          Length = 166

 Score =  137 bits (344), Expect = 5e-31
 Identities = 70/161 (43%), Positives = 99/161 (61%), Gaps = 6/161 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++L+ A A +  IG +N +PW LP DLA FKR T+  PVIMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLVVARARNNTIGRDNTLPWRLPEDLAHFKRTTMGAPVIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQPGTDDRVTWVK---SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S  P  D R+   +   S+++A   C    +I +IGG ++Y + +P A +L +T IDA
Sbjct: 63  VVSRNP--DLRIEGAEVAASLEDAQRLCVGAEQIFLIGGAQLYAEAMPCADRLVVTEIDA 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +VEGD  FP  +   W     E H ++A N   Y F   ER
Sbjct: 121 DVEGDAFFPAIDRTQWVETARETHHSEA-NGFDYAFVTYER 160



>UniRef100_A3L075 Dihydrofolate reductase n=1 Tax=Pseudomonas
           aeruginosa C3719 RepID=A3L075_PSEAE
          Length = 168

 Score =  137 bits (344), Expect = 5e-31
 Identities = 73/165 (44%), Positives = 102/165 (61%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++IAAL  +R IG++N +PW LPADL  FK  TL KPVIMGR TW+S+GRPLPGR N++
Sbjct: 5   LAMIAALGENRAIGIDNRLPWRLPADLKHFKAMTLGKPVIMGRKTWDSLGRPLPGRLNLV 64

Query: 62  LSSQPGTD-DRVTWVKSVD------EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q     +      S+D      EA A   D  E+M+IGG ++Y + LP+A +LYLT 
Sbjct: 65  VSRQAALALEGAEVFASLDAALARAEAWAQAEDADELMLIGGAQLYAEALPRAARLYLTR 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +    EGD  FP+ +   W  + S    A A ++ +Y FE+ ERR
Sbjct: 125 VGLAPEGDAFFPEIDGAAWR-LASSIEHAAADDAPAYAFEVWERR 168



>UniRef100_Q88AF3 Dihydrofolate reductase n=1 Tax=Pseudomonas
           syringae pv. tomato RepID=Q88AF3_PSESM
          Length = 170

 Score =  136 bits (343), Expect = 6e-31
 Identities = 72/166 (43%), Positives = 105/166 (63%), Gaps = 12/166 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNLV 66

Query: 62  LSSQPGTDDRVTWVK---SVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S Q  TD ++   +   S+D A+           V E+M+IGG ++Y Q L +A +LYL
Sbjct: 67  VSRQ--TDLQLEGAEVFPSLDAAVVRAEQWAQEQGVDEVMLIGGAQLYAQGLAQADRLYL 124

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T +    EGD  FP+++   W ++ S   +A      +Y FE+ ER
Sbjct: 125 TRVALSPEGDAWFPEFDTAQW-ALVSNAENAAVDEKPAYSFEVWER 169



>UniRef100_B3R5A7 Dihydrofolate reductase type I n=1 Tax=Cupriavidus
           taiwanensis RepID=B3R5A7_CUPTR
          Length = 166

 Score =  136 bits (343), Expect = 6e-31
 Identities = 68/159 (42%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++L+ A A +  IG +N +PW LP DLA FKR T+  PVIMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLVVARARNGTIGRDNTLPWRLPEDLAHFKRTTMGAPVIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  P    +      S+++A   C    +I +IGG ++Y + +P A +L +T IDA+V
Sbjct: 63  VVSRNPDLRLEGAEVAPSLEDAQRLCVGAEQIFLIGGAQLYAEAMPSADRLVVTEIDADV 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP+ +   W     E H + A N   Y F   ER
Sbjct: 123 EGDAFFPEIDRTQWIETARETHHS-AANGFDYAFVTYER 160



>UniRef100_B2T5Z4 Dihydrofolate reductase n=1 Tax=Burkholderia
           phytofirmans PsJN RepID=B2T5Z4_BURPP
          Length = 166

 Score =  136 bits (343), Expect = 6e-31
 Identities = 73/163 (44%), Positives = 99/163 (60%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P+IMGR T ESIGRPLPGR+NII
Sbjct: 4   LTLIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNII 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++        G D   T   ++   +AA    PE  +IGG ++Y + L +A KL +T I 
Sbjct: 64  VTRDATRRFQGCDAATTLEDAL--KLAAQDQAPEAFLIGGAQLYAEGLRQADKLIITEIS 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A+ EGD  FP  + ++WE V  E H ADA N   Y F   +R+
Sbjct: 122 ADFEGDATFPALDENEWEEVAHETHRADAPNDFDYAFVTYKRK 164



>UniRef100_B1HZG5 Dihydrofolate reductase type 3 n=1
           Tax=Lysinibacillus sphaericus C3-41 RepID=B1HZG5_LYSSC
          Length = 158

 Score =  136 bits (343), Expect = 6e-31
 Identities = 72/160 (45%), Positives = 103/160 (64%), Gaps = 3/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A   + VIG  N MPW+LP DL +FK  T+ KP+IMGR T+ESIGRPLPGR+NI
Sbjct: 1   MISLIVAHDDNHVIGYNNGMPWHLPGDLQYFKNKTMGKPMIMGRKTFESIGRPLPGRRNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++       + +  V S++EAI   GDV EIM+IGG +++   +  A +LY+T I+   
Sbjct: 61  VITRDENYRAEGIEIVTSLEEAITMAGDVQEIMIIGGEQIFRLSMEIADRLYITKINHSF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP YE  D+  V +E     A   +++ ++I ER+
Sbjct: 121 QGDTFFPSYE-QDFVEVAAE-QPETASEGYTFQYQIFERK 158



>UniRef100_D7BGN7 Dihydrofolate reductase n=1 Tax=Meiothermus
           silvanus DSM 9946 RepID=D7BGN7_9DEIN
          Length = 161

 Score =  136 bits (343), Expect = 6e-31
 Identities = 74/159 (46%), Positives = 99/159 (62%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+  +R IG    +PW+LP DL  FK  TL   V+MGR T+ESIGRPLPGR+N++
Sbjct: 6   LTLIAAMDRNRAIGKGGRLPWHLPDDLRRFKALTLGHTVLMGRKTFESIGRPLPGRRNVV 65

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-E 120
           L+  P        V    +A  A G   EIMVIGGG VY   LP A++++LT +D E+ E
Sbjct: 66  LTRNPNFQAEGVEVVPTLQAGLAGG---EIMVIGGGEVYALALPLARRMWLTLVDTEITE 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            DT FP+++P +W      FH AD Q+  S+ F  LERR
Sbjct: 123 ADTFFPEFDPSEWRETGRAFHPADGQHPFSFSFLDLERR 161



>UniRef100_Q0AHA5 Dihydrofolate reductase n=1 Tax=Nitrosomonas
           eutropha C91 RepID=Q0AHA5_NITEC
          Length = 176

 Score =  136 bits (342), Expect = 8e-31
 Identities = 67/160 (41%), Positives = 100/160 (62%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++AA++ +RVIG+ N++PW+LPADL  FK+ T    V+MGR T++SIG+PLP R N++
Sbjct: 11  LAILAAISANRVIGLNNSLPWHLPADLKHFKQLTTGHIVVMGRRTFDSIGKPLPDRTNVV 70

Query: 62  LSSQPGTD-DRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS Q   D   +    S+ E +     D  +I VIGG  +Y Q LP  Q+LYLT I  + 
Sbjct: 71  LSRQHVLDVPGIITAHSIQEVLDHFANDDRQIFVIGGAELYRQTLPLCQRLYLTEIQEDF 130

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+Y+ DDW+ +  E H     +   Y F +L+ +
Sbjct: 131 EGDTFFPEYDHDDWQEISREIHHETGGSGLEYHFVMLDHK 170



>UniRef100_B7JMG6 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           AH820 RepID=B7JMG6_BACC0
          Length = 162

 Score =  136 bits (342), Expect = 8e-31
 Identities = 63/160 (39%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEVFVEKGXTDEKNPYTYYYHVYEKQ 161



>UniRef100_Q4MHD3 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           G9241 RepID=Q4MHD3_BACCE
          Length = 162

 Score =  136 bits (342), Expect = 8e-31
 Identities = 63/160 (39%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEIDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_C7ILG0 Dihydrofolate reductase n=1 Tax=Clostridium
           papyrosolvens DSM 2782 RepID=C7ILG0_9CLOT
          Length = 160

 Score =  136 bits (342), Expect = 8e-31
 Identities = 66/159 (41%), Positives = 103/159 (64%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A+  +  +G +N MPW++PAD A+FKR T+ K VIMGR T++S+G+PLPGRKNI
Sbjct: 1   MISMIWAMGRNNALGCKNRMPWHIPADFAYFKRITMGKTVIMGRKTFDSLGKPLPGRKNI 60

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ +   + +  T V S+ +A+   G+  E  +IGG  +Y++FLP A +LYLT I+ E 
Sbjct: 61  VITRATDYSPEGCTTVHSIKKAMEYIGE-EEAFIIGGAEIYKEFLPSADRLYLTLIEKEF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E D  FP+ +   W+ +  E    D +N + Y + + ER
Sbjct: 120 EADVFFPEIDYSQWKQISGELGTKDEKNPYEYKWLVYER 158



>UniRef100_C3I065 Dihydrofolate reductase n=9 Tax=Bacillus cereus
           group RepID=C3I065_BACTU
          Length = 165

 Score =  136 bits (342), Expect = 8e-31
 Identities = 63/160 (39%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 5   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 65  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHYAF 124

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 125 EGDTFFPEMDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 164



>UniRef100_D5TYB8 Dihydrofolate reductase n=9 Tax=Bacillus cereus
           group RepID=D5TYB8_BACTK
          Length = 162

 Score =  136 bits (342), Expect = 8e-31
 Identities = 63/160 (39%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEIDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_A1V6H9 Dihydrofolate reductase n=17 Tax=pseudomallei
           group RepID=A1V6H9_BURMS
          Length = 167

 Score =  136 bits (342), Expect = 8e-31
 Identities = 72/161 (44%), Positives = 99/161 (61%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+D+  A+AA     E  +IGG ++YE+ L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTVTSLDDALALAARDGAAEAFLIGGAQLYEEGLRHADKLIVTEIDQD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  RR
Sbjct: 124 FEGDASFPAPDPAQWEAVSRDAHRAAQPNDFTYAFVVYRRR 164



>UniRef100_Q7NZ94 Dihydrofolate reductase n=1 Tax=Chromobacterium
           violaceum RepID=Q7NZ94_CHRVO
          Length = 165

 Score =  135 bits (341), Expect = 1e-30
 Identities = 66/139 (47%), Positives = 90/139 (64%), Gaps = 1/139 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+AA+A +R IG++N +PW+LP DL  FK  TL KPVIMGR TW+SIGRPLPGR+NI+
Sbjct: 9   LTLVAAMAANRTIGVDNKLPWHLPEDLKHFKAATLGKPVIMGRKTWDSIGRPLPGRRNIV 68

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ Q     D      S+ EA+A  G V E  +IGG  +Y Q +  A +L LT I  + +
Sbjct: 69  VTRQAAWRADGAETAHSLQEALALAGAVEEACLIGGADLYRQAMALADRLCLTEIARDYD 128

Query: 121 GDTHFPDYEPDDWESVFSE 139
           GD HFP +  D+W  V  E
Sbjct: 129 GDAHFPAFAADEWREVSRE 147



>UniRef100_D2ZXL7 Dihydrofolate reductase n=1 Tax=Neisseria mucosa
           ATCC 25996 RepID=D2ZXL7_NEIMU
          Length = 163

 Score =  135 bits (341), Expect = 1e-30
 Identities = 65/142 (45%), Positives = 91/142 (64%), Gaps = 2/142 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           I+LIAA A  R IG+ N MPW+LP D A+FK  T  KPV+MGR TWES+  +PLPGR+NI
Sbjct: 6   ITLIAAYAAHRCIGINNTMPWHLPEDFAFFKTYTTGKPVVMGRKTWESLPKKPLPGRRNI 65

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ Q     +    V  ++EA+A C D  EI+++GG ++Y Q LP A  L LT +  +V
Sbjct: 66  VITRQSDYLAEGAETVSELEEALALCADAQEIIIMGGAQIYAQALPYATDLRLTEVSLDV 125

Query: 120 EGDTHFPDYEPDDWESVFSEFH 141
            GD  FP++  D+W+    E H
Sbjct: 126 SGDAFFPEFSSDEWKEQLRETH 147



>UniRef100_D1F9R4 Dihydrofolate reductase n=1 Tax=Brucella
           melitensis bv. 3 str. Ether RepID=D1F9R4_BRUME
          Length = 172

 Score =  135 bits (341), Expect = 1e-30
 Identities = 71/166 (42%), Positives = 105/166 (63%), Gaps = 7/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S++ A + + VIG EN MPW L  DL  FK  TL KPVIMGR TW+S+GRPLPGR NI
Sbjct: 5   LVSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANI 64

Query: 61  ILSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++       +    V S+++A+      AA G V  I VIGGG+++ Q +P A +L+LT
Sbjct: 65  VITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDAICVIGGGQIFVQAMPLADRLHLT 124

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + + +EGDT+FP+  P DW+ + SE   A  ++S+   + + ERR
Sbjct: 125 RVLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170



>UniRef100_C3H0I3 Dihydrofolate reductase n=1 Tax=Bacillus
           thuringiensis serovar huazhongensis BGSC 4BD1
           RepID=C3H0I3_BACTU
          Length = 162

 Score =  135 bits (341), Expect = 1e-30
 Identities = 62/160 (38%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P++MGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLVMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_C2QSJ2 Dihydrofolate reductase n=2 Tax=Bacillus cereus
           group RepID=C2QSJ2_BACCE
          Length = 162

 Score =  135 bits (341), Expect = 1e-30
 Identities = 63/160 (39%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPFVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEIDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_B5UX12 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           AH1134 RepID=B5UX12_BACCE
          Length = 162

 Score =  135 bits (341), Expect = 1e-30
 Identities = 63/160 (39%), Positives = 101/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGYPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +    V SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVVHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_B1GA87 Dihydrofolate reductase n=1 Tax=Burkholderia
           graminis C4D1M RepID=B1GA87_9BURK
          Length = 166

 Score =  135 bits (341), Expect = 1e-30
 Identities = 72/163 (44%), Positives = 99/163 (60%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P+IMGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++        G D   T  +++   +AA    PE  +IGG ++Y + L  A KL +T I 
Sbjct: 64  VTRDATRRFQGCDAATTLGEAL--KLAAQDQAPEAFLIGGAQLYVEGLRLADKLIVTEIS 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A+ +GD  FP  +PD+WE V  E H A A N   Y F   +R+
Sbjct: 122 ADFQGDATFPAVDPDEWEEVAHETHRAHAPNDFDYAFVTYKRK 164



>UniRef100_A6F446 Dihydrofolate reductase n=1 Tax=Marinobacter
           algicola DG893 RepID=A6F446_9ALTE
          Length = 163

 Score =  135 bits (341), Expect = 1e-30
 Identities = 65/158 (41%), Positives = 98/158 (62%), Gaps = 12/158 (7%)

Query: 11  DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD 70
           +RVIG  N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++S  P  + 
Sbjct: 4   NRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVISRNPEWEA 63

Query: 71  RVTWV--KSVDEAIAAC--------GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
               V  +S+++A+           GD  E+M+IGGG++Y + LP   ++Y+T + AEV+
Sbjct: 64  PAGTVAAESLEDALVKAEAQAEIEGGD--EVMIIGGGQIYAEVLPMVDRIYITQVHAEVD 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD  FP+   ++WE +  E   A   N + Y F + +R
Sbjct: 122 GDAFFPEVNWEEWEELGREDFSASDNNPYDYSFVVYQR 159



>UniRef100_A3I5X4 Dihydrofolate reductase n=1 Tax=Bacillus sp.
           B14905 RepID=A3I5X4_9BACI
          Length = 158

 Score =  135 bits (341), Expect = 1e-30
 Identities = 73/160 (45%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A   + VIG  N MPW+LP DL +FK  T+ KP+IMGR T+ESIGRPLPGR+NI
Sbjct: 1   MISLIVAHDDNHVIGYNNGMPWHLPGDLQYFKNKTMGKPMIMGRKTFESIGRPLPGRRNI 60

Query: 61  ILSSQPGTDDRVT-WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++         T  V S++EAIA  GDV EIM+IGG +++   +  A +LY+T I+   
Sbjct: 61  VITRDENYHAEGTETVTSLEEAIAIAGDVEEIMIIGGEQIFRLSMEMADRLYITKINHSF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP YE + +  V +E     A   +++ ++I ER+
Sbjct: 121 RGDTFFPSYE-EKFVEVSAE-QPETASEGYTFQYQIFERK 158



>UniRef100_D3RVQ7 Dihydrofolate reductase n=1 Tax=Allochromatium
           vinosum DSM 180 RepID=D3RVQ7_ALLVD
          Length = 172

 Score =  135 bits (340), Expect = 1e-30
 Identities = 73/162 (45%), Positives = 104/162 (64%), Gaps = 6/162 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I+L+AA+   RVIG +NA+PW LPADLA FK  TL+KP++MGR TWES+   LP R+++
Sbjct: 14  VIALVAAMDEARVIGRDNALPWRLPADLAHFKALTLDKPILMGRKTWESLPGLLPRRRHL 73

Query: 61  ILSSQPGTDDRVTWVK---SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S  P  D R    +   S++ AIAA  D PE+M++GG  +Y Q LP A +L+LT +  
Sbjct: 74  VISRDP--DYRAEGCEVFGSLETAIAAV-DEPELMIVGGASIYAQSLPLADRLHLTIVQT 130

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            V GD  FP + P +W +V      AD +N+ +  F  LERR
Sbjct: 131 RVTGDAWFPAWNPVEWNAVARVERPADERNAFAMTFVDLERR 172



>UniRef100_D7HV19 Dihydrofolate reductase n=1 Tax=Pseudomonas
           savastanoi pv. savastanoi NCPPB 3335 RepID=D7HV19_PSESS
          Length = 170

 Score =  135 bits (340), Expect = 1e-30
 Identities = 71/166 (42%), Positives = 106/166 (63%), Gaps = 12/166 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNLV 66

Query: 62  LSSQPGTDDRVTWVK---SVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S Q  TD ++   +   S+D A+           V E+M+IGG ++Y Q L +A +LYL
Sbjct: 67  VSRQ--TDLQLEGAEVFPSLDAAVVRAEQWAQEQGVDEVMLIGGAQLYAQGLAQADRLYL 124

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T +    +GD  FP+++   W ++ S+  +A      +Y FE+ ER
Sbjct: 125 TRVALSPDGDAWFPEFDTAQW-ALVSDTENAAVDGKPAYNFEVWER 169



>UniRef100_Q48CM2 Dihydrofolate reductase n=1 Tax=Pseudomonas
           syringae pv. phaseolicola 1448A RepID=Q48CM2_PSE14
          Length = 170

 Score =  135 bits (339), Expect = 2e-30
 Identities = 71/166 (42%), Positives = 106/166 (63%), Gaps = 12/166 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GR LPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRLLPGRLNLV 66

Query: 62  LSSQPGTDDRVTWVK---SVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S Q  TD ++   +   S+D A+           V E+M+IGG ++Y Q LP+A +LYL
Sbjct: 67  VSRQ--TDLQLEGAEVFASLDAAVVRAEQWAQEQGVDEVMLIGGAQLYAQGLPEADRLYL 124

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T +    +GD  FP+++   W ++ S   +A   +  +Y FE+ ER
Sbjct: 125 TRVALSPDGDAWFPEFDTAQW-ALVSNIENAAVDDKPAYNFEVWER 169



>UniRef100_C3AL65 Dihydrofolate reductase n=3 Tax=Bacillus
           RepID=C3AL65_BACMY
          Length = 162

 Score =  135 bits (339), Expect = 2e-30
 Identities = 64/160 (40%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS + A+  ++VIG +N +PW+LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IISFMVAMDENKVIGKDNKLPWHLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++       +     +SV+E    C +  EI + GG ++YE FLP   KLY+T I    
Sbjct: 62  IVTRNMNYHVEGCEIAQSVEEVFELCKNEEEIFIFGGAQIYELFLPYVNKLYITKIHHSF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+    +W+ VF E    D +N ++Y + I E++
Sbjct: 122 EGDTFFPEMNMKEWKEVFVEKGVTDEKNPYTYYYHIYEKQ 161



>UniRef100_C2QBJ3 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           R309803 RepID=C2QBJ3_BACCE
          Length = 162

 Score =  135 bits (339), Expect = 2e-30
 Identities = 63/160 (39%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHYAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMKNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_B8L0L5 Dihydrofolate reductase n=1 Tax=Stenotrophomonas
           sp. SKA14 RepID=B8L0L5_9GAMM
          Length = 159

 Score =  135 bits (339), Expect = 2e-30
 Identities = 74/159 (46%), Positives = 100/159 (62%), Gaps = 3/159 (1%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +I AL  +R IG  NAMPW+LP D   FK  TL KP++MGR T ESIGR LPGR N++L+
Sbjct: 1   MIVALDRNRGIGQGNAMPWHLPDDFKHFKALTLGKPILMGRKTAESIGRVLPGRTNLVLT 60

Query: 64  SQPGTD-DRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
                  + +  V S+DEA  IA      E+ +IGGG ++ Q L +A  LYLT +DAEV 
Sbjct: 61  RSGQVPFEGMRAVASLDEAKAIAEGEGANELCIIGGGEIFHQLLDQASDLYLTWVDAEVP 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            DTHFP+ +  DW+ V SE H AD ++++++ F    RR
Sbjct: 121 ADTHFPEVDARDWQEVSSEPHPADERHAYAFRFVHYVRR 159



>UniRef100_A9VTX1 Dihydrofolate reductase n=22 Tax=Bacillus cereus
           group RepID=A9VTX1_BACWK
          Length = 162

 Score =  135 bits (339), Expect = 2e-30
 Identities = 63/160 (39%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_A6DH01 Dihydrofolate reductase n=1 Tax=Lentisphaera
           araneosa HTCC2155 RepID=A6DH01_9BACT
          Length = 161

 Score =  135 bits (339), Expect = 2e-30
 Identities = 67/157 (42%), Positives = 94/157 (59%), Gaps = 1/157 (0%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           S+I A+A +R IG +N +PW L  DL  FK  T+ K ++MGR T+ESIGRPLPGR+N+IL
Sbjct: 4   SMICAMASNRGIGYKNTLPWRLSNDLQHFKALTMGKAIVMGRKTYESIGRPLPGRRNLIL 63

Query: 63  SSQPGTDDRVT-WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           S  P  +   T    S DE    C    E+ +IGG ++YE    +   L+LT IDAE+  
Sbjct: 64  SRDPNLEIPGTECFTSYDEIRENCAQEEEVFIIGGAQIYEILFDEVDTLHLTLIDAEIVA 123

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           D  FP+++   W+    E H AD++N + Y F  LE+
Sbjct: 124 DAFFPEFDHSQWKETSRERHKADSKNDYDYSFVTLEK 160



>UniRef100_Q3K556 Dihydrofolate reductase n=1 Tax=Pseudomonas
           fluorescens Pf0-1 RepID=Q3K556_PSEPF
          Length = 170

 Score =  134 bits (338), Expect = 2e-30
 Identities = 70/164 (42%), Positives = 106/164 (64%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S++ A+    +      V E+M+IGG ++Y Q L +A +LYLT 
Sbjct: 67  VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +    EGD  FP+++ + W+ V +  + A+  +  +Y FE+ E+
Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPAEG-DKPAYNFEVWEK 169



>UniRef100_B7KQG1 Dihydrofolate reductase n=1 Tax=Methylobacterium
           chloromethanicum CM4 RepID=B7KQG1_METC4
          Length = 166

 Score =  134 bits (338), Expect = 2e-30
 Identities = 69/158 (43%), Positives = 101/158 (63%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+AA+A + VIG +N++ W L +DL  FK  T+ KP++MGR TW+SIGRPLPGR++++
Sbjct: 6   ISLVAAIARNGVIGRDNSLAWRLSSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSLV 65

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++     T   VT V   DEA+AA GD  E+MV+GG  +Y   LP A +L+LT +DA  E
Sbjct: 66  ITRDRSLTLSDVTVVHDWDEALAAAGD-DELMVVGGAEIYRLALPHADRLHLTEVDAAPE 124

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP ++   +     E H    ++  ++ F  LER
Sbjct: 125 GDAYFPPFDRSLFRETLREAHGPGERDEFAFHFVDLER 162



>UniRef100_A0RDM0 Dihydrofolate reductase n=4 Tax=Bacillus cereus
           group RepID=A0RDM0_BACAH
          Length = 185

 Score =  134 bits (338), Expect = 2e-30
 Identities = 63/160 (39%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 25  IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 84

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 85  IVTRNGGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 144

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 145 EGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 184



>UniRef100_C4KS28 Dihydrofolate reductase n=1 Tax=Burkholderia
           pseudomallei MSHR346 RepID=C4KS28_BURPS
          Length = 167

 Score =  134 bits (338), Expect = 2e-30
 Identities = 71/161 (44%), Positives = 99/161 (61%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+++  A+AA     E  +IGG ++YE+ L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTVTSLEDALALAARDGAAEAFLIGGAQLYEEGLRHADKLIVTEIDQD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  RR
Sbjct: 124 FEGDASFPAPDPAQWEAVSRDTHRAAQPNDFTYAFVVYRRR 164



>UniRef100_C0Y9S3 Dihydrofolate reductase n=1 Tax=Burkholderia
           pseudomallei Pakistan 9 RepID=C0Y9S3_BURPS
          Length = 167

 Score =  134 bits (338), Expect = 2e-30
 Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D      S+D+  A+AA     E  +IGG ++YE+ L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTATSLDDALALAARDGAAEAFLIGGAQLYEEGLRHADKLIVTEIDQD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  RR
Sbjct: 124 FEGDASFPAPDPAQWEAVSRDTHRAAQPNDFTYAFVVYRRR 164



>UniRef100_B3ZGR0 Dihydrofolate reductase n=3 Tax=Bacillus cereus
           group RepID=B3ZGR0_BACCE
          Length = 162

 Score =  134 bits (338), Expect = 2e-30
 Identities = 62/160 (38%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_Q3JQ22 Dihydrofolate reductase n=4 Tax=Burkholderia
           pseudomallei RepID=Q3JQ22_BURP1
          Length = 167

 Score =  134 bits (338), Expect = 2e-30
 Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D      S+D+  A+AA     E  +IGG ++YE+ L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTATSLDDALALAARDGAAEAFLIGGAQLYEEGLRHADKLIVTEIDQD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  RR
Sbjct: 124 FEGDASFPAPDPAQWEAVSRDAHRAAQPNDFTYAFVVYRRR 164



>UniRef100_A6EGV0 Dihydrofolate reductase n=1 Tax=Pedobacter sp.
           BAL39 RepID=A6EGV0_9SPHI
          Length = 161

 Score =  134 bits (338), Expect = 2e-30
 Identities = 65/160 (40%), Positives = 98/160 (61%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S+I ALA D  IG +N + W+LPADL +FK  T    +IMGR T++SIGRPLP R+NI
Sbjct: 2   IVSIIVALAEDHGIGRDNQLLWHLPADLKFFKNTTTGHTIIMGRKTYDSIGRPLPNRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     +      + S+ EAIA C +  E+ VIGG  +Y+  LP A +LY+T ++   
Sbjct: 62  VITRNAALEIPGAEVLTSLTEAIALCMEEKEVFVIGGAELYKHALPLANRLYVTQVEGSY 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FP++  ++W     E H  D +N+ +Y F   ER+
Sbjct: 122 EADTFFPEFSEEEWLETHREAHLPDEKNTVAYTFITFERK 161



>UniRef100_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri
           RepID=A4IUE2_YERRU
          Length = 191

 Score =  134 bits (337), Expect = 3e-30
 Identities = 66/160 (41%), Positives = 100/160 (62%), Gaps = 5/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLI A+A +  IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+
Sbjct: 27  IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACG-----DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           ++S     +     +   D ++A        +V EIM++GG ++Y   LP   +LYLTH+
Sbjct: 87  VISRSLEKEALPGCLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLYLTHV 146

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
            A +EGDT  P ++      +F E H  D +N + Y FEI
Sbjct: 147 HANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEI 186



>UniRef100_UPI00016A667D Dihydrofolate reductase n=1
           Tax=Burkholderia ubonensis Bu RepID=UPI00016A667D
          Length = 166

 Score =  134 bits (336), Expect = 4e-30
 Identities = 69/161 (42%), Positives = 100/161 (62%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + +IG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGIIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+ +  A+AA    PE  +IGG ++Y + L  A KL +T IDA+
Sbjct: 64  VTRDGSRRFDGCDTVTSLADALALAARDGAPEAFLIGGAQLYAEGLALADKLVVTEIDAD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +GD  FP  +P  W+ V  + H A A N+  Y F + E++
Sbjct: 124 FDGDASFPAPDPAQWQEVSRDPHQAAAPNTFGYAFVVYEKK 164



>UniRef100_Q3SH97 Dihydrofolate reductase n=1 Tax=Thiobacillus
           denitrificans ATCC 25259 RepID=Q3SH97_THIDA
          Length = 167

 Score =  134 bits (336), Expect = 4e-30
 Identities = 70/159 (44%), Positives = 97/159 (61%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+IAALA +RVIG+EN +PW LP DLA FK  TL+ PV+MGR T+ES+GRPLP R N++
Sbjct: 9   VSVIAALAKNRVIGIENRLPWRLPEDLAHFKALTLDHPVLMGRKTFESLGRPLPRRTNVV 68

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++       D      S+  AIA C    EI  IGG  +Y Q +P A +LYLT +DAE E
Sbjct: 69  ITRNADYRPDGCLVAASMPAAIALCQGADEIFFIGGAELYAQAIPLADRLYLTEVDAEPE 128

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP+++   +  +    H  +  +   + F + ERR
Sbjct: 129 GDAWFPEFDRAAFREISRASHVGEKGDVLRFDFVVYERR 167



>UniRef100_D3SBJ1 Dihydrofolate reductase n=1 Tax=Thioalkalivibrio
           sp. K90mix RepID=D3SBJ1_THISK
          Length = 163

 Score =  134 bits (336), Expect = 4e-30
 Identities = 72/160 (45%), Positives = 101/160 (63%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI AL  + VIG +N +PW+LP DL  FKR T   P+IMGR T+ESIGRPLP R+N++
Sbjct: 6   IHLIVALDPNHVIGRDNDLPWHLPKDLQHFKRVTDGHPMIMGRRTFESIGRPLPKRRNLV 65

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+ Q   D R   V+   +  +A   +P+    VIGG  ++ + LP+A  L+LT +    
Sbjct: 66  LTRQ--ADWRADGVEVYPDLDSALASIPQGPAFVIGGAGLFAEALPRASVLHLTRVHEPH 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP   PDDW+ V+SE H+ D +++ ++ FE LERR
Sbjct: 124 AGDTWFPAINPDDWDCVWSERHEPDDRHACAFTFERLERR 163



>UniRef100_C4ZPF3 Dihydrofolate reductase n=1 Tax=Thauera sp. MZ1T
           RepID=C4ZPF3_THASP
          Length = 164

 Score =  134 bits (336), Expect = 4e-30
 Identities = 70/155 (45%), Positives = 96/155 (61%), Gaps = 5/155 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA+A +  IG +N +PW L ADL  F+  TL  P++MGR TW+S+GRPLPGR+N++
Sbjct: 6   IVLIAAVARNGTIGRDNELPWRLKADLQHFRALTLGHPILMGRKTWQSLGRPLPGRRNLV 65

Query: 62  LSSQPGTDDRVTWVKSVDE---AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S  P  D R    +   +   AIAA G+   + VIGG ++Y Q LP A +L LT + A+
Sbjct: 66  VSRTP--DYRAEGAECFADPAAAIAAAGEAQTLFVIGGAQLYAQLLPLADRLELTEVKAD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           VEGD HFP  +P  +     E H ADA N+  + F
Sbjct: 124 VEGDAHFPAVDPARFVEERRETHHADADNAFDFDF 158



>UniRef100_C5TPR0 Dihydrofolate reductase n=1 Tax=Neisseria
           flavescens SK114 RepID=C5TPR0_NEIFL
          Length = 160

 Score =  134 bits (336), Expect = 4e-30
 Identities = 64/141 (45%), Positives = 91/141 (64%), Gaps = 1/141 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I+LIAA A  R IG+ N MPW+LP D A+FK  T  KPVIMGR TWES+ R PLPGR+NI
Sbjct: 4   ITLIAAYATRRCIGINNTMPWHLPEDFAFFKSYTTGKPVIMGRKTWESLPRKPLPGRQNI 63

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ Q    +      S+++A+A C  V E++++GG ++Y Q LP A  L LT +  +V+
Sbjct: 64  VITRQDYQAEGAQTAASLEDALALCQGVEEVIIMGGAQIYAQALPIATDLRLTEVGLDVD 123

Query: 121 GDTHFPDYEPDDWESVFSEFH 141
           GD  FP++  + W+    E H
Sbjct: 124 GDAFFPEFSTETWQEASRENH 144



>UniRef100_C0ER02 Putative uncharacterized protein n=1 Tax=Neisseria
           flavescens NRL30031/H210 RepID=C0ER02_NEIFL
          Length = 160

 Score =  134 bits (336), Expect = 4e-30
 Identities = 64/141 (45%), Positives = 91/141 (64%), Gaps = 1/141 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I+LIAA A  R IG+ N MPW+LP D A+FK  T  KPVIMGR TWES+ R PLPGR+NI
Sbjct: 4   ITLIAAYAARRCIGINNTMPWHLPEDFAFFKSYTTGKPVIMGRKTWESLPRKPLPGRQNI 63

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ Q    +      S+++A+A C  V E++++GG ++Y Q LP A  L LT +  +V+
Sbjct: 64  VITRQDYQAEGAQTAASLEDALALCQGVEEVIIMGGAQIYAQALPIATDLRLTEVGLDVD 123

Query: 121 GDTHFPDYEPDDWESVFSEFH 141
           GD  FP++  + W+    E H
Sbjct: 124 GDAFFPEFSAETWQEASRENH 144



>UniRef100_UPI00016AD9D2 dihydrofolate reductase n=1
           Tax=Burkholderia thailandensis MSMB43
           RepID=UPI00016AD9D2
          Length = 167

 Score =  133 bits (335), Expect = 5e-30
 Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRRTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+D   A+AA     E  +IGG ++Y + L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTVTSLDGALALAARDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A A N  +Y F +  R+
Sbjct: 124 FEGDASFPAPDPAQWEAVSRDAHRAAAPNDFAYAFVVYRRK 164



>UniRef100_Q2KYI7 Dihydrofolate reductase n=1 Tax=Bordetella avium
           197N RepID=Q2KYI7_BORA1
          Length = 160

 Score =  133 bits (335), Expect = 5e-30
 Identities = 66/157 (42%), Positives = 92/157 (58%), Gaps = 2/157 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A +RVIG +N +PW LP DLA FKR+TL  P++MGR+TWES+GRPLPGRKNI+
Sbjct: 4   LTLIVAYARNRVIGRDNTLPWRLPGDLAHFKRSTLGHPIVMGRNTWESLGRPLPGRKNIV 63

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           +S  P        V    ++     +  E+ VIGG ++Y Q LP A ++  T I A V G
Sbjct: 64  VSRNPDYRAEGAIVVPDLQSALKMAEADEVFVIGGAQIYSQALPLATRIIATEIQANVAG 123

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           D +FP     +W     +      +N + Y F + ER
Sbjct: 124 DAYFPPLAQTEWRETSRQ--PQPEENGYHYDFVVYER 158



>UniRef100_Q1IGG6 Dihydrofolate reductase type I, trimethoprim
           resistance n=1 Tax=Pseudomonas entomophila L48
           RepID=Q1IGG6_PSEE4
          Length = 171

 Score =  133 bits (335), Expect = 5e-30
 Identities = 73/166 (43%), Positives = 102/166 (61%), Gaps = 11/166 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAALA +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAALAENRVIGIDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPGTDDRVTWV-KSVDEAIAACGD------VPEIMVIGGGRVYEQFLPK--AQKLYL 112
           +S QPG +     V  S+D A+           V E+M+IGG ++Y Q L K    ++YL
Sbjct: 67  VSRQPGLELAGAEVFASLDAALVRAEQWAREQGVGELMLIGGAQLYGQALEKGLVSRMYL 126

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T ++   EGD  FP+++   W+   S       +    Y FEI +R
Sbjct: 127 TRVELSPEGDAWFPEFDKGQWQ--LSSSAPQAEEGKPVYHFEIWDR 170



>UniRef100_D2QJY0 Dihydrofolate reductase n=1 Tax=Spirosoma linguale
           DSM 74 RepID=D2QJY0_SPILD
          Length = 163

 Score =  133 bits (335), Expect = 5e-30
 Identities = 71/160 (44%), Positives = 105/160 (65%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+
Sbjct: 3   ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+ +   +   VT V ++D+AIA    +   EI VIGG  +Y+  LP A  LYLT I  +
Sbjct: 63  LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +GD +FP+++ ++W+ V    H AD +++ S+ F   E+
Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162



>UniRef100_C7C7F5 Dihydrofolate reductase n=1 Tax=Methylobacterium
           extorquens DM4 RepID=C7C7F5_METED
          Length = 166

 Score =  133 bits (335), Expect = 5e-30
 Identities = 69/158 (43%), Positives = 101/158 (63%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+AA+A + VIG +N++ W L +DL  FK  T+ KP++MGR TW+SIGRPLPGR++++
Sbjct: 6   ISLVAAIARNGVIGRDNSLAWRLSSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSLV 65

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++     T   VT V   DEA+AA GD  E+MV+GG  +Y   LP A +L+LT +DA  E
Sbjct: 66  ITRDRSLTLPDVTVVHDWDEALAAAGD-DELMVVGGAEIYRLALPHADRLHLTEVDAAPE 124

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP ++   +     E H    ++  ++ F  LER
Sbjct: 125 GDAYFPPFDRALFRETLREAHGPGERDEFAFQFVDLER 162



>UniRef100_C5AD54 Dihydrofolate reductase n=1 Tax=Burkholderia
           glumae BGR1 RepID=C5AD54_BURGB
          Length = 167

 Score =  133 bits (335), Expect = 5e-30
 Identities = 72/160 (45%), Positives = 95/160 (59%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LSLIVARARNGVIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D      S+ EA+AA       E  +IGG ++Y + L  A KL +T IDA+
Sbjct: 64  VTRDATRRFDGCDVAGSLAEALAAAARDGAAEAFLIGGAQLYAEGLHAADKLIVTEIDAD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +GD HFP  +P  W  V  E H A A N   Y F +  R
Sbjct: 124 FDGDAHFPAPDPAQWREVSRERHHAAAPNDFDYAFVVYVR 163



>UniRef100_C1D4I6 Dihydrofolate reductase n=1 Tax=Laribacter
           hongkongensis HLHK9 RepID=C1D4I6_LARHH
          Length = 167

 Score =  133 bits (335), Expect = 5e-30
 Identities = 72/135 (53%), Positives = 91/135 (67%), Gaps = 3/135 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA A + VIG++N MPW+LP DLA+FKR TL KPV+MGR T+ESIGRPLPGR NI+
Sbjct: 7   LALIAARARNGVIGLDNRMPWHLPEDLAYFKRVTLGKPVVMGRKTFESIGRPLPGRLNIV 66

Query: 62  LSSQPGTDDR-VTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++  P      V    S+D   A+AA     EIM+IGG  +Y Q LP+A  LYLT IDAE
Sbjct: 67  VTRNPDWQAAGVQVAHSLDAALALAAAAAPEEIMLIGGAELYRQALPQADVLYLTEIDAE 126

Query: 119 VEGDTHFPDYEPDDW 133
             GD  FP+ +   W
Sbjct: 127 FAGDAFFPEVDLARW 141



>UniRef100_B1M531 Dihydrofolate reductase n=1 Tax=Methylobacterium
           radiotolerans JCM 2831 RepID=B1M531_METRJ
          Length = 166

 Score =  133 bits (335), Expect = 5e-30
 Identities = 67/159 (42%), Positives = 100/159 (62%), Gaps = 3/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SL+AA+A + VIG +N + W+L +DL  FK  T+ KP++MGR TW+SIGRPLPGR+ +
Sbjct: 8   LVSLVAAVARNGVIGRDNGLAWHLSSDLKRFKALTMGKPMLMGRRTWDSIGRPLPGRRTL 67

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+   G   + V  V   D A+AA G   E+MV+GG  +Y   LP A +L+LT ++AE 
Sbjct: 68  VLTRDTGFRAEGVETVHDWDSALAAAG--AELMVVGGAEIYALALPHADRLHLTEVEAEP 125

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            GD  FP ++   +   F E H A  ++ H++ F   ER
Sbjct: 126 AGDVRFPAFDRARFRETFREAHPAGPRDEHAFAFVDWER 164



>UniRef100_C2UUU4 Dihydrofolate reductase n=4 Tax=Bacillus cereus
           group RepID=C2UUU4_BACCE
          Length = 162

 Score =  133 bits (335), Expect = 5e-30
 Identities = 61/160 (38%), Positives = 100/160 (62%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      +V+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHTVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_Q738X6 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           ATCC 10987 RepID=Q738X6_BACC1
          Length = 162

 Score =  133 bits (334), Expect = 7e-30
 Identities = 62/160 (38%), Positives = 99/160 (61%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+   +IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHSLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ +F E    D +N ++Y + + E+R
Sbjct: 122 EGDTFFPEMDMTNWKEIFVEKGLTDEKNPYTYYYHVYEKR 161



>UniRef100_C3K3P6 Dihydrofolate reductase n=1 Tax=Pseudomonas
           fluorescens SBW25 RepID=C3K3P6_PSEFS
          Length = 181

 Score =  133 bits (334), Expect = 7e-30
 Identities = 72/168 (42%), Positives = 101/168 (60%), Gaps = 16/168 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR N++
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNLV 66

Query: 62  LSSQ-----------PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKL 110
           +S Q           P  D  V       EA A    V E+M+IGG ++Y Q L +A +L
Sbjct: 67  VSRQTDLALEGAEVFPSLDAAVERA----EAWALEQGVDELMLIGGAQLYAQGLEQADRL 122

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YLT +    EGD  FP ++   W ++ S   +A   +  +Y FE+ E+
Sbjct: 123 YLTRVALSPEGDAWFPQFDAGQW-TLVSNVENAAEGDKPAYSFEVWEK 169



>UniRef100_B1ZDL8 Dihydrofolate reductase n=1 Tax=Methylobacterium
           populi BJ001 RepID=B1ZDL8_METPB
          Length = 166

 Score =  133 bits (334), Expect = 7e-30
 Identities = 69/158 (43%), Positives = 99/158 (62%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAA+A + VIG +N + W + +DL  FK  T+ KP++MGR TW+SIGRPLPGR++++
Sbjct: 6   VSLIAAVARNGVIGRDNDLVWRISSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSLV 65

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+     T   VT V   DEA+AA G   E+MV+GG  +Y   LP A +L+LT +DA  E
Sbjct: 66  LTRDRALTLSDVTIVHDWDEALAAAGG-DELMVVGGAEIYRLALPHADRLHLTEVDAAPE 124

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP ++   +     E H    ++  ++ F  LER
Sbjct: 125 GDVHFPPFDRTAYRETLREAHGPGERDEFAFQFVDLER 162



>UniRef100_C5AUJ5 Dihydrofolate reductase n=2 Tax=Methylobacterium
           extorquens RepID=C5AUJ5_METEA
          Length = 166

 Score =  133 bits (334), Expect = 7e-30
 Identities = 68/158 (43%), Positives = 100/158 (63%), Gaps = 2/158 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+AA+A + VIG +N++ W L +DL  FK  T+ KP++MGR TW+SIGRPLPGR++++
Sbjct: 6   ISLVAAIARNGVIGRDNSLAWRLSSDLKRFKALTMGKPILMGRKTWDSIGRPLPGRRSLV 65

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++         VT V   DEA+AA GD  E+MV+GG  +Y   LP A +L+LT +DA  E
Sbjct: 66  ITRDRSLALSDVTVVHDWDEALAAAGD-DELMVVGGAEIYRLALPHADRLHLTEVDAAPE 124

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP ++   +     E H    ++  ++ F  LER
Sbjct: 125 GDAYFPPFDRSLFRETLREAHGPGERDEFAFQFVDLER 162



>UniRef100_B9BA87 Dihydrofolate reductase n=3 Tax=Burkholderia
           multivorans RepID=B9BA87_9BURK
          Length = 166

 Score =  133 bits (334), Expect = 7e-30
 Identities = 69/161 (42%), Positives = 99/161 (61%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + +IG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGIIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+ +  A+AA     E  +IGG ++Y + L +A KL +T IDA+
Sbjct: 64  VTRDASRRFDGCDTVTSLADALALAARDGAAEAFLIGGAQLYAEGLAQADKLIVTEIDAD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  W+ V  + H A A N+  Y F +  R+
Sbjct: 124 FEGDASFPAPDPAQWQEVSRDAHQAAAPNTFGYAFVVYARK 164



>UniRef100_A4ABY4 Dihydrofolate reductase n=1 Tax=Congregibacter
           litoralis KT71 RepID=A4ABY4_9GAMM
          Length = 171

 Score =  133 bits (334), Expect = 7e-30
 Identities = 71/158 (44%), Positives = 101/158 (63%), Gaps = 8/158 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++I A A + VIG  NA+PW++P DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+
Sbjct: 6   IAVIVAAADNGVIGRNNALPWDVPGDLAHFKRTTMGKPILMGRLTFESIGRPLPGRTNIV 65

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S  PG + + V  V+S+D+AIA    +       E+MVIGG ++Y   LP+A +LYLT 
Sbjct: 66  ISRDPGYEAEGVRSVESLDDAIALAESIALIDGSDELMVIGGAQIYALALPRASRLYLTR 125

Query: 115 IDAEVEGDTHFPDYEPDDWESVF-SEFHDADAQNSHSY 151
           + AE  GD      +  +WE V   E  + D   +H++
Sbjct: 126 VHAEPAGDAFLTGIDWGEWEEVARQENAEEDGTPAHTF 163



>UniRef100_A3TMG5 Probable dihydrofolate reductase oxidoreductase
           protein n=1 Tax=Janibacter sp. HTCC2649
           RepID=A3TMG5_9MICO
          Length = 154

 Score =  133 bits (334), Expect = 7e-30
 Identities = 65/145 (44%), Positives = 91/145 (62%), Gaps = 1/145 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+  + VIG +N MPW+LP D A+FKR T+   ++MGR T++SIGR LPGR+ I+
Sbjct: 4   VTLIAAVGRNGVIGADNDMPWHLPEDFAFFKRTTMGHAMVMGRKTFDSIGRALPGRRTIV 63

Query: 62  LSSQPGTDDR-VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ QP      V  V S+D+A+   G V E+ V GGG +Y Q +P A +L +T +D E E
Sbjct: 64  ITRQPDWHHADVETVHSLDDALGLAGPVGEVFVAGGGEIYAQAMPFAHRLLITEVDQEPE 123

Query: 121 GDTHFPDYEPDDWESVFSEFHDADA 145
           GD  FPD +P  W     E  D  A
Sbjct: 124 GDVRFPDIDPAQWHESAREERDGFA 148



>UniRef100_UPI00016A6DB3 dihydrofolate reductase n=1
           Tax=Burkholderia oklahomensis C6786 RepID=UPI00016A6DB3
          Length = 167

 Score =  132 bits (332), Expect = 1e-29
 Identities = 70/161 (43%), Positives = 97/161 (60%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+D+  A+AA     E  +IGG ++Y + L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTVTSLDDALALAARDGAAEAFLIGGAQLYAEGLRHADKLVVTEIDKD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE V  + H A   N  +Y F +  R+
Sbjct: 124 FEGDASFPAPDPAQWEEVSRDAHRAAEPNDFTYAFVVYRRK 164



>UniRef100_Q473Z0 Dihydrofolate reductase n=1 Tax=Ralstonia eutropha
           JMP134 RepID=Q473Z0_RALEJ
          Length = 166

 Score =  132 bits (332), Expect = 1e-29
 Identities = 67/159 (42%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++L+ A A +  IG  N +PW LP DLA FKR T+  P+IMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLVVARARNGTIGRNNTLPWRLPEDLAHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S       +   V  S+++A   C  V ++ +IGG ++Y + LP A +L +T IDA+V
Sbjct: 63  VVSRNADLKLQGAEVATSLEDAQRLCVGVEQVFLIGGAQLYAEALPSADRLVVTEIDADV 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP  +   W     E H ++A N   Y F   +R
Sbjct: 123 EGDAFFPAIDQAKWIETSRETHHSEA-NGFDYAFVTYDR 160



>UniRef100_D3N350 Dihydrofolate reductase n=1 Tax=Burkholderia sp.
           CCGE1003 RepID=D3N350_9BURK
          Length = 166

 Score =  132 bits (332), Expect = 1e-29
 Identities = 73/165 (44%), Positives = 98/165 (59%), Gaps = 11/165 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P+IMGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARANNGVIGRDNQLPWRLPEDLAFFKRTTMGAPIIMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++        G D   T    +DEA  +AA    PE  +IGG ++Y + L  A KL +T 
Sbjct: 64  VTRDATRRFQGCDAATT----LDEALKLAAQDQAPEAFLIGGAQLYVEGLRLADKLIVTE 119

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           I A+ +GD  FP  +P +W+ V  E H A A N   Y F    R+
Sbjct: 120 ISADFKGDATFPAVDPHEWQEVAHETHRAHAPNDFDYAFVTYTRK 164



>UniRef100_C2YR77 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           AH1271 RepID=C2YR77_BACCE
          Length = 161

 Score =  132 bits (332), Expect = 1e-29
 Identities = 63/160 (39%), Positives = 99/160 (61%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+   +IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHSLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI V GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFVFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEIDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_B9Z6Q0 Dihydrofolate reductase n=1 Tax=Lutiella
           nitroferrum 2002 RepID=B9Z6Q0_9NEIS
          Length = 162

 Score =  132 bits (332), Expect = 1e-29
 Identities = 66/144 (45%), Positives = 93/144 (64%), Gaps = 1/144 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+L+AA+A +RVIG++N +PW+LP DL  FK  TL KPVIMGR T++SIGRPLPGR+NI+
Sbjct: 6   ITLVAAMAANRVIGIDNRLPWHLPEDLKHFKAVTLGKPVIMGRKTYDSIGRPLPGRRNIV 65

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ Q   +   V    S++ A+A   +     +IGG  +Y Q LP A +L LT I    +
Sbjct: 66  VTRQHDWSAAGVEVAHSLEAALALVAEAESACIIGGADLYRQALPLAHRLELTEIAGNYQ 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDAD 144
           GD HFPD+    W+ V  E H ++
Sbjct: 126 GDAHFPDFGSGGWQEVQRESHRSE 149



>UniRef100_UPI00016A3836 dihydrofolate reductase n=1
           Tax=Burkholderia oklahomensis EO147 RepID=UPI00016A3836
          Length = 167

 Score =  132 bits (331), Expect = 2e-29
 Identities = 70/161 (43%), Positives = 97/161 (60%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGVIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+D+  A+AA     E  +IGG ++Y + L  A KL +T ID +
Sbjct: 64  VTRDAARRFDGCDTVTSLDDALALAARDGAAEAFLIGGAQLYAEGLRHADKLVVTEIDKD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE V  + H A   N  +Y F +  R+
Sbjct: 124 FEGDASFPAPDPAQWEEVSRDAHRAVEPNDFTYAFVVYRRK 164



>UniRef100_Q39IC3 Dihydrofolate reductase n=1 Tax=Burkholderia sp.
           383 RepID=Q39IC3_BURS3
          Length = 166

 Score =  132 bits (331), Expect = 2e-29
 Identities = 68/163 (41%), Positives = 99/163 (60%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + +IG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 4   LTLIVARARNGIIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++        G D   +   ++  A+AA    PE  +IGG ++Y + L  A KL +T ID
Sbjct: 64  VTRDATRRFDGCDTVTSLADAL--ALAARDGAPEAFLIGGAQLYTEGLALADKLVVTEID 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A+ +GD  FP  +   W+ V  + H A A N+  Y F + ER+
Sbjct: 122 ADFDGDASFPAPDAAQWQEVSRDAHHAAAPNTFGYAFVVYERK 164



>UniRef100_Q1LK80 Dihydrofolate reductase n=1 Tax=Cupriavidus
           metallidurans CH34 RepID=Q1LK80_RALME
          Length = 166

 Score =  132 bits (331), Expect = 2e-29
 Identities = 66/159 (41%), Positives = 94/159 (59%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG  N +PW LP DL  FKR T+  P+IMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++       +    V S+++A   C    ++ +IGG ++Y + LP A +L +T IDA+V
Sbjct: 63  VVTRNRDLHIEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADV 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP  +   W     E H ++  N   Y F   ER
Sbjct: 123 EGDAFFPAVDRTTWVETARELHHSET-NGFDYAFVTYER 160



>UniRef100_C6J4X9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp.
           oral taxon 786 str. D14 RepID=C6J4X9_9BACL
          Length = 161

 Score =  132 bits (331), Expect = 2e-29
 Identities = 69/161 (42%), Positives = 103/161 (63%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+LI A++ + VIG  N +PW LPADL +FK NT  K ++MGR TWES+G +PLP R +
Sbjct: 1   MITLIWAMSRNGVIGRNNQLPWRLPADLKFFKANTTGKTIVMGRKTWESMGSKPLPNRHS 60

Query: 60  IILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++++ P    +    V SV+EA+    +  E+M+IGG  V++ FLP A +L +T I+ +
Sbjct: 61  VVMTADPSYKAEGADVVHSVEEAL-TYAERGELMIIGGAGVFKHFLPLADRLIVTRIEED 119

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGD  FPD+  +D+E V  E    D +N + Y F   ERR
Sbjct: 120 IEGDVFFPDFSWEDFELVHEEQGVQDEKNPYDYRFLTYERR 160



>UniRef100_C2PEK5 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           MM3 RepID=C2PEK5_BACCE
          Length = 163

 Score =  132 bits (331), Expect = 2e-29
 Identities = 62/160 (38%), Positives = 99/160 (61%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+   +IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHSLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHYAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_Q88CP8 Dihydrofolate reductase n=1 Tax=Pseudomonas putida
           KT2440 RepID=Q88CP8_PSEPK
          Length = 171

 Score =  131 bits (330), Expect = 2e-29
 Identities = 71/166 (42%), Positives = 103/166 (62%), Gaps = 11/166 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAA A +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAAYAENRVIGIDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPGTDDRVTWV-KSVDEAIAACGD------VPEIMVIGGGRVYEQFLPK--AQKLYL 112
           +S QPG +     V  S++EA+           V E+M+IGG ++Y Q L K    ++YL
Sbjct: 67  VSRQPGLELAGAEVFASLEEALVRAEQWAREQGVGELMLIGGAQLYGQALEKGLVSRMYL 126

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T ++   EGD  FP ++   W    SE    + +   +Y FE+ ++
Sbjct: 127 TRVELAPEGDAWFPAFDEGQWRLTSSEAQAEEGK--PAYHFEVWDK 170



>UniRef100_C5DAR3 Dihydrofolate reductase n=1 Tax=Geobacillus sp.
           WCH70 RepID=C5DAR3_GEOSW
          Length = 162

 Score =  131 bits (330), Expect = 2e-29
 Identities = 70/161 (43%), Positives = 98/161 (60%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +RVIG +N +PW+LPADLA+FK+ T+   +IMGR T+ESIGRPLPGR+N+
Sbjct: 1   MISHIVAMDQNRVIGKDNRLPWHLPADLAYFKKVTMGHAIIMGRKTFESIGRPLPGRENV 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           I++           V    EAI   A     E+ VIGG  +++  LP A +LY+T I+A 
Sbjct: 61  IVTRNRSFQAEGCTVIHSIEAIRQFAAKRDDEVFVIGGAELFQATLPFADRLYITKIEAN 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             GDT +PD+E  +W  V       D +N + Y F + ER+
Sbjct: 121 FPGDTFYPDFEESEWRLVSYTKGIKDEKNPYDYAFIVYERK 161



>UniRef100_A9ADR8 Dihydrofolate reductase n=2 Tax=Burkholderia
           multivorans ATCC 17616 RepID=A9ADR8_BURM1
          Length = 209

 Score =  131 bits (330), Expect = 2e-29
 Identities = 68/161 (42%), Positives = 98/161 (60%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + +IG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 47  LTLIVARARNGIIGRDNQLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 106

Query: 62  LSSQPGTD-DRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D    V S+ +  A+AA     E  +IGG ++Y + L +A KL +T IDA+
Sbjct: 107 VTRDASRRFDGCDTVTSLADALALAARDGAAEAFLIGGAQLYAEGLAQADKLIVTEIDAD 166

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  W+ V  + H A   N+  Y F +  R+
Sbjct: 167 FEGDASFPAPDPAQWQEVSRDAHQAATPNTFGYAFVVYARK 207



>UniRef100_D5R6D4 Dihydrofolate reductase n=1 Tax=Clostridium
           lentocellum DSM 5427 RepID=D5R6D4_9FIRM
          Length = 162

 Score =  131 bits (330), Expect = 2e-29
 Identities = 70/160 (43%), Positives = 103/160 (64%), Gaps = 3/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI LIAA++ +  IG+ N MPW++P DLA+F+  T    VIMGR T+ESIG+PLP R N+
Sbjct: 1   MICLIAAVSKNNQIGLHNQMPWHIPEDLAYFREVTSGHTVIMGRKTFESIGKPLPHRTNM 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +L++ P  + + V  + S++EA+  C    E + VIGGG +Y+ FLP A+ LY+T ID  
Sbjct: 61  VLTTNPNFSAEGVVVLHSLNEALELCKTTTEAVFVIGGGEIYKAFLPFAEYLYITLIDEV 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           VEGDT FPDY+  D++ + S    +     H + F + +R
Sbjct: 121 VEGDTCFPDYQ-KDFQLIKSTCSKSQTSTGHYFFFTLWKR 159



>UniRef100_C2XTJ8 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           AH603 RepID=C2XTJ8_BACCE
          Length = 162

 Score =  131 bits (330), Expect = 2e-29
 Identities = 60/160 (37%), Positives = 99/160 (61%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW++P++L + K+ T+  P+IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNKLPWHIPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++       +      S +E    C D  EI + GG ++Y+ FLP  +KLY+T I    
Sbjct: 62  IVTRNGDYHVEGCEVAHSAEEVFELCKDEEEIFIFGGAQIYDLFLPYVEKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+ +  DW+ V  E    D +N ++Y + + E++
Sbjct: 122 DGDTFFPEMDMTDWKEVIVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_C2SJJ2 Dihydrofolate reductase n=1 Tax=Bacillus cereus
           BDRD-ST196 RepID=C2SJJ2_BACCE
          Length = 162

 Score =  131 bits (330), Expect = 2e-29
 Identities = 62/160 (38%), Positives = 99/160 (61%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++S + A+  +RVIG +N +PW LP++L + K+ T+   +IMGR  +E+IGRPLPGR+NI
Sbjct: 2   IVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHSLIMGRKNYEAIGRPLPGRRNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++   G   +      SV+E    C +  EI + GG ++Y+ FLP   KLY+T I    
Sbjct: 62  IVTRNEGYRVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP+ +  +W+ VF E    D +N ++Y + + E++
Sbjct: 122 EGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 161



>UniRef100_UPI000038402E COG0262: Dihydrofolate reductase n=1
           Tax=Magnetospirillum magnetotacticum MS-1
           RepID=UPI000038402E
          Length = 168

 Score =  131 bits (329), Expect = 3e-29
 Identities = 71/162 (43%), Positives = 100/162 (61%), Gaps = 9/162 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+A + VIG +N +PW++P DL WFK NTL KPVIMGR TW+SIGRPLP R NI+
Sbjct: 10  VSLIVAIASNGVIGKDNQLPWHIPEDLKWFKENTLGKPVIMGRKTWDSIGRPLPKRPNIV 69

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDV----PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++ Q     +      S+DEA+    ++     E+MVIGG  ++ + L +A +LYLT I 
Sbjct: 70  VTRQLDWRAEGAHAAHSLDEALKLAAELAPEASELMVIGGNALFAEALARATRLYLTEIR 129

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT FP ++   W+ V    +D D     ++ F IL+R
Sbjct: 130 RAYEGDTVFPAFDRARWKEVTRRPNDGDP----AFDFVILDR 167



>UniRef100_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp.
           JDR-2 RepID=C6CYL9_PAESJ
          Length = 163

 Score =  131 bits (329), Expect = 3e-29
 Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+   R IG+ N +PW LPA++A+F R+T  K V+MGR T+ES+ +PL  R N++
Sbjct: 3   ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ QP    +    V SV EAI   G+  E+MVIGG  +Y QFLP A K+ LT +D  +E
Sbjct: 63  ITRQPEYAKEGCEVVHSVQEAIDRYGE-GELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121

Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GD  FP +   +WE V +E  ++D +N+ S+ F+   RR
Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161



>UniRef100_B8IF21 Dihydrofolate reductase region n=1
           Tax=Methylobacterium nodulans ORS 2060
           RepID=B8IF21_METNO
          Length = 163

 Score =  131 bits (329), Expect = 3e-29
 Identities = 69/162 (42%), Positives = 97/162 (59%), Gaps = 9/162 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LIAA+A +RVIG +N + W L +DL  F+  T+ KPV+MGR TW+SIGRPLPGR+ I+
Sbjct: 4   ITLIAAVAKNRVIGRDNDLAWRLRSDLRHFRALTMGKPVVMGRRTWDSIGRPLPGRRVIV 63

Query: 62  LS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++     S PG +    W       +A      EIMV GG  ++   LP+A +L+LT ++
Sbjct: 64  MTRNPGWSAPGVESAADW----PAVLARTEGADEIMVAGGAEIFALTLPQADRLHLTEVE 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           A  EGDT FP+  P  +  V SE H A   + H++ F  L R
Sbjct: 120 AAPEGDTLFPEIPPGAFREVASESHPAGPDDEHAFRFVTLLR 161



>UniRef100_B1YHM1 Dihydrofolate reductase n=1 Tax=Exiguobacterium
           sibiricum 255-15 RepID=B1YHM1_EXIS2
          Length = 161

 Score =  131 bits (329), Expect = 3e-29
 Identities = 67/159 (42%),