GenePage for the cysZ gene of Escherichia coli K-12

Primary Gene Name: cysZ
EcoGene Accession Number: EG10003
K-12 Gene Accession Number: ECK2408
MG1655 Gene Identifier: b2413
Gene Name Mnemonic: Cysteine
Alternate Gene Symbols: None
Description: Sulfate transporter, sulfite inhibited
  # bp Upstream # bp Downstream
MW: 29305.00 ---------253 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2531463
Left Intergenic Region

Name: zipA_cysZ

Length: 229 bp gap

Orientation: Divergent

Left_end: 2531234

Right_end: 2531462

Centisome: 54.53

Genomic Address
Clockwise
Minute or Centisome (%) = 54.54
Right End: 2532224
Right Intergenic Region

Name: cysZ_cysK

Length: 184 bp gap

Orientation: Codirectional+

Left_end: 2532225

Right_end: 2532408

Centisome: 54.55

CysZ is a sulfite-inhibited pH-dependent sulfate transporter that is specialized for sulfate import for cysteine synthesis (Zhang, 2014). cysZ mutants are defective in sulfate assimilation, thought to be due to a defect in sulfate transport (Britton, 1983; Parra, 1983; Aguilar-Barajas, 2011). The etoposide-induced protein 2.4 family (EI24, PF0726), formerly known as DUF540, is named after the eukaryotic EI24 protein induced by the cytotoxic drug etoposide; ei24 is a p53 response gene involved in growth suppression and apoptosis (Gu, 2000). CysZ is an inner membrane protein with the C-terminus in the cytoplasm (Daley, 2005). otherPDB (I. loihiensis): 3TX3.

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BamHI EcoRI HindIII