GenePage for the yaaA gene of Escherichia coli K-12

Primary Gene Name: yaaA
EcoGene Accession Number: EG10011
K-12 Gene Accession Number: ECK0006
MG1655 Gene Identifier: b0006
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Peroxide resistance protein, lowers intracellular iron
  # bp Upstream # bp Downstream
MW: 29585.83 ---------258 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 5683
Left Intergenic Region

Name: yaaX_yaaA

Length: 152 bp gap

Orientation: Convergent

Left_end: 5531

Right_end: 5682

Centisome: 0.12

Genomic Address
Counterclockwise
Minute or Centisome (%) = 0.12
Right End: 6459
Right Intergenic Region

Name: yaaA_yaaJ

Length: 69 bp gap

Orientation: Codirectional-

Left_end: 6460

Right_end: 6528

Centisome: 0.14

Mutants of yaaA in an Hpx- background (katE katG ahpCF) grow poorly, have extensive DNA damage and are filamentous; these phenotypes are due to elevated unincorporated intracellular iron levels that are suppressible by iron chelators (Liu, 2011). Although previous microarray results demonstrated a 4-fold elevation of yaaA expression by hydrogen peroxide in an oxyR mutant, this activation could not be reproduced with LacZ fusions or real time PCR (Zheng, 2001; Liu, 2011). Low abundance protein. UPF0246 family.

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BamHI EcoRI HindIII