GenePage for the alkB gene of Escherichia coli K-12

Primary Gene Name: alkB
EcoGene Accession Number: EG10037
K-12 Gene Accession Number: ECK2204
MG1655 Gene Identifier: b2212
Gene Name Mnemonic: Alkylation
Alternate Gene Symbols: aidD
Description: Alkylated DNA repair enzyme; alpha-ketoglutarate- and Fe(II)-dependent dioxygenase; releases replication blocks by oxidative demethylation of 1-methyladenine and 3-methylcytosine residues in ssDNA and dsDNA
  # bp Upstream # bp Downstream
Verified Start MW: 24075.53 ---------216 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2308691
Left Intergenic Region

Name: yojI_alkB

Length: 75 bp gap

Orientation: Codirectional-

Left_end: 2308616

Right_end: 2308690

Centisome: 49.74

Genomic Address
Counterclockwise
Minute or Centisome (%) = 49.74
Right End: 2309341
Right Intergenic Region

Name: alkB_ada

Length: 1 bp overlap

Orientation: Codirectional-

Left_end: 2309341

Right_end: 2309341

Centisome: 49.75

AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.

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BamHI EcoRI HindIII