GenePage for the asnA gene of Escherichia coli K-12

Primary Gene Name: asnA
EcoGene Accession Number: EG10091
K-12 Gene Accession Number: ECK3738
MG1655 Gene Identifier: b3744
Gene Name Mnemonic: Asparagine
Alternate Gene Symbols: None
Description: Asparagine synthase A; aspartate-ammonia ligase
  # bp Upstream # bp Downstream
Verified Start MW: 36650.55 ---------330 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3927155
Left Intergenic Region

Name: asnC_asnA

Length: 151 bp gap

Orientation: Divergent

Left_end: 3927004

Right_end: 3927154

Centisome: 84.60

Genomic Address
Clockwise
Minute or Centisome (%) = 84.61
Right End: 3928147
Right Intergenic Region

Name: asnA_viaA

Length: 4 bp gap

Orientation: Convergent

Left_end: 3928148

Right_end: 3928151

Centisome: 84.63

AsnA is related to class II aa-tRNA synthetases (Nakatsu, 1998). AsnA and AsnB are redundant; an asparagine auxotrophy requires that both genes be mutated. AsnA uses ammonia as the nitrogen source. Residues 199-203 of zwf encode a NNWDN peptide involved in MazF(ChpA) toxicity that is likely converted to NNWNN by AsnA since an asnA deletion prevents NNWNN activity (Kolodkin-Gal, 2007).

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BamHI EcoRI HindIII