GenePage for the bglG gene of Escherichia coli K-12

Primary Gene Name: bglG
EcoGene Accession Number: EG10116
K-12 Gene Accession Number: ECK3716
MG1655 Gene Identifier: b3723
Gene Name Mnemonic: beta-Glucoside
Alternate Gene Symbols: bglC; bglR; bglS
Description: Transcription antiterminator for cryptic bglGFBH operon; RNA-binding protein; dimerization and activity modulated by phosphorylation state; binds kinase/dephosphorylase BglF
  # bp Upstream # bp Downstream
MW: 32097.14 ---------278 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3905731
Left Intergenic Region

Name: bglF_bglG

Length: 133 bp gap

Orientation: Codirectional-

Left_end: 3905598

Right_end: 3905730

Centisome: 84.14

Genomic Address
Counterclockwise
Minute or Centisome (%) = 84.15
Right End: 3906567
Right Intergenic Region

Name: bglG_phoU

Length: 285 bp gap

Orientation: Codirectional-

Left_end: 3906568

Right_end: 3906852

Centisome: 84.16

The non-phosphorylated BglG dimer binds to RNA and allows readthrough of transcription. BglG has an N-terminal RNA-binding domain followed by two PTS-regulation and dimerization (PRD) domains, PRD1 and PRD2, which contain the phosphorylated sites. BglG is activated by phospho-HPr(PtsH)-mediated phosphorylation and is deactivated by BglF-mediated phosphorylation at a second site; the inducing beta-glucoside sugar causes BglF to dephosphylate BglG at the second site, leading to cytoplasmic localization of BglG, BglG dimerization, and activation of BglG-mediated antitermination of the bgl operon (Amster-Choder, 1992; Görke, 1999). BglG is homologus to LicT of B. subtilis.

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BamHI EcoRI HindIII