GenePage for the cadA gene of Escherichia coli K-12

Primary Gene Name: cadA
EcoGene Accession Number: EG10131
K-12 Gene Accession Number: ECK4125
MG1655 Gene Identifier: b4131
Gene Name Mnemonic: Cadaverine
Alternate Gene Symbols: ldcI
Description: Lysine decarboxylase, inducible; decameric
  # bp Upstream # bp Downstream
Verified Start MW: 81260.12 ---------715 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4356470
Left Intergenic Region

Name: dtpC_cadA

Length: 58 bp gap

Orientation: Codirectional-

Left_end: 4356412

Right_end: 4356469

Centisome: 93.85

Genomic Address
Counterclockwise
Minute or Centisome (%) = 93.86
Right End: 4358617
Right Intergenic Region

Name: cadA_cadB

Length: 79 bp gap

Orientation: Codirectional-

Left_end: 4358618

Right_end: 4358696

Centisome: 93.90

ppGpp binds to and inhibits CadA(LdcI) in vitro and in vivo (Kanjee, 2011). Induction of the cadAB operon under acidic conditions and in the presence of lysine neutralized the extracellular environment and enables production of CO(2); production of cadaverine and aminopropylcadaverine instead of putrescine and spermidine also resulted. cadAB operon induction also generated a proton motive force. Lack of cadBA operon induction results in an increase in speF-potE operon expression. CadA(LdcI) is required for full pathogenicity of Salmonella and Vibrio. CadA(LdcI) and RavA ATPase form a complex.

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BamHI EcoRI HindIII