GenePage for the cspA gene of Escherichia coli K-12

Primary Gene Name: cspA
EcoGene Accession Number: EG10166
K-12 Gene Accession Number: ECK3543
MG1655 Gene Identifier: b3556
Gene Name Mnemonic: Cold shock protein
Alternate Gene Symbols: None
Description: Cold-inducible RNA chaperone and antiterminator; aids gene expression at low temperature; cold shock protein CS7.4; binds ssRNA and ssDNA
  # bp Upstream # bp Downstream
Verified Start MW: 7403.28 ---------70 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3720049
Left Intergenic Region

Name: yiaG_cspA

Length: 280 bp gap

Orientation: Codirectional+

Left_end: 3719769

Right_end: 3720048

Centisome: 80.14

Genomic Address
Clockwise
Minute or Centisome (%) = 80.14
Right End: 3720261
Right Intergenic Region

Name: cspA_hokA

Length: 186 bp gap

Orientation: Convergent

Left_end: 3720262

Right_end: 3720447

Centisome: 80.15

CspA is a transcription antiterminator (Bae, 2000). The cspABEG deletion strain BX04 is cold-sensitive for growth and forms filaments at 15C (Xia, 2001). A cspA deletion grows slow below 8C (as enabled by transgenic Oleispira antarctica Cpn10/60). CspA is similar to Y-box DNA binding proteins of eukaryotes. Mutant has increased aggregation. Binds TrxA (Kumar, 2004).

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BamHI EcoRI HindIII