GenePage for the eda gene of Escherichia coli K-12

Primary Gene Name: eda
EcoGene Accession Number: EG10256
K-12 Gene Accession Number: ECK1851
MG1655 Gene Identifier: b1850
Gene Name Mnemonic: Entner-Douderoff aldolase
Alternate Gene Symbols: hga; kdgA; kga
Description: KHG/KDPG aldolase; 2-dehydro-3-deoxy-phosphogluconate/4-hydroxy-2-oxoglutarate aldolase; trimeric
  # bp Upstream # bp Downstream
Verified Start MW: 22284.03 ---------213 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1932115
Left Intergenic Region

Name: purT_eda

Length: 55 bp gap

Orientation: Convergent

Left_end: 1932060

Right_end: 1932114

Centisome: 41.62

Genomic Address
Counterclockwise
Minute or Centisome (%) = 41.63
Right End: 1932756
Right Intergenic Region

Name: eda_edd

Length: 36 bp gap

Orientation: Codirectional-

Left_end: 1932757

Right_end: 1932792

Centisome: 41.64

Eda and Edd are enzymes unique to the Enter-Doudoroff pathway (Conway, 1992; Peekhaus, 1998; Flamholz, 2013). KDG is derived from pectin, a common plant heteropolysaccharide, although E. coli K-12 does not secrete pectinases or uptake pectin oligosaccharides and has only the core KDG regulon as compared to plant pathogens like Erwinia chrysanthemi, whose extracellular pectate lyases and intacellular oligogalacturonate lyase breaks pectin down mainly into 5-keto-4-deoxyuronate (DKI) monomers and to a lesser extent polygalacturonase-generated galacturonate; in E. coli K-12 galacturonate uptake and degradation is mediated by the ExuT permease and the UxaABC catabolic enzymes producing KDG, respectively, and DKI is imported by the KdgR-regulated KDG importer KdgT and catabolized to KDG by the KdgR-regulated KduID enyzymes, also producing KDG; KDG is converted to pyruvate and glyceraldehyde-3-phosphate by KdsK and Eda(KdsA) (Rodionov, 2004; Hugouvieux-Cotte-Pattat, 1996). 2-keto-4-hydroxyglutarate aldolase is also known as 4-hydroxy-2-oxoglutarate aldolase. KdgR regulon.

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BamHI EcoRI HindIII