GenePage for the fimH gene of Escherichia coli K-12

Primary Gene Name: fimH
EcoGene Accession Number: EG10315
K-12 Gene Accession Number: ECK4311
MG1655 Gene Identifier: b4320
Gene Name Mnemonic: Fimbriae
Alternate Gene Symbols: None
Description: Minor type 1 fimbrial subunit; membrane-specific adhesin; mediates mannose-binding to host surfaces
  # bp Upstream # bp Downstream
Verified Start MW: 31473.49 ---------300 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4548808
Left Intergenic Region

Name: fimG_fimH

Length: 19 bp gap

Orientation: Codirectional+

Left_end: 4548789

Right_end: 4548807

Centisome: 98.00

Genomic Address
Clockwise
Minute or Centisome (%) = 98.00
Right End: 4549710
Right Intergenic Region

Name: fimH_gntP

Length: 242 bp gap

Orientation: Convergent

Left_end: 4549711

Right_end: 4549952

Centisome: 98.02

The crystal structure of the pilus elongation complex in which the tip complex assembly composed of FimC, FimF, FimG and FimH passes through the usher porin FimD has been determined (Geibel, 2013). Mutants of FimH have been isolated that auto-aggregate (Schembri, 2001). FimH has a false positive lipoprotein prediction and has a verified 21 aa cleavable typeI signal peptide. Prototype of the FimH family.

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BamHI EcoRI HindIII