GenePage for the ftsZ gene of Escherichia coli K-12

Primary Gene Name: ftsZ
EcoGene Accession Number: EG10347
K-12 Gene Accession Number: ECK0096
MG1655 Gene Identifier: b0095
Gene Name Mnemonic: Filamentation, temperature sensitive
Alternate Gene Symbols: sfiB; sulB
Description: Septal ring GTPase required for cell division and growth; initiation of septation; tubulin-like protein
  # bp Upstream # bp Downstream
Verified Start MW: 40323.92 ---------383 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 105305
Left Intergenic Region

Name: ftsA_ftsZ

Length: 60 bp gap

Orientation: Codirectional+

Left_end: 105245

Right_end: 105304

Centisome: 2.27

Genomic Address
Clockwise
Minute or Centisome (%) = 2.27
Right End: 106456
Right Intergenic Region

Name: ftsZ_lpxC

Length: 100 bp gap

Orientation: Codirectional+

Left_end: 106457

Right_end: 106556

Centisome: 2.29

SlmA disassembles FtsZ polymers in vitro (Cho, 2011). ZapA(YgfE) binding promotes FtsZ polymer bundling and inhibits the GTPase activity of FtsZ (Small, 2007). ZapC binding promotes FtsZ polymer bundling (lateral interactions) and inhibits the GTPase activity of FtsZ (Hale, 2011; Durand-Heredia, 2011). Overexpression of ZapC causes filamentation and aberrant FtsZ filaments (Hale, 2011; Durand-Heredia, 2011). FtsZ is stored in a dynamic helical FtsZ cytoskeleton upon disassembly of the Z ring in daughter cells. Overexpression causes filamentous biofilm formation. Binds TrxA (Kumar, 2004). Divisome protein. ZapA has been shown by FRET to directly interact with itself, FtsN, FtsZ and FtsI (Alexeeva, 2010).

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BamHI EcoRI HindIII