GenePage for the glnB gene of Escherichia coli K-12

Primary Gene Name: glnB
EcoGene Accession Number: EG10384
K-12 Gene Accession Number: ECK2550
MG1655 Gene Identifier: b2553
Gene Name Mnemonic: Glutamine
Alternate Gene Symbols: None
Description: PII regulatory protein for glutamine synthase; potent activator of NRII/GlnL/NtrB phosphatase and inhibitor of NRII autophosphorylation; activates adenylation of GlnA by GlnE
  # bp Upstream # bp Downstream
Verified Start MW: 12425.45 ---------112 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2687070
Left Intergenic Region

Name: hmp_glnB

Length: 44 bp gap

Orientation: Convergent

Left_end: 2687026

Right_end: 2687069

Centisome: 57.89

Genomic Address
Counterclockwise
Minute or Centisome (%) = 57.89
Right End: 2687408
Right Intergenic Region

Name: glnB_glrR

Length: 60 bp gap

Orientation: Codirectional-

Left_end: 2687409

Right_end: 2687468

Centisome: 57.90

GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. In nitrogen limitation GlnB is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. GlnB interacts with and regulates the activities of the histidine protein kinase NtrB, which controls phosphorylation of NtrC. It also regulates the activity of adenylyltransferase (GlnE) which in turn regulates the activity of glutamine synthetase (GlnA). glnK is a glnB paralog. [Comment provided by EcoTeam member Mike Merrick, 11.16.06]

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BamHI EcoRI HindIII