GenePage for the hflK gene of Escherichia coli K-12

Primary Gene Name: hflK
EcoGene Accession Number: EG10436
K-12 Gene Accession Number: ECK4170
MG1655 Gene Identifier: b4174
Gene Name Mnemonic: High frequency lysogenization
Alternate Gene Symbols: hflA; hslY
Description: Membrane bound protease complex with FtsH and HflC; regulates lysogeny; non-essential
  # bp Upstream # bp Downstream
MW: 45544.88 ---------419 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4402038
Left Intergenic Region

Name: hflX_hflK

Length: 85 bp gap

Orientation: Codirectional+

Left_end: 4401953

Right_end: 4402037

Centisome: 94.84

Genomic Address
Clockwise
Minute or Centisome (%) = 94.84
Right End: 4403297
Right Intergenic Region

Name: hflK_hflC

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 4403298

Right_end: 4403299

Centisome: 94.86

Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. Null hflC or hflK alleles stabilize cytoplasmic substrate cII. hflCK is a multicopy suppressor of ftsH htpX double mutant. HflC and HflK have periplasmic prohibitin homology (PHB) domains. The PHB domain is also called the SPFH domain, named after the proteins Stomatin, Prohibitin, Flotillin and HflK/C (Tavernarakis, 1999; Morrow, 2005; Rivera-Milla, 2006; Browman, 2007). HflK belongs to subfamily SPFH3a (Hinderhofer, 2009).

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BamHI EcoRI HindIII