GenePage for the hfq gene of Escherichia coli K-12

Primary Gene Name: hfq
EcoGene Accession Number: EG10438
K-12 Gene Accession Number: ECK4168
MG1655 Gene Identifier: b4172
Gene Name Mnemonic: Host factor for Q beta
Alternate Gene Symbols: None
Description: Global regulator of sRNA function; host factor for RNA phage Q beta replication; HF-I; DNA- and RNA-binding protein; RNA chaperone; binds ATP and RNAP
  # bp Upstream # bp Downstream
Verified Start MW: 11166.39 ---------102 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4400288
Left Intergenic Region

Name: miaA_hfq

Length: 85 bp gap

Orientation: Codirectional+

Left_end: 4400203

Right_end: 4400287

Centisome: 94.80

Genomic Address
Clockwise
Minute or Centisome (%) = 94.80
Right End: 4400596
Right Intergenic Region

Name: hfq_hflX

Length: 75 bp gap

Orientation: Codirectional+

Left_end: 4400597

Right_end: 4400671

Centisome: 94.81

The C-terminal of Hfq is not necessary for hexamerization. RNA binding is located primarily at the N-terminal. Although Hfq has been reported to have intrinsic ATPase activity, a subsequent study identifies the Hfq-associated ATPase activity as a heat-labile contaminant (Sukhodolets, 2003; Arluison, 2007; Hämmerle, 2012). Hfq has multiple regulatory roles including the destabilzation of ompA mRNA, improved rpoS translation, and as a co-factor for the DsrA sRNA DsrA.

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII