GenePage for the hsdS gene of Escherichia coli K-12

Primary Gene Name: hsdS
EcoGene Accession Number: EG10460
K-12 Gene Accession Number: ECK4338
MG1655 Gene Identifier: b4348
Gene Name Mnemonic: Host specificity
Alternate Gene Symbols: hsp; hss
Description: Specificity determinant for HsdM and HsdR
  # bp Upstream # bp Downstream
MW: 51395.27 ---------464 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4580068
Left Intergenic Region

Name: symR_hsdS

Length: 156 bp gap

Orientation: Convergent

Left_end: 4579912

Right_end: 4580067

Centisome: 98.67

Genomic Address
Counterclockwise
Minute or Centisome (%) = 98.67
Right End: 4581462
Right Intergenic Region

Name: hsdS_hsdM

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 4581459

Right_end: 4581462

Centisome: 98.70

Substitution of Trp212 to Arg alters the protein-protein interaction with HsdM, in turn effecting the DNA binding of the molecule; DNA binding in the mutant is restored by HsdR binding.

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BamHI EcoRI HindIII