GenePage for the ilvH gene of Escherichia coli K-12

Primary Gene Name: ilvH
EcoGene Accession Number: EG10499
K-12 Gene Accession Number: ECK0080
MG1655 Gene Identifier: b0078
Gene Name Mnemonic: Isoleucine-valine (requirement)
Alternate Gene Symbols: brnP
Description: Acetolactate synthase 3 small regulatory subunit; acetohydroxy acid synthase III; heterotetrameric AHAS-III
  # bp Upstream # bp Downstream
MW: 17976.76 ---------163 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 87357
Left Intergenic Region

Name: ilvI_ilvH

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 87355

Right_end: 87356

Centisome: 1.88

Genomic Address
Clockwise
Minute or Centisome (%) = 1.88
Right End: 87848
Right Intergenic Region

Name: ilvH_cra

Length: 179 bp gap

Orientation: Codirectional+

Left_end: 87849

Right_end: 88027

Centisome: 1.89

The IlvH small subunit is required for full activity and valine-sensitivity of the IlvIH holoenzyme; IlvI alone exhibits only 5% of the holoenzyme activity (Vyazmensky, 1996). In addition to the ACT-like domain, also found in acetolactate synthase small regulatory subunit proteins IlvM and IlvN, IlvH has an additional C-terminal tandem ferridoxin domain of unknown function (Mendel, 2003; Kaplun, 2006). The stoichiometry of the acetolactate synthase 3 holoenzyme is IlvI(2)IlvH(2), a dimer of dimers. The valine binding site is probably at the interface of the two IlvH subunits (Kaplun, 2006).

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BamHI EcoRI HindIII