GenePage for the lepB gene of Escherichia coli K-12

Primary Gene Name: lepB
EcoGene Accession Number: EG10530
K-12 Gene Accession Number: ECK2566
MG1655 Gene Identifier: b2568
Gene Name Mnemonic: Leader peptidase
Alternate Gene Symbols: lep
Description: Signal peptidase I; SPI; responsible for type I signal cleavages of periplasmic, OM, some IM, and extracellular proteins
  # bp Upstream # bp Downstream
MW: 35960.35 ---------324 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2704335
Left Intergenic Region

Name: rnc_lepB

Length: 271 bp gap

Orientation: Codirectional-

Left_end: 2704064

Right_end: 2704334

Centisome: 58.26

Genomic Address
Counterclockwise
Minute or Centisome (%) = 58.26
Right End: 2705309
Right Intergenic Region

Name: lepB_lepA

Length: 15 bp gap

Orientation: Codirectional-

Left_end: 2705310

Right_end: 2705324

Centisome: 58.28

LepB has a blocked N-terminus. False positive lipoprotein prediction, shown to have no signal peptide. Targetted by SRP/FtsY to Sec/YidC for membrane insertion.

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BamHI EcoRI HindIII