GenePage for the lysC gene of Escherichia coli K-12

Primary Gene Name: lysC
EcoGene Accession Number: EG10550
K-12 Gene Accession Number: ECK4016
MG1655 Gene Identifier: b4024
Gene Name Mnemonic: Lysine
Alternate Gene Symbols: apk
Description: Lysine-sensitive aspartokinase 3
  # bp Upstream # bp Downstream
Verified Start MW: 48531.73 ---------449 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4231884
Left Intergenic Region

Name: yjbD_lysC

Length: 252 bp gap

Orientation: Codirectional-

Left_end: 4231632

Right_end: 4231883

Centisome: 91.17

Genomic Address
Counterclockwise
Minute or Centisome (%) = 91.17
Right End: 4233233
Right Intergenic Region

Name: lysC_pgi

Length: 524 bp gap

Orientation: Divergent

Left_end: 4233234

Right_end: 4233757

Centisome: 91.20

Mutations in an L box riboswitch regulated by free lysine is in the lysC mRNA 5' UTR confer resistance to S-(2-aminoethyl)-L-cysteine (AEC) by derepressing lysine biosynthesis and outcompeting AEC inhibition of LysRS (Ataide, 2007). The lysC riboswitch also regulates lysC mRNA decay by sequestering RNase E cleavage sites (Caron, 2012).

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII