GenePage for the mraY gene of Escherichia coli K-12

Primary Gene Name: mraY
EcoGene Accession Number: EG10604
K-12 Gene Accession Number: ECK0088
MG1655 Gene Identifier: b0087
Gene Name Mnemonic: Murein cluster a
Alternate Gene Symbols: murX
Description: UDP-N-acetylmuramoyl-pentapeptide:undecaprenyl-PO4 phosphatase
  # bp Upstream # bp Downstream
MW: 39874.75 ---------360 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 96002
Left Intergenic Region

Name: murF_mraY

Length: 7 bp overlap

Orientation: Codirectional+

Left_end: 96002

Right_end: 96008

Centisome: 2.07

Genomic Address
Clockwise
Minute or Centisome (%) = 2.07
Right End: 97084
Right Intergenic Region

Name: mraY_murD

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 97085

Right_end: 97086

Centisome: 2.09

The aspartic acid residues DD115, D116, and D267 are necessary for catalysis. The model suggested indicates that D115 and D116 chelate the Mg2+ cofactor, which in turn binds the pyrophosphate bridge of the UDP-MurNAc-pentapeptide, and D267 acts as the catalytic nucleophile. otherPDB(A.aeolicus): 4J72 (Chung, 2013).

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII