GenePage for the mutS gene of Escherichia coli K-12

Primary Gene Name: mutS
EcoGene Accession Number: EG10625
K-12 Gene Accession Number: ECK2728
MG1655 Gene Identifier: b2733
Gene Name Mnemonic: Mutator
Alternate Gene Symbols: ant; fdv; plm
Description: Methyl-directed mismatch repair protein, weak ATPase; dimeric/tetrameric
  # bp Upstream # bp Downstream
MW: 95246.90 ---------853 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2857093
Left Intergenic Region

Name: ygbA_mutS

Length: 286 bp gap

Orientation: Divergent

Left_end: 2856807

Right_end: 2857092

Centisome: 61.55

Genomic Address
Clockwise
Minute or Centisome (%) = 61.55
Right End: 2859654
Right Intergenic Region

Name: mutS_pphB

Length: 105 bp gap

Orientation: Codirectional+

Left_end: 2859655

Right_end: 2859759

Centisome: 61.61

The sdsR(ryeB) sRNA negatively regulates mutS mRNA stability, revealing a probably RpoS-dependent mechanism of ampicillin-induced mutagenesis (Gutierrez, 2013). MutS is a member of the P-loop NTPase clan and the ABC-ATPase superfamily, has weak ATPase activity, and is involved in recognition of a DNA mismatch. MutS C-terminus dimerization, not tetramerization, is required for mismatch repair (Mendillo, 2007).

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BamHI EcoRI HindIII