GenePage for the oxyR gene of Escherichia coli K-12

Primary Gene Name: oxyR
EcoGene Accession Number: EG10681
K-12 Gene Accession Number: ECK3953
MG1655 Gene Identifier: b3961
Gene Name Mnemonic: Oxygen
Alternate Gene Symbols: momR; mor
Description: Oxidative and nitrosative stress transcriptional regulator
  # bp Upstream # bp Downstream
Verified Start MW: 34275.93 ---------305 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4158490
Left Intergenic Region

Name: oxyS_oxyR

Length: 95 bp gap

Orientation: Divergent

Left_end: 4158395

Right_end: 4158489

Centisome: 89.59

Genomic Address
Clockwise
Minute or Centisome (%) = 89.59
Right End: 4159407
Right Intergenic Region

Name: oxyR_sthA

Length: 18 bp overlap

Orientation: Convergent

Left_end: 4159390

Right_end: 4159407

Centisome: 89.61

OxyR responds to hydrogen peroxide by forming a Cys109-Cys208 disulphide bond which activates OxyR to up-regulate transcription of the oxidative stress regulon and the oxyS sRNA; OxyS then regulates expression of additional genes (Tao, 1989; Storz, 1990; Christman, 1989; Altuvia, 1997; Zheng, 1998; Lee, 2004). Both oxidized and reduced OxyR negatively auto-represses its own transcription, hence OxyR is a dual mode transcriptional regulator (Christman, 1989; Tao, 1991). During anaerobic respiration OxyR is S-nitrosylated due to nitrosative stress, activating OxyR to up-regulate genes in a distinct regulon that protect against S-nitrosothiols (Hausladen, 1996; Seth, 2012). Glutathionylation of OxyR in response to redox signaling may activate a third distinct OxyR regulon (Kim, 2002). Transcription of the catalase inhibitor protein YchF mRNA is repressed by OxyR (Wenk, 2012).

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BamHI EcoRI HindIII