GenePage for the pcm gene of Escherichia coli K-12

Primary Gene Name: pcm
EcoGene Accession Number: EG10689
K-12 Gene Accession Number: ECK2738
MG1655 Gene Identifier: b2743
Gene Name Mnemonic: Protein carboxyl methyltransferase
Alternate Gene Symbols: None
Description: Protein-L-isoaspartate O-methyltransferase, SAM-dependent; repair of isoaspartyl residues; mutant is suseptible to secondary stresses and has a competitive disadvantage in stationary phase; monomeric; overexpression confers tolerance to thermal str
  # bp Upstream # bp Downstream
Verified Start MW: 23257.77 ---------208 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2868893
Left Intergenic Region

Name: nlpD_pcm

Length: 139 bp gap

Orientation: Codirectional-

Left_end: 2868754

Right_end: 2868892

Centisome: 61.80

Genomic Address
Counterclockwise
Minute or Centisome (%) = 61.81
Right End: 2869519
Right Intergenic Region

Name: pcm_umpG

Length: 7 bp overlap

Orientation: Codirectional-

Left_end: 2869513

Right_end: 2869519

Centisome: 61.82

Pcm may work with SurE: they are co-transcribed and have addictive effects on isoaspartyl accumulation during stationary phase. Pcm was originally thought to be required for stationary phase and heat-stress survival, but this was due to a secondary rpoS mutation. otherPDB (P. furiosus): 1JG1.

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BamHI EcoRI HindIII