GenePage for the phnO gene of Escherichia coli K-12

Primary Gene Name: phnO
EcoGene Accession Number: EG10724
K-12 Gene Accession Number: ECK4086
MG1655 Gene Identifier: b4093
Gene Name Mnemonic: Phosphonate
Alternate Gene Symbols: None
Description: Aminoalkylphosphonate N-acetyltransferase
  # bp Upstream # bp Downstream
MW: 16569.85 ---------144 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4315104
Left Intergenic Region

Name: phnP_phnO

Length: 1 bp gap

Orientation: Codirectional-

Left_end: 4315103

Right_end: 4315103

Centisome: 92.96

Genomic Address
Counterclockwise
Minute or Centisome (%) = 92.96
Right End: 4315538
Right Intergenic Region

Name: phnO_phnN

Length: 14 bp overlap

Orientation: Codirectional-

Left_end: 4315525

Right_end: 4315538

Centisome: 92.97

PhnO is an aminoalkylphosphonate N-acetyltransferase whose physiological roles include detoxification of the D-alanine analog (S)-1-aminoethylphosphonate, as well as (S)-1-aminoethylphosphonate and aminomethylphosphonate catabolism (Hove-Jensen, 2012). The PhnO enzymatic activity was initially characterized in Salmonella typhimurium and is activated by a divalent cation (Errey, 2006). The Salmonella typhimurium N-terminal methionine is cleaved as determined by whole protein mass spectrometry (observed MW of 16,499 daltons) (Errey, 2006). Phosphonate utilization is cryptic in K-12. PhnO is a member of the GNAT acetyltransferase family.

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BamHI EcoRI HindIII