GenePage for the sdiA gene of Escherichia coli K-12

Primary Gene Name: sdiA
EcoGene Accession Number: EG10935
K-12 Gene Accession Number: ECK1915
MG1655 Gene Identifier: b1916
Gene Name Mnemonic: Suppress division inhibitors
Alternate Gene Symbols: uvrX
Description: Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones
  # bp Upstream # bp Downstream
MW: 28117.36 ---------240 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1996110
Left Intergenic Region

Name: yecF_sdiA

Length: 67 bp gap

Orientation: Convergent

Left_end: 1996043

Right_end: 1996109

Centisome: 43.00

Genomic Address
Counterclockwise
Minute or Centisome (%) = 43.00
Right End: 1996832
Right Intergenic Region

Name: sdiA_yecC

Length: 229 bp gap

Orientation: Codirectional-

Left_end: 1996833

Right_end: 1997061

Centisome: 43.02

Suppresses inhibitory effect of the MinC/MinD division inhibitor. N-acyl homoserine lactones act as folding switches for SdiA. LuxR family. SdiA has other global transcription targets such as uvrY, csrB, recN and nei. E. coli makes an unknown weak auto-inducer when grown in rich media. Most phenotypic effects require overproduction of SdiA. sdiA mutants are more sensitive to fluoroquinolones and have reduced AcrB protein, but are not defective in cell division. An sdiA ydiV double mutant has twofold reduced cAMP levels than inhibits quorum sensing system 2 (Zhou, 2008).

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BamHI EcoRI HindIII