GenePage for the thyA gene of Escherichia coli K-12

Primary Gene Name: thyA
EcoGene Accession Number: EG11002
K-12 Gene Accession Number: ECK2823
MG1655 Gene Identifier: b2827
Gene Name Mnemonic: Thymine
Alternate Gene Symbols: None
Description: Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer
  # bp Upstream # bp Downstream
Verified Start MW: 30479.69 ---------264 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2964361
Left Intergenic Region

Name: ppdA_thyA

Length: 183 bp gap

Orientation: Codirectional-

Left_end: 2964178

Right_end: 2964360

Centisome: 63.86

Genomic Address
Counterclockwise
Minute or Centisome (%) = 63.86
Right End: 2965155
Right Intergenic Region

Name: thyA_lgt

Length: 6 bp gap

Orientation: Codirectional-

Left_end: 2965156

Right_end: 2965161

Centisome: 63.88

Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.

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BamHI EcoRI HindIII