GenePage for the tyrA gene of Escherichia coli K-12

Primary Gene Name: tyrA
EcoGene Accession Number: EG11039
K-12 Gene Accession Number: ECK2597
MG1655 Gene Identifier: b2600
Gene Name Mnemonic: Tyrosine
Alternate Gene Symbols: None
Description: Tyrosine synthesis: chorismate mutase/prephenate dehydrogenase
  # bp Upstream # bp Downstream
Verified Start MW: 42042.52 ---------373 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2738948
Left Intergenic Region

Name: pheA_tyrA

Length: 42 bp gap

Orientation: Convergent

Left_end: 2738906

Right_end: 2738947

Centisome: 59.01

Genomic Address
Counterclockwise
Minute or Centisome (%) = 59.01
Right End: 2740069
Right Intergenic Region

Name: tyrA_aroF

Length: 10 bp gap

Orientation: Codirectional-

Left_end: 2740070

Right_end: 2740079

Centisome: 59.03

Bifunctional protein, mutase is N-terminal domain. TyrR regulon. tyrA is in the PurR regulon (Marbach, 2012). N-terminal protein sequencing identified a faint band of uncleaved precursor, indicating that some TyrA protein is not processed (Hudson, 1984). 2/904 TyrA peptide masses from MS analysis confirm this start codon and indicate that the initial Met is removed; 1/904 peptide masses indicate that occasionally the initial Met is not removed (Maillet, 2007).

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BamHI EcoRI HindIII