GenePage for the sfmZ gene of Escherichia coli K-12

Primary Gene Name: sfmZ
EcoGene Accession Number: EG11103
K-12 Gene Accession Number: ECK0528
MG1655 Gene Identifier: b0535
Gene Name Mnemonic: Salmonella fimbriae
Alternate Gene Symbols: fimZ(S.t.); ybcA
Description: Orphan two-component system response regulator protein; predicted DNA-binding transcriptional regulator; putative sfm operon positive regulator
  # bp Upstream # bp Downstream
MW: 23663.53 ---------210 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 563848
Left Intergenic Region

Name: sfmF_sfmZ

Length: 2 bp gap

Orientation: Convergent

Left_end: 563846

Right_end: 563847

Centisome: 12.15

Genomic Address
Counterclockwise
Minute or Centisome (%) = 12.15
Right End: 564480
Right Intergenic Region

Name: sfmZ_argU

Length: 242 bp gap

Orientation: Divergent

Left_end: 564481

Right_end: 564722

Centisome: 12.16

Salmonella FimZ is a positve regulator of Salmonella fim operon expression (Yeh, 1995). The sfmACDHF-sfmZ genes in centisome 12 are a remnant of a region that is orthologous to the Salmonella enterica fimA[I]CDHF-fim[WY]Z convergent operons also in centisome 12; both are adjacent to the argU tRNA gene; an ancestral sfmWYZ operon was apparently disrupted by the insertion of the DLP prophage, resulting in the loss of the sfmWY genes; fimI (like E. coli fimI) and STM05551 (between fimW and fimY) are specific to Salmonella. The cognate sensor histidine kinase for SfmZ(FimZ) and the orphan response regulator FimZ in Salmonella is unknown, but evidence suggests it should exist elsewhere where on the Salmonella chromosome, and by analogy also SfmZ might have a cognate sensor elsewhere; both fimY and fimZ are needed for fim expression in Salmonella; FimW is a FimZ-interacting proteni that does not bind DNA although it appears to be distantly related to the DNA-binding response regulators (Zeiner, 2013). SfmZ(FimZ) has an N-terminal response regulator receiver domain (PF00072) and a C-terminal LuxR-type DNA-binding HTH transcriptional regulator output domain (PF00196).

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BamHI EcoRI HindIII