GenePage for the entH gene of Escherichia coli K-12

Primary Gene Name: entH
EcoGene Accession Number: EG11105
K-12 Gene Accession Number: ECK0590
MG1655 Gene Identifier: b0597
Gene Name Mnemonic: Enterochelin
Alternate Gene Symbols: ybdB
Description: Enterobactin synthesis proofreading thioesterase
  # bp Upstream # bp Downstream
MW: 14970.10 ---------137 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 629300
Left Intergenic Region

Name: entA_entH

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 629298

Right_end: 629299

Centisome: 13.56

Genomic Address
Clockwise
Minute or Centisome (%) = 13.56
Right End: 629713
Right Intergenic Region

Name: entH_cstA

Length: 180 bp gap

Orientation: Codirectional+

Left_end: 629714

Right_end: 629893

Centisome: 13.57

EntH corrects misacylation of the aryl carrier protein domain of EntB (Guo, 2009; Chen, 2009). EntH is a member of the HotDog superfamily of thioesterases and dehydratases (Pfam CL0050, PF03061; PDB 1VH9) (Dillon, 2004; Badger, 2005). EntH has acyl-CoA esterase activity in vitro (Kuznetsova, 2005). EntH has low level DHNA-CoA thioesterase activity but entH still mutants synthesize enterobactin (Chen, 2013). In addition to its role in iron acquisition, enterobactin plays a role in oxidative stress protection and is required to form colonies on M9 minimal media aerobically (Adler, 2014).

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BamHI EcoRI HindIII