GenePage for the ybgC gene of Escherichia coli K-12

Primary Gene Name: ybgC
EcoGene Accession Number: EG11110
K-12 Gene Accession Number: ECK0725
MG1655 Gene Identifier: b0736
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Acyl-CoA thioesterase; possibly involved in phospholipid metabolism; binds ACP; acyl-ACP could be native substrate
  # bp Upstream # bp Downstream
MW: 15562.00 ---------134 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 774752
Left Intergenic Region

Name: ybgE_ybgC

Length: 149 bp gap

Orientation: Codirectional+

Left_end: 774603

Right_end: 774751

Centisome: 16.69

Genomic Address
Clockwise
Minute or Centisome (%) = 16.69
Right End: 775156
Right Intergenic Region

Name: ybgC_tolQ

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 775153

Right_end: 775156

Centisome: 16.70

YbgC-ACP forms an inner membrane complex with PssA and PlsB and is therefore presumed to be involved in phospholipid biosynthesis, possibly in the release of lipids from ACP or in the regulation of the stability or activity of the phospholipid synthetic enzymes PssA and PlsB, however a ybgC mutant did not exhibit qualitative differences in phospholipid composition (Gully, 2006). A ybgC insertion mutation has no obvious phenotype and is not polar on tolQ (Sun, 1987). It was suggested that YbgC might be DHNA-CoA thioesterase since the YbgC homolog Slr0204 of Synechocystis catalyzes DHNA-CoA hydrolysis, but it was subsequently shown that YbgC has no DHNA-CoA thioesterase activity and the real DHNA-CoA thioesterase is MenI(YdiI) (Jiang, 2010; Chen, 2013). ybgC is the first gene in the ybgC-tolQRA operon (Vianney, 1996; Muller, 1997). YbgC is not part of the Tol-Pal complex. YbgC is a low abundance protein (Fountoulakis, 1999). YbgC is a member of the hotdog superfamily of thioesterases and dehydratases (Pfam CL0050, PF03061; PDB 1S5U) (Dillon, 2004; Kim Y., Joachimiak A., Skarina T., Savchenko A., Edwards A., unpublished).

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BamHI EcoRI HindIII