GenePage for the melR gene of Escherichia coli K-12

Primary Gene Name: melR
EcoGene Accession Number: EG11230
K-12 Gene Accession Number: ECK4111
MG1655 Gene Identifier: b4118
Gene Name Mnemonic: Melibiose
Alternate Gene Symbols: None
Description: Transcriptional activator for melAB, AraC family; autoregulatory repressor in absence of co-activator melibiose
  # bp Upstream # bp Downstream
MW: 34927.88 ---------302 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4340720
Left Intergenic Region

Name: adiA_melR

Length: 198 bp gap

Orientation: Codirectional-

Left_end: 4340522

Right_end: 4340719

Centisome: 93.51

Genomic Address
Counterclockwise
Minute or Centisome (%) = 93.52
Right End: 4341628
Right Intergenic Region

Name: melR_melA

Length: 282 bp gap

Orientation: Divergent

Left_end: 4341629

Right_end: 4341910

Centisome: 93.54

The C-terminal domain of the RNA polymerase alpha subunit is important for MelR-dependent activation of the melAB promoter. An 18 base pair MelR binding site is necessary for MelR transcription activation because it ensures correct interactions with RNA polymerase sigma subunit.

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BamHI EcoRI HindIII