GenePage for the nfsA gene of Escherichia coli K-12

Primary Gene Name: nfsA
EcoGene Accession Number: EG11261
K-12 Gene Accession Number: ECK0842
MG1655 Gene Identifier: b0851
Gene Name Mnemonic: Nitrofurazone sensitivity
Alternate Gene Symbols: mda18; mdaA; snrA(S.t.); ybjB
Description: Nitroreductase A; oxygen-insensitive, NADPH, FMN-dependent, major; reduces a variety of nitroaromatics, e.g. dihydropteridine, nitrofurantoin, nitrofurazone, quinones; SoxS regulon; homodimeric
  # bp Upstream # bp Downstream
MW: 26800.69 ---------240 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 891184
Left Intergenic Region

Name: ybjC_nfsA

Length: 17 bp overlap

Orientation: Codirectional+

Left_end: 891184

Right_end: 891200

Centisome: 19.20

Genomic Address
Clockwise
Minute or Centisome (%) = 19.20
Right End: 891906
Right Intergenic Region

Name: nfsA_rimK

Length: 60 bp gap

Orientation: Codirectional+

Left_end: 891907

Right_end: 891966

Centisome: 19.22

NfsA overexpression results in resistance to cytotoxic drugs including Adriamycin and the tumoricidal agent DMP 840. nfsA is in the MprA regulon (Marbach, 2012). nfsA is co-transcribed with ybjC. nfsA, nfsB, rutE, and ydjA are paralogs. 16/258 NfsA peptide masses from MS analysis confirm this start codon and indicate that the initial Met is not removed (Maillet, 2007).

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BamHI EcoRI HindIII