GenePage for the ychF gene of Escherichia coli K-12

Primary Gene Name: ychF
EcoGene Accession Number: EG11404
K-12 Gene Accession Number: ECK1191
MG1655 Gene Identifier: b1203
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: engD; gtp1
Description: Catalase inhibitor protein; ATPase, K+-dependent, ribosome-associated; monomeric
  # bp Upstream # bp Downstream
Verified Start MW: 39667.32 ---------363 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1256721
Left Intergenic Region

Name: ycgV_ychF

Length: 768 bp gap

Orientation: Codirectional-

Left_end: 1255953

Right_end: 1256720

Centisome: 27.06

Genomic Address
Minute or Centisome (%) = 27.07
Right End: 1257812
Right Intergenic Region

Name: ychF_pth

Length: 116 bp gap

Orientation: Codirectional-

Left_end: 1257813

Right_end: 1257928

Centisome: 27.10

Overexpression of YchF causes hydrogen peroxide hypersensitivity probably due to direct binding and inhibition of the catalase-peroxidase KatG by YchF, dependent on the ATPase activity of YchF and regulated by the YchF phosphorylation state at Ser16; ychF transcription is repressed by OxyR (Wenk, 2012). ychF is in the pth operon and is an obgE paralog; pth transcript stability depends on ychF integrity. otherPDB (H. influenzae): 1JAL. H. influenzae YchF binds GTP and dsDNA. A ychF deletion is reported to form filaments at 42C by Dassain (1999). ychF null mutant forms small colonies. YchF has potassium-dependent ATPase activity and ATP-independent 50S and 30S ribosomal subunit binding activity (Tomar, 2011).

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