GenePage for the wrbA gene of Escherichia coli K-12

Primary Gene Name: wrbA
EcoGene Accession Number: EG11540
K-12 Gene Accession Number: ECK0995
MG1655 Gene Identifier: b1004
Gene Name Mnemonic: W(Trp) repressor binding
Alternate Gene Symbols: None
Description: NAD(P)H:quinone oxidoreductase, type IV NQO; may protect against oxidative stress; dimeric, binds one FMN per monomer
  # bp Upstream # bp Downstream
Verified Start MW: 20845.56 ---------198 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1067112
Left Intergenic Region

Name: yccJ_wrbA

Length: 20 bp gap

Orientation: Codirectional-

Left_end: 1067092

Right_end: 1067111

Centisome: 22.99

Genomic Address
Counterclockwise
Minute or Centisome (%) = 22.99
Right End: 1067708
Right Intergenic Region

Name: wrbA_ymdF

Length: 372 bp gap

Orientation: Divergent

Left_end: 1067709

Right_end: 1068080

Centisome: 23.00

WrbA was originally identified as a stationary phase TrpR-binding protein that affected the interaction of TrpR with its operator sites in vitro (Yang, 1993). However, subsequent experiments found similar effects with BSA, concluding that WrbA does not influence TrpR-operator binding in vitro (Grandori, 1998). Although WrbA may affect the association between Trp repressor and operators in stationary phase in vivo (Yang, 1993), this may be a non-specific effect. EcoArray search results indicate that wrbA transcripts are altered by rpoS, relA, trpA and trpR mutations, among others. wrbA is repressed by OxyS overexpression (Tjaden, 2006). otherPDB: 1ZWL(P.aeruginosa).

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BamHI EcoRI HindIII