GenePage for the lptD gene of Escherichia coli K-12

Primary Gene Name: lptD
EcoGene Accession Number: EG11569
K-12 Gene Accession Number: ECK0055
MG1655 Gene Identifier: b0054
Gene Name Mnemonic: LPS transport
Alternate Gene Symbols: imp; ostA; yabG
Description: LPS assembly OM complex LptDE, beta-barrel component
  # bp Upstream # bp Downstream
Verified Start MW: 89671.14 ---------784 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 54755
Left Intergenic Region

Name: surA_lptD

Length: 52 bp gap

Orientation: Codirectional-

Left_end: 54703

Right_end: 54754

Centisome: 1.18

Genomic Address
Counterclockwise
Minute or Centisome (%) = 1.18
Right End: 57109
Right Intergenic Region

Name: lptD_djlA

Length: 254 bp gap

Orientation: Divergent

Left_end: 57110

Right_end: 57363

Centisome: 1.23

LptDE is the terminal LPS OM receptor for ABC LPS exporter complex LptBFGC; LptE binds LPS (Chng, 2010). The outer membrane of an lptD(imp) mutant is permeable to large maltodextrins and sensitive to antibiotics and detergents (Sampson, 1989, Eggert, 2001). lptD is stress induced. lptD is paralogous to lptA. The lptD(imp) gene encodes an essential outer membrane protein (Braun, 2002, Wu, 2006). A deletion mutant of lptD is non-viable (Baba, 2006). The LptDE structure from S. flexneri (an E. coli strain) in PDB 4Q35 differs in only 3 amino acids out of 784 for LptD and 1/175 for LptE (Qiao, 2014).

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BamHI EcoRI HindIII