GenePage for the mfd gene of Escherichia coli K-12

Primary Gene Name: mfd
EcoGene Accession Number: EG11619
K-12 Gene Accession Number: ECK1100
MG1655 Gene Identifier: b1114
Gene Name Mnemonic: Mutation frequency decline
Alternate Gene Symbols: None
Description: Transcription repair coupling factor
  # bp Upstream # bp Downstream
MW: 129982.73 ---------1148 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1170518
Left Intergenic Region

Name: ldtC_mfd

Length: 143 bp gap

Orientation: Codirectional-

Left_end: 1170375

Right_end: 1170517

Centisome: 25.21

Genomic Address
Counterclockwise
Minute or Centisome (%) = 25.22
Right End: 1173964
Right Intergenic Region

Name: mfd_ycfT

Length: 127 bp gap

Orientation: Codirectional-

Left_end: 1173965

Right_end: 1174091

Centisome: 25.29

Mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. Arrested (backtracked) RNAP complexes are are also rescued by Mfd promoting forward translocation. Mfd structure resembles UvrB, including UvrA binding site, but no ATP-binding site.

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BamHI EcoRI HindIII