GenePage for the dgcZ gene of Escherichia coli K-12

Primary Gene Name: dgcZ
EcoGene Accession Number: EG11643
K-12 Gene Accession Number: ECK1528
MG1655 Gene Identifier: b1535
Gene Name Mnemonic: Diguanylate cyclase, zinc-sensing
Alternate Gene Symbols: ydeG; ydeH
Description: Diguanylate cyclase, zinc-sensing
  # bp Upstream # bp Downstream
MW: 33863.49 ---------296 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1622960
Left Intergenic Region

Name: mgrR_dgcZ

Length: 45 bp gap

Orientation: Codirectional-

Left_end: 1622915

Right_end: 1622959

Centisome: 34.96

Genomic Address
Counterclockwise
Minute or Centisome (%) = 34.97
Right End: 1623850
Right Intergenic Region

Name: dgcZ_ydeI

Length: 254 bp gap

Orientation: Codirectional-

Left_end: 1623851

Right_end: 1624104

Centisome: 34.98

DgcZ(YdeH) is a zinc-sensing diguanylate cyclase that inhibits biofilm formation (Zähringer, 2013). Full induction of pgaD requires c-di-GMP specifically produced by DgcZ(YdeH) (Boehm, 2009). DgcZ(YdeH) mRNA is translationally repressed by CsrA (Jonas, 2008). DgcZ(YdeH) overexpression causes a 20-fold increase in c-di-GMP and represses motility, but a dgcZ(ydeH) mutant has little effect (Jonas, 2008). The results of Jonas (2008) might indicate that although the c-di-GMP spike inhibits motility it is not known if this is the normal function of the overproduced diguanylate cyclase or if the overexpression induced non-physiological crosstalk. DgcZ(YdeH) has an N-terminal MCP-signal associated domain (PF13682) that is often C-terminal to an MCP-signal domain (PF00015) not found in DgcZ(YdeH) family proteins but may be indicative of a physiological role in chemotaxis or motility; DgcZ(YdeH) has a C-terminal diguanylate cyclase GGDEF domain.

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BamHI EcoRI HindIII