GenePage for the gpmA gene of Escherichia coli K-12

Primary Gene Name: gpmA
EcoGene Accession Number: EG11699
K-12 Gene Accession Number: ECK0744
MG1655 Gene Identifier: b0755
Gene Name Mnemonic: Glycerol P mutase
Alternate Gene Symbols: gpm
Description: Phosphoglycerate mutase, 2,3-bisphosphoglycerate-dependent; dPGM; Fur regulon; dimeric
  # bp Upstream # bp Downstream
Verified Start MW: 28556.40 ---------250 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 786843
Left Intergenic Region

Name: aroG_gpmA

Length: 157 bp gap

Orientation: Convergent

Left_end: 786686

Right_end: 786842

Centisome: 16.95

Genomic Address
Counterclockwise
Minute or Centisome (%) = 16.95
Right End: 787595
Right Intergenic Region

Name: gpmA_galM

Length: 201 bp gap

Orientation: Codirectional-

Left_end: 787596

Right_end: 787796

Centisome: 16.97

Purified GpmA has 10-20 times higher specific actvity than GpmM (Fraser, 1999; Foster, 2010). gpmA mutants exhibit a long lag when overnight minimal medium-grown cells are plated on rich medium; gpmA or gpmM clones rescued the defect (Foster, 2010). GpmA does not have phosphatase activity against para-nitrophenyl phosphate (Foster, 2010). gpmM and gpmA are non-essential genes but phosphoglycerate mutase is an essential enzyme since a gpmA gpmM double mutation is lethal (Foster, 2010). GpmA is a member of the histidine phosphatase superfamily, represented by the InterPro superfamily profile IPR013078 and CDD cl11399 (also called the dPGM superfamily) including phosphatases and fructose 2,6-bisphosphatases as well as factor-dependent phosphoglycerate mutases; the histidine phosphatase superfamily is characterized by a conserved histidine that is transiently phosphorylated during the catalytic cycle (Fothergill-Gilmore, 1989; Fothergill-Gilmore, 1990; Jedrzejas, 2000; Johnsen, 2007; Rigden, 2008; Foster, 2010). HT_Cmplx25_Cyt: GpmA+GpmM.

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BamHI EcoRI HindIII