GenePage for the cbrA gene of Escherichia coli K-12

Primary Gene Name: cbrA
EcoGene Accession Number: EG11714
K-12 Gene Accession Number: ECK3682
MG1655 Gene Identifier: b3690
Gene Name Mnemonic: CreB-regulated
Alternate Gene Symbols: yidS
Description: Colicin M resistance protein; FAD-binding protein, predicted polyisoprenoid oxidoreductase
  # bp Upstream # bp Downstream
MW: 40142.44 ---------354 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3869377
Left Intergenic Region

Name: yidR_cbrA

Length: 67 bp gap

Orientation: Divergent

Left_end: 3869310

Right_end: 3869376

Centisome: 83.36

Genomic Address
Clockwise
Minute or Centisome (%) = 83.36
Right End: 3870441
Right Intergenic Region

Name: cbrA_dgoT

Length: 4 bp overlap

Orientation: Convergent

Left_end: 3870438

Right_end: 3870441

Centisome: 83.38

CbrA overexpression increases resistance to colicin M (Cma) and osmotic shock while a cbrA mutant is more sensitive to colicin M; purified CbrA has non-covalently bound FAD; CbrA may modify the Colicin M substrate, the C55 polyisoprenyl-PP- 525 MurNAc(pentapeptide)-GlcNAc, rendering it resistant to cleavage by Colicin M but this could not be demonstrated in vitro probably due to the insoluble nature of isolated CbrA protein (Helbig, 2012). cbrA is in the creBC regulon and is induced by the AI-2 pheromone.

Go to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePageGo to GenePage

BamHI EcoRI HindIII