GenePage for the hchA gene of Escherichia coli K-12

Primary Gene Name: hchA
EcoGene Accession Number: EG11755
K-12 Gene Accession Number: ECK1963
MG1655 Gene Identifier: b1967
Gene Name Mnemonic: Heat-inducible CHaperone
Alternate Gene Symbols: gloC; yedU; yzzC
Description: Glyoxalase III and molecular chaperone Hsp31, heat-inducible; weak aminopeptidase activity; homodimeric
  # bp Upstream # bp Downstream
Verified Start MW: 31190.46 ---------283 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2035835
Left Intergenic Region

Name: yedS_hchA

Length: 591 bp gap

Orientation: Codirectional+

Left_end: 2035244

Right_end: 2035834

Centisome: 43.85

Genomic Address
Clockwise
Minute or Centisome (%) = 43.86
Right End: 2036686
Right Intergenic Region

Name: hchA_yedV

Length: 107 bp gap

Orientation: Convergent

Left_end: 2036687

Right_end: 2036793

Centisome: 43.88

Hsp31(HchA) is glyoxalase III, which catalyzes a cofactor-independent conversion of methylglyoxal to D-lactate (Misra, 1995; Subedi, 2011). Glyoxalase III (HchA) is a stationary phase enzyme regulated by RpoS (Benov, 2004). Hsp31(HchA) chaperone activity is inhibited at high temperature by ATP. HchA is involved in the processing of 8-12mer peptides in vivo. HchA is a weak active site cysteine peptidase. HchA is a member of a family variously called the C56 peptidase family, the PfpI/HchA peptidase/chaperone family, or the DJ-1/PARK7 superfamily.

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BamHI EcoRI HindIII