GenePage for the grcA gene of Escherichia coli K-12

Primary Gene Name: grcA
EcoGene Accession Number: EG11784
K-12 Gene Accession Number: ECK2577
MG1655 Gene Identifier: b2579
Gene Name Mnemonic: Glycine Radical Cofactor, Autonomous
Alternate Gene Symbols: yfiD
Description: Autonomous glycine radical cofactor; can reactivate pyruvate formate lyase after oxidative stress; induced by low pH or propionate; pyruvate formate lyase homolog, spare part for PFL
  # bp Upstream # bp Downstream
Verified Start MW: 14284.19 ---------127 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2716066
Left Intergenic Region

Name: eamB_grcA

Length: 55 bp gap

Orientation: Convergent

Left_end: 2716011

Right_end: 2716065

Centisome: 58.51

Genomic Address
Counterclockwise
Minute or Centisome (%) = 58.52
Right End: 2716449
Right Intergenic Region

Name: grcA_ung

Length: 304 bp gap

Orientation: Divergent

Left_end: 2716450

Right_end: 2716753

Centisome: 58.52

GrcA(YfiD) is required for MazF-mediated cell death after either DNA damage or inhibition of translation (Amitai, 2009). A grcA(yfiD) mutant excretes increased levels of organic acids when grown under oxygen-starved conditions. Radical activation mediated by PflA; deactivation not mediated by AdhE. Regulated by FNR, ArcA and PdhR. HT_Cmplx8_Cyt: GrcA(YfiD)+PflB. HT_Cmplx9_Cyt: GrcA(YfiD)+TdcE.

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BamHI EcoRI HindIII