GenePage for the rpoE gene of Escherichia coli K-12

Primary Gene Name: rpoE
EcoGene Accession Number: EG11897
K-12 Gene Accession Number: ECK2571
MG1655 Gene Identifier: b2573
Gene Name Mnemonic: RNA polymerase
Alternate Gene Symbols: sigE
Description: RNA polymerase sigma E factor; role in extracytoplasmic, high temperature and oxidative stress responses; sigma 24 initiation factor
  # bp Upstream # bp Downstream
MW: 21695.74 ---------191 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2709437
Left Intergenic Region

Name: rseA_rpoE

Length: 32 bp gap

Orientation: Codirectional-

Left_end: 2709405

Right_end: 2709436

Centisome: 58.37

Genomic Address
Counterclockwise
Minute or Centisome (%) = 58.37
Right End: 2710012
Right Intergenic Region

Name: rpoE_nadB

Length: 407 bp gap

Orientation: Divergent

Left_end: 2710013

Right_end: 2710419

Centisome: 58.38

RpoE encodes Sigma E, a Group IV sigma factor that promotes open complex formation by flipping out a single nucleotide from the non-template DNA strand at the -10 element (Campagne, 2014). rpoE is transiently induced after a cold shock, dependent on the presence of PNPase. rpoE is induced by, and increases resistance to, Cd(II), Zn(II) and Cu(II). rpoE is an essential gene that can be disrupted only in the presence of unlinked suppressor mutations, e.g. ydcQ (De Las Penas, 1997, Button, 2006). RpoE is a type IV sigma factor. 7/56 RpoE peptide masses from MS analysis confirm this start codon and indicate that the initial Met is removed (Maillet, 2007).

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BamHI EcoRI HindIII