GenePage for the aphA gene of Escherichia coli K-12

Primary Gene Name: aphA
EcoGene Accession Number: EG11934
K-12 Gene Accession Number: ECK4047
MG1655 Gene Identifier: b4055
Gene Name Mnemonic: Acid phosphatase
Alternate Gene Symbols: hobH; napA; yjbP
Description: Acid phosphatase, periplasmic, class B, nucleotidase; active on 3'- and 5'-mononucleotides and monodeoxynucleotides; glucose-repressed; monomeric
  # bp Upstream # bp Downstream
Verified Start MW: 26103.54 ---------237 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4269414
Left Intergenic Region

Name: yjbS_aphA

Length: 401 bp gap

Orientation: Divergent

Left_end: 4269013

Right_end: 4269413

Centisome: 91.97

Genomic Address
Clockwise
Minute or Centisome (%) = 91.98
Right End: 4270127
Right Intergenic Region

Name: aphA_yjbQ

Length: 110 bp gap

Orientation: Codirectional+

Left_end: 4270128

Right_end: 4270237

Centisome: 92.00

A misidentification of the Salmonella pncC gene occurred when a selection for NMN catabolism mutants identified a gene (aphA) with a metabolic activity required for NMN uptake, not the catabolic enzyme NMN deamidase; the periplasmic AphA is required for the de-phosphorylation of MNM to form nicotinamide riboside, the PnuC transporter substrate (Cheng, 1995; Grose, 2005). Mutants arrest cell division after hyperosmoshock and overexpress SeqA; also binds hemi-methylated oriC DNA in vitro. As a periplasmic DNA-binding protein, AphA may play a role during DNA transformation.

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BamHI EcoRI HindIII