GenePage for the nikA gene of Escherichia coli K-12

Primary Gene Name: nikA
EcoGene Accession Number: EG12075
K-12 Gene Accession Number: ECK3460
MG1655 Gene Identifier: b3476
Gene Name Mnemonic: Nickel
Alternate Gene Symbols: hydC; hydD
Description: Nickel/heme ABC transporter periplasmic binding protein
  # bp Upstream # bp Downstream
Verified Start MW: 58719.02 ---------524 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3613667
Left Intergenic Region

Name: acpT_nikA

Length: 110 bp gap

Orientation: Codirectional+

Left_end: 3613557

Right_end: 3613666

Centisome: 77.85

Genomic Address
Clockwise
Minute or Centisome (%) = 77.85
Right End: 3615241
Right Intergenic Region

Name: nikA_nikB

Length: 1 bp overlap

Orientation: Codirectional+

Left_end: 3615241

Right_end: 3615241

Centisome: 77.89

NikA binds hemin and protoporphyrin IX (Shepherd, 2007). NikA binds nickel as Ni-(L-His)(2) (Chivers, 2012). Mutants display nickel-remediated formate hydrogen-lyase, hydrogenase, and hydrogenase-related fumarase defects. FNR regulon. Although previously suggested to be a Tar-dependent Ni-repellant chemosensor, NikA is not involved in the Ni(2+) repellant chemotactic response (de Pina, 1996; Englert, 2010).

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BamHI EcoRI HindIII