GenePage for the yjjG gene of Escherichia coli K-12

Primary Gene Name: yjjG
EcoGene Accession Number: EG12115
K-12 Gene Accession Number: ECK4365
MG1655 Gene Identifier: b4374
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: Noncanonical pyrimidine nucleotide house-cleaning phosphatase; dUMP phosphatase activity
  # bp Upstream # bp Downstream
MW: 25300.62 ---------225 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4608646
Left Intergenic Region

Name: rimI_yjjG

Length: 14 bp gap

Orientation: Codirectional+

Left_end: 4608632

Right_end: 4608645

Centisome: 99.29

Genomic Address
Clockwise
Minute or Centisome (%) = 99.29
Right End: 4609323
Right Intergenic Region

Name: yjjG_prfC

Length: 90 bp gap

Orientation: Codirectional+

Left_end: 4609324

Right_end: 4609413

Centisome: 99.30

Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. (2005, 2006). yjjG mutants are sensitive to 5-fluoropyrimidine derivatives, such as 5-fluoro-2'-deoxyuridine (Titz, 2007). YjjG has a strict metal requirement for catalytic activity. Poorly utilized substrates include UDP, TDP and a variety of nucleotide monophosphates. A yjjG mutation blocks the utilization of thymine to feed a thyA auxotroph since it must first be converted to thymidine and dUMP dephosphorylated by YjjG is needed for that conversion (Weiss, 2006). YjjG is also called nucleoside 5'-monophosphate phosphohydrolase. HAD superfamily.

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BamHI EcoRI HindIII