GenePage for the rssB gene of Escherichia coli K-12

Primary Gene Name: rssB
EcoGene Accession Number: EG12121
K-12 Gene Accession Number: ECK1230
MG1655 Gene Identifier: b1235
Gene Name Mnemonic: Regulation of Sigma S
Alternate Gene Symbols: hnr; mviA(S.t.); sprE; verA; ychL
Description: Response regulator binding RpoS to initiate proteolysis by ClpXP; required for the PcnB-degradosome interaction during stationary phase; major cognate sensor kinase is ArcB
  # bp Upstream # bp Downstream
MW: 37302.22 ---------337 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1290242
Left Intergenic Region

Name: rssA_rssB

Length: 91 bp gap

Orientation: Codirectional+

Left_end: 1290151

Right_end: 1290241

Centisome: 27.80

Genomic Address
Clockwise
Minute or Centisome (%) = 27.80
Right End: 1291255
Right Intergenic Region

Name: rssB_galU

Length: 201 bp gap

Orientation: Codirectional+

Left_end: 1291256

Right_end: 1291456

Centisome: 27.82

The protyolysis initiated by RssB binding to RpoS is inhibited by three anti-RssB anti-adaptor proteins IraP, IraM, and IraD in response to different stresses (Bougdour, 2006; Bougdour, 2008). RssB and ArcA are both phosphorylated by the ArcA sensor histidine protein kinase as part of a three-component system (Mika, 2005). RssB-initiated protyolysis of RpoS does not require the RssB response regulator phosphorylation site (Peterson, 2004). A yliE rssB9(hnr) double null mutant has significantly increased lycopene production in 1X M9; the effect may be salt-suppressible as it is not seen in 2X M9 (Alper, 2008). RssB is not a transcriptional regulator and does not have a DNA-binding domain typical of most response regulators. RssB(SprE) is required to maintain the association of PcnB with the degradosome during stationary phase (Carabetta, 2010).

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BamHI EcoRI HindIII