GenePage for the pagP gene of Escherichia coli K-12

Primary Gene Name: pagP
EcoGene Accession Number: EG12180
K-12 Gene Accession Number: ECK0615
MG1655 Gene Identifier: b0622
Gene Name Mnemonic: PhoP-activated gene
Alternate Gene Symbols: crcA; ybeG
Description: Phospholipid:lipid A palmitoyltransferase; confers resistance to cationic antimicrobial peptides; multicopy suppressor of camphor-induced or mukB mutant chromosome condensation
  # bp Upstream # bp Downstream
Verified Start MW: 21769.58 ---------186 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 656557
Left Intergenic Region

Name: dcuC_pagP

Length: 588 bp gap

Orientation: Divergent

Left_end: 655969

Right_end: 656556

Centisome: 14.13

Genomic Address
Clockwise
Minute or Centisome (%) = 14.14
Right End: 657117
Right Intergenic Region

Name: pagP_cspE

Length: 174 bp gap

Orientation: Codirectional+

Left_end: 657118

Right_end: 657291

Centisome: 14.16

PagP(CrcA) transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A (or its precursors). A cspE-flc(crcB) double mutant confers camphor-sensitivity and exacerbates the phenotypes of topo IV and MukB mutants (Sand, 2003). A cspE-pagP-flc(crcB) clone compensates for a loss of the normal condensin MukBEF and recondenses chromosomes decondensed by camphor treatment (Hu, 1996; Sand, 2003). A cspE-pagP-flc(crcB) clone increases plasmid DNA supercoiling and reduces DNA gyrase and topoisomerase IV mutant phenotypes (Sand, 2003). The phoP-activation phenotype was initially characterized in Salmonella then confirmed in E. coli (Jia, 2004). SignalP-NN incorrectly predicts a 27 aa signal peptide, but the verified cleavage site after 25 aa is predicted as a second possible cleavage site by SignalP-NN and as the only cleavage site by the more recent SignalP-HMM predictor (see SignalP button below). Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced-expression subset.

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BamHI EcoRI HindIII