GenePage for the chbG gene of Escherichia coli K-12

Primary Gene Name: chbG
EcoGene Accession Number: EG12198
K-12 Gene Accession Number: ECK1731
MG1655 Gene Identifier: b1733
Gene Name Mnemonic: Chitobiose
Alternate Gene Symbols: celG; ydjC
Description: Chito-oligosaccharide deacetylase
  # bp Upstream # bp Downstream
MW: 27773.72 ---------249 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1816386
Left Intergenic Region

Name: katE_chbG

Length: 257 bp gap

Orientation: Convergent

Left_end: 1816129

Right_end: 1816385

Centisome: 39.13

Genomic Address
Counterclockwise
Minute or Centisome (%) = 39.13
Right End: 1817135
Right Intergenic Region

Name: chbG_chbF

Length: 12 bp gap

Orientation: Codirectional-

Left_end: 1817136

Right_end: 1817147

Centisome: 39.15

ChbG is a chitobiose and chitotriose deacetylase with a role in both regulation and catabolism of chito-oligosaccharides (Verma, 2012). ChbG(YdjC) has promiscuous phosphonoesterase activity against a xenobiotic phosphorylated phosphonate (Kheronsky, 2011). chbG(ydjC) is a gene in the chb chitobiose catabolism operon. ChbG(YdjC) is a member of the InterPro IPR002509 polysaccharide deacetylase superfamily including yeast chitin deacetylase. The chb operon is induced by N,N'-diacetylchitobiose. The chb operon was previously thought to encode a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose-independent, but a fully induced operon did not support growth on cellobiose, implying a mutation altering the substrate specificity is needed; several candidate mutations were noted in Genbank, but not proven to alter the specificity of the system (Keyhani, 1997). In contrast, a later study claim that mutations making the operon expression high-level constitutive by chbR and nagC mutations are sufficient for the Cel+ phenotype and that no mutations altering substrate specificity are required (Kachroo, 2007). UPF0249 family.

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BamHI EcoRI HindIII