GenePage for the kdgK gene of Escherichia coli K-12

Primary Gene Name: kdgK
EcoGene Accession Number: EG12253
K-12 Gene Accession Number: ECK3511
MG1655 Gene Identifier: b3526
Gene Name Mnemonic: Ketodeoxygluconate
Alternate Gene Symbols: yhjI
Description: 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase
  # bp Upstream # bp Downstream
MW: 33962.36 ---------309 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3679419
Left Intergenic Region

Name: yhjH_kdgK

Length: 231 bp gap

Orientation: Divergent

Left_end: 3679188

Right_end: 3679418

Centisome: 79.26

Genomic Address
Clockwise
Minute or Centisome (%) = 79.27
Right End: 3680348
Right Intergenic Region

Name: kdgK_yhjJ

Length: 95 bp gap

Orientation: Convergent

Left_end: 3680349

Right_end: 3680443

Centisome: 79.29

KDG is derived from pectin, a common plant heteropolysaccharide, although E. coli K-12 does not secrete pectinases or uptake pectin oligosaccharides and has only the core KDG regulon as compared to plant pathogens like Erwinia chrysanthemi, whose extracellular pectate lyases and intacellular oligogalacturonate lyase breaks pectin down mainly into 5-keto-4-deoxyuronate (DKI) monomers and to a lesser extent polygalacturonase-generated galacturonate; in E. coli K-12 galacturonate uptake and degradation is mediated by the ExuT permease and the UxaABC catabolic enzymes producing KDG, respectively, and DKI is imported by the KdgR-regulated KDG importer KdgT and catabolized to KDG by the KdgR-regulated KduID enyzymes, also producing KDG; KDG is converted to pyruvate and glyceraldehyde-3-phosphate by KdsK and Eda(KdsA) (Rodionov, 2004; Hugouvieux-Cotte-Pattat, 1996). KdgK is elevated 3-5X during growth at 4C (enabled by Oleispira antarctica Cpn10/60 transgene). This reliable gene assignment of kdgK is based on DNA and protein sequence analysis consistent with the published map position and function, respectively, of KdgK (Sofia, 1994). HT_Cmplx44_Mem: GlpC+KdgK+YahK.

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BamHI EcoRI HindIII