GenePage for the ettA gene of Escherichia coli K-12

Primary Gene Name: ettA
EcoGene Accession Number: EG12343
K-12 Gene Accession Number: ECK4383
MG1655 Gene Identifier: b4391
Gene Name Mnemonic: Energy-dependent translational throttle
Alternate Gene Symbols: yjjK
Description: Energy-dependent translational throttle A; ABC-F family protein
  # bp Upstream # bp Downstream
Verified Start MW: 62442.88 ---------555 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4628855
Left Intergenic Region

Name: nadR_ettA

Length: 307 bp gap

Orientation: Convergent

Left_end: 4628548

Right_end: 4628854

Centisome: 99.72

Genomic Address
Counterclockwise
Minute or Centisome (%) = 99.72
Right End: 4630522
Right Intergenic Region

Name: ettA_slt

Length: 210 bp gap

Orientation: Divergent

Left_end: 4630523

Right_end: 4630732

Centisome: 99.76

EttA is an energy-dependent translational throttle that gates ribosome entry into the elongation cycle, sensitive to ATP/ADP ratio because the ATP-bound form of EttA binds to the ribosomal tRNA-exit site and restricts ribosomal and tRNA movements, inhibiting protein synthesis; EttA is a procaryotic ABC-F family member defined by two ABC transporter-related predicted ATP-binding domains (Pfam:PF0005) joined by a linker domain with a P-site tRNA-interaction motif (PtIM) (Pfam: PF12848); an ettA mutation impairs fitness in long-term stationary phase; other ABC-F family members include eucaryotic translation-related factors and the E. coli K-12 proteins Uup, YbiT, and YheS (Boël, 2014; Chen, 2014). Low abundance protein.

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BamHI EcoRI HindIII