GenePage for the rseP gene of Escherichia coli K-12

Primary Gene Name: rseP
EcoGene Accession Number: EG12436
K-12 Gene Accession Number: ECK0175
MG1655 Gene Identifier: b0176
Gene Name Mnemonic: Regulator of sigma E, protease; involved in cleaved signal peptide degradation
Alternate Gene Symbols: ecfE; yaeL
Description: Inner membrane zinc RIP metalloprotease; activates RpoE by degrading RseA; multicopy rpoE suppresses rseP mutation
  # bp Upstream # bp Downstream
MW: 49071.32 ---------450 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 196546
Left Intergenic Region

Name: cdsA_rseP

Length: 11 bp gap

Orientation: Codirectional+

Left_end: 196535

Right_end: 196545

Centisome: 4.23

Genomic Address
Clockwise
Minute or Centisome (%) = 4.23
Right End: 197898
Right Intergenic Region

Name: rseP_bamA

Length: 29 bp gap

Orientation: Codirectional+

Left_end: 197899

Right_end: 197927

Centisome: 4.26

RseP is involved in cleaved signal peptide degradation (Saito, 2011). RpoE regulon. RseP activates RpoE and releases membrane-bound RseA-RpoE complexes. Cleavage occurs around RseA membrane domain generating the N-terminal and the soluable product. rseP is an essential gene, but deletion of ompCF or ompCA (or an sRNA rseX clone, which suppresses ompCA translation) allows growth. RseP or some other protease degrades RseA in the released complexes. The RseA periplasmic domain must be first clipped or degraded by DegS before it is a substrate for RseP. RseP is related to the E. faecalis Eep protein involved in bacterial regulated intramembrane proteolysis (RIP). RseP has been topology mapped using protein fusions. RseP is reported to degrade RpoE and RpoH in vitro and to be an negative, not positive, effector of RpoE action in vivo, but the physiological relevance and/or accuracy of this has subsequently been strongly challenged (Dartigalongue, 2001).

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BamHI EcoRI HindIII